ZA200603873B - Hydroxamic acid esters and pharmaceutical use thereof - Google Patents
Hydroxamic acid esters and pharmaceutical use thereofInfo
- Publication number
- ZA200603873B ZA200603873B ZA200603873A ZA200603873A ZA200603873B ZA 200603873 B ZA200603873 B ZA 200603873B ZA 200603873 A ZA200603873 A ZA 200603873A ZA 200603873 A ZA200603873 A ZA 200603873A ZA 200603873 B ZA200603873 B ZA 200603873B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid esters
- hydroxamic acid
- pharmaceutical use
- pharmaceutical
- hydroxamic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D213/53—Nitrogen atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52626203P | 2003-12-03 | 2003-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200603873B true ZA200603873B (en) | 2008-10-29 |
Family
ID=34652435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200603873A ZA200603873B (en) | 2003-12-03 | 2004-12-02 | Hydroxamic acid esters and pharmaceutical use thereof |
Country Status (20)
Country | Link |
---|---|
US (1) | US8034811B2 (xx) |
EP (1) | EP1697312B1 (xx) |
JP (1) | JP2007513098A (xx) |
KR (1) | KR20070026337A (xx) |
CN (1) | CN1906155B (xx) |
AR (1) | AR046785A1 (xx) |
AT (1) | ATE517081T1 (xx) |
AU (1) | AU2004295022A1 (xx) |
BR (1) | BRPI0417158A (xx) |
CA (1) | CA2549242A1 (xx) |
HK (1) | HK1098127A1 (xx) |
IL (1) | IL175480A0 (xx) |
MX (1) | MXPA06006210A (xx) |
NO (1) | NO20062905L (xx) |
NZ (1) | NZ547231A (xx) |
RU (1) | RU2357952C2 (xx) |
TW (1) | TW200529815A (xx) |
UA (1) | UA89035C2 (xx) |
WO (1) | WO2005054179A2 (xx) |
ZA (1) | ZA200603873B (xx) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
EP1657241A1 (en) * | 2004-11-03 | 2006-05-17 | Schering Aktiengesellschaft | Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors |
US7241625B2 (en) * | 2005-06-02 | 2007-07-10 | Sumika Chemical Analysis Service, Limited | Carbonyl compound scavenger and method of quantifying carbonyl compound using the same |
WO2008061866A1 (en) * | 2006-11-20 | 2008-05-29 | Bayer Cropscience Sa | New benzamide derivatives |
CN101677979A (zh) * | 2007-04-19 | 2010-03-24 | 利奥制药有限公司 | Src家族激酶抑制剂 |
DE102007022007A1 (de) * | 2007-05-08 | 2008-11-13 | Schebo Biotech Ag | Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes |
KR101523345B1 (ko) * | 2008-04-28 | 2015-05-28 | 주식회사 지엔티파마 | 재관류 손상의 치료 또는 예방용 약학 조성물 |
AR073216A1 (es) | 2008-08-27 | 2010-10-20 | Leo Pharma As | Derivados de piridina como receptor de vegfr-2 e inhibidores de proteina tirosina quinasa y uso farmaceutico de los mismos |
DE102010007281A1 (de) * | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
SI2627316T1 (sl) * | 2010-10-13 | 2019-06-28 | Medivir Ab | Farmacevtska formulacija za zaviralce histonske deacetilaze |
JP2014524434A (ja) * | 2011-08-18 | 2014-09-22 | ビーエーエスエフ ソシエタス・ヨーロピア | 有害無脊椎動物を駆除するためのカルバモイルメトキシベンズアミドおよびカルバモイルメチルチオベンズアミドおよびカルバモイルメチルアミノベンズアミド |
EP2744782A1 (en) | 2011-08-18 | 2014-06-25 | Basf Se | Carbamoylmethoxy- and carbamoylmethylthio- and carbamoylmethylamino benzamides for combating invertebrate pests |
IN2014CN01216A (xx) | 2011-08-18 | 2015-04-24 | Basf Se | |
EP2822931B1 (en) | 2012-03-09 | 2017-05-03 | Inception 2, Inc. | Triazolone compounds and uses thereof |
WO2014099503A1 (en) | 2012-12-20 | 2014-06-26 | Inception 2, Inc. | Triazolone compounds and uses thereof |
AU2013363957B2 (en) | 2012-12-21 | 2018-03-22 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
CN103288684B (zh) * | 2013-05-03 | 2014-12-10 | 西安交通大学 | 一种具有抗肿瘤活性的联苯脲化合物及其制备方法 |
GB201312492D0 (en) * | 2013-07-12 | 2013-08-28 | Syngenta Ltd | Herbicidal compounds |
KR20160048988A (ko) | 2013-09-06 | 2016-05-04 | 인셉션 2 인코퍼레이티드 | 트라이아졸론 화합물 및 이의 용도 |
CN104628663A (zh) * | 2013-11-08 | 2015-05-20 | 中山奕安泰医药科技有限公司 | 3-氯甲基-1,2,4-***啉-5-酮的合成方法 |
CN106660982B (zh) | 2014-06-25 | 2020-09-08 | 赛尔基因昆蒂赛尔研究公司 | 组蛋白脱甲基酶抑制剂 |
US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
CN107098869B (zh) * | 2017-05-03 | 2019-05-10 | 贵州大学 | 含1,3,4-噁二唑基的双酰胺类化合物及其制备方法及应用 |
CN107286101B (zh) * | 2017-07-27 | 2020-04-21 | 云南大学 | 1-芳醛肟尿嘧啶及其制备方法 |
CN108314630B (zh) * | 2018-02-08 | 2020-11-06 | 广西民族大学 | 一种肟醚类衍生物及其制备方法与应用 |
CN109553585A (zh) * | 2018-12-29 | 2019-04-02 | 凯瑞斯德生化(苏州)有限公司 | 一种3-氯甲基-1,2,4-***啉-5-酮的合成方法 |
CN111135161A (zh) * | 2019-12-30 | 2020-05-12 | 谭竞 | 一种具有抗肿瘤活性的扛板归提取物的用途及其制备方法 |
EP4334298A1 (en) | 2021-06-14 | 2024-03-13 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409668A (en) | 1964-11-07 | 1968-11-05 | Palazzo Giuseppe | Substituted anthranilamides and process for the preparation thereof |
DE1240873B (de) | 1964-12-08 | 1967-05-24 | Hoechst Ag | Verfahren zur Herstellung von 4-Halogen-5-sulfamylanthranilsaeure-hydroxamiden |
GB1343036A (en) * | 1970-04-20 | 1974-01-10 | Gyogyszerkutato Intezet | Pyridyl methoxyamines |
NL7314532A (xx) * | 1972-10-27 | 1974-05-01 | ||
US5155110A (en) | 1987-10-27 | 1992-10-13 | Warner-Lambert Company | Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition |
IL99246A0 (en) * | 1990-09-10 | 1992-07-15 | Abbott Lab | Angiotensin ii receptor antagonists and pharmaceutical compositions containing them |
FR2689508B1 (fr) * | 1992-04-01 | 1994-06-17 | Fournier Ind & Sante | Derives de l'imidazole, leur procede de preparation et leur application en therapeutique. |
GB9405347D0 (en) * | 1994-03-18 | 1994-05-04 | Agrevo Uk Ltd | Fungicides |
US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
GB9518993D0 (en) | 1995-09-16 | 1995-11-15 | Agrevo Uk Ltd | Fungicides |
WO1997030047A1 (en) | 1996-02-17 | 1997-08-21 | Agrevo Uk Limited | Fungicidal 1,2,4-oxadiazoles and analogues |
DE69735429T2 (de) | 1996-09-30 | 2006-08-10 | Nihon Nohyaku Co., Ltd. | Bisthiadiazolderivate und ihre salze, mittel zur bekaempfung von pflanzenkrankheiten in landwirtschaft und gartenbau und methode zur anwendung dieser mittel |
AU4802797A (en) * | 1996-10-02 | 1998-04-24 | Du Pont Pharmaceuticals Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv rever se transcriptase inhibitors and intermediates and processes for making the same |
US6235787B1 (en) | 1997-06-30 | 2001-05-22 | Hoffmann-La Roche Inc. | Hydrazine derivatives |
EP0993439B1 (en) * | 1997-07-01 | 2004-09-29 | Warner-Lambert Company LLC | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as mek inhibitors |
US6326379B1 (en) * | 1998-09-16 | 2001-12-04 | Bristol-Myers Squibb Co. | Fused pyridine inhibitors of cGMP phosphodiesterase |
GB9824579D0 (en) | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
CA2346448A1 (en) * | 1998-12-16 | 2000-06-22 | Warner-Lambert Company | Treatment of arthritis with mek inhibitors |
US6147107A (en) * | 1998-12-20 | 2000-11-14 | Virginia Commonwealth University | Specific inhibition of the P42/44 mitogen activated protein (map) kinase cascade sensitizes tumor cells |
WO2000040235A2 (en) | 1999-01-07 | 2000-07-13 | Warner-Lambert Company | Treatment of asthma with mek inhibitors |
WO2000041505A2 (en) | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Anthranilic acid derivatives |
JP2000281659A (ja) * | 1999-03-30 | 2000-10-10 | Sumitomo Pharmaceut Co Ltd | チオウレア誘導体 |
GB9924862D0 (en) | 1999-10-20 | 1999-12-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
ES2241781T3 (es) | 2000-02-09 | 2005-11-01 | Novartis Ag | Derivados de piridina inhibidores de la angiogenesis y/o del receptor tirosina quinasa de vegf. |
JP2003527379A (ja) | 2000-03-15 | 2003-09-16 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Mex阻害物質としての5−アミド置換ジアリールアミン類 |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
DE10021246A1 (de) | 2000-04-25 | 2001-10-31 | Schering Ag | Substituierte Benzoesäureamide und deren Verwendung als Arzneimittel |
DE10023484A1 (de) | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
DE10023492A1 (de) | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
DE10023485A1 (de) | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylalkyl- und -cycloalkylamide und deren Verwendung als Arzneimittel |
JP2002006453A (ja) | 2000-06-27 | 2002-01-09 | Konica Corp | 黒白ハロゲン化銀写真感光材料用現像剤及び処理方法 |
DZ3401A1 (fr) * | 2000-07-19 | 2002-01-24 | Warner Lambert Co | Esters oxygenes d'acides 4-iodophenylamino benzhydroxamiques |
EA200300187A1 (ru) | 2000-08-25 | 2003-08-28 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл Эл Си | Способ получения n-арилантраниловых кислот и их производных |
US20020147198A1 (en) * | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
JP2002322169A (ja) * | 2001-02-21 | 2002-11-08 | Sankyo Co Ltd | クロメン誘導体 |
WO2002066454A1 (en) | 2001-02-21 | 2002-08-29 | Sankyo Company, Limited | Chromene derivatives |
EP1377312A4 (en) | 2001-03-22 | 2004-10-06 | Andel Inst Van | ANTHRAX LETAL FACTOR INHIBITS TUMOR GROWTH AND ANGIOGENESIS |
GB0111078D0 (en) | 2001-05-04 | 2001-06-27 | Novartis Ag | Organic compounds |
DE50213703D1 (de) | 2001-05-08 | 2009-09-03 | Bayer Schering Pharma Ag | Selektive anthranylamidpyridinamide als vegfr-2 und vegfr-3 inhibitoren |
DK1387838T3 (da) | 2001-05-08 | 2006-08-14 | Schering Ag | Cyanoanthranylamid-derivater og deres anvendelse som lægemidler |
WO2002090349A1 (de) | 2001-05-08 | 2002-11-14 | Schering Aktiengesellschaft | N-oxidanthranylamid-derivate und deren verwendung als arzneimittel |
TW200724033A (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
GB0126901D0 (en) | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
GB0126902D0 (en) | 2001-11-08 | 2002-01-02 | Novartis Ag | Organic compounds |
AU2002348791A1 (en) * | 2001-12-21 | 2003-07-09 | Warner-Lambert Company Llc | Modified mek1 and mek2, crystal of a peptide: ligand: cofactor complex containing such modified mek1 or mek2, and methods of use thereof |
JP2005515253A (ja) * | 2002-01-23 | 2005-05-26 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | N−(4−置換フェニル)−アントラニル酸ヒドロキサメートエステル |
DOP2003000556A (es) | 2002-01-23 | 2003-10-31 | Warner Lambert Co | Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico. |
JP2004075614A (ja) | 2002-08-20 | 2004-03-11 | Sankyo Co Ltd | クロメン誘導体を含有する医薬 |
WO2004037853A2 (en) | 2002-10-21 | 2004-05-06 | Irm Llc | Quinolones with anti-hiv activity |
SI1585743T1 (sl) | 2002-12-19 | 2007-08-31 | Pfizer | Spojine 2-(1H-indazol-6-ilamino)-benzamida kot inhibitorji protein-kinaz, uporabnih pri zdravljenju očesnih bolezni |
WO2004085382A1 (ja) * | 2003-03-27 | 2004-10-07 | Kirin Beer Kabushiki Kaisha | 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬 |
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2004
- 2004-02-12 UA UAA200607301A patent/UA89035C2/ru unknown
- 2004-12-02 TW TW093137194A patent/TW200529815A/zh unknown
- 2004-12-02 AU AU2004295022A patent/AU2004295022A1/en not_active Abandoned
- 2004-12-02 AR ARP040104494A patent/AR046785A1/es not_active Application Discontinuation
- 2004-12-02 AT AT04801164T patent/ATE517081T1/de not_active IP Right Cessation
- 2004-12-02 RU RU2006123459/04A patent/RU2357952C2/ru not_active IP Right Cessation
- 2004-12-02 BR BRPI0417158-6A patent/BRPI0417158A/pt not_active IP Right Cessation
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- 2004-12-02 MX MXPA06006210A patent/MXPA06006210A/es active IP Right Grant
- 2004-12-02 JP JP2006541802A patent/JP2007513098A/ja active Pending
- 2004-12-02 NZ NZ547231A patent/NZ547231A/en unknown
- 2004-12-02 WO PCT/DK2004/000840 patent/WO2005054179A2/en active Application Filing
- 2004-12-02 KR KR1020067010826A patent/KR20070026337A/ko not_active Application Discontinuation
- 2004-12-02 EP EP04801164A patent/EP1697312B1/en active Active
- 2004-12-02 CA CA002549242A patent/CA2549242A1/en not_active Abandoned
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- 2004-12-02 ZA ZA200603873A patent/ZA200603873B/xx unknown
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Also Published As
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TW200529815A (en) | 2005-09-16 |
IL175480A0 (en) | 2006-09-05 |
BRPI0417158A (pt) | 2007-03-06 |
CN1906155B (zh) | 2010-06-23 |
RU2357952C2 (ru) | 2009-06-10 |
CA2549242A1 (en) | 2005-06-16 |
MXPA06006210A (es) | 2006-08-25 |
NZ547231A (en) | 2010-02-26 |
WO2005054179A3 (en) | 2005-08-04 |
US20070244117A1 (en) | 2007-10-18 |
US8034811B2 (en) | 2011-10-11 |
HK1098127A1 (en) | 2007-07-13 |
RU2006123459A (ru) | 2008-01-10 |
ATE517081T1 (de) | 2011-08-15 |
EP1697312A2 (en) | 2006-09-06 |
JP2007513098A (ja) | 2007-05-24 |
WO2005054179A2 (en) | 2005-06-16 |
UA89035C2 (ru) | 2009-12-25 |
AR046785A1 (es) | 2005-12-21 |
NO20062905L (no) | 2006-06-21 |
EP1697312B1 (en) | 2011-07-20 |
KR20070026337A (ko) | 2007-03-08 |
AU2004295022A1 (en) | 2005-06-16 |
CN1906155A (zh) | 2007-01-31 |
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