AR068657A1 - Derivados de piperidina y piperazina - Google Patents
Derivados de piperidina y piperazinaInfo
- Publication number
- AR068657A1 AR068657A1 ARP080104328A ARP080104328A AR068657A1 AR 068657 A1 AR068657 A1 AR 068657A1 AR P080104328 A ARP080104328 A AR P080104328A AR P080104328 A ARP080104328 A AR P080104328A AR 068657 A1 AR068657 A1 AR 068657A1
- Authority
- AR
- Argentina
- Prior art keywords
- nnr2
- atoms
- hal
- nhet
- mono
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la formula (1), en donde R1 es un heterociclo insaturado o aromático bicíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con A, Hal, NR2, (CR2)nCN, OR5 y/u =O (oxígeno del carbonilo); D es C o S; G es N o C, en caso de que G = N, R2 está ausente; en caso de que G = O, R2 es H o Ar1 o también junto con el átomo de C al que está unido el R2 y con E-W un radical espirocíclico seleccionado del grupo de formulas (2); Q es alquileno no ramificado o ramificado con 1, 2, 3 o 4 átomos de C, en donde 1-5 átomos de H pueden estar reemplazados por A, (CR2)n[X(CR2)n]p-Y, F y/o Cl; R3 es H, A, Ar, OR, SR, NR2, Hal, No2, CN, o (CR2)n[X(CR2)n]p-Y; X es O, NR o CR2; Y es OR o NR2; R5 es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por F y/o Cl; E es COO(CR2)n, COO(CRR4), CO(CR2)mO, CONH(CR2)n, C(=S)NH(CR2)n, S(O)qNH(CR2)n, S(O)q(CR2)n, CO(CR2)n, (CR2)n, CO(CR2)mO(CR2)n, CO(CR2)mNH(CR2)n, CO(CH2)nCO, COCHR6CHR7, C(=S)O(CR2)n, CO(CRR4)(CR2)n, COO(CRR4), (CRR4)(CR2)n, S(O)qCR=CR, COCR=CR, (CR2)mCO, CONH(CR2)mCRR4 O (CR2)mCONR; R4 es COOR5, Ar1, (CR2)nNR2, OH, NRCOOR8 o NRCOOA; R6, R7 son juntos (CH2)1-4; R8 es fenilo, naftilo o fluorenilo; R es H o alquilo no ramificado o ramificado con 1, 2, 3, 4, 5 o 6 átomos de carbono; W es Ar o Het; Ar es fenilo, indanilo, naftilo o bifenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, A, (CR2)nOR, O(CR2)n, Ar1, (CR2)nNR2, SR, No2, CN, COOR, CONR2, NRCOA, NRSo2A, So2NR2, S(O)qA, CO-Het, (CR2)nHet, O(CR2)nNR2, O(CR2)nHet, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet, CR5=CR5Ar1, So2Het, NHCONH(CR2)nNR2, NHCONH(CR2)nHet, OCONH(CR2)nNR2, OCONH(CR2)nHet, CONR(CR2)nNR2, CONR(CR2)nHet y/o COA; Het es un heterociclo saturado, insaturado o aromático mono-, di- o tricíclico con 1 a 4 átomos de N, O y/o S, que puede no estar sustituido o que puede estar mono-, di- o trisustituido con Hal, A, (CR2)nAr1, O(CR2)nAr1, (CR2)nOR, (CR2)nNR2, SR, No2, CN, COOR, CONR2, NRCOA, NRSo2A, So2NR2, S(O)qA, CO-Het1, (CR2)nHet1, O(CR2)nNR2, O(CR2)nHet1, NHCOOA, NHCONR2, NHCOO(CR2)nNR2, NHCOO(CR2)nHet1, NHCONH(CR2)nNR2, NHCONH(CR2)nHet1, OCONH(CR2)nNR2, OCONH(CR2)nHet1, CO-Het1, CHO, COA, =S, =NH, =NA y/u =O (oxígeno del carbonilo); Het1 es un heterociclo saturado monocíclico con 1 a 2 N y/o átomos de O, que puede estar mono- o disustituido con A, OA, OH, Hal y/u =O (oxígeno del carbonilo); Ar1 es fenilo no sustituido o mono-, di-, tri-, tetra- o pentasustituido con Hal, CN, A y/o (CR2)nOR; A es alquilo no ramificado o ramificado con 1-10 átomos de C, en donde 1-7 átomos de H pueden estar reemplazados por OR, CN, NR2, F y/o Cl y/o en donde uno o dos grupos CH2 no adyacentes pueden estar reemplazados por O, NH, s, so, so2 y/o por grupos CH=CH, o alquilo cíclico con 3-7 átomos de C; m es 1, 2, 3, 4, 5 o 6; n es 0, 1, 2, 3, 4, 5, 6, 7 u 8; p es 1, 2, 3, 4, 5 o 6; q es 0, 1 o 2; Hal es F, Cl, Br o l; así como sus tautomeros, sales y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones, se pueden utilizar para el tratamiento de tumores. Medicamento en base al compuesto (y uso de este para preparar los medicamentos) y procedimiento de preparacion del compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007047737A DE102007047737A1 (de) | 2007-10-05 | 2007-10-05 | Piperidin- und Piperazinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR068657A1 true AR068657A1 (es) | 2009-11-25 |
Family
ID=40089983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104328A AR068657A1 (es) | 2007-10-05 | 2008-10-03 | Derivados de piperidina y piperazina |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US8791111B2 (es) |
| EP (2) | EP2426106B1 (es) |
| JP (2) | JP5597538B2 (es) |
| KR (1) | KR20100075601A (es) |
| CN (1) | CN101808988A (es) |
| AR (1) | AR068657A1 (es) |
| AU (1) | AU2008310067B2 (es) |
| BR (1) | BRPI0817644A2 (es) |
| CA (1) | CA2701519C (es) |
| CY (2) | CY1113757T1 (es) |
| DE (1) | DE102007047737A1 (es) |
| DK (2) | DK2426106T3 (es) |
| EA (1) | EA017787B1 (es) |
| ES (2) | ES2392475T3 (es) |
| HR (2) | HRP20120802T1 (es) |
| IL (1) | IL204562A0 (es) |
| MX (1) | MX2010003366A (es) |
| PL (2) | PL2426106T3 (es) |
| PT (2) | PT2193118E (es) |
| SI (2) | SI2193118T1 (es) |
| WO (1) | WO2009046841A2 (es) |
| ZA (1) | ZA201003124B (es) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007047737A1 (de) * | 2007-10-05 | 2009-04-30 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| US8841324B2 (en) * | 2009-04-02 | 2014-09-23 | Merck Patent Gmbh | Heterocyclic compounds as autotaxin inhibitors |
| DE102009049211A1 (de) | 2009-10-13 | 2011-04-28 | Merck Patent Gmbh | Sulfoxide |
| EP2687531B1 (en) | 2011-03-18 | 2016-07-13 | ONO Pharmaceutical Co., Ltd. | Tetrahydrocarboline derivative |
| US8828874B2 (en) * | 2011-03-28 | 2014-09-09 | Sinmat, Inc. | Chemical mechanical polishing of group III-nitride surfaces |
| WO2013061297A1 (en) * | 2011-10-28 | 2013-05-02 | Pfizer Limited | Pyridazine Derivatives Useful in Therapy |
| WO2013070879A1 (en) | 2011-11-10 | 2013-05-16 | Bristol-Myers Squibb Company | Methods for treating spinal cord injury with lpa receptor antagonists |
| EP4190777A1 (en) * | 2012-04-13 | 2023-06-07 | Epizyme, Inc. | Hbr salt form for ezh2 inhibition |
| NZ702334A (en) * | 2012-06-13 | 2016-11-25 | Hoffmann La Roche | New diazaspirocycloalkane and azaspirocycloalkane |
| DK2900669T3 (da) * | 2012-09-25 | 2019-11-04 | Hoffmann La Roche | Hexahydropyrrolo[3,4-C]pyrrolderivater og relaterede forbindelser som autotaxin (ATX)-inhibitorer og som inhibitorer af lysophosphatidsyre (LPA)-produktion til behandling af f.eks. nyresygdomme |
| US9409895B2 (en) | 2012-12-19 | 2016-08-09 | Novartis Ag | Autotaxin inhibitors |
| US20140171404A1 (en) | 2012-12-19 | 2014-06-19 | Novartis Ag | Autotaxin inhibitors |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| EP3046909A4 (en) | 2013-09-17 | 2017-03-29 | Pharmakea, Inc. | Heterocyclic vinyl autotaxin inhibitor compounds |
| JP2016530209A (ja) | 2013-09-17 | 2016-09-29 | ファーマケア，インク． | ビニルオートタキシン阻害剤化合物 |
| WO2015048301A1 (en) | 2013-09-26 | 2015-04-02 | Pharmakea, Inc. | Autotaxin inhibitor compounds |
| CN104557739B (zh) * | 2013-10-25 | 2016-11-09 | 山东先达农化股份有限公司 | 三酮类化合物及其制备方法和应用 |
| CN105764903B (zh) | 2013-11-22 | 2018-09-18 | 法玛克亚公司 | 四环自分泌运动因子抑制剂 |
| SI3071561T1 (sl) | 2013-11-22 | 2021-11-30 | Sabre Therapeutics Llc | Spojine, ki inhibirajo avtotaksin |
| WO2015078803A1 (en) | 2013-11-26 | 2015-06-04 | F. Hoffmann-La Roche Ag | NEW OCTAHYDRO-CYCLOBUTA [1,2-c;3,4-c']DIPYRROL-2-YL |
| JP6554481B2 (ja) | 2014-03-26 | 2019-07-31 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物 |
| AU2015238537B2 (en) | 2014-03-26 | 2019-08-01 | F. Hoffmann-La Roche Ag | Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors |
| US9783522B2 (en) | 2014-04-24 | 2017-10-10 | Mitsubishi Tanabe Pharma Corporation | 2-amino-pyridine and 2-amino-pyrimidine derivatives and medicinal use thereof |
| WO2015162558A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Autotaxin inhibitors |
| US9051320B1 (en) | 2014-08-18 | 2015-06-09 | Pharmakea, Inc. | Methods for the treatment of metabolic disorders by a selective small molecule autotaxin inhibitor |
| GB201501870D0 (en) | 2015-02-04 | 2015-03-18 | Cancer Rec Tech Ltd | Autotaxin inhibitors |
| GB201502020D0 (en) | 2015-02-06 | 2015-03-25 | Cancer Rec Tech Ltd | Autotaxin inhibitory compounds |
| CN104758286B (zh) * | 2015-03-05 | 2016-09-14 | 南京工业大学 | 1-苄基-4-(2,4-二氯苯乙胺基)哌啶在制备抗肿瘤药物中的应用 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| IL280863B1 (en) | 2015-05-27 | 2024-03-01 | Sabre Therapeutics Llc | Ototaxin inhibitors and their uses |
| CA2988306A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
| RU2746481C1 (ru) | 2015-09-04 | 2021-04-14 | Ф. Хоффманн-Ля Рош Аг | Феноксиметильные производные |
| MX2018002217A (es) | 2015-09-24 | 2018-03-23 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores de autotaxina (atx). |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| RU2018112230A (ru) | 2015-09-24 | 2019-10-30 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов atx |
| RU2725138C2 (ru) | 2015-09-24 | 2020-06-30 | Ф. Хоффманн-Ля Рош Аг | Новые бициклические соединения в качестве двойных ингибиторов аутотаксина (atx)/карбоангидразы (ca) |
| WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
| WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
| WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
| JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ．ホフマン－ラ ロシュ アーゲー | Ａｔｘインヒビターとしての新規二環式化合物 |
| WO2018167001A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | Heterocyclic compounds useful as dual atx/ca inhibitors |
| US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
| KR101798840B1 (ko) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물 |
| CN107266356B (zh) * | 2017-07-25 | 2020-06-26 | 山西省生物研究院有限公司 | 一种作为自分泌运动因子抑制剂的咔唑类化合物及其制备方法和应用 |
| SG11202012524YA (en) | 2018-07-27 | 2021-01-28 | Mitsubishi Tanabe Pharma Corp | Novel 3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same |
| CN112028903A (zh) * | 2020-01-17 | 2020-12-04 | 平顶山学院 | 四氢萘并呋喃酮螺吡咯烷酮化合物及其制备方法 |
| CN113461640B (zh) * | 2021-06-17 | 2023-08-11 | 中央民族大学 | Lpar1抑制剂、医药用途及其制备方法 |
| WO2023046727A1 (en) * | 2021-09-21 | 2023-03-30 | Westfaelische Wilhelms-Universitaet Muenster | Autotaxin-inhibitors |
| CN114378108B (zh) * | 2022-03-24 | 2022-07-22 | 神美科技有限公司 | 一种重金属螯合剂及其在去除生活垃圾中重金属中的用途 |
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| CA2381630A1 (en) | 2001-04-23 | 2002-10-23 | Leonard Theodore Meltzer | Method for preventing dyskinesias |
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| EP1736474A4 (en) | 2004-04-07 | 2010-04-21 | Kyowa Hakko Kirin Co Ltd | piperidine |
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| TWI415845B (zh) * | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
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-
2007
- 2007-10-05 DE DE102007047737A patent/DE102007047737A1/de not_active Withdrawn
-
2008
- 2008-09-19 EP EP11007349.1A patent/EP2426106B1/de not_active Not-in-force
- 2008-09-19 KR KR1020107009776A patent/KR20100075601A/ko not_active Application Discontinuation
- 2008-09-19 EA EA201000549A patent/EA017787B1/ru not_active IP Right Cessation
- 2008-09-19 PT PT08802402T patent/PT2193118E/pt unknown
- 2008-09-19 BR BRPI0817644 patent/BRPI0817644A2/pt not_active IP Right Cessation
- 2008-09-19 US US12/681,440 patent/US8791111B2/en not_active Expired - Fee Related
- 2008-09-19 CA CA2701519A patent/CA2701519C/en not_active Expired - Fee Related
- 2008-09-19 CN CN200880109583A patent/CN101808988A/zh active Pending
- 2008-09-19 SI SI200830792T patent/SI2193118T1/sl unknown
- 2008-09-19 PL PL11007349T patent/PL2426106T3/pl unknown
- 2008-09-19 MX MX2010003366A patent/MX2010003366A/es not_active Application Discontinuation
- 2008-09-19 PL PL08802402T patent/PL2193118T3/pl unknown
- 2008-09-19 PT PT110073491T patent/PT2426106E/pt unknown
- 2008-09-19 EP EP08802402A patent/EP2193118B1/de not_active Not-in-force
- 2008-09-19 DK DK11007349.1T patent/DK2426106T3/da active
- 2008-09-19 ES ES08802402T patent/ES2392475T3/es active Active
- 2008-09-19 ES ES11007349T patent/ES2429843T3/es active Active
- 2008-09-19 AU AU2008310067A patent/AU2008310067B2/en not_active Ceased
- 2008-09-19 SI SI200831052T patent/SI2426106T1/sl unknown
- 2008-09-19 WO PCT/EP2008/007893 patent/WO2009046841A2/de active Application Filing
- 2008-09-19 DK DK08802402.1T patent/DK2193118T3/da active
- 2008-09-19 JP JP2010527349A patent/JP5597538B2/ja not_active Expired - Fee Related
- 2008-10-03 AR ARP080104328A patent/AR068657A1/es unknown
-
2010
- 2010-03-16 IL IL204562A patent/IL204562A0/en active IP Right Grant
- 2010-05-04 ZA ZA2010/03124A patent/ZA201003124B/en unknown
-
2012
- 2012-08-22 US US13/591,765 patent/US8754097B2/en not_active Expired - Fee Related
- 2012-10-05 HR HRP20120802AT patent/HRP20120802T1/hr unknown
- 2012-10-17 CY CY20121100967T patent/CY1113757T1/el unknown
-
2013
- 2013-10-03 HR HRP20130929AT patent/HRP20130929T1/hr unknown
- 2013-10-25 CY CY20131100944T patent/CY1114574T1/el unknown
-
2014
- 2014-04-09 JP JP2014079895A patent/JP5847226B2/ja not_active Expired - Fee Related
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