ECSP099662A - Nuevos Derivados de 3-([1,2,4]triazolo[4,3-a]piridin-7-il)benzamida - Google Patents
Nuevos Derivados de 3-([1,2,4]triazolo[4,3-a]piridin-7-il)benzamidaInfo
- Publication number
- ECSP099662A ECSP099662A EC2009009662A ECSP099662A ECSP099662A EC SP099662 A ECSP099662 A EC SP099662A EC 2009009662 A EC2009009662 A EC 2009009662A EC SP099662 A ECSP099662 A EC SP099662A EC SP099662 A ECSP099662 A EC SP099662A
- Authority
- EC
- Ecuador
- Prior art keywords
- triazolo
- benzamide
- pyridin
- new derivatives
- mitogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Esta invención se refiere a nuevos inhibidores de la proteína quinasa p38 activada por mitógenos que tienen la fórmula general (I) (I)a procedimientos para su preparación; a composiciones farmacéuticas que los contienen; y a su uso en terapia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200700565A ES2320955B1 (es) | 2007-03-02 | 2007-03-02 | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP099662A true ECSP099662A (es) | 2009-10-30 |
Family
ID=38610969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2009009662A ECSP099662A (es) | 2007-03-02 | 2009-09-29 | Nuevos Derivados de 3-([1,2,4]triazolo[4,3-a]piridin-7-il)benzamida |
Country Status (19)
Country | Link |
---|---|
US (1) | US8258122B2 (es) |
EP (1) | EP2118100A1 (es) |
JP (1) | JP5318785B2 (es) |
KR (1) | KR20090115978A (es) |
CN (1) | CN101679413B (es) |
AR (1) | AR065556A1 (es) |
AU (1) | AU2008224179A1 (es) |
CA (1) | CA2682756A1 (es) |
CL (1) | CL2008000612A1 (es) |
CO (1) | CO6220952A2 (es) |
EC (1) | ECSP099662A (es) |
ES (1) | ES2320955B1 (es) |
NZ (1) | NZ579917A (es) |
PE (1) | PE20081800A1 (es) |
RU (1) | RU2009136299A (es) |
TW (1) | TW200900062A (es) |
UY (1) | UY30942A1 (es) |
WO (1) | WO2008107125A1 (es) |
ZA (1) | ZA200906736B (es) |
Families Citing this family (38)
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GB0420722D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
ES2301380B1 (es) | 2006-08-09 | 2009-06-08 | Laboratorios Almirall S.A. | Nuevos derivados de 1,7-naftiridina. |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
KR20100065191A (ko) | 2007-09-14 | 2010-06-15 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 1,3-이치환된 4-(아릴-x-페닐)-1h-피리딘-2-온 |
CN101801951B (zh) | 2007-09-14 | 2013-11-13 | 杨森制药有限公司 | 1’,3’-二取代的-4-苯基-3,4,5,6-四氢-2h,1’h-[1,4’]二吡啶-2’-酮 |
TW200927731A (en) | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
ES2637794T3 (es) | 2007-11-14 | 2017-10-17 | Janssen Pharmaceuticals, Inc. | Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2 |
EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
RU2510396C2 (ru) | 2008-09-02 | 2014-03-27 | Янссен Фармасьютикалз, Инк. | 3-азабицикло[3.1.0]гексильные производные в качестве модуляторов метаботропных глутаматных рецепторов |
BRPI0920354A2 (pt) | 2008-10-16 | 2017-06-27 | Addex Pharmaceuticals Sa | derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos |
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JP5707390B2 (ja) | 2009-05-12 | 2015-04-30 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
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EP2322176A1 (en) | 2009-11-11 | 2011-05-18 | Almirall, S.A. | New 7-phenyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives |
EP2649069B1 (en) | 2010-11-08 | 2015-08-26 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
EP2643320B1 (en) | 2010-11-08 | 2015-03-04 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
CA2860479A1 (en) * | 2011-12-09 | 2013-06-13 | Chiesi Farmaceutici S.P.A. | Kinase inhibitors |
CN102746252A (zh) * | 2012-06-14 | 2012-10-24 | 盛世泰科生物医药技术(苏州)有限公司 | 一种3-氯-1,2,4-恶二唑的合成方法 |
KR102092988B1 (ko) | 2012-09-28 | 2020-03-25 | 벤더르빌트 유니버시티 | 선택성 bmp 저해제로써 융합된 헤테로 고리 화합물들 |
KR102191469B1 (ko) | 2013-02-06 | 2020-12-16 | 바이엘 애니멀 헬스 게엠베하 | 해충 방제제로서의 할로겐-치환된 피라졸 유도체 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
DK3431106T3 (da) | 2014-01-21 | 2021-03-15 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
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KR102549952B1 (ko) | 2017-02-13 | 2023-06-29 | 브리스톨-마이어스 스큅 컴퍼니 | 키나제 억제제로서의 아미노트리아졸로피리딘 |
JP6934562B2 (ja) | 2017-08-22 | 2021-09-15 | ギリアード サイエンシーズ, インコーポレイテッド | 治療用複素環式化合物 |
EP3765460A1 (en) | 2018-03-14 | 2021-01-20 | Vanderbilt University | Inhibition of bmp signaling, compounds, compositions and uses thereof |
CN108299426B (zh) * | 2018-03-20 | 2020-09-04 | 宝鸡文理学院 | 一种[1,2,4]-***并[4,3-a]吡啶类化合物及其合成方法 |
CN111116582B (zh) * | 2019-12-18 | 2022-07-29 | 大连大学 | 一种mGluR2拮抗剂 |
AR123793A1 (es) | 2020-10-19 | 2023-01-11 | Bristol Myers Squibb Co | Compuestos de triazolopiridinilo como inhibidores de quinasas |
WO2023114472A1 (en) * | 2021-12-16 | 2023-06-22 | Icahn School Of Medicine At Mount Sinai | Heterocyclic compounds as 5ht2a biased agonists |
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-
2007
- 2007-03-02 ES ES200700565A patent/ES2320955B1/es not_active Withdrawn - After Issue
-
2008
- 2008-02-27 UY UY30942A patent/UY30942A1/es unknown
- 2008-02-28 CL CL200800612A patent/CL2008000612A1/es unknown
- 2008-02-29 CA CA002682756A patent/CA2682756A1/en not_active Abandoned
- 2008-02-29 EP EP08716139A patent/EP2118100A1/en not_active Withdrawn
- 2008-02-29 WO PCT/EP2008/001616 patent/WO2008107125A1/en active Application Filing
- 2008-02-29 NZ NZ579917A patent/NZ579917A/en unknown
- 2008-02-29 TW TW097107188A patent/TW200900062A/zh unknown
- 2008-02-29 KR KR1020097020637A patent/KR20090115978A/ko not_active Application Discontinuation
- 2008-02-29 RU RU2009136299/04A patent/RU2009136299A/ru not_active Application Discontinuation
- 2008-02-29 AR ARP080100852A patent/AR065556A1/es not_active Application Discontinuation
- 2008-02-29 JP JP2009552107A patent/JP5318785B2/ja not_active Expired - Fee Related
- 2008-02-29 AU AU2008224179A patent/AU2008224179A1/en not_active Abandoned
- 2008-02-29 US US12/529,490 patent/US8258122B2/en not_active Expired - Fee Related
- 2008-02-29 PE PE2008000414A patent/PE20081800A1/es not_active Application Discontinuation
- 2008-02-29 CN CN2008800067485A patent/CN101679413B/zh not_active Expired - Fee Related
-
2009
- 2009-09-28 ZA ZA200906736A patent/ZA200906736B/xx unknown
- 2009-09-29 EC EC2009009662A patent/ECSP099662A/es unknown
- 2009-09-30 CO CO09107328A patent/CO6220952A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20090115978A (ko) | 2009-11-10 |
CN101679413A (zh) | 2010-03-24 |
EP2118100A1 (en) | 2009-11-18 |
ZA200906736B (en) | 2010-10-27 |
AU2008224179A1 (en) | 2008-09-12 |
AR065556A1 (es) | 2009-06-17 |
US20100120731A1 (en) | 2010-05-13 |
JP2010520245A (ja) | 2010-06-10 |
UY30942A1 (es) | 2008-07-31 |
WO2008107125A1 (en) | 2008-09-12 |
CL2008000612A1 (es) | 2008-09-05 |
US8258122B2 (en) | 2012-09-04 |
JP5318785B2 (ja) | 2013-10-16 |
ES2320955B1 (es) | 2010-03-16 |
CA2682756A1 (en) | 2008-09-12 |
TW200900062A (en) | 2009-01-01 |
NZ579917A (en) | 2011-03-31 |
ES2320955A1 (es) | 2009-05-29 |
RU2009136299A (ru) | 2011-04-10 |
CN101679413B (zh) | 2013-07-03 |
CO6220952A2 (es) | 2010-11-19 |
PE20081800A1 (es) | 2008-12-18 |
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