AR043405A1 - Anticuerpos humanos especificos para la interleuquina 15 (il-15) - Google Patents

Anticuerpos humanos especificos para la interleuquina 15 (il-15)

Info

Publication number
AR043405A1
AR043405A1 ARP040100605A AR043405A1 AR 043405 A1 AR043405 A1 AR 043405A1 AR P040100605 A ARP040100605 A AR P040100605A AR 043405 A1 AR043405 A1 AR 043405A1
Authority
AR
Argentina
Prior art keywords
human
antibodies
homologous
human antibodies
disclosed
Prior art date
Application number
Other languages
English (en)
Original Assignee
Genmab As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/374,932 external-priority patent/US7329405B2/en
Priority claimed from US10/379,741 external-priority patent/US7247304B2/en
Application filed by Genmab As filed Critical Genmab As
Publication of AR043405A1 publication Critical patent/AR043405A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

Se revelan anticuerpos monoclonales humanos aislados que se unen especialmente a la IL-15 (por ejemplo la IL-15 humana), y composiciones y moléculas relacionadas basadas en anticuerpos. Los anticuerpos humanos se pueden producir en un transfectoma o en un animal transgénico no humano, por ejemplo un ratón transgénico, capaz de producir isotipos múltiples de anticuerpos monoclonales humanos al someterse a un cambio de isotipo y recombinación V-D-J: También se revelan composiciones farmacéuticas que comprenden anticuerpos humanos, animales transgénicos no humanos, e hibridomas que producen los anticuerpos humanos, y métodos terapéuticos y de diagnóstico para utilizar los anticuerpos humanos. Reivindicación 1: Un anticuerpo monoclonal humano aislado que se une especialmente a la IL-15 humana, que comprende al menos una secuencia de CDR seleccionada del grupo formado por: (i) SEC ID Nos: 5, 6, 7, 8, 9, y 10; (ii) secuencias que son al menos 90% homólogas, preferentemente al menos 95% homólogas, y más preferentemente al menos 98%, o al menos 99% homólogas a las secuencias definidas en (i); y (iii) fragmentos de las secuencias definidas en (i) o (ii), que retienen la capacidad de unirse específicamente a la IL-15 humana.
ARP040100605 2003-02-26 2004-02-26 Anticuerpos humanos especificos para la interleuquina 15 (il-15) AR043405A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/374,932 US7329405B2 (en) 2001-08-23 2003-02-26 Human antibodies specific for interleukin 15 (IL-15)
US10/379,741 US7247304B2 (en) 2001-08-23 2003-03-05 Methods of treating using anti-IL-15 antibodies

Publications (1)

Publication Number Publication Date
AR043405A1 true AR043405A1 (es) 2005-07-27

Family

ID=36770634

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100605 AR043405A1 (es) 2003-02-26 2004-02-26 Anticuerpos humanos especificos para la interleuquina 15 (il-15)

Country Status (6)

Country Link
JP (1) JP4892335B2 (es)
CN (1) CN1780856A (es)
AR (1) AR043405A1 (es)
EA (1) EA015897B1 (es)
RS (1) RS20050724A (es)
ZA (1) ZA200506724B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2769984T3 (en) 2007-05-11 2017-10-16 Altor Bioscience Corp Fusion molecules and IL-15 variants
PT2918607T (pt) 2010-09-21 2018-01-11 Altor Bioscience Corp Moléculas de fusão de il-15 multiméricas solúveis e métodos de produção e utilização das mesmas
US11053299B2 (en) 2010-09-21 2021-07-06 Immunity Bio, Inc. Superkine
CN102250243B (zh) * 2011-07-01 2013-08-28 华绍炳 抗白细胞介素-15抗体
EP3912637A1 (en) 2014-06-30 2021-11-24 Altor BioScience Corporation Il-15-based molecules and methods of use thereof
EP2963057A1 (en) * 2014-07-02 2016-01-06 Calypso Biotech SA Antibodies to IL-15
MX2018015363A (es) * 2016-06-15 2019-04-15 Amgen Inc Metodos y composiciones para el tratamiento de la enfermedad celiaca, de la sensibilidad al gluten no celiaca y de la enfermedad celiaca refractaria.
US20180200366A1 (en) 2016-10-21 2018-07-19 Altor Bioscience Corporation Multimeric il-15-based molecules
US11267883B2 (en) * 2016-12-21 2022-03-08 Cephalon, Inc. Antibodies that specifically bind to human IL-15 and uses thereof
WO2021129766A1 (zh) * 2019-12-25 2021-07-01 江苏集萃药康生物科技股份有限公司 一种il-15人源化小鼠模型及其用途
CN114377133A (zh) * 2022-01-20 2022-04-22 山东大学 靶向肾脏cd8+trm形成与活化在肾小球损伤中的应用
CN115362984B (zh) * 2022-07-07 2024-01-16 成都中医药大学 一种小鼠自身免疫性甲状腺炎模型的构建方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
GB9814892D0 (en) * 1998-07-10 1998-09-09 Kennedy Rheumatology Inst Treatment of celiac disease
AU6689700A (en) * 1999-07-06 2001-01-22 Silvia Bulfone-Paus Method of treating psoriasis with il-15 antagonist
JP4359503B2 (ja) * 2001-08-23 2009-11-04 ゲンマブ エー／エス インターロイキン１５（ｉｌ−１５）に特異的なヒト抗体

Also Published As

Publication number Publication date
CN1780856A (zh) 2006-05-31
EA015897B1 (ru) 2011-12-30
RS20050724A (en) 2007-11-15
JP2007528348A (ja) 2007-10-11
EA200501362A1 (ru) 2006-02-24
JP4892335B2 (ja) 2012-03-07
ZA200506724B (en) 2007-03-28

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