ZA200309204B - A coated nicotine-containing chewing gum, manufacture and use thereof. - Google Patents
A coated nicotine-containing chewing gum, manufacture and use thereof. Download PDFInfo
- Publication number
- ZA200309204B ZA200309204B ZA200309204A ZA200309204A ZA200309204B ZA 200309204 B ZA200309204 B ZA 200309204B ZA 200309204 A ZA200309204 A ZA 200309204A ZA 200309204 A ZA200309204 A ZA 200309204A ZA 200309204 B ZA200309204 B ZA 200309204B
- Authority
- ZA
- South Africa
- Prior art keywords
- nicotine
- chewing gum
- product according
- coating
- subject
- Prior art date
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims description 329
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims description 324
- 229960002715 nicotine Drugs 0.000 title claims description 322
- 235000015218 chewing gum Nutrition 0.000 title claims description 154
- 229940112822 chewing gum Drugs 0.000 title claims description 144
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 238000000034 method Methods 0.000 claims description 87
- 238000000576 coating method Methods 0.000 claims description 76
- 239000011248 coating agent Substances 0.000 claims description 73
- 230000000391 smoking effect Effects 0.000 claims description 66
- 239000011247 coating layer Substances 0.000 claims description 60
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims description 58
- 241000208125 Nicotiana Species 0.000 claims description 56
- 239000000203 mixture Substances 0.000 claims description 43
- 239000000779 smoke Substances 0.000 claims description 34
- 239000012458 free base Substances 0.000 claims description 33
- 230000009467 reduction Effects 0.000 claims description 33
- 210000003296 saliva Anatomy 0.000 claims description 28
- 239000000654 additive Substances 0.000 claims description 24
- 239000000872 buffer Substances 0.000 claims description 24
- -1 nicotine cation Chemical class 0.000 claims description 21
- 210000004369 blood Anatomy 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 17
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 claims description 15
- 238000009495 sugar coating Methods 0.000 claims description 15
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- 230000002459 sustained effect Effects 0.000 claims description 13
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 10
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 7
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 7
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- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
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- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical group O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 4
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 4
- 239000003381 stabilizer Substances 0.000 claims description 4
- 239000010457 zeolite Substances 0.000 claims description 4
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 claims description 4
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- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims description 2
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- 239000000383 hazardous chemical Substances 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
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- 229960004903 invert sugar Drugs 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
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- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
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- 239000008101 lactose Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
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- 238000012423 maintenance Methods 0.000 description 1
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
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- 210000003928 nasal cavity Anatomy 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000000025 natural resin Substances 0.000 description 1
- JAWHBPAGSGRFSG-DYLYSONESA-N nrc-10 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(C)=O)C(C)C)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 JAWHBPAGSGRFSG-DYLYSONESA-N 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
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- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 description 1
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- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011600 potassium glycerophosphate Substances 0.000 description 1
- 235000000491 potassium glycerophosphate Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 235000013533 rum Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
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- 235000020046 sherry Nutrition 0.000 description 1
- 235000020374 simple syrup Nutrition 0.000 description 1
- 229940124535 smoking cessation aid Drugs 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
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- 208000011117 substance-related disease Diseases 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 239000007852 tooth bleaching agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 235000019798 tripotassium phosphate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 239000005418 vegetable material Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23B—PRESERVING, e.g. BY CANNING, MEAT, FISH, EGGS, FRUIT, VEGETABLES, EDIBLE SEEDS; CHEMICAL RIPENING OF FRUIT OR VEGETABLES; THE PRESERVED, RIPENED, OR CANNED PRODUCTS
- A23B4/00—General methods for preserving meat, sausages, fish or fish products
- A23B4/10—Coating with a protective layer; Compositions or apparatus therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/02—Apparatus specially adapted for manufacture or treatment of chewing gum
- A23G4/04—Apparatus specially adapted for manufacture or treatment of chewing gum for moulding or shaping
- A23G4/043—Apparatus specially adapted for manufacture or treatment of chewing gum for moulding or shaping for composite chewing gum
- A23G4/046—Apparatus specially adapted for manufacture or treatment of chewing gum for moulding or shaping for composite chewing gum with a centre made of chewing gum
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/18—Chewing gum characterised by shape, structure or physical form, e.g. aerated products
- A23G4/20—Composite products, e.g. centre-filled, multi-layer, laminated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0102197A SE0102197D0 (sv) | 2001-06-20 | 2001-06-20 | New product and use and manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200309204B true ZA200309204B (en) | 2005-02-23 |
Family
ID=20284551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200309204A ZA200309204B (en) | 2001-06-20 | 2003-11-26 | A coated nicotine-containing chewing gum, manufacture and use thereof. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20040194793A1 (ja) |
| EP (1) | EP1404306B1 (ja) |
| JP (2) | JP4571402B2 (ja) |
| AR (1) | AR034527A1 (ja) |
| AT (1) | ATE485034T1 (ja) |
| AU (1) | AU2002345454B2 (ja) |
| BR (1) | BR0210342A (ja) |
| CA (1) | CA2449298C (ja) |
| CZ (1) | CZ20033458A3 (ja) |
| DE (1) | DE60238054D1 (ja) |
| DK (1) | DK1404306T3 (ja) |
| ES (1) | ES2352681T3 (ja) |
| IL (2) | IL159425A0 (ja) |
| MX (1) | MXPA03011557A (ja) |
| NZ (1) | NZ529780A (ja) |
| RU (1) | RU2291688C2 (ja) |
| SE (1) | SE0102197D0 (ja) |
| WO (1) | WO2002102357A1 (ja) |
| ZA (1) | ZA200309204B (ja) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1578422E (pt) | 2002-12-20 | 2007-06-14 | Niconovum Ab | Material particulado contendo nicotina fisicamente e quimicamente estável |
| SE0302947D0 (sv) | 2003-01-24 | 2003-11-07 | Magle Ab | A composition material for transmucosal delivery |
| EP1617823B1 (en) * | 2003-01-24 | 2019-01-09 | Nicachet AB | A pouch comprising a nicotine composition for transmucosal delivery |
| ATE369750T1 (de) * | 2003-02-04 | 2007-09-15 | Gumlink As | Gepresste kaugummitablette |
| EP1449525A1 (en) * | 2003-02-20 | 2004-08-25 | Cross Chem Llc | chewing gum in the form of multi-layer tablets |
| US8529875B2 (en) | 2004-06-29 | 2013-09-10 | Fertin Pharma A/S | Tobacco alkaloid releasing chewing gum |
| BRPI0513465B1 (pt) * | 2004-08-11 | 2015-08-11 | Intercontinental Great Brands Llc | Composições orais, artigo comestível, composições para balas e goma de mascar, métodos para preparação do referido artigo e para fornercer sensação às áreas receptoras orais |
| US7780981B2 (en) | 2004-09-13 | 2010-08-24 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| CN101039587B (zh) | 2004-10-08 | 2012-07-18 | 古木林科有限公司 | 糖果产品 |
| US8524196B2 (en) | 2004-11-30 | 2013-09-03 | Fertin Pharma A/S | Method of providing fast relief to a user of a nicotine chewing gum |
| US8323683B2 (en) | 2005-05-18 | 2012-12-04 | Mcneil-Ppc, Inc. | Flavoring of drug-containing chewing gums |
| US8709502B2 (en) * | 2005-09-23 | 2014-04-29 | Chanel Parfums Beaute | Extract of Vanilla planifolia |
| US8024911B2 (en) | 2006-02-16 | 2011-09-27 | Mcneil Ab | Method for blister packing |
| EP1998754A2 (en) * | 2006-03-16 | 2008-12-10 | NicoNovum AB | Stable lozenge compositions providing rapid release of nicotine |
| EP1998748B1 (en) | 2006-03-16 | 2015-01-14 | NicoNovum AB | Improved snuff composition |
| US20070269386A1 (en) | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
| US8642016B2 (en) * | 2006-07-21 | 2014-02-04 | Jsrnti, Llc | Medicinal delivery system, and related methods |
| AU2012241150B2 (en) * | 2006-07-21 | 2015-04-16 | Jsrnti, Llc | Medicinal delivery system and related methods |
| US20100209359A1 (en) * | 2007-02-26 | 2010-08-19 | Revolymer Limited | Medicated chewing gum |
| CA2682323A1 (en) * | 2007-04-02 | 2008-10-09 | Parkinson's Institute | Methods and compositions for reduction of side effects of therapeutic treatments |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
| JP2010538669A (ja) * | 2007-09-18 | 2010-12-16 | ニコノヴァム エービー | ニコチンの迅速な放出をもたらす、マルチトールを含有する安定なチューイングガム組成物 |
| JP2009102287A (ja) * | 2007-10-19 | 2009-05-14 | Seiji Sakao | 禁煙用の辛い唐辛子 |
| WO2009080022A1 (en) * | 2007-12-20 | 2009-07-02 | Fertin Pharma A/S | Compressed chewing gum tablet |
| DK2229156T3 (en) | 2007-12-20 | 2017-02-06 | Fertin Pharma As | CHEW GUM TABLE AND PROCEDURE FOR DOSING PHARMACEUTICAL ACTIVE INGREDIENTS IN SUCH CHEW GUM TABLE |
| DK2229157T3 (en) | 2007-12-20 | 2016-12-05 | Fertin Pharma As | Compressed chewing gum tablet |
| CL2009001025A1 (es) | 2008-05-01 | 2010-09-24 | Smithkline Beecham Corp | Composicion de pastilla para chupar que comprende: a) un granulo patron con al menos: un agente tampon alcalino, un modificador de la disolucion y una carga, b) un principio activo de nicotina definido extragranular y al menos un agente tampon alcalino; procedimiento de preparacion; util para eliminar o reducir el uso de tabaco. |
| AR071850A1 (es) | 2008-05-21 | 2010-07-21 | Novartis Ag | Gomas de mascar en forma de tableta |
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-
2001
- 2001-06-20 SE SE0102197A patent/SE0102197D0/xx unknown
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2002
- 2002-06-14 JP JP2003504945A patent/JP4571402B2/ja not_active Expired - Lifetime
- 2002-06-14 CA CA2449298A patent/CA2449298C/en not_active Expired - Lifetime
- 2002-06-14 MX MXPA03011557A patent/MXPA03011557A/es active IP Right Grant
- 2002-06-14 BR BR0210342-7A patent/BR0210342A/pt not_active Application Discontinuation
- 2002-06-14 WO PCT/SE2002/001158 patent/WO2002102357A1/en active Application Filing
- 2002-06-14 US US10/481,053 patent/US20040194793A1/en not_active Abandoned
- 2002-06-14 AU AU2002345454A patent/AU2002345454B2/en not_active Expired
- 2002-06-14 RU RU2003137595/15A patent/RU2291688C2/ru active
- 2002-06-14 NZ NZ529780A patent/NZ529780A/en not_active IP Right Cessation
- 2002-06-14 DE DE60238054T patent/DE60238054D1/de not_active Expired - Lifetime
- 2002-06-14 AT AT02744014T patent/ATE485034T1/de not_active IP Right Cessation
- 2002-06-14 DK DK02744014.8T patent/DK1404306T3/da active
- 2002-06-14 CZ CZ20033458A patent/CZ20033458A3/cs unknown
- 2002-06-14 ES ES02744014T patent/ES2352681T3/es not_active Expired - Lifetime
- 2002-06-14 IL IL15942502A patent/IL159425A0/xx active IP Right Grant
- 2002-06-14 EP EP02744014A patent/EP1404306B1/en not_active Expired - Lifetime
- 2002-06-19 AR ARP020102308A patent/AR034527A1/es unknown
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2003
- 2003-11-26 ZA ZA200309204A patent/ZA200309204B/en unknown
- 2003-12-17 IL IL159425A patent/IL159425A/en unknown
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2009
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2011
- 2011-09-30 US US13/249,619 patent/US20120017924A1/en not_active Abandoned
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| WO2002102357A1 (en) | 2002-12-27 |
| RU2003137595A (ru) | 2005-02-10 |
| DE60238054D1 (de) | 2010-12-02 |
| CA2449298C (en) | 2011-08-02 |
| AR034527A1 (es) | 2004-02-25 |
| JP4571402B2 (ja) | 2010-10-27 |
| AU2002345454B2 (en) | 2006-07-20 |
| US20040194793A1 (en) | 2004-10-07 |
| CA2449298A1 (en) | 2002-12-27 |
| IL159425A0 (en) | 2004-06-01 |
| MXPA03011557A (es) | 2004-03-18 |
| US20120017924A1 (en) | 2012-01-26 |
| SE0102197D0 (sv) | 2001-06-20 |
| ES2352681T3 (es) | 2011-02-22 |
| NZ529780A (en) | 2006-04-28 |
| ATE485034T1 (de) | 2010-11-15 |
| EP1404306A1 (en) | 2004-04-07 |
| IL159425A (en) | 2006-12-10 |
| BR0210342A (pt) | 2004-07-13 |
| EP1404306B1 (en) | 2010-10-20 |
| JP2010070564A (ja) | 2010-04-02 |
| RU2291688C2 (ru) | 2007-01-20 |
| CZ20033458A3 (en) | 2004-05-12 |
| JP2005500296A (ja) | 2005-01-06 |
| DK1404306T3 (da) | 2011-01-24 |
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