AR056519A1 - 4-feniltetrahidroisoquinolinas sustituidas, composiciones farmaceuticas que las contienen y usos terapeuticos en trastornos renales, respiratorios y otros - Google Patents
4-feniltetrahidroisoquinolinas sustituidas, composiciones farmaceuticas que las contienen y usos terapeuticos en trastornos renales, respiratorios y otrosInfo
- Publication number
- AR056519A1 AR056519A1 ARP060104073A ARP060104073A AR056519A1 AR 056519 A1 AR056519 A1 AR 056519A1 AR P060104073 A ARP060104073 A AR P060104073A AR P060104073 A ARP060104073 A AR P060104073A AR 056519 A1 AR056519 A1 AR 056519A1
- Authority
- AR
- Argentina
- Prior art keywords
- carbon atoms
- hydrogen
- zero
- alkyl
- phenylthethrahyrochinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Reivindicacion 1: Un compuesto de formula (1), en donde: R1, R2, R3 y R4, son cada uno, de manera independiente, hidrogeno, F, Cl, Br, I, CN, NO2 o R11-(CmH2m)-An-; m es cero, 1, 2, 3 o 4; n es cero o 1; R11 es hidrogeno, metilo o CpF2p+1; A es oxígeno, NH, N(CH3) o S(O)q; p es 1, 2 o 3; q es cero, 1 o 2; R5 es hidrogeno, alquilo con 1, 2, 3, 4, 5 o 5 átomos de carbono o cicloalquilo con 3, 4, 5, o 6 átomos de carbono; R6 es hidrogeno, OH, F, CF3, alquilo con 1, 2, 3, o 4 átomos de carbono o cicloalquilo con 3, 4, 5 o 6 átomos de carbono; R7 y R8, son cada uno, de manera independiente, hidrogeno, F, Cl, Br, CN, CO2R12, NR13R14 o R16-(CmmH2mm)-Enn-; R12 es hidrogeno, alquilo con 1, 2, 3 o 4 átomos de carbono o cicloaquilo con 3, 4, 5, o 6 átomos de carbono; R13 y R14, son cada uno, de manera independiente, hidrogeno, alquilo con 1, 2, 3 o 4 átomos de carbono o cicloalquilo con 3, 4, 5 o 6 átomos de carbono; o R13 y R14, con el átomo de nitrogeno al que están unidos, forman un anillo de 4, 5, 6 o 7 miembros, en donde un grupo CH2 puede estar reemplazando por NR15, S u oxígeno; R15 es hidrogeno, alquilo con 1, 2, 3, o 4 átomos de carbono o cicloalquilo con 3, 4, 5 o 6 átomos de carbono; mm es cero, 1, 2, 3 o 4; nn es cero o 1; R16 es hidrogeno, metilo o CppF2pp+1; E es oxígeno o S(O)qq; pp es 1, 2 o 3; qq es cero, 1 o 2; y también sus sales y trifluoroacetatos farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005044817A DE102005044817A1 (de) | 2005-09-20 | 2005-09-20 | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056519A1 true AR056519A1 (es) | 2007-10-10 |
Family
ID=37595895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104073A AR056519A1 (es) | 2005-09-20 | 2006-09-18 | 4-feniltetrahidroisoquinolinas sustituidas, composiciones farmaceuticas que las contienen y usos terapeuticos en trastornos renales, respiratorios y otros |
Country Status (18)
Country | Link |
---|---|
US (1) | US8455515B2 (es) |
EP (1) | EP1928836B1 (es) |
JP (1) | JP5231229B2 (es) |
KR (1) | KR101462060B1 (es) |
CN (1) | CN101268054B (es) |
AR (1) | AR056519A1 (es) |
AU (1) | AU2006294136B2 (es) |
BR (1) | BRPI0616316A2 (es) |
CA (1) | CA2623462C (es) |
DE (1) | DE102005044817A1 (es) |
ES (1) | ES2550141T3 (es) |
HK (1) | HK1124321A1 (es) |
IL (1) | IL189914A (es) |
MX (1) | MX2008003014A (es) |
MY (1) | MY150702A (es) |
PL (1) | PL1928836T3 (es) |
TW (1) | TWI401247B (es) |
WO (1) | WO2007033773A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005044815A1 (de) * | 2005-09-20 | 2007-03-22 | Sanofi-Aventis Deutschland Gmbh | Verwendung von Inhibitoren des Na+/H+ Austauschers, Subtyp 5 (NHE5) zur Gedächtnisverbesserung |
DE102006012544A1 (de) * | 2006-03-18 | 2007-09-27 | Sanofi-Aventis | Substituierte 1-Amino 4-phenyl-dihydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
FR2921935B1 (fr) * | 2007-10-05 | 2011-10-28 | Centre Nat Rech Scient | Procede de criblage de composes utilisables pour le traitement de troubles respiratoires |
WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
KR101766619B1 (ko) | 2008-12-31 | 2017-08-08 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료 시에 nhe-매개된 역수송을 억제하는 화합물 및 방법 |
US10543207B2 (en) * | 2008-12-31 | 2020-01-28 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
KR102138390B1 (ko) | 2012-08-21 | 2020-07-27 | 알데릭스, 인코포레이티드 | 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 nhe-매개된 역수송 저해를 위한 화합물 및 방법 |
US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
EP2983667B1 (en) | 2013-04-12 | 2019-03-20 | Ardelyx, Inc. | Nhe3-binding compounds and methods for inhibiting phosphate transport |
CN106536502B (zh) * | 2014-07-25 | 2019-03-05 | 大正制药株式会社 | 被杂芳基取代的苯基四氢异喹啉化合物 |
EP3337497B1 (en) | 2015-08-21 | 2023-07-12 | SRX Cardio, LLC | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity |
WO2017034990A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate pcsk9 protein activity |
WO2017034997A1 (en) | 2015-08-21 | 2017-03-02 | Portola Pharmaceuticals, Inc. | Phenylpiperazine proprotein convertase subtilisin/kexin type 9 (pcsk9) modulators and their use |
US20180318324A1 (en) | 2015-11-04 | 2018-11-08 | Prescient Pharma Llc | Anti-aging compositions and methods for using same |
WO2017147328A1 (en) | 2016-02-23 | 2017-08-31 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
WO2018129552A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
AU2018206479B2 (en) | 2017-01-09 | 2022-07-14 | Ardelyx, Inc. | Inhibitors of NHE-mediated antiport |
WO2019060051A1 (en) | 2017-08-04 | 2019-03-28 | Ardelyx, Inc. | GLYCYRRHETINIC ACID DERIVATIVES FOR THE TREATMENT OF HYPERKALIEMIA |
WO2020163642A1 (en) | 2019-02-07 | 2020-08-13 | Ardelyx, Inc. | Glycyrrhetinic acid derivatives for use in treating hyperkalemia |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2111138A1 (en) * | 1993-01-15 | 1994-07-16 | Thierry Godel | Octahydrophenanthrene derivatives |
CA2404910C (en) * | 2000-03-30 | 2009-10-13 | British Telecommunications Public Limited Company | Data networks |
DE10019062A1 (de) * | 2000-04-18 | 2001-10-25 | Merck Patent Gmbh | 2-Guanidino-4-aryl-chinazoline als NHE-3 Inhibitoren |
MXPA04005343A (es) * | 2001-12-05 | 2004-09-27 | Aventis Pharma Gmbh | 4-fenil-tetrahidro-isoquinolinas sustituidas, procedimiento para su preparacion, su uso como medicamento, y medicamento que las contiene. |
DE10163914A1 (de) * | 2001-12-22 | 2003-07-03 | Aventis Pharma Gmbh | Substituierte 4-Phenyltetrahydroisochinolinium-Salze, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
DK2301544T3 (da) | 2002-07-25 | 2013-01-02 | Janssen Pharmaceutica Nv | Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer |
DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
US7241775B2 (en) * | 2003-03-24 | 2007-07-10 | Sanofi-Aventis Deutschland Gmbh | Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines |
DE102004046492A1 (de) * | 2004-09-23 | 2006-03-30 | Sanofi-Aventis Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
-
2005
- 2005-09-20 DE DE102005044817A patent/DE102005044817A1/de not_active Withdrawn
-
2006
- 2006-09-08 CN CN2006800346094A patent/CN101268054B/zh not_active Expired - Fee Related
- 2006-09-08 MX MX2008003014A patent/MX2008003014A/es active IP Right Grant
- 2006-09-08 KR KR1020087006830A patent/KR101462060B1/ko not_active IP Right Cessation
- 2006-09-08 JP JP2008531569A patent/JP5231229B2/ja not_active Expired - Fee Related
- 2006-09-08 AU AU2006294136A patent/AU2006294136B2/en not_active Ceased
- 2006-09-08 PL PL06805671T patent/PL1928836T3/pl unknown
- 2006-09-08 EP EP06805671.2A patent/EP1928836B1/de not_active Not-in-force
- 2006-09-08 ES ES06805671.2T patent/ES2550141T3/es active Active
- 2006-09-08 CA CA2623462A patent/CA2623462C/en not_active Expired - Fee Related
- 2006-09-08 WO PCT/EP2006/008770 patent/WO2007033773A1/de active Application Filing
- 2006-09-08 MY MYPI20080496 patent/MY150702A/en unknown
- 2006-09-08 BR BRPI0616316-5A patent/BRPI0616316A2/pt not_active IP Right Cessation
- 2006-09-18 AR ARP060104073A patent/AR056519A1/es not_active Application Discontinuation
- 2006-09-18 TW TW095134388A patent/TWI401247B/zh not_active IP Right Cessation
-
2008
- 2008-03-04 IL IL189914A patent/IL189914A/en not_active IP Right Cessation
- 2008-03-12 US US12/046,928 patent/US8455515B2/en not_active Expired - Fee Related
-
2009
- 2009-02-24 HK HK09101735.9A patent/HK1124321A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU2006294136A1 (en) | 2007-03-29 |
IL189914A0 (en) | 2008-08-07 |
PL1928836T3 (pl) | 2015-12-31 |
US8455515B2 (en) | 2013-06-04 |
WO2007033773A1 (de) | 2007-03-29 |
CN101268054A (zh) | 2008-09-17 |
TWI401247B (zh) | 2013-07-11 |
KR101462060B1 (ko) | 2014-11-17 |
BRPI0616316A2 (pt) | 2011-06-14 |
DE102005044817A1 (de) | 2007-03-22 |
IL189914A (en) | 2013-08-29 |
TW200806630A (en) | 2008-02-01 |
CN101268054B (zh) | 2012-08-22 |
ES2550141T3 (es) | 2015-11-04 |
CA2623462A1 (en) | 2007-03-29 |
JP5231229B2 (ja) | 2013-07-10 |
KR20080046675A (ko) | 2008-05-27 |
MY150702A (en) | 2014-02-28 |
EP1928836B1 (de) | 2015-07-15 |
HK1124321A1 (en) | 2009-07-10 |
CA2623462C (en) | 2014-08-19 |
EP1928836A1 (de) | 2008-06-11 |
US20080194621A1 (en) | 2008-08-14 |
AU2006294136B2 (en) | 2012-07-05 |
JP2009508889A (ja) | 2009-03-05 |
MX2008003014A (es) | 2008-03-24 |
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