AR048376A1 - C- glicosidos heterociclos fusionados sustituidos - Google Patents
C- glicosidos heterociclos fusionados sustituidosInfo
- Publication number
- AR048376A1 AR048376A1 ARP040102728A ARP040102728A AR048376A1 AR 048376 A1 AR048376 A1 AR 048376A1 AR P040102728 A ARP040102728 A AR P040102728A AR P040102728 A ARP040102728 A AR P040102728A AR 048376 A1 AR048376 A1 AR 048376A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- glycycles
- glycycle
- fusioned
- absent
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
Abstract
La presente se refiere a composiciones que contienen estos compuestos, y métodos para utilizarlos, por ejemplo para el tratamiento o rofilaxis de la diabetes y el Síndrome X. Reivindicacion 1: Un compuesto de la formula (1) en la cual: una de las líneas punteadas entre NR1 y X o entre X e Y está presente, o ambas están ausentes; dos de V. M y W son H y el tercero es como se muestra en la formula (2), R1 es H, alquilo C1-4, cuando la línea punteada entre NR1 y X está presente, R1 está ausente; X es N, C=O, CH; o C-Q-Z. Y es N-Q-Z o C-Q-Z, cuando X es N, C=O o CH; Y es CH, cuando X es C-Q-Z; Q=-(CH2)n-, donde n = 1 o 2; P = H, acilo C1-7 o (alcoxi C1-6)carbonilo; Z cestá sustituido o sin sustituir, y se selecciona de cicloalquilo C3-7, fenilo, heteroarilo de 5 o 6 miembros que presentan 1 o 2 heteroátomos independientemente seleccionados de N, O y S, un biarilo, biciclilo fusionado de 9 o 10 miembros y un heterobiciclilo fusionado, donde dicho heterobiciclilo fusionado presenta entre 1 y 4 heteroátomos independientemente seleccionados de N, O y S; o una sal aceptable desde el punto de vista farmacéutico del mismo.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49153403P | 2003-08-01 | 2003-08-01 | |
US49152303P | 2003-08-01 | 2003-08-01 | |
US51921003P | 2003-11-12 | 2003-11-12 | |
US57973004P | 2004-06-15 | 2004-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048376A1 true AR048376A1 (es) | 2006-04-26 |
Family
ID=34120044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040102728A AR048376A1 (es) | 2003-08-01 | 2004-07-30 | C- glicosidos heterociclos fusionados sustituidos |
Country Status (9)
Country | Link |
---|---|
US (4) | US7094763B2 (es) |
EP (1) | EP1679965A4 (es) |
AR (1) | AR048376A1 (es) |
AU (1) | AU2004261660A1 (es) |
CA (1) | CA2549015A1 (es) |
EA (1) | EA009768B1 (es) |
IL (1) | IL175489A0 (es) |
TW (1) | TW200521131A (es) |
WO (1) | WO2005012318A2 (es) |
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CA2444481A1 (en) | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
EP1400529A4 (en) | 2001-05-30 | 2007-12-19 | Kissei Pharmaceutical | GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND MEDICINAL AND INTERMEDIARY USE THEREOF |
JP4399254B2 (ja) | 2001-06-20 | 2010-01-13 | キッセイ薬品工業株式会社 | 含窒素複素環誘導体、それを含有する医薬組成物、その医薬用途およびその製造中間体 |
JPWO2003011880A1 (ja) | 2001-07-31 | 2004-11-18 | キッセイ薬品工業株式会社 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物、その医薬用途及びその製造中間体 |
WO2003020737A1 (en) | 2001-09-05 | 2003-03-13 | Bristol-Myers Squibb Company | O-pyrazole glucoside sglt2 inhibitors and method of use |
US6617313B1 (en) * | 2002-03-13 | 2003-09-09 | Council Of Scientific And Industrial Research | Glucopyranoside and process of isolation thereof from pterocarpus marsupium pharmaceutical composition containing the same and use thereof |
US6562791B1 (en) * | 2002-03-29 | 2003-05-13 | Council Of Scientific And Industrial Research | Glucopyranoside, process for isolation thereof, pharmaceutical composition containing same and use thereof |
CN1280290C (zh) | 2002-04-08 | 2006-10-18 | 科学与工业研究委员会 | 新型吡喃糖苷葡萄糖及其离析方法与含有此物质的药用组合物及其用法 |
US7202350B2 (en) | 2003-03-14 | 2007-04-10 | Astellas Pharma Inc. | C-glycoside derivatives and salts thereof |
JP2004300102A (ja) | 2003-03-31 | 2004-10-28 | Kissei Pharmaceut Co Ltd | 縮合複素環誘導体、それを含有する医薬組成物およびその医薬用途 |
EA009768B1 (ru) * | 2003-08-01 | 2008-04-28 | Янссен Фармацевтика Нв | Замещенные конденсированные гетероциклические с-гликозиды |
-
2004
- 2004-07-30 EA EA200601552A patent/EA009768B1/ru not_active IP Right Cessation
- 2004-07-30 EP EP04779628A patent/EP1679965A4/en not_active Withdrawn
- 2004-07-30 AU AU2004261660A patent/AU2004261660A1/en not_active Abandoned
- 2004-07-30 US US10/903,136 patent/US7094763B2/en active Active
- 2004-07-30 TW TW093122974A patent/TW200521131A/zh unknown
- 2004-07-30 WO PCT/US2004/024625 patent/WO2005012318A2/en active Application Filing
- 2004-07-30 AR ARP040102728A patent/AR048376A1/es not_active Application Discontinuation
- 2004-07-30 CA CA002549015A patent/CA2549015A1/en not_active Abandoned
-
2006
- 2006-05-08 IL IL175489A patent/IL175489A0/en unknown
- 2006-06-15 US US11/453,728 patent/US7482330B2/en active Active
-
2008
- 2008-12-18 US US12/337,918 patent/US20090105162A1/en not_active Abandoned
-
2009
- 2009-09-11 US US12/557,728 patent/US7816328B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1679965A4 (en) | 2009-05-27 |
EA200601552A1 (ru) | 2007-02-27 |
US7816328B2 (en) | 2010-10-19 |
WO2005012318A2 (en) | 2005-02-10 |
US7094763B2 (en) | 2006-08-22 |
US20100004160A1 (en) | 2010-01-07 |
EA009768B1 (ru) | 2008-04-28 |
AU2004261660A1 (en) | 2005-02-10 |
EP1679965A2 (en) | 2006-07-19 |
US20090105162A1 (en) | 2009-04-23 |
TW200521131A (en) | 2005-07-01 |
US7482330B2 (en) | 2009-01-27 |
US20050037980A1 (en) | 2005-02-17 |
US20060229260A1 (en) | 2006-10-12 |
WO2005012318A3 (en) | 2005-12-15 |
CA2549015A1 (en) | 2005-02-10 |
IL175489A0 (en) | 2009-02-11 |
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