PE20090493A1 - DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA - Google Patents

DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA

Info

Publication number
PE20090493A1
PE20090493A1 PE2008001220A PE2008001220A PE20090493A1 PE 20090493 A1 PE20090493 A1 PE 20090493A1 PE 2008001220 A PE2008001220 A PE 2008001220A PE 2008001220 A PE2008001220 A PE 2008001220A PE 20090493 A1 PE20090493 A1 PE 20090493A1
Authority
PE
Peru
Prior art keywords
pyridazin
pyridazine
alkylene
alkyl
imidazo
Prior art date
Application number
PE2008001220A
Other languages
English (en)
Inventor
Philippe Burnier
Combes Sylvain Cote Des
Li Adrien Tak
Frederic Puech
Yulin Chiang
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20090493A1 publication Critical patent/PE20090493A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA DE FORMULA (I) DONDE R2 ES ARILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C6), ALQUIL(C1-C6)-TIO, -CN, ENTRE OTROS; A ES ALQUILENO(C1-C7) OPCIONALMENTE SUSTITUIDO CON Ra; B ES ALQUILENO(C1-C7) OPCIONALMENTE SUSTITUIDO CON Rb; L ES N OPCIONALMENTE SUSTITUIDO CON UN Rc O Rd, O ES C SUSTITUIDO CON UN Re1 Y UN Rd, ENTRE OTROS, DONDE DOS GRUPOS Ra PUEDEN FORMAR UN ALQUILENO(C1-C6), Ra Y Rb PUEDEN FORMAR UN ENLACE O UN ALQUILENO(C1-C6), Ra Y Rc PUEDEN FORMAR UN ENLACE O UN ALQUILENO(C1-C6), Rb Y Rc PUEDEN FORMAR UN ENLACE O UN ALQUILENO(C1-C6); Rd ES H, ALQUILO(C1-C6), HIDROXI-ALQUILO(C1-C6), FLUOROALQUILO(C1-C6), ENTRE OTROS, Re1 ES -NR4R5, ENTRE OTROS, EN DONDE R4 Y R5 SON CADA UNO H, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS; R7 Y R8 SON CADA UNO H O ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: 2-(4-FLUORO-FENIL)-6-PIPERAZIN-1-IL-3-PIRIDAZIN-4-IL-IMIDAZO[1,2-b]PIRIDAZINA, 2-(4-FLUORO-FENIL)-6-((R)-3-METIL-PIPERAZIN-1-IL)-3-PIRIDAZIN-4-IL-IMIDAZO[1,2-b]PIRIDAZINA, 6-(3,3-DIMETIL-PIPERAZIN-1-IL)-2-(4-FLUORO-FENIL)-3-PIRIDAZIN-4-IL-IMIDAZO[1,2-b]PIRIDAZINA, ENTRE OTROS. SE REFIERE TAMBIEN UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA FOSFORILACION DE LA CASEINA POR LAS CASEINA CINASAS 1 EPSILON Y DELTA SIENDO UTILES EN EL TRATAMIENTO DEL INSOMNIO PRIMARIO, SOMNOLENCIA EXCESIVA, TRASTORNOS DE ANSIEDAD
PE2008001220A 2007-07-19 2008-07-17 DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA PE20090493A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95071107P 2007-07-19 2007-07-19
FR0705224A FR2918986B1 (fr) 2007-07-19 2007-07-19 Derives de 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]- pyridazine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20090493A1 true PE20090493A1 (es) 2009-05-27

Family

ID=39183122

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001220A PE20090493A1 (es) 2007-07-19 2008-07-17 DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA

Country Status (22)

Country Link
US (2) US8455491B2 (es)
EP (1) EP2178879B1 (es)
JP (1) JP5431319B2 (es)
KR (1) KR20100041771A (es)
CN (1) CN101784552A (es)
AR (1) AR069272A1 (es)
AU (1) AU2008300449A1 (es)
BR (1) BRPI0814510A2 (es)
CA (1) CA2693116A1 (es)
CL (1) CL2008002138A1 (es)
CO (1) CO6290690A2 (es)
EA (1) EA016376B1 (es)
ES (1) ES2429765T3 (es)
FR (1) FR2918986B1 (es)
MA (1) MA31616B1 (es)
NZ (1) NZ582683A (es)
PA (1) PA8789901A1 (es)
PE (1) PE20090493A1 (es)
TW (1) TW200914456A (es)
UY (1) UY31236A1 (es)
WO (1) WO2009037394A2 (es)
ZA (1) ZA201001214B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
BRPI0814294A2 (pt) 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
FR2939134A1 (fr) * 2008-12-01 2010-06-04 Sanofi Aventis Derives de 6-cycloamino-3-(1h-pyrrolo°2,3-b!pyridin-4-yl) imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940285A1 (fr) 2008-12-19 2010-06-25 Sanofi Aventis Derives de 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo °1,2-b!-pyridazine et 6-cycloamino-2-furanyl-3- (pyridin-4-yl)imidazo°1,2-b!-pyridazine, leur preparation et leur application en therapeutique
FR2940284B1 (fr) * 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
ES2497566T3 (es) 2009-10-01 2014-09-23 Cymabay Therapeutics, Inc. Sales de tetrazol-1-il-fenoximetil-tiazol-2-il-piperidinil-pirimidina sustituida
CN102781942B (zh) * 2009-10-23 2015-09-23 詹森药业有限公司 用作食欲肽受体调节剂的二取代八氢吡咯并[3,4-c]吡咯
WO2011050202A1 (en) 2009-10-23 2011-04-28 Janssen Pharmaceutica Nv Fused heterocyclic compounds as orexin receptor modulators
EP2491034B1 (en) 2009-10-23 2013-12-18 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds as orexin receptor modulators
CN102596961B (zh) 2009-10-30 2015-12-02 詹森药业有限公司 咪唑并[1，2-b]哒嗪衍生物及其作为PDE10抑制剂的用途
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
WO2011163090A1 (en) 2010-06-23 2011-12-29 Metabolex, Inc. Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
RU2562833C2 (ru) 2010-08-09 2015-09-10 НБ Хелс Лаборатори Ко. Лтд. Ингибитор казеинкиназы 1 дельта и казеинкиназы 1 е
CN103298460B (zh) 2010-12-14 2016-06-01 电泳有限公司 酪蛋白激酶1δ(CK1δ)抑制剂
WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
AU2013283426B2 (en) 2012-06-26 2018-02-22 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
ES2607184T3 (es) 2012-07-09 2017-03-29 Janssen Pharmaceutica, N.V. Inhibidores de la enzima fosfodiesterasa 10
WO2014100540A1 (en) * 2012-12-21 2014-06-26 Bristol-Myers Squibb Company Pyrazole substituted imidazopyrazines as casein kinase 1 d/e inhibitors
JP6267231B2 (ja) * 2012-12-21 2018-01-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ カゼインキナーゼ１δ／ε阻害剤としての新規な置換イミダゾール
GB201321734D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
WO2015106158A1 (en) * 2014-01-09 2015-07-16 Intra-Cellular Therapies, Inc. Organic compounds
CN108883110B (zh) 2016-03-10 2022-05-27 詹森药业有限公司 使用食欲素-2受体拮抗剂治疗抑郁症的方法
JP2019527693A (ja) 2016-08-03 2019-10-03 サイマベイ・セラピューティクス・インコーポレイテッドＣｙｍａＢａｙ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 炎症性胃腸疾患または胃腸状態を治療するためのオキシメチレンアリール化合物
EA201992215A1 (ru) 2017-03-20 2020-02-06 Форма Терапьютикс, Инк. Пирролопирроловые композиции в качестве активаторов пируваткиназы (pkr)
CN111989327A (zh) 2018-02-05 2020-11-24 奥克梅斯公司 用于治疗疼痛的化合物
EP3852791A4 (en) 2018-09-19 2022-06-15 Forma Therapeutics, Inc. ACTIVATION OF PYRUVATE KINASE R
US20220031671A1 (en) 2018-09-19 2022-02-03 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
US20230192699A1 (en) * 2020-03-27 2023-06-22 Gritscience Biopharmaceuticals Co., Ltd. Compounds as casein kinase inhibitors
CN115335057A (zh) * 2020-03-27 2022-11-11 北京原基华毅生物科技有限公司 抑制酪蛋白激酶的方法
CA3235146A1 (en) 2021-10-14 2023-04-20 Incyte Corporation Quinoline compounds as inhibitors of kras

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001333A1 (en) * 1987-08-07 1989-02-23 The Australian National University IMIDAZO[1,2-b]PYRIDAZINES
KR100722176B1 (ko) 1999-06-08 2007-05-29 아벤티스 파마슈티칼스 인크. 일주기 리듬 단백질을 변화시키기 위한 스크리닝 방법
PL1747220T3 (pl) * 2003-12-11 2009-09-30 Aventis Pharma Inc Podstawione 1H-pirolo[3,2-b, 3,2-c i 2,3-c]pirydyno-2-karboksyamidy oraz pokrewne analogi jako inhibitory kinazy kazeinowej l epsilon
CA2555263A1 (en) * 2004-02-12 2005-09-01 Neurogen Corporation Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands
GB0515026D0 (en) * 2005-07-21 2005-08-31 Novartis Ag Organic compounds
WO2007013673A1 (en) * 2005-07-29 2007-02-01 Astellas Pharma Inc. Fused heterocycles as lck inhibitors
DE102005042742A1 (de) * 2005-09-02 2007-03-08 Schering Ag Substituierte Imidazo[1,2b]pyridazine als Kinase-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

Also Published As

Publication number Publication date
EA201070161A1 (ru) 2010-08-30
CN101784552A (zh) 2010-07-21
BRPI0814510A2 (pt) 2015-02-03
WO2009037394A3 (fr) 2009-06-18
CO6290690A2 (es) 2011-06-20
EP2178879A2 (fr) 2010-04-28
FR2918986A1 (fr) 2009-01-23
KR20100041771A (ko) 2010-04-22
CA2693116A1 (fr) 2009-03-26
EA016376B1 (ru) 2012-04-30
US20100152157A1 (en) 2010-06-17
PA8789901A1 (es) 2009-02-09
WO2009037394A2 (fr) 2009-03-26
UY31236A1 (es) 2009-03-02
MA31616B1 (fr) 2010-08-02
NZ582683A (en) 2011-07-29
AR069272A1 (es) 2010-01-13
US8455491B2 (en) 2013-06-04
US20130245023A1 (en) 2013-09-19
FR2918986B1 (fr) 2009-09-04
ZA201001214B (en) 2011-05-25
CL2008002138A1 (es) 2009-10-23
US9108971B2 (en) 2015-08-18
AU2008300449A1 (en) 2009-03-26
EP2178879B1 (fr) 2013-07-03
JP5431319B2 (ja) 2014-03-05
ES2429765T3 (es) 2013-11-15
JP2010533686A (ja) 2010-10-28
TW200914456A (en) 2009-04-01

Similar Documents

Publication Publication Date Title
PE20090493A1 (es) DERIVADOS DE LA 6-CICLOAMINO-3-(PIRIDAZIN-4-IL)IMIDAZO[1,2-b]-PIRIDAZINA, SU PREPARACION Y SU APLICACION EN TERAPEUTICA
JP6385954B2 (ja) キナーゼ調節のための化合物および方法、ならびにその適応
JP2018519343A5 (es)
PE20190336A1 (es) Nuevos derivados de amonio, un proceso para su preparacion y composiciones farmaceuticas que los contienen
PE20150218A1 (es) Nuevos derivados fosfatos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
PE20090506A1 (es) DERIVADOS DE IMIDAZO-[1,2-b]-PIRIDAZIN COMO INHIBIDORES DE ALK5 Y/O ALK4
PE20110545A1 (es) Compuestos de triazolopiridina como inhibidores de jak
PE20130012A1 (es) Derivados de pirazol como inhibidores de jak
AR074052A1 (es) Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa
PE20110572A1 (es) DERIVADOS DE IMIDAZO[1,2-a]PIRIDINA COMO INHIBIDORES DE MET
AR053728A1 (es) Pirimidinas condensadas como agonistas del receptor de acido nicotinico para el tratamiento de dislipidemia y composiciones farmaceuticas que las contienen en combinacion con otros agentes terapeuticos
PE20090714A1 (es) Imidazopiridazinas y pirrolo-pirimidinas sustituidas como inhibidores de cinasa de lipido
PE20090370A1 (es) Derivados de heterociclo fusionado como inhibidores de quinasa
EA023824B1 (ru) ПРОИЗВОДНЫЕ 3,4-ДИГИДРОПИРРОЛО[1,2-a]ПИРАЗИН-1-ИЛАМИНА, ПРИГОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE)
PE20140390A1 (es) Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak
PE20161246A1 (es) Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo
PE20151249A1 (es) Derivados de pirazolopirimidina como inhibidores de jak quinasas
PE20130611A1 (es) Triazolopiridinas sustituidas
AR093077A1 (es) ANTAGONISTAS DE mGlu2/3 PARA EL TRATAMIENTO DE LOS TRASTORNOS AUTISTAS
PE20120534A1 (es) PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
PE20141351A1 (es) Triazolopiridinas
PE20090651A1 (es) Derivados de isoquinolinilo e isoindolinilo como antagonistas de histamina-3
PE20110560A1 (es) NUEVOS DERIVADOS DE TRIAZOLO[4,3-a]PIRIDINA, SU PROCEDIMIENTO DE PREPARACION, SU APLICACION COMO MEDICAMENTOS, COMPOSICIONES FARMACEUTICAS Y NUEVA UTILIZACION PARTICULARMENTE COMO INHIBIDORES DE MET
PE20090960A1 (es) Derivados de quinazolinadiona, su preparacion y sus aplicaciones terapeuticas
PE20090944A1 (es) PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT

Legal Events

Date Code Title Description
FC Refusal