RS20050724A - Human antibodies specific for interleukin 15(il-15) - Google Patents
Human antibodies specific for interleukin 15(il-15)Info
- Publication number
- RS20050724A RS20050724A YUP-2005/0724A YUP20050724A RS20050724A RS 20050724 A RS20050724 A RS 20050724A YU P20050724 A YUP20050724 A YU P20050724A RS 20050724 A RS20050724 A RS 20050724A
- Authority
- RS
- Serbia
- Prior art keywords
- human
- human antibodies
- antibodies
- interleukin
- antibodies specific
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Abstract
Otkrivena su izolovana humana monoklonalna antitela koja se specifično vezuju za IL-15 (na primer, humani IL-15) i srodne kompozicije i molekuli koji se baziraju na antitelima. Humana antitela mogu se proizvesti u transfektomi ili u ne-humanoj transgenoj životinji, na primer transgenom mišu, koja je sposobna da proizvodi višestruke izotipove humanih monklonalnih antitela putem V-D-J rekombinacije i putem zamene izotipa. Takođe su otkrivene farmaceutske kompozicije humanih antitela, ne-humanih transgenih životinja i hibridome koje proizvode humana antitela i dijagnostičke i terapeutske metode za upotrebu humanih antitela.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/374,932 US7329405B2 (en) | 2001-08-23 | 2003-02-26 | Human antibodies specific for interleukin 15 (IL-15) |
US10/379,741 US7247304B2 (en) | 2001-08-23 | 2003-03-05 | Methods of treating using anti-IL-15 antibodies |
PCT/IB2004/000484 WO2004076620A2 (en) | 2003-02-26 | 2004-02-25 | Human antibodies specific for interleukin 15 (il-15) |
Publications (1)
Publication Number | Publication Date |
---|---|
RS20050724A true RS20050724A (en) | 2007-11-15 |
Family
ID=36770634
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0724A RS20050724A (en) | 2003-02-26 | 2004-02-25 | Human antibodies specific for interleukin 15(il-15) |
Country Status (6)
Country | Link |
---|---|
JP (1) | JP4892335B2 (sr) |
CN (1) | CN1780856A (sr) |
AR (1) | AR043405A1 (sr) |
EA (1) | EA015897B1 (sr) |
RS (1) | RS20050724A (sr) |
ZA (1) | ZA200506724B (sr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2690825C (en) | 2007-05-11 | 2019-02-12 | Altor Bioscience Corporation | Fusion molecules and il-15 variants |
US11053299B2 (en) | 2010-09-21 | 2021-07-06 | Immunity Bio, Inc. | Superkine |
KR20140020228A (ko) | 2010-09-21 | 2014-02-18 | 알토 바이오사이언스 코포레이션 | 다량체성 아이엘 15 용해성 융합 분자 및 그의 제조 및 사용 방법 |
CN102250243B (zh) * | 2011-07-01 | 2013-08-28 | 华绍炳 | 抗白细胞介素-15抗体 |
US9925247B2 (en) | 2014-06-30 | 2018-03-27 | Altor Bioscience Corporation | IL-15-based molecules and methods of use thereof |
EP2963057A1 (en) * | 2014-07-02 | 2016-01-06 | Calypso Biotech SA | Antibodies to IL-15 |
BR112018076287A2 (pt) * | 2016-06-15 | 2019-03-26 | Amgen Inc. | métodos e composições para o tratamento de doença celíaca, sensibilidade ao glúten não celíaca e doença celíaca refratária |
SG11201903306SA (en) | 2016-10-21 | 2019-05-30 | Altor Bioscience Corp | Multimeric il-15-based molecules |
AR110414A1 (es) * | 2016-12-21 | 2019-03-27 | Cephalon Inc | Anticuerpos que se unen específicamente a il-15 humana y usos de estos |
US20220354097A1 (en) * | 2019-12-25 | 2022-11-10 | Gempharmatech Co., Ltd. | Il-15 humanized mouse model and use thereof |
CN114377133A (zh) * | 2022-01-20 | 2022-04-22 | 山东大学 | 靶向肾脏cd8+trm形成与活化在肾小球损伤中的应用 |
CN115362984B (zh) * | 2022-07-07 | 2024-01-16 | 成都中医药大学 | 一种小鼠自身免疫性甲状腺炎模型的构建方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5795966A (en) * | 1995-02-22 | 1998-08-18 | Immunex Corp | Antagonists of interleukin-15 |
GB9814892D0 (en) * | 1998-07-10 | 1998-09-09 | Kennedy Rheumatology Inst | Treatment of celiac disease |
AU6689700A (en) * | 1999-07-06 | 2001-01-22 | Silvia Bulfone-Paus | Method of treating psoriasis with il-15 antagonist |
AU2002332628B2 (en) * | 2001-08-23 | 2007-07-26 | Genmab A/S | Human antibodies specific for interleukin 15 (IL-15) |
-
2004
- 2004-02-25 ZA ZA200506724A patent/ZA200506724B/en unknown
- 2004-02-25 RS YUP-2005/0724A patent/RS20050724A/sr unknown
- 2004-02-25 EA EA200501362A patent/EA015897B1/ru not_active IP Right Cessation
- 2004-02-25 CN CN 200480011288 patent/CN1780856A/zh active Pending
- 2004-02-25 JP JP2006502466A patent/JP4892335B2/ja not_active Expired - Lifetime
- 2004-02-26 AR ARP040100605 patent/AR043405A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP4892335B2 (ja) | 2012-03-07 |
EA015897B1 (ru) | 2011-12-30 |
CN1780856A (zh) | 2006-05-31 |
AR043405A1 (es) | 2005-07-27 |
ZA200506724B (en) | 2007-03-28 |
EA200501362A1 (ru) | 2006-02-24 |
JP2007528348A (ja) | 2007-10-11 |
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