EA200500835A1 - Человеческие моноклональные антитела против cd25 - Google Patents

Человеческие моноклональные антитела против cd25

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Publication number
EA200500835A1
EA200500835A1 EA200500835A EA200500835A EA200500835A1 EA 200500835 A1 EA200500835 A1 EA 200500835A1 EA 200500835 A EA200500835 A EA 200500835A EA 200500835 A EA200500835 A EA 200500835A EA 200500835 A1 EA200500835 A1 EA 200500835A1
Authority
EA
Eurasian Patent Office
Prior art keywords
human
monoclonal antibodies
antibodies
human monoclonal
antibodies against
Prior art date
Application number
EA200500835A
Other languages
English (en)
Other versions
EA013677B1 (ru
Inventor
Янин Схюрман
Катарина Эманюэль Герарда Хавенит
Пауль Паррен
Ян Г.Й. Ван Де Винкель
Дениз Ли Уильямс
Йорген Петерсен
Оле Д. М. Ск. Бодсгорд
Original Assignee
Генмаб А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Генмаб А/С filed Critical Генмаб А/С
Publication of EA200500835A1 publication Critical patent/EA200500835A1/ru
Publication of EA013677B1 publication Critical patent/EA013677B1/ru

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

Abstract

Охватываются выделенные человеческие моноклональные антитела, которые связываются с человеческим CD25 и ингибируют его, и родственные композиции и молекулы на основе антител. Человеческие антитела можно продуцировать при использовании гибридомы, трансфектомы или в организме отличного от человека трансгенного животного, например в трансгенной мыши, способной продуцировать многие изотипы человеческих моноклональных антител при использовании V-D-J рекомбинации и переключения изотипа. Также охватываются фармацевтические композиции, содержащие человеческие антитела, отличные от человека трансгенные животные, гибридомы и трансфектомы, которые продуцируют человеческие антитела, и диагностические методы для применения человеческих антител.
EA200500835A 2002-11-15 2003-11-14 Человеческие моноклональные антитела против cd25 и их применение EA013677B1 (ru)

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