DK0709384T3 - Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder - Google Patents

Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder

Info

Publication number
DK0709384T3
DK0709384T3 DK95116458T DK95116458T DK0709384T3 DK 0709384 T3 DK0709384 T3 DK 0709384T3 DK 95116458 T DK95116458 T DK 95116458T DK 95116458 T DK95116458 T DK 95116458T DK 0709384 T3 DK0709384 T3 DK 0709384T3
Authority
DK
Denmark
Prior art keywords
amino acid
binding sites
high affinity
receptor binding
acid receptor
Prior art date
Application number
DK95116458T
Other languages
English (en)
Inventor
Rudolf Gottschlich
Helmut Pruecher
Joachim Leibrock
Harry Schwartz
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4438810A external-priority patent/DE4438810A1/de
Priority claimed from DE1995126269 external-priority patent/DE19526269A1/de
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of DK0709384T3 publication Critical patent/DK0709384T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK95116458T 1994-10-31 1995-10-19 Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder DK0709384T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4438810A DE4438810A1 (de) 1994-10-31 1994-10-31 Benzylpiperidinderivate
DE1995126269 DE19526269A1 (de) 1995-07-19 1995-07-19 Benzylpiperidinderivate

Publications (1)

Publication Number Publication Date
DK0709384T3 true DK0709384T3 (da) 1999-08-23

Family

ID=25941544

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95116458T DK0709384T3 (da) 1994-10-31 1995-10-19 Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder

Country Status (23)

Country Link
US (1) US5698553A (da)
EP (1) EP0709384B1 (da)
JP (1) JPH08225569A (da)
KR (1) KR100388593B1 (da)
CN (1) CN1064358C (da)
AT (1) ATE174915T1 (da)
AU (1) AU703487B2 (da)
BR (1) BR9505008A (da)
CA (1) CA2161618A1 (da)
CZ (1) CZ288039B6 (da)
DE (1) DE59504622D1 (da)
DK (1) DK0709384T3 (da)
ES (1) ES2128629T3 (da)
FI (1) FI955184A (da)
GR (1) GR3029771T3 (da)
HU (1) HUT76068A (da)
NO (1) NO310023B1 (da)
PL (1) PL182210B1 (da)
RU (1) RU2160259C2 (da)
SK (1) SK282476B6 (da)
TR (1) TR199501331A2 (da)
TW (1) TW394770B (da)
UA (1) UA41927C2 (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59504622D1 (de) * 1994-10-31 1999-02-04 Merck Patent Gmbh Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
DE19643790A1 (de) * 1996-10-30 1998-05-07 Merck Patent Gmbh Benzoxazol-Derivat
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
CA2282390A1 (en) * 1997-04-17 1998-10-22 Yukio Fujisawa Thermogenic composition and benzazepine thermogenics
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
US6130235A (en) * 1998-05-22 2000-10-10 Scios Inc. Compounds and methods to treat cardiac failure and other disorders
WO1999061426A1 (en) * 1998-05-22 1999-12-02 Scios Inc. Heterocyclic compounds and methods to treat cardiac failure and other disorders
US6448257B1 (en) 1998-05-22 2002-09-10 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6340685B1 (en) 1998-05-22 2002-01-22 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6589954B1 (en) 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
US6867209B1 (en) 1998-05-22 2005-03-15 Scios, Inc. Indole-type derivatives as inhibitors of p38 kinase
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
IL146309A (en) 1999-05-21 2008-03-20 Scios Inc Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
JPWO2003035641A1 (ja) * 2001-10-22 2005-02-10 塩野義製薬株式会社 新規カルバモイルピロリドン誘導体
DE10210779A1 (de) * 2002-03-12 2003-10-09 Merck Patent Gmbh Cyclische Amide
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
WO2003104844A1 (en) * 2002-06-11 2003-12-18 The Regents Of The University Of California Method and system for seafloor geological survey using vertical electric field measurement
EP1736474A4 (en) * 2004-04-07 2010-04-21 Kyowa Hakko Kirin Co Ltd piperidine
SG163545A1 (en) * 2007-01-03 2010-08-30 Servier Lab 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses
DE102007047737A1 (de) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
TWI410420B (zh) * 2008-02-05 2013-10-01 Dainippon Sumitomo Pharma Co 苄基哌啶化合物
CA2769977A1 (en) 2009-08-04 2011-02-10 Dainippon Sumitomo Pharma Co., Ltd. Benzylpiperidine compound
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
US20130270486A1 (en) * 2010-12-21 2013-10-17 Sumitomo Chemical Company, Limited Polymer compound and light-emitting device using same
WO2012086668A1 (ja) * 2010-12-21 2012-06-28 住友化学株式会社 高分子化合物及びそれを用いた発光素子
KR102277538B1 (ko) * 2015-06-08 2021-07-14 주식회사 대웅제약 신규한 헤테로 고리 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물
AR110963A1 (es) 2017-02-07 2019-05-22 Dae Woong Pharma Compuestos heterocíclicos, su método de preparación y composición farmacéutica que los comprende

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.
JPS57142972A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
JPH0753913B2 (ja) * 1990-11-14 1995-06-07 新日本製鐵株式会社 有機複合めっき鋼板の製造方法
US5338361A (en) * 1991-11-04 1994-08-16 Measurex Corporation Multiple coat measurement and control apparatus and method
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
DE59504622D1 (de) * 1994-10-31 1999-02-04 Merck Patent Gmbh Benzylpiperidinderivate mit hoher Affinität zu Bindungsstellen von Aminosäure-Rezeptoren

Also Published As

Publication number Publication date
TW394770B (en) 2000-06-21
FI955184A0 (fi) 1995-10-30
CZ281695A3 (en) 1996-05-15
EP0709384B1 (de) 1998-12-23
TR199501331A2 (tr) 1996-06-21
ES2128629T3 (es) 1999-05-16
NO954349L (no) 1996-05-02
UA41927C2 (uk) 2001-10-15
NO954349D0 (no) 1995-10-30
GR3029771T3 (en) 1999-06-30
AU703487B2 (en) 1999-03-25
FI955184A (fi) 1996-05-01
KR960014119A (ko) 1996-05-22
US5698553A (en) 1997-12-16
JPH08225569A (ja) 1996-09-03
KR100388593B1 (ko) 2003-09-19
CN1064358C (zh) 2001-04-11
BR9505008A (pt) 1997-10-14
SK282476B6 (sk) 2002-02-05
CZ288039B6 (cs) 2001-04-11
HU9503101D0 (en) 1995-12-28
CN1128762A (zh) 1996-08-14
EP0709384A1 (de) 1996-05-01
PL311185A1 (en) 1996-05-13
ATE174915T1 (de) 1999-01-15
NO310023B1 (no) 2001-05-07
HUT76068A (en) 1997-06-30
CA2161618A1 (en) 1996-05-01
SK135595A3 (en) 1996-06-05
AU3443595A (en) 1996-05-09
RU2160259C2 (ru) 2000-12-10
PL182210B1 (pl) 2001-11-30
DE59504622D1 (de) 1999-02-04

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