PT2049500E - Ciclopenta[d]pirimidinas como inibidores da proteína quinase akt - Google Patents

Ciclopenta[d]pirimidinas como inibidores da proteína quinase akt

Info

Publication number
PT2049500E
PT2049500E PT07799329T PT07799329T PT2049500E PT 2049500 E PT2049500 E PT 2049500E PT 07799329 T PT07799329 T PT 07799329T PT 07799329 T PT07799329 T PT 07799329T PT 2049500 E PT2049500 E PT 2049500E
Authority
PT
Portugal
Prior art keywords
cyclopenta
pyrimidines
protein kinase
kinase inhibitors
akt protein
Prior art date
Application number
PT07799329T
Other languages
English (en)
Inventor
Dengming Xiao
Ian S Mitchell
James F Blake
Rui Xu
Nicholas C Kallan
Keith Lee Spencer
Josef R Bencsik
Jun Liang
Brian Safina
Jun Li
Christine Chabot
Anna L Banka
Stephen T Schlachter
Eli M Wallace
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2049500(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of PT2049500E publication Critical patent/PT2049500E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
PT07799329T 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas como inibidores da proteína quinase akt PT2049500E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06

Publications (1)

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PT2049500E true PT2049500E (pt) 2011-12-23

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ID=38686844

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PT07799329T PT2049500E (pt) 2006-07-06 2007-07-05 Ciclopenta[d]pirimidinas como inibidores da proteína quinase akt

Country Status (32)

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US (3) US8003651B2 (pt)
EP (1) EP2049500B1 (pt)
JP (3) JP5268904B2 (pt)
KR (2) KR101527232B1 (pt)
CN (2) CN103288753A (pt)
AR (1) AR061844A1 (pt)
AT (1) ATE523499T1 (pt)
AU (1) AU2007269052B2 (pt)
BR (1) BRPI0713555A2 (pt)
CA (1) CA2656618C (pt)
CL (1) CL2007001992A1 (pt)
CO (1) CO6160229A2 (pt)
CR (2) CR10601A (pt)
CY (1) CY1112142T1 (pt)
DK (1) DK2049500T3 (pt)
ES (1) ES2372955T3 (pt)
HK (1) HK1126758A1 (pt)
HR (1) HRP20110882T1 (pt)
IL (1) IL196051A (pt)
MA (1) MA30952B1 (pt)
MX (1) MX2008016203A (pt)
MY (1) MY147628A (pt)
NO (1) NO20090580L (pt)
NZ (1) NZ573979A (pt)
PL (1) PL2049500T3 (pt)
PT (1) PT2049500E (pt)
RS (1) RS52210B (pt)
RU (1) RU2481336C2 (pt)
SI (1) SI2049500T1 (pt)
TW (1) TWI428335B (pt)
UA (1) UA99597C2 (pt)
WO (1) WO2008006032A1 (pt)

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UA95641C2 (en) * 2006-07-06 2011-08-25 Эррей Биофарма Инк. Hydroxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
EP2049546B1 (en) 2006-07-06 2010-12-29 Array Biopharma, Inc. Dihydrofuro pyrimidines as akt protein kinase inhibitors
ATE523499T1 (de) 2006-07-06 2011-09-15 Array Biopharma Inc Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
US8063050B2 (en) * 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
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US20100233733A1 (en) * 2009-02-10 2010-09-16 Nodality, Inc., A Delaware Corporation Multiple mechanisms for modulation of the pi3 kinase pathway
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