YU46803A - Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski oblici - Google Patents
Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski obliciInfo
- Publication number
- YU46803A YU46803A YU46803A YUP46803A YU46803A YU 46803 A YU46803 A YU 46803A YU 46803 A YU46803 A YU 46803A YU P46803 A YUP46803 A YU P46803A YU 46803 A YU46803 A YU 46803A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- piperidine derivatives
- preparation
- compositions containing
- containing same
- radical
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
Pronalazak se odnosi na heterocikloalkil piperidin derivate opšte formule (I), gde X1, X2, X3, X4, i X5 su >C-R'5 do >C-R'5 gde jedan ili više njih je N; R2 je COOH alkiloksikarbonil, cikloalkiloksikarbonil, CN, -CONRaRb ili R2 je CH2OH, alkil supstituisani -CH=CH-Rc; R3 je fenil, heterociklil, alk-R03; Y predstavlja >CH-Re ili difluormetilen, karbonil, hidroksiiminometilen, alkiloksiimonometilen, cikloalkiloksiiminometilen radikal, ili cikloalkilen-1,1 radikal; i n=o do 4 gde se podrazumeva da radikali ili fenil ili heterociklične grupe koje su gore spomenute opcionalno mogu biti zamenjene, u enantiomernim ili diastereoizomernim oblicima ili njihovim smešama, i/ili kao što može biti slučaj u njihovim sin ili anti formama ili njihovim smešama i njihovim solima.[The invention concerns heterocyclylalkyl piperidine derivatives of general formula (I), wherein X1, X2, X3, X4 and X5 are >C-R'1 to >C-R'5 or one at most represents N; R2 is COOH, alkyloxycarbonyl, cycloalkyloxycarbonyl, CN, -CONRaRb or R2 is CH2OH, alkyl substituted or R2 is -CF2-Rc, -C(CH3)2-Rc, -CO-Rc, -CHOH-Rc, -C(cycloalkyl)-Rc or -CH=CH-Rc; R3 is phenyl, heterocyclyl. alk-RГє3; Y represents >CH-Re or a difluoromethylene, carbonyl, hydroxyiminomethylene, alkyloxyiminomethylene, cycloalkyloxyiminomethylene radical, or a cycloalkylene-1,1 radical; and n = 0 to 4 provided that the radicals or phenyl or heterocyclyl portions mentioned above can optionally be substituted, in the enantiomeric or diastereoisomeric forms or mixtures thereof, and/or as the case may be in their syn or anti form or mixture thereof and their salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0014738A FR2816618B1 (fr) | 2000-11-15 | 2000-11-15 | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
Publications (1)
Publication Number | Publication Date |
---|---|
YU46803A true YU46803A (sh) | 2006-05-25 |
Family
ID=8856503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU46803A YU46803A (sh) | 2000-11-15 | 2001-11-14 | Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski oblici |
Country Status (28)
Country | Link |
---|---|
EP (2) | EP1695964A1 (sh) |
JP (1) | JP2004514661A (sh) |
KR (1) | KR100849608B1 (sh) |
CN (1) | CN1483031A (sh) |
AR (1) | AR034006A1 (sh) |
AT (1) | ATE337311T1 (sh) |
AU (2) | AU2002218365B2 (sh) |
BG (1) | BG107793A (sh) |
BR (1) | BR0115312A (sh) |
CA (1) | CA2429311A1 (sh) |
CZ (1) | CZ20031316A3 (sh) |
DE (1) | DE60122567T2 (sh) |
DK (1) | DK1337529T3 (sh) |
EA (1) | EA200300568A1 (sh) |
EE (1) | EE200300207A (sh) |
ES (1) | ES2271119T3 (sh) |
FR (1) | FR2816618B1 (sh) |
HR (1) | HRP20030379A2 (sh) |
HU (1) | HUP0303758A3 (sh) |
IL (1) | IL155841A0 (sh) |
NO (2) | NO20032187L (sh) |
PL (1) | PL363004A1 (sh) |
PT (1) | PT1337529E (sh) |
SK (1) | SK5822003A3 (sh) |
TN (1) | TNSN01160A1 (sh) |
WO (1) | WO2002040474A2 (sh) |
YU (1) | YU46803A (sh) |
ZA (1) | ZA200303794B (sh) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60125373T2 (de) | 2000-07-26 | 2007-10-18 | Smithkline Beecham P.L.C., Brentford | Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0118238D0 (en) * | 2001-07-26 | 2001-09-19 | Smithkline Beecham Plc | Medicaments |
WO2003064431A2 (en) | 2002-01-29 | 2003-08-07 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
EP2181996A1 (en) | 2002-01-29 | 2010-05-05 | Glaxo Group Limited | Aminopiperidine derivatives |
AR040336A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
FR2842807A1 (fr) * | 2002-07-23 | 2004-01-30 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant |
GB0217294D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
FR2844270B1 (fr) | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
FR2844268B1 (fr) | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
DE10256405A1 (de) * | 2002-12-02 | 2004-06-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen, die Topoisomerase IV inhibieren |
JP4704755B2 (ja) | 2002-11-05 | 2011-06-22 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗菌剤 |
EP1567520B1 (en) | 2002-12-04 | 2008-10-15 | Glaxo Group Limited | Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents |
FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
US7232833B2 (en) | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
FR2862301B1 (fr) * | 2003-11-17 | 2007-12-21 | Aventis Pharma Sa | Nouveau procede de preparation de quinoleines 3-fluorees |
FR2867472B1 (fr) * | 2004-03-12 | 2008-07-18 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
WO2006081178A2 (en) | 2005-01-25 | 2006-08-03 | Glaxo Group Limited | Antibacterial agents |
US7605169B2 (en) | 2005-01-25 | 2009-10-20 | Glaxo Group Limited | Antibacterial agents |
JP2008528587A (ja) | 2005-01-25 | 2008-07-31 | グラクソ グループ リミテッド | 抗菌剤 |
EP1846418A4 (en) | 2005-01-25 | 2009-12-23 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
JP2008531709A (ja) | 2005-03-01 | 2008-08-14 | ワイス | シンノリン化合物および肝臓x受容体調節物質としてのそれらの使用 |
MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
CA2635126A1 (en) | 2006-01-26 | 2007-08-02 | Actelion Pharmaceuticals Ltd | Tetrahydropyrane antibiotics |
WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
ATE520687T1 (de) | 2007-06-15 | 2011-09-15 | Actelion Pharmaceuticals Ltd | 3-amino-6-(1-amino-ethyl)-tetrahydropyranderiva e |
EP2080761A1 (en) | 2008-01-18 | 2009-07-22 | Glaxo Group Limited | Compounds |
WO2010043714A1 (en) | 2008-10-17 | 2010-04-22 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
EP2379554B1 (en) | 2009-01-15 | 2015-11-11 | Glaxo Group Limited | Naphthyridin-2(1h)-one compounds useful as antibacterials |
JP6389174B2 (ja) * | 2012-08-15 | 2018-09-12 | グラクソ グループ リミテッドGlaxo Group Limited | 化学的方法 |
EA031589B1 (ru) | 2014-08-22 | 2019-01-31 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Трициклические азотсодержащие соединения для лечения инфекции, вызываемой neisseria gonorrhoeae |
WO2016138988A1 (en) * | 2015-03-02 | 2016-09-09 | University Of Copenhagen | Piperazine inhibitors of bacterial gyrase and topoisomerase iv |
UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7908031A (nl) | 1979-11-01 | 1981-06-01 | Acf Chemiefarma Nv | Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen. |
JPH0239546A (ja) | 1988-07-29 | 1990-02-08 | Origin Electric Co Ltd | 混成集積回路の製造方法 |
AU623474B2 (en) | 1989-01-16 | 1992-05-14 | Laboratoire Roger Bellon | New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them |
ES2201674T3 (es) * | 1998-01-26 | 2004-03-16 | Smithkline Beecham Plc | Derivados de quinolina con propiedades antibacterianas. |
AU2437900A (en) * | 1999-01-20 | 2000-08-07 | Smithkline Beecham Plc | Piperidinylquinolines as protein tyrosine kinase inhibitors |
FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
-
2000
- 2000-11-15 FR FR0014738A patent/FR2816618B1/fr not_active Expired - Fee Related
-
2001
- 2001-11-13 AR ARP010105289A patent/AR034006A1/es unknown
- 2001-11-14 ES ES01996538T patent/ES2271119T3/es not_active Expired - Lifetime
- 2001-11-14 EA EA200300568A patent/EA200300568A1/ru unknown
- 2001-11-14 EP EP06010725A patent/EP1695964A1/fr not_active Withdrawn
- 2001-11-14 AU AU2002218365A patent/AU2002218365B2/en not_active Ceased
- 2001-11-14 CN CNA018210996A patent/CN1483031A/zh active Pending
- 2001-11-14 KR KR1020037006600A patent/KR100849608B1/ko not_active IP Right Cessation
- 2001-11-14 YU YU46803A patent/YU46803A/sh unknown
- 2001-11-14 EP EP01996538A patent/EP1337529B1/fr not_active Expired - Lifetime
- 2001-11-14 PL PL01363004A patent/PL363004A1/xx not_active Application Discontinuation
- 2001-11-14 AT AT01996538T patent/ATE337311T1/de not_active IP Right Cessation
- 2001-11-14 PT PT01996538T patent/PT1337529E/pt unknown
- 2001-11-14 JP JP2002543484A patent/JP2004514661A/ja active Pending
- 2001-11-14 CZ CZ20031316A patent/CZ20031316A3/cs unknown
- 2001-11-14 EE EEP200300207A patent/EE200300207A/xx unknown
- 2001-11-14 BR BR0115312-9A patent/BR0115312A/pt not_active Application Discontinuation
- 2001-11-14 DE DE60122567T patent/DE60122567T2/de not_active Expired - Fee Related
- 2001-11-14 AU AU1836502A patent/AU1836502A/xx active Pending
- 2001-11-14 TN TNTNSN01160A patent/TNSN01160A1/fr unknown
- 2001-11-14 HU HU0303758A patent/HUP0303758A3/hu unknown
- 2001-11-14 DK DK01996538T patent/DK1337529T3/da active
- 2001-11-14 IL IL15584101A patent/IL155841A0/xx unknown
- 2001-11-14 WO PCT/FR2001/003559 patent/WO2002040474A2/fr active IP Right Grant
- 2001-11-14 SK SK582-2003A patent/SK5822003A3/sk unknown
- 2001-11-14 CA CA002429311A patent/CA2429311A1/en not_active Abandoned
-
2003
- 2003-05-09 BG BG107793A patent/BG107793A/bg unknown
- 2003-05-13 HR HR20030379A patent/HRP20030379A2/hr not_active Application Discontinuation
- 2003-05-14 NO NO20032187A patent/NO20032187L/no unknown
- 2003-05-15 ZA ZA200303794A patent/ZA200303794B/xx unknown
-
2007
- 2007-04-25 NO NO20072142A patent/NO20072142L/no not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
YU46803A (sh) | Heterociklilalkil piperidin derivati, njihova priprema i njihovi farmaceutski oblici | |
WO2003082798A8 (es) | Compuestos naturales y derivados de éstos para la prevención y el tratamiento de enfermedades cardiovasculares, hepáticas, renales y para aplicaciones cosméticas | |
AP9701039A0 (en) | Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one. | |
ATE334666T1 (de) | Neue fettsäureanaloge zur behandlung der fettleber | |
GR75353B (sh) | ||
MXPA04006322A (es) | Derivados de 6-fluorobiciclo[3.1.0]hexano. | |
CA2113229A1 (en) | Anti-fibrotic quinazolinone-containing compositions and methods for the use thereof | |
IS8448A (is) | Lifrarbólgu C-veirutálmar | |
HK1040985A1 (en) | Cell adhesion-inibiting antiinflammatory and immunesuppressive compounds. | |
AU2003228674A1 (en) | Muscarinic antagonists | |
SE9802974D0 (sv) | New crystalline forms | |
ATE171188T1 (de) | In 15-stellung substituierte 4-azasteroide | |
MX9604483A (es) | Derivados de benzamida, composiciones que contienen dicho derivado y uso de las mismas. | |
IL136359A (en) | Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same | |
ES2010853A6 (es) | Composiciones de tensoactivos sinergicos. | |
BG105919A (en) | Erythromycin derivatives | |
HK1068332A1 (en) | Pyrane derivatives as both ace-and nep-inhibitors | |
BG100884A (en) | Benzamide derivative, compositions containing said derivative and use thereof | |
ATE240299T1 (de) | Diester prodrugs von decahydroischinoline-3- carbonsäure | |
WO2003013456A3 (en) | Personal care compositions | |
GR3017348T3 (en) | Novel isoindolinone derivative, preparation thereof, and pharmaceutical compositions containing same. | |
WO2000071538A3 (en) | 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives | |
TW235294B (sh) | ||
TW231965B (sh) | ||
CA2124835A1 (en) | Cyclopropyl n-hydroxyureas and n-hydroxyacetamides which inhibit lipoxygenase |