US7091181B2
(en)
|
1994-12-12 |
2006-08-15 |
Omeros Corporation |
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
|
US20020028798A1
(en)
*
|
1995-12-12 |
2002-03-07 |
Omeros Medical Systems |
Irrigation solution and method for inhibition of pain and inflammation
|
AU3215197A
(en)
*
|
1996-05-30 |
1998-01-05 |
Merck & Co., Inc. |
A method of treating cancer
|
US6251943B1
(en)
|
1997-02-28 |
2001-06-26 |
Warner-Lambert Company |
Method of treating or preventing septic shock by administering a MEK inhibitor
|
US6007991A
(en)
*
|
1997-03-28 |
1999-12-28 |
The Research Foundation Of Suny |
Antisense oligonucleotides for mitogen-activated protein kinases as therapy for cancer
|
AU6472998A
(en)
|
1997-03-28 |
1998-10-22 |
Research Foundation Of The State University Of New York, The |
Antisense oligonucleotides for mitogen-activated protein kinases as therapy for breast cancer
|
US6310060B1
(en)
|
1998-06-24 |
2001-10-30 |
Warner-Lambert Company |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
|
DE69826662T2
(de)
*
|
1997-07-01 |
2005-02-17 |
Warner-Lambert Co. Llc |
4-brom or 4-iod-phenylamino-benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
|
NZ501277A
(en)
*
|
1997-07-01 |
2002-12-20 |
Warner Lambert Co |
-2(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
|
US6821963B2
(en)
|
1997-07-01 |
2004-11-23 |
Warner-Lambert Company |
4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
|
US6506798B1
(en)
|
1997-07-01 |
2003-01-14 |
Warner-Lambert Company |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
|
US6150401A
(en)
*
|
1998-01-06 |
2000-11-21 |
The General Hospital Corporation |
Use of MEK1 inhibitors as protective agents against damage due to ischemia
|
US6319955B1
(en)
|
1998-01-06 |
2001-11-20 |
The General Hospital Corporation |
Use of MEK1 inhibitors as protective agents against damage due to ischemia
|
US6098631A
(en)
*
|
1998-01-21 |
2000-08-08 |
The Regents Of The University Of Michigan |
Compositions and methods for treating autoimmune disease
|
EP2311495B1
(en)
*
|
1998-03-24 |
2014-09-24 |
Chugai Seiyaku Kabushiki Kaisha |
Vascularization inhibitors
|
US6846799B1
(en)
|
1998-08-18 |
2005-01-25 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
US20030219427A1
(en)
*
|
1998-08-18 |
2003-11-27 |
Allen Hamish J. |
TPL-2/COT kinase and methods of use
|
US7354894B2
(en)
*
|
1998-08-18 |
2008-04-08 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
AU1127700A
(en)
*
|
1998-10-20 |
2000-05-08 |
Omeros Medical Systems, Inc. |
Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
|
KR20010101203A
(ko)
*
|
1998-12-15 |
2001-11-14 |
로즈 암스트롱, 크리스틴 에이. 트러트웨인 |
Mek 저해제의 이식 조직 거부를 예방하기 위한 용도
|
EP1143957A3
(en)
*
|
1998-12-16 |
2002-02-27 |
Warner-Lambert Company |
Treatment of arthritis with mek inhibitors
|
US6696440B1
(en)
*
|
1999-01-07 |
2004-02-24 |
Warner-Lambert Company |
Treatment of asthma with MEK inhibitors
|
SK9832001A3
(en)
|
1999-01-13 |
2003-02-04 |
Warner Lambert Co |
Benzoheterocycles and their use as MEK inhibitors
|
CA2349832A1
(en)
|
1999-01-13 |
2000-07-20 |
Warner-Lambert Company |
Benzenesulfonamide derivatives and their use as mek inhibitors
|
CA2349467A1
(en)
*
|
1999-01-13 |
2000-07-20 |
Warner-Lambert Company |
Sulphohydroxamic acids and sulphohydroxamates and their use as mek inhibitors
|
CN1149204C
(zh)
|
1999-01-13 |
2004-05-12 |
沃尼尔·朗伯公司 |
1-杂环取代的二芳基胺
|
CA2348236A1
(en)
*
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
WO2000050030A1
(en)
*
|
1999-02-25 |
2000-08-31 |
Ted Ebendal |
New use
|
GB9920910D0
(en)
*
|
1999-09-03 |
1999-11-10 |
Indena Spa |
Novel chalcones
|
GB9920908D0
(en)
*
|
1999-09-03 |
1999-11-10 |
Indena Spa |
Chalcone coumarins
|
US7001905B2
(en)
*
|
2000-03-15 |
2006-02-21 |
Warner-Lambert Company |
Substituted diarylamines as MEK inhibitors
|
WO2002017952A2
(en)
|
2000-09-01 |
2002-03-07 |
Van Andel Institute |
Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma
|
US20040122058A1
(en)
*
|
2001-03-06 |
2004-06-24 |
Dorian Bevec |
Use of specific compounds particularly kinase inhibitors for treating viral infections
|
US6806293B1
(en)
*
|
2001-03-12 |
2004-10-19 |
Darley Pharmaceuticals Ltd |
Use of pheromone compounds having MAP kinase modulating activity
|
AU2001243556A1
(en)
*
|
2001-03-12 |
2002-09-24 |
Alydar Pharmaceuticals, Inc. |
Screening non-peptide, non-steroid invertebrate pheromone compounds for mitogen-activated protein kinase modulating activity
|
CA2442015A1
(en)
*
|
2001-03-22 |
2002-10-03 |
Van Andel Institute |
Anthrax lethal factor inhibits tumor growth and angiogenesis
|
IL149462A0
(en)
*
|
2001-05-09 |
2002-11-10 |
Warner Lambert Co |
Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
|
KR20020096368A
(ko)
*
|
2001-06-19 |
2002-12-31 |
주식회사 티지 바이오텍 |
연골세포의 분화촉진, 연골세포의 탈분화 억제 또는탈분화된 연골세포의 재분화 촉진제, 그것의 스크리닝방법 및 그것을 이용한 연골세포의 제조방법
|
KR20020096367A
(ko)
*
|
2001-06-19 |
2002-12-31 |
주식회사 티지 바이오텍 |
관절염 예방 또는 치료제 및 그것의 스크리닝 방법
|
EP1467968A1
(en)
*
|
2002-01-23 |
2004-10-20 |
Warner-Lambert Company LLC |
N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
|
DOP2003000556A
(es)
*
|
2002-01-23 |
2003-10-31 |
Warner Lambert Co |
Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
|
WO2004087941A1
(en)
*
|
2002-02-15 |
2004-10-14 |
The General Hospital Corporation |
Map-kinase inhibitors as regulators of tumor-associated antigen expression
|
US20030216460A1
(en)
*
|
2002-03-13 |
2003-11-20 |
Wallace Eli M. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
EP2275102B1
(en)
|
2002-03-13 |
2015-07-29 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
US7235537B2
(en)
*
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
JP2006516117A
(ja)
*
|
2002-11-21 |
2006-06-22 |
ジェネンテック・インコーポレーテッド |
抗ErbB2抗体を用いた非悪性疾病または疾患の治療
|
EP1598079B1
(en)
*
|
2003-02-26 |
2009-04-22 |
Kowa Co., Ltd. |
Remedies for allergic contact dermatitis
|
US20050049276A1
(en)
*
|
2003-07-23 |
2005-03-03 |
Warner-Lambert Company, Llc |
Imidazopyridines and triazolopyridines
|
CA2532067C
(en)
*
|
2003-07-24 |
2010-12-21 |
Stephen Douglas Barrett |
N-methyle-substituted benzamidazoles
|
US7144907B2
(en)
*
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
US7538120B2
(en)
*
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
US7732616B2
(en)
*
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
US7517994B2
(en)
*
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
AU2004293018B2
(en)
|
2003-11-19 |
2010-02-18 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
RU2006121990A
(ru)
*
|
2003-11-21 |
2007-12-27 |
Эррэй Биофарма Инк. (Us) |
Ингибиторы протеинкиназ акт
|
EP1699477A2
(en)
*
|
2003-12-11 |
2006-09-13 |
Theravance, Inc. |
Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
|
BRPI0518192B8
(pt)
|
2004-10-20 |
2021-05-25 |
Applied Res Systems Ars Holding N V |
derivados de 3-arilamino piridina, seu uso e seu processo de fabricação, e composição farmacêutica
|
AU2005308956A1
(en)
*
|
2004-11-24 |
2006-06-01 |
Merck Serono Sa |
Novel 4-arylamino pyridone derivatives as MEK inhibitors for the treatment of hyperproliferative disorders
|
PT2361905E
(pt)
|
2005-05-18 |
2013-03-18 |
Array Biopharma Inc |
Inibidores heterocíclicos de mek e seus métodos de utilização
|
WO2007021933A2
(en)
*
|
2005-08-12 |
2007-02-22 |
The General Hospital Corporation |
Methods and compositions for use in treating vascular diseases and conditions
|
EP1953148B1
(en)
|
2005-10-28 |
2012-02-29 |
Takeda Pharmaceutical Company Limited |
Heterocyclic amide compound and use thereof
|
PT2049500E
(pt)
|
2006-07-06 |
2011-12-23 |
Array Biopharma Inc |
Ciclopenta[d]pirimidinas como inibidores da proteína quinase akt
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
CA2656566C
(en)
|
2006-07-06 |
2014-06-17 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
JP5231411B2
(ja)
|
2006-07-06 |
2013-07-10 |
アレイ バイオファーマ、インコーポレイテッド |
Aktプロテインキナーゼ阻害剤としてのジヒドロチエノピリミジン
|
KR20150089099A
(ko)
|
2007-07-05 |
2015-08-04 |
어레이 바이오파마 인크. |
Akt 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
|
CN101918373B
(zh)
*
|
2007-07-05 |
2013-06-05 |
阵列生物制药公司 |
作为akt蛋白激酶抑制剂的嘧啶基环戊烷
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
CA2693340A1
(en)
*
|
2007-07-31 |
2009-02-05 |
Limerick Biopharma, Inc. |
Pyrone analog compositions and methods
|
US20090062255A1
(en)
*
|
2007-08-17 |
2009-03-05 |
Thallion Pharmaceuticals Inc. |
Tumor-targeting evaluation methodology and compounds related thereto
|
ES2401685T3
(es)
*
|
2008-01-09 |
2013-04-23 |
Array Biopharma, Inc. |
Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
|
EP2247578B1
(en)
*
|
2008-01-09 |
2013-05-22 |
Array Biopharma, Inc. |
Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
|
JP2011529963A
(ja)
*
|
2008-08-04 |
2011-12-15 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
新規フェニルアミノイソニコチンアミド化合物
|
US8993630B2
(en)
|
2008-11-10 |
2015-03-31 |
Bayer Intellectual Property Gmbh |
Substituted sulphonamido phenoxybenzamides
|
CA2777071A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
EP2491016A1
(en)
|
2009-10-21 |
2012-08-29 |
Bayer Pharma Aktiengesellschaft |
Substituted benzosulphonamides
|
EP2560640A1
(en)
|
2010-04-19 |
2013-02-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
|
ES2575995T3
(es)
|
2010-08-05 |
2016-07-04 |
Case Western Reserve University |
Inhibidores de ERK para trastornos del desarrollo de la conectividad neuronal
|
US9045429B2
(en)
|
2010-10-29 |
2015-06-02 |
Bayer Intellectual Property Gmbh |
Substituted phenoxypyridines
|
EP2694072B1
(en)
|
2011-04-01 |
2017-11-29 |
Genentech, Inc. |
Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments
|
JP6147246B2
(ja)
|
2011-04-01 |
2017-06-14 |
ジェネンテック, インコーポレイテッド |
Akt及びmek阻害剤化合物の組み合わせ、及び使用方法
|
US20140228418A1
(en)
*
|
2011-05-23 |
2014-08-14 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitory compounds with mek inhibitors
|
ES2597052T3
(es)
|
2011-05-25 |
2017-01-13 |
Université Paris Descartes |
Inhibidores de ERK para su uso en el tratamiento de atrofia muscular espinal
|
JP2014534228A
(ja)
|
2011-11-02 |
2014-12-18 |
シンタ ファーマシューティカルズ コーポレーション |
白金含有剤とhsp90阻害剤の組合せ療法
|
US9439899B2
(en)
|
2011-11-02 |
2016-09-13 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of HSP90 inhibitors with topoisomerase I inhibitors
|
WO2013074594A1
(en)
|
2011-11-14 |
2013-05-23 |
Synta Pharmaceuticals Corp. |
Combination therapy of hsp90 inhibitors with braf inhibitors
|
AU2014218807A1
(en)
|
2013-02-22 |
2015-09-03 |
Cellular Dynamics International, Inc. |
Hepatocyte production via forward programming by combined genetic and chemical engineering
|
WO2015038704A1
(en)
|
2013-09-11 |
2015-03-19 |
The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone |
Compositions for preparing cardiomyocytes
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
WO2015164228A1
(en)
|
2014-04-21 |
2015-10-29 |
Cellular Dynamics International, Inc. |
Hepatocyte production via forward programming by combined genetic and chemical engineering
|
CA2963091A1
(en)
|
2014-10-06 |
2016-04-14 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
US11471538B2
(en)
|
2017-02-10 |
2022-10-18 |
INSERM (Institut National de la Santéet de la Recherche Medicale) |
Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the MAPK pathway
|
WO2020051370A1
(en)
*
|
2018-09-06 |
2020-03-12 |
North Carolina Central University |
Discovery of novel potent inhibitors of the map3k mekk2
|
US20220288040A1
(en)
|
2019-09-02 |
2022-09-15 |
Inserm (Institut National De La Santé Et De La Recherche Médicale)) |
Use of pyrvinium for the treatment of a ras pathway mutated acute myeloid leukemia
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|