PE20040531A1 - Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen - Google Patents

Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen

Info

Publication number
PE20040531A1
PE20040531A1 PE2003000523A PE2003000523A PE20040531A1 PE 20040531 A1 PE20040531 A1 PE 20040531A1 PE 2003000523 A PE2003000523 A PE 2003000523A PE 2003000523 A PE2003000523 A PE 2003000523A PE 20040531 A1 PE20040531 A1 PE 20040531A1
Authority
PE
Peru
Prior art keywords
isoindolone
derivatives
contain
pharmaceutical compositions
intermediate compounds
Prior art date
Application number
PE2003000523A
Other languages
English (en)
Inventor
Antony Bigot
Jean-Christophe Carry
Baptiste Ronan
Heinz-Werner Kleemann
Serge Mignani
Armin Hofmeister
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20040531A1 publication Critical patent/PE20040531A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 Y R2 SON CADA UNO H, ALQUILO C1-C4, ALQUENILO C2-C6, HALOGENO, ENTRE OTROS; R3 ES H, ARILO, HETEROARILO, ENTRE OTROS; R4, R5 Y R6 SON CADA UNO H, ALQUILO LINEAL O RAMIFICADO C1-C4. SON COMPUESTOS PREFERIDOS: N-[2-(2-ISOBUTIL-3-OXO-2,3-DIHIDRO-1H-ISOINDOL-1-IL)-2-METILPROPIONIL]GUANIDINA; N-[2-(2-CICLOPROPILMETIL-3-OXO-2,3-DIHIDRO-1H-ISOINDOL-1-IL)-2-METILPROPIONIL]GUANIDINA Y N-[(3-OXO-2-(3,3,3-TRIFLUOROPROPIL)-2,3-DIHIDRO-1H-ISOINDOL-1-IL)ACETIL]GUANIDINA. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE CONTIENE DICHOS COMPUESTOS, LOS QUE SON UTILES EN EL TRATAMIENTO Y PROFILAXIS DEL INFARTO, Y TRATAMIENTO DE ANGINA DE PECHO
PE2003000523A 2002-06-03 2003-05-29 Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen PE20040531A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0206783A FR2840302B1 (fr) 2002-06-03 2002-06-03 Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
PE20040531A1 true PE20040531A1 (es) 2004-09-27

Family

ID=29558914

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000523A PE20040531A1 (es) 2002-06-03 2003-05-29 Derivados de isoindolona, proceso de preparacion, compuestos intermedios de este proceso y composiciones farmaceuticas que los contienen

Country Status (42)

Country Link
US (2) US7078428B2 (es)
EP (1) EP1528923B1 (es)
JP (1) JP4634793B2 (es)
KR (1) KR101149771B1 (es)
CN (1) CN1290833C (es)
AR (1) AR039927A1 (es)
AT (1) ATE324889T1 (es)
AU (1) AU2003240677B2 (es)
BR (1) BR0311556A (es)
CA (1) CA2488373C (es)
CY (1) CY1105115T1 (es)
DE (1) DE60305042T2 (es)
DK (1) DK1528923T3 (es)
EC (1) ECSP045472A (es)
EG (1) EG24784A (es)
ES (1) ES2261939T3 (es)
FR (1) FR2840302B1 (es)
HK (1) HK1076383A1 (es)
HN (1) HN2003000162A (es)
HR (1) HRP20041151B1 (es)
IL (1) IL165520A (es)
JO (1) JO2357B1 (es)
MA (1) MA27308A1 (es)
ME (1) MEP27508A (es)
MX (1) MXPA04011931A (es)
MY (1) MY142502A (es)
NO (1) NO329224B1 (es)
NZ (1) NZ536953A (es)
OA (1) OA12864A (es)
PA (1) PA8574701A1 (es)
PE (1) PE20040531A1 (es)
PL (1) PL372188A1 (es)
PT (1) PT1528923E (es)
RS (1) RS51636B (es)
RU (1) RU2318809C2 (es)
SI (1) SI1528923T1 (es)
TN (1) TNSN04237A1 (es)
TW (1) TWI286545B (es)
UA (1) UA81118C2 (es)
UY (1) UY27835A1 (es)
WO (1) WO2003101450A1 (es)
ZA (1) ZA200409094B (es)

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US7531569B2 (en) 2003-12-02 2009-05-12 Sanofi-Aventis Deutschland Gmbh Process for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl) acetylguanidine derivatives
KR100518184B1 (ko) * 2003-12-27 2005-10-04 한국화학연구원 퓨란카보닐구아니딘 유도체, 그의 제조방법 및 그를포함하는 약학적 조성물
TW200613272A (en) 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
US7807706B2 (en) 2005-08-12 2010-10-05 Astrazeneca Ab Metabotropic glutamate-receptor-potentiating isoindolones
US20070161648A1 (en) * 2005-10-14 2007-07-12 Hughes Terry V Substituted dihydro-isoindolones useful in treating kinase disorders
TW200812962A (en) * 2006-07-12 2008-03-16 Astrazeneca Ab New compounds I/418
TWI417100B (zh) 2007-06-07 2013-12-01 Astrazeneca Ab 二唑衍生物及其作為代謝型麩胺酸受體增效劑-８４２之用途
US7790760B2 (en) 2008-06-06 2010-09-07 Astrazeneca Ab Metabotropic glutamate receptor isoxazole ligands and their use as potentiators 286
GB0811643D0 (en) 2008-06-25 2008-07-30 Cancer Rec Tech Ltd New therapeutic agents
US8697690B2 (en) 2010-07-01 2014-04-15 Merck Sharp & Dohme Corp. Isoindolone M1 receptor positive allosteric modulators
US8895571B2 (en) 2011-10-14 2014-11-25 Incyte Corporation Isoindolinone and pyrrolopyridinone derivatives as Akt inhibitors
CN103193794B (zh) * 2013-04-12 2016-04-06 中国药科大学 一种异吲哚酮并异噁唑类稠环化合物及其合成方法
GB201517217D0 (en) 2015-09-29 2015-11-11 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
GB201517216D0 (en) 2015-09-29 2015-11-11 Cancer Res Technology Ltd And Astex Therapeutics Ltd Pharmaceutical compounds
CN106316922B (zh) * 2016-08-17 2019-02-01 华东师范大学 一种含c-3全取代氧化吲哚衍生物及其合成方法和应用
WO2018058109A1 (en) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions and methods for treating metabolic disorders
GB201704965D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
GB201704966D0 (en) 2017-03-28 2017-05-10 Astex Therapeutics Ltd Pharmaceutical compounds
CN110664803B (zh) * 2019-09-19 2023-08-29 中山大学 异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用

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EP0612723B1 (de) * 1993-02-20 1997-08-27 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
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Also Published As

Publication number Publication date
RS104804A (en) 2006-12-15
UA81118C2 (en) 2007-12-10
CA2488373A1 (en) 2003-12-11
ECSP045472A (es) 2005-01-28
DE60305042T2 (de) 2007-05-24
OA12864A (en) 2006-09-15
UY27835A1 (es) 2003-12-31
EP1528923B1 (en) 2006-05-03
KR101149771B1 (ko) 2012-06-08
TW200404780A (en) 2004-04-01
CN1658869A (zh) 2005-08-24
ZA200409094B (en) 2005-08-31
CN1290833C (zh) 2006-12-20
US7589117B2 (en) 2009-09-15
NO20045660L (no) 2004-12-27
SI1528923T1 (sl) 2006-08-31
NO329224B1 (no) 2010-09-20
EP1528923A1 (en) 2005-05-11
JP4634793B2 (ja) 2011-02-16
HRP20041151B1 (hr) 2013-06-30
AU2003240677A1 (en) 2003-12-19
DK1528923T3 (da) 2006-09-04
US7078428B2 (en) 2006-07-18
HRP20041151A2 (en) 2005-06-30
MY142502A (en) 2010-11-30
RU2004138789A (ru) 2005-06-27
FR2840302B1 (fr) 2004-07-16
IL165520A0 (en) 2006-01-15
WO2003101450A1 (en) 2003-12-11
DE60305042D1 (de) 2006-06-08
RS51636B (en) 2011-08-31
TWI286545B (en) 2007-09-11
PA8574701A1 (es) 2004-05-07
EG24784A (en) 2010-09-01
BR0311556A (pt) 2005-04-12
TNSN04237A1 (en) 2007-03-12
JP2005533034A (ja) 2005-11-04
ES2261939T3 (es) 2006-11-16
IL165520A (en) 2009-12-24
FR2840302A1 (fr) 2003-12-05
ATE324889T1 (de) 2006-06-15
JO2357B1 (en) 2006-12-12
HK1076383A1 (en) 2006-01-20
KR20050010855A (ko) 2005-01-28
RU2318809C2 (ru) 2008-03-10
MEP27508A (en) 2010-06-10
AU2003240677B2 (en) 2008-07-17
CA2488373C (en) 2012-07-17
CY1105115T1 (el) 2010-03-03
NZ536953A (en) 2007-10-26
MXPA04011931A (es) 2005-03-31
MA27308A1 (fr) 2005-05-02
US20060148880A1 (en) 2006-07-06
AR039927A1 (es) 2005-03-09
US20040048916A1 (en) 2004-03-11
HN2003000162A (es) 2004-05-05
PT1528923E (pt) 2006-08-31
PL372188A1 (en) 2005-07-11

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