NO20062905L - Nye hydroksaminsyreestere og farmasoytisk anvendelse derav - Google Patents

Nye hydroksaminsyreestere og farmasoytisk anvendelse derav

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Publication number
NO20062905L
NO20062905L NO20062905A NO20062905A NO20062905L NO 20062905 L NO20062905 L NO 20062905L NO 20062905 A NO20062905 A NO 20062905A NO 20062905 A NO20062905 A NO 20062905A NO 20062905 L NO20062905 L NO 20062905L
Authority
NO
Norway
Prior art keywords
acid esters
hydroxamic acid
pharmaceutical use
novel hydroxamic
novel
Prior art date
Application number
NO20062905A
Other languages
English (en)
Inventor
Jacob Thorhauge
Jef Fensholdt
Bjarne Norremark
Original Assignee
Leo Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma As filed Critical Leo Pharma As
Publication of NO20062905L publication Critical patent/NO20062905L/no

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Oppfinnelsen vedrører forbindelser med den generelle formel I hvori D, E, F, G, W, Y, R1, A, R9, X, B; R8 er som definert i beskrivelsen, og farmasøytisk akseptable salter, hydrater eller solvater derav, for anvendelse - alene eller i kombinasjon med en eller flere andre farmasøytisk aktive forbindelser - i terapi, for behandling av sykdommer forbundet med deregulert angiogenese, så som kreft.
NO20062905A 2003-12-03 2006-06-21 Nye hydroksaminsyreestere og farmasoytisk anvendelse derav NO20062905L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52626203P 2003-12-03 2003-12-03
PCT/DK2004/000840 WO2005054179A2 (en) 2003-12-03 2004-12-02 Hydroxamic acid esters and pharmaceutical use thereof

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NO20062905L true NO20062905L (no) 2006-06-21

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US (1) US8034811B2 (no)
EP (1) EP1697312B1 (no)
JP (1) JP2007513098A (no)
KR (1) KR20070026337A (no)
CN (1) CN1906155B (no)
AR (1) AR046785A1 (no)
AT (1) ATE517081T1 (no)
AU (1) AU2004295022A1 (no)
BR (1) BRPI0417158A (no)
CA (1) CA2549242A1 (no)
HK (1) HK1098127A1 (no)
IL (1) IL175480A0 (no)
MX (1) MXPA06006210A (no)
NO (1) NO20062905L (no)
NZ (1) NZ547231A (no)
RU (1) RU2357952C2 (no)
TW (1) TW200529815A (no)
UA (1) UA89035C2 (no)
WO (1) WO2005054179A2 (no)
ZA (1) ZA200603873B (no)

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US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
EP1657241A1 (en) * 2004-11-03 2006-05-17 Schering Aktiengesellschaft Novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors
US7241625B2 (en) * 2005-06-02 2007-07-10 Sumika Chemical Analysis Service, Limited Carbonyl compound scavenger and method of quantifying carbonyl compound using the same
WO2008061866A1 (en) * 2006-11-20 2008-05-29 Bayer Cropscience Sa New benzamide derivatives
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