WO2013002213A1 - 自動分析システム - Google Patents
自動分析システム Download PDFInfo
- Publication number
- WO2013002213A1 WO2013002213A1 PCT/JP2012/066265 JP2012066265W WO2013002213A1 WO 2013002213 A1 WO2013002213 A1 WO 2013002213A1 JP 2012066265 W JP2012066265 W JP 2012066265W WO 2013002213 A1 WO2013002213 A1 WO 2013002213A1
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- WO
- WIPO (PCT)
- Prior art keywords
- sample
- opening
- plug
- closing
- sample container
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/026—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B01L3/50825—Closing or opening means, corks, bungs
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
- G01N2035/00287—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material) movable lid/cover for sample or reaction tubes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0412—Block or rack elements with a single row of samples
- G01N2035/0415—Block or rack elements with a single row of samples moving in two dimensions in a horizontal plane
Definitions
- the present invention relates to an automatic analyzer for analyzing biological samples such as blood and urine, and more particularly to an automatic analysis system provided with a container opening / closing unit.
- the automatic analysis system is an automatic analysis system including an automatic analyzer that performs analysis by measuring physical properties of a sample to be measured (for example, a biological sample such as serum or urine, or a mixture of these with a reagent). And a processing unit for performing various processes such as a container opening process, a dispensing process, a container closing process, a stirring process, and an analysis process.
- a sample to be measured for example, a biological sample such as serum or urine, or a mixture of these with a reagent.
- a processing unit for performing various processes such as a container opening process, a dispensing process, a container closing process, a stirring process, and an analysis process.
- Patent Documents 1 to 4 As prior art of an open / close apparatus for opening and closing a sample container (hereinafter referred to as opening processing and closing processing) in the container opening / closing step of such an automatic analysis system, for example, Patent Documents 1 to 4 There are the opening and closing means described in. Moreover, there exists a transfer means of patent document 5 as a prior art which conveys a container, for example in the container conveyance process of an automatic analysis system.
- the opening device disclosed in Patent Document 1 is provided with an opening method in which a plurality of openings are simultaneously opened.
- an opening and closing method is provided in which the opening and closing device rotates and moves in a state in which the plug is gripped and performs dispensing and closing at the same position as the opening. ing.
- the opening and closing device described in Patent Document 3 there is provided a method in which the opening and closing device moves in a state of holding the plug after opening the container and performs dispensing and closing at the same position as the opening processing. .
- the opening / closing device holds the plug after the opening processing of the container, and the container rotates and performs dispensing processing at a position different from the opening position, and the opening is closed at the same position as the opening processing A scheme for performing the process is provided.
- a rack buffer mechanism provided with a plurality of storage positions is provided.
- the opening and closing device moves in a state in which the plug is gripped, and performs the dispensing process and the closing process at the same position as the opening process. Is provided.
- the processing capacity is determined by the time required for the cycle from opening to closing. When the time required from opening to closing is 10 seconds, the processing capacity of about 360 test / hour is the limit.
- An object of the present invention is to provide an automatic analysis system provided with a plug opening and closing mechanism which solves the above problems and improves the throughput.
- one aspect of the present invention is as follows.
- An automatic analysis system including a transport device for transporting a sample container containing a removable sample and containing a plug, the sample processing unit performing processing on the sample stored in the sample container, and the sample container
- the transport apparatus includes a first transport line for transporting the sample container to the sample processing unit, a second transport line for transporting the sample container for which the sample processing unit has finished processing the sample, and the first transport line.
- the sample container is transported from the transport line and the second transport line to the plug opening / closing device, and the sample container which has been subjected to the opening / closing process of the plug is again subjected to the first transport line or the second transport line.
- a third transport line returned to the second transport line.
- FIG. 7 is an operation pattern diagram in the dispensing and plugging steps of the first sample container according to the first embodiment of the present invention.
- FIG. 7 is an operation pattern diagram in the dispensing and plugging steps of the first sample container according to the first embodiment of the present invention.
- FIG. 7 is an operation pattern diagram in the dispensing and plugging steps of the first sample container according to the first embodiment of the present invention.
- FIG. 7 is an operation pattern diagram in the dispensing and plugging steps of the first sample container according to the first embodiment of the present invention.
- FIG. 7 is an operation pattern diagram in the dispensing and plugging steps of the first sample container according to the first embodiment of the present invention.
- FIG. 14 is an operation pattern diagram in the dispensing to closing step of the third sample container and the opening to closing step of the fourth sample container according to the second embodiment of the present invention.
- FIG. 14 is an operation pattern diagram in the dispensing to closing step of the third sample container and the opening to closing step of the fourth sample container according to the second embodiment of the present invention.
- FIG. 14 is an operation pattern diagram in the dispensing to closing step of the third sample container and the opening to closing step of the fourth sample container according to the second embodiment of the present invention.
- FIG. 14 is an operation pattern diagram in the dispensing to closing step of the third sample container and the opening to closing step of the fourth sample container according to the second embodiment of the present invention.
- FIG. 14 is an operation pattern diagram in the dispensing to closing step of the third sample container and the opening to closing step of the fourth sample container according to the second embodiment of the present invention. It is a flowchart which shows the operation
- FIG. 6 is an operation pattern diagram in the sample container opening step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container opening step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container opening step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container opening step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container opening step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention.
- FIG. 6 is an operation pattern diagram in the sample container closing step according to the first embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is an operation pattern figure in the opening and closing process of a sample container concerning a second embodiment of the present invention. It is the schematic which shows the whole structure of the automatic analysis system provided
- FIG. 1 is a schematic plan view showing the overall configuration of the automatic analysis system according to the first embodiment of the present invention.
- the automatic analysis system 100 has a stopper 7 and is a transport device for loading and transporting a sample container 6 containing a sample such as a biological sample such as blood or urine on a rack 5 8 and an open / close device 4 for opening and closing the sample container 6 transported by the transport device 8.
- the transport device 8 is described to transport the sample container 6 mounted on the rack 5, the transport device 8 may be configured to be transported as a single sample container 6 without being mounted on the rack 5.
- the rack 5 shown in the drawing is of a type carrying a plurality of samples, it may be of a type in which only one is transported.
- a reaction disc 2 rotatable in one direction is provided on the housing 1.
- the reaction disk 2 is configured such that a plurality of reaction containers 9 can be regularly arranged along the circumference.
- a reagent disc 3 is provided next to the reaction disc 2.
- the reagent disc 3 is configured to be rotatable in both directions, and is configured to rotate in a direction in which the required reagent is in a position close to the reagent probe 10.
- the reagent disk 3 is configured such that reagent containers 11 each containing a plurality of various reagents used for analysis can be mounted on the entire circumference.
- the reagent probe 10 is connected to a reagent pump not shown in the figure.
- the reagent probe 10 is configured to dispense a predetermined amount of reagent from the reagent container 11 disposed on the reagent disk 3 into the reaction container 9 on the reaction disk 2.
- the transport device 8 is configured by a supply line 81, a first transport line 83, a sample line 12, a second transport line 84, a third transport line 85, and a return line 82.
- the transport device 8 includes a supply line 81, a first transport line 83, a sample line 12, a second transport line 84, a third transport line 85, and a return line 82 for the convenience of description.
- the supply line 81 and the return line 82 may not be provided, and the first conveyance line 84 may be configured to include the supply line 82.
- 85 may be configured to include return line 82.
- the sample line 12 is described as being independently provided for convenience of description, the sample line 12 may be configured to be included in, for example, the first conveyance line 83 and the second conveyance line 84 without being provided independently.
- the supply line 81 is connected to a loading port (not shown) for loading the sample container 6 from the outside of the automatic analysis system 100 at one end side of the housing 1.
- the supply line 81 extends from one end of the housing 1 to the front of the reaction disk 2, and the other end is connected to one end of the first transfer line 83.
- the supply line 81 is configured to be able to advance the rack 5 in the longitudinal direction of the rack 5.
- the first transport line 83 is configured to extend in the lateral direction of the rack 5 of the supply line 81.
- the sample line 12 is a line for transporting the rack 5 in the vicinity of the reaction disk 2. Between the reaction container 9 and the sample line 12, a sample probe 13 which can rotate and move up and down is installed.
- the sample probe 13 may be attached not only to the vertical rotational movement but also to the XYZ transport mechanism, and is connected to a sample pump not clearly shown in the figure.
- a stopper opening / closing device 4 is disposed around the sample line 12. In this embodiment, it is located between the first transfer line 83 and the second transfer line 84, and is located on the third transfer line 85 which can be carried in and out in both directions from any line.
- the absence of the opening / closing device 4 on any of the first conveyance line 83 and the second conveyance line 84 can prevent the rack from stagnating on the conveyance device due to the opening / closing process. Further, since access is possible from any of the first transport line 83 and the second transport line 84, the plug removed in the opening processing can be attached to the sample container again in the closing processing.
- a stirring device 15, a light source 16, a detection optical device 17, and a container washing mechanism 18 are disposed around the reaction disk 2.
- the container cleaning mechanism 18 is connected to a cleaning pump not shown in the figure.
- a washing port 19 is installed in the operation range of each of the sample probe 13, the reagent probe 10, and the stirring device 15.
- the sample pump, the reagent pump, the washing pump, the detection optical device 17, the reaction container 9, the reagent disc 3, the reagent probe 10, and the sample probe 13 not shown in the figure are respectively supplied to the control computer 200 as a control unit. Connected.
- the sample information identification device 14 and the ID reader 20 enclosed in the sample container 6 are disposed in the vicinity of the opening / closing device 4.
- the sample information identification device 14 is, for example, an imaging device such as a CCD, and analyzes the image of the sample container 6 to identify the type of the sample container 6 (diameter, height, type), and the opening condition of the sample container 6 Determination of the presence or absence of the plug 7 and identification of the type of the plug 7 are performed.
- the sample information identification device 14 may specify the presence or absence of the plug and the type of the plug by a method other than plug detection by image recognition.
- the light emitting element and the light receiving element may be disposed to face each other, and the output of the light receiving element may be detected to recognize the presence or absence of the plug 7 and the type of the plug 7. The presence or absence may be detected.
- the ID reader 20 is a device for specifying the sample information stored in the sample container, and a barcode reader, an RFID reading antenna, an imaging device, etc. are assumed.
- the sample information is, for example, the reception date or the reception number of the sample, the patient attribute, etc., and is stored in a storage medium such as a barcode attached to the sample container or an information medium such as RFID attached to the carrier of the sample container. It is done.
- the process content of the sample may be determined based on the information from the upper control computer.
- the transport device 8, the opening / closing device 4, the sample information identification device 14, and the ID reader 20 are electrically connected to a control computer 200 as a control unit.
- FIG. 2A and 2B are perspective views of a sample container 6 provided with a plurality of types of stoppers 7.
- the sample container 6 has an opening for containing and removing the sample, and the stopper 7 is used to prevent contamination of the contents, evaporation and concentration of the contents, and spilling of the sample during falling. It is closed by
- the sample containers 6 are mounted on the rack 5a and the holder 5b in a state of being sealed by the stopper 7, and are put into the automatic analysis system by the operator.
- the carrier for transporting the sample container may be a rack type capable of transporting a plurality of sample containers at one time as shown in FIG. 2A, or shown in (A), (B) and (C) of FIG. 2B. As described above, a holder type may be used to individually transport the sample containers one by one.
- FIG. 3A is an example of a schematic view of the switchgear 401.
- the main components of the open / close device 401 are a transfer arm 43, a chuck up-and-down mechanism 47, a chuck rotation mechanism 48, a clamp mechanism 49 for the sample container 6, and a chuck mechanism 41.
- the transfer arm 43 moves the chuck mechanism 41 (411 to 415).
- the drawing discloses a system having an XZ axis and moving the plug chuck mechanism along the XZ direction, the present invention is not limited to this system.
- the chuck mechanism may be rotationally moved about an axis.
- the clamp mechanism 49 performs fixing and lifting operations of the sample container 6 which is required at the time of opening and closing operation.
- the chuck mechanism 41 performs opening processing and closing processing of the plug 7.
- the chuck mechanism 41 is also provided with a function of performing opening and closing processing by the up-and-down mechanism 47 and the rotation mechanism 48 and holding the plug 7 after the opening processing for use in the closing processing.
- the disposal place 701 of the plug 7 may be provided in the vicinity of the opening and closing device 401 so that the plug 7 can be discarded if it is not necessary to close it.
- the supply location 702 of the plug 7 may be installed in the vicinity of the opening / closing device 401. Thereby, it is also possible to cope with the case of closing with the plug 7 dedicated for closing.
- sample information identification device 14 is provided in the vicinity of the opening / closing device 401 so that the retry operation is performed a predetermined number of times set in advance for the sample container 6 in which the opening or closing treatment of the sample container 6 fails. You may configure.
- a temperature control mechanism 711, a humidifying mechanism 712 and a cleaning mechanism 713 not shown in the figure are provided in the vicinity of the opening / closing device 401, and temperature control and humidity control are performed on the plug 7 after opening processing.
- the sample attached to the plug 7 may be prevented from drying, and the sample attached to the plug 7 may be washed by the plug cleaning mechanism 713 not shown in the figure.
- the maintenance is exemplified by inspection of the detection optical device 17, cleaning of the reaction container 9, cleaning of various probes such as the sample probe 13, and the like. Thereafter, a sample to be tested, such as blood and urine, is enclosed in the sample container 6, placed on the rack 5 without being opened and transported by the transport device 8.
- Sample information such as identification (diameter, height, type) of the sample container 6 is read by the sample information identification device 14 provided around the transport device 8. Further, detection of presence / absence and type (rubber plug, plastic guard plug, screw plug, etc.) of the plug 7 in the sample container 6 is simultaneously performed by the sample information identification device 14.
- the sample information identification device 14 picks up the sample container 6 to acquire an image, analyzes the image, determines the opening condition of the sample container 6 (presence or absence of the plug 7), and specifies the type of the plug 7 I do.
- the type and attributes of the sample container 6 and the stopper 7 are stored in the storage unit 201 of the control computer 200 as the information on the sample container 6, together with the reception date and the reception number of the sample, the patient attributes, etc. .
- the sample information management unit 202 in the control computer 200 determines whether or not the sample container 6 is opened and closed.
- the sample information management unit 202 in the control computer 200 determines the processing content of the sample (presence or absence of opening processing, destination of the rack 5) based on the analysis information. Regarding this point, a method of determining the processing content of the sample based on the information from the upper control computer 200 may be used. Based on the identification processing read in this manner, the destination of the rack 5 (the opening position of the plug opening / closing device 401 or the opening position of the opening / closing device 402) is determined.
- the sample information management unit 202 information (torque, operating conditions, determination conditions at the time of abnormality) and the like necessary for opening and closing the plug suitable for the type of the sample container 6 (for example, blood collection tube) are registered in advance. .
- information regarding the use condition of the switchgears includes, for example, information as to whether or not an opening process, a closing process is performed, or whether a plug after opening is held.
- identification processing for the rack 5 and the sample container 6 is performed by the ID reader 20.
- the ID reader 20 reads identification information for identifying a sample, such as a sample ID, from the RFID or the sample barcode attached to the rack 5 or the sample container 6.
- the identification information of the read sample is transmitted to the sample information management unit 202 in the control computer 200, and the information of the opening / closing device 4 that performs opening processing, the type (diameter, height, type) of the sample container 6 of the sample, It registers with the information regarding the presence or absence of the stopper 7, the kind of stopper (a rubber stopper, a plastic guard stopper, a screw stopper, etc.).
- the rack 5 whose sample container 6 has been identified by the ID reader 20 is transferred to the stopper opening / closing device (401, 402).
- the optimum operating condition of the opening and closing device 4 is determined from the condition registered in the sample information management unit 202, and the opening processing based on that is opened and closed. It implements with an apparatus (401, 402).
- the type of plug 7 is recognized in accordance with the RFID or sample barcode information in which sample information is registered, and the plug opening / closing device 4 operates. At this time, the opening and closing device 4 of the plug holds the plug 7 that has been opened. Details of the opening and closing process of the plug body 7 will be described later.
- the sample container 6 from which the stopper 7 has been removed is transported by the transport device 8 to the sample line 12.
- the sample container 6 transferred onto the sample line 12 is transported to the sampling position, and the sample probe 13 performs a sample dispensing process.
- the sample collected by the sample probe 13 is dispensed into the reaction container 9 arrayed on the reaction disk 2, and a predetermined amount of reagent is dispensed from the reagent container 11 installed on the reagent disk 3 by the reagent probe 10.
- the detection optical device 17 measures the absorbance, spectrum, etc. of the sample contained in the reaction container 9, and outputs it to the control computer 200 as the measurement result.
- the sample dispensing operation is repeated.
- the process is repeated until the sample dispensing process of the set measurement item is completed.
- the rack 5 for which the sample dispensing process has been completed is transferred again to the open / close position of the open / close device 4 that has been opened.
- the information of the rack 5 on which the sample container 6 having been dispensed is loaded is read by the ID reader 20, and the opening / closing device of the stopper to be closed is specified.
- the sample container transferred to the same opening / closing position of the same apparatus as the opening / closing apparatus which opened the stopper 7 For 6, the same fitting plug 7 as before the dispensing process is attached to the sample container 6.
- the sample container 6 to which the stopper 7 is attached is transferred by the transport device 8 to a sample storage portion not clearly shown in the figure.
- FIGS. 3B and 3C are schematic plan views in the case where the first opening / closing device 401 and the second opening / closing device 402 are provided, and the transfer line A45 and the transfer line B46 are provided as the third transfer line of each opening / closing device. Show.
- the open / close position of the rack 5 transferred by the transfer device 8 is determined by the sample information identification device 14 on the condition of the plug. If the control computer determines that the opening process is necessary, the control device refers to the sample information management unit 202 to that effect, and replies to the transport apparatus about the opening / closing device capable of performing the opening process on the rack.
- the transport device transports the rack along the first transport line.
- the ID reader 20 installed around the same.
- the identification information of the sample container or rack is read by the The read identification information is transmitted to the sample information management unit 202 of the control computer, and is stored together with information for identifying the opening / closing device on which the opening process is performed.
- the opening and closing devices (401, 402) of the stopper perform opening and closing processing of the stopper, and the chuck mechanism (41, 42) for holding and managing the stopper, the transport arm (43, 44) for transporting the chuck mechanism, and the rack 5
- a transfer line A45 capable of reciprocating transfer and a transfer line B46 are roughly provided.
- the transfer arm (43, 44) generally includes a drive mechanism capable of moving the chuck mechanism (41, 42) in three axial directions (X direction, Y direction, Z direction). By this chuck mechanism (41, 42), the plug 7 can be opened and closed, and the plug 7 that has been opened and removed can be held until the plugging processing.
- the transport arm may move the chuck mechanism in two axial directions and move the test tube accordingly.
- FIG. 3C is a schematic view in which the chuck mechanisms (41, 42) and the transfer arms (43, 44) of the stopper opening / closing device (401, 402) are hidden.
- a transfer line A 45 including a transfer line 451 is provided as a transfer line to be opened and closed by the first opening / closing device 401, and a transfer line 461 as a transfer line to be opened and closed by the second opening / closing device 402 Transfer line B46 is provided.
- the plurality of sample containers 6 mounted on the rack 5 can be opened and closed at one time.
- 7A to 7F show operation procedures of the opening process and the closing process when the transfer line A 45 (opening and closing position) of the rack 5 according to the first embodiment is one.
- the rack 5 carried from the supply line 81 to the first transfer line 83 is transferred to the open position of the transfer line 451, which is the third transfer line, for the opening process.
- the transport arm 43 which is not clearly shown in the figure moves in three axial directions, and the stopper chuck mechanism (411 to 65) is positioned at a position suitable for opening the stoppers of the sample containers 61 to 65 installed in the rack 5. 415), and stands by at the opening position (FIG. 7A).
- the chuck mechanism (412, 414) grips the stopper of the sample container (62, 64) and performs appropriate opening processing based on the type of stopper.
- the stoppers (72, 74) removed from the sample container (62, 64) are held by the opened chuck mechanism (412, 414) (FIG. 7C).
- the chuck mechanism (411, 413, 415) grips the stopper of the sample container (61, 63, 65) and performs an appropriate opening processing based on the type of stopper.
- the stoppers (71, 73, 75) removed from the sample container (61, 63, 65) are held by the opened chuck mechanism (411, 413, 415) (FIG. 7E).
- FIGS. 7G to 7L are schematic operations of the plugging process.
- the rack 5 for which the dispensing process is finished is transported from the second transport line 84 to the closing position of the transfer line 451.
- the transport arm 43 which is not clearly shown in the figure, moves in three axial directions, and transports the chuck mechanism 411 to 415 of the stopper to a position suitable for closing the stopper of the sample container mounted in the rack 5. It stands by at the closing position (FIG. 7G).
- the chuck mechanism (411, 413, 415) holding the plug performs an appropriate closing process based on the type of plug held to the sample container (61, 63, 65). .
- the original stopper (71, 73, 75) removed by the chuck mechanism (411, 413, 415) before the dispensing process is attached to the sample container (61, 63, 65) (FIG. 7K) .
- the movement pattern of the rack from the opening process to the closing process is shown in FIG. 4A to FIG. 4J using the opening and closing device 4 of the stopper thus configured.
- the rack 51 transported from the supply line 81 to the first transport line 83 is transferred by the slide mechanism of the transport device 8 to the transfer line 451 that can be opened and closed by the opening and closing device 4.
- the transfer line 451 (opening / closing position of the stopper) is determined by the ID reader 20 and the control computer 200 (FIG. 4A).
- the control computer 200 refers to the state of the opening / closing device 4 (whether the opening processing or closing processing of another sample container is being carried out, the stopper of another sample container is held, etc.) Then, it is determined whether the sample container can be transported to the opening / closing device 4 or not.
- the transport device 8 transports the sample container to the transfer line 451 or causes the sample container to stand by on the first transport line 83 based on the determination result.
- the rack 51 is mounted with five sample containers, and at the time of processing 1-1, the state is shown in which the stoppers are attached to all the sample containers.
- the sample probe 13 performs a dispensing process on each of the samples (61 to 65) (FIG. 4E).
- the rack 51 is moved from the sample line 12 to the second transport line. Thereafter, it is transferred to the open / close position at which the opening processing is performed in the processing 1-1 to the processing 1-3. Whether to permit the transfer line 451 to pull in the rack 5 is determined by the ID reading device 20 and the control computer 200 which is not clearly shown in the figure. In the determination process, when the ID reader 20 identifies sample information, the sample information management unit 202 of the control computer 200 is inquired.
- the control computer 200 checks the condition of the opening / closing device 4 (the condition in which the opening treatment or closing treatment of another sample container is performed, or the state in which the stopper of another sample container different from the sample container is held, Whether the sample container can be transported to the opening / closing device 4 is determined with reference to the etc.).
- the transport device 8 transports the sample container to the transfer line 451 or causes the sample container to stand by on the first transport line 83 based on the determination result.
- the rack 51 permitted to be pulled in from the second transport line 84 to the transfer line 451 is transported to the open / close position where the original plug body (71 to 75) is held (FIG. 4F).
- the transport arm 43 of the chuck mechanism 41 of the opening / closing device 4 is moved in the Y direction, and is positioned at a position where the plugging processing can be performed on the remaining sample containers to which the plug is not attached. .
- the stoppers (51, 53, 55) held by the chuck mechanism (411, 413, 415) of the opening / closing device 4 are attached to the sample containers (61, 63, 65) of the rack 51 (FIG. 4H).
- FIGS. 3D and 3E A second embodiment is shown in FIGS. 3D and 3E.
- the second embodiment a case will be described in which there are two transfer lines which are third transfer lines for one opening / closing device.
- the maintenance is exemplified by inspection of the detection optical device 17, cleaning of the reaction container 9, cleaning of various probes such as the sample probe 13, and the like. Thereafter, a sample to be tested, such as blood and urine, is enclosed in the sample container 6, placed on the rack 5 without being opened and transported by the transport device 8.
- Reading of information such as identification (diameter, height, type) of the sample container 6 is performed by the sample information identification device 14 provided around the transport device 8. Further, detection of presence / absence and type (rubber plug, plastic guard plug, screw plug, etc.) of the plug 7 in the sample container 6 is simultaneously performed by the sample information identification device 14.
- the sample information identification device 14 picks up the sample container 6 to acquire an image, analyzes the image, determines the opening condition of the sample container 6 (presence or absence of the plug 7), and specifies the type of the plug 7 I do.
- the type and attributes of the sample container 6 and the stopper 7 are stored in the storage unit 201 of the control computer 200 as the information on the sample container 6, together with the reception date and the reception number of the sample, the patient attributes, etc. .
- the sample information management unit 202 in the control computer 200 determines whether or not the sample container 6 is opened and closed.
- the sample information management unit 202 in the control computer 200 determines the processing content of the sample (presence or absence of opening processing, destination of the rack 5) based on the analysis information. Regarding this point, a method of determining the processing content of the sample based on the information from the upper control computer 200 may be used. Based on the identification processing read in this manner, the destination of the rack 5 (the opening position of the plug opening / closing device 401 or the opening position of the opening / closing device 402) is determined.
- the sample information management unit 202 information (torque, operating conditions, determination conditions at the time of abnormality) and the like necessary for opening and closing the plug suitable for the type of the sample container 6 (for example, blood collection tube) are registered in advance. .
- information regarding the use condition of the switchgears includes, for example, information as to whether or not an opening process, a closing process is performed, or whether a plug after opening is held.
- identification processing for the rack 5 and the sample container 6 is performed by the ID reader 20.
- the ID reader 20 reads identification information for identifying a sample, such as a sample ID, from the RFID or the sample barcode attached to the rack 5 or the sample container 6.
- the identification information of the read sample is transmitted to the sample information management unit 202 in the control computer 200, and the information of the opening / closing device 4 that performs opening processing, the type (diameter, height, type) of the sample container 6 of the sample, It registers with the information regarding the presence or absence of the stopper 7, the kind of stopper (a rubber stopper, a plastic guard stopper, a screw stopper, etc.).
- the rack 5 whose sample container 6 has been identified by the ID reader 20 is transferred to the stopper opening / closing device (401, 402).
- the optimum operating condition of the opening and closing device 4 is determined from the condition registered in the sample information management unit 202, and the opening processing based on that is opened and closed. It implements with an apparatus (401, 402).
- the type of plug 7 is recognized in accordance with the RFID or sample barcode information in which sample information is registered, and the plug opening / closing device 4 operates. At this time, the opening and closing device 4 of the plug holds the plug 7 that has been opened. Details of the opening and closing process of the plug body 7 will be described later.
- the sample container 6 from which the stopper 7 has been removed is transported by the transport device 8 to the sample line 12.
- the sample container 6 transferred onto the sample line 12 is transported to the sampling position, and the sample probe 13 performs a sample dispensing process.
- the sample collected by the sample probe 13 is dispensed into the reaction container 9 arrayed on the reaction disk 2, and a predetermined amount of reagent is dispensed from the reagent container 11 installed on the reagent disk 3 by the reagent probe 10.
- the absorbance, spectrum, etc. of the sample contained in the reaction container 9 are measured by the detection optical device 17 and control not shown in the figure as a measurement result It is output to the computer 200.
- the sample dispensing operation is repeated.
- the process is repeated until the sample dispensing process of the set measurement item is completed.
- the rack 5 for which the sample dispensing process has been completed is transferred again to the open / close position of the open / close device 4 that has been opened.
- the information of the rack 5 on which the sample container 6 having been dispensed is loaded is read by the ID reader 20, and the opening / closing device of the stopper to be closed is specified.
- the same compatible plug 7 as that before the dispensing process is attached to the sample container 6.
- the sample container 6 to which the stopper 7 is attached is transferred by the transport device 8 to a sample storage portion not clearly shown in the figure.
- FIG. 3E is a schematic view in which the chuck mechanisms (41, 42) and the transfer arms (43, 44) of the stopper opening / closing device (401, 402) are hidden.
- Transfer line A 45 and transfer line B 46 which are the third transfer line of rack 5 are a set of transfer line A (45) consisting of transfer lines 451 and 452 and a set of transfer lines B consisting of transfer lines 461 and 462, respectively. (46) is provided.
- a transfer line A45 including transfer lines 451 and 452 is provided as a transfer line to be opened and closed by the first opening and closing device 401, and a transfer line as a transfer line to be opened and closed by the second opening and closing device 402.
- a transfer line B46 consisting of 461 and 462 is provided.
- FIGS. 8A to 8F the operation procedure of the opening process and the closing process in the second embodiment is shown in FIGS. 8A to 8F.
- the chuck mechanism (412, 414) holding the stopper grips the sample container (62, 64) mounted on the rack 51, and performs appropriate plugging processing based on the type of the held stopper. At this time, it is the same plug as the plug (72, 74) removed before the dispensing processing that is to be plugged into the sample container (62, 64). At this time, the rack 52 is positioned at the open / close position of the transfer line 452 (FIG. 8C).
- the stoppers (71, 73, 75) held by the chuck mechanism (411, 413, 415) are appropriately selected based on the type of the stopper, and the sample containers (61, 63, Attach to 65). Further, the chuck mechanism (412, 414) opens the stopper (72, 74) of the sample container (62, 64) of the rack 52 based on the type of the stopper by an appropriate opening processing method, and the chuck mechanism 412, Hold at 414 (FIG. 8E).
- the sample containers (61, 63, 65) of the rack 51 on which the closing processing of all mounted sample containers is finished are mounted on the rack 5 by the holding mechanism of the sample container not shown in the figure. It is lowered to the position.
- the rack 51 is transported from the transfer line 451.
- the sample container (62, 64) of the rack 52 is lowered by the holding mechanism of the sample container not shown in the figure.
- the sample container (61, 63, 65) mounted on the rack 52 and not completely opened is lifted to a predetermined height by the holding mechanism of the sample container not clearly shown in the figure.
- the sample container is opened (FIG. 8F).
- FIGS. 5A to 5T and FIGS. 6A and 6B The movement pattern of the rack from the opening process to the closing process is shown in FIGS. 5A to 5T and FIGS. 6A and 6B by using the opening and closing device 4 of the stopper thus configured.
- FIG. 5 is an embodiment of the second embodiment.
- the operation patterns are shown in FIGS. 5A to 5T.
- processing 1-1 to processing 1-9 is for the first rack 51
- processing 2-1 to processing 2-9 is for the second rack 52
- processing 3-1 to the third rack 53 Shows the process of The operations from FIG. 5A to FIG. 5F, (process 1-1) to (process 1-6) are the same as the operation of the transfer line 451 of FIG. 4A to FIG. 4F.
- the rack 51 carried into the first transfer line 83 via the supply line 81 is transferred to the transfer line 451 or 452 of the opening / closing device 4. It is determined by the ID reading device 20 and the control computer 200 which transport line is to be transported (FIG. 5A). In the determination process, when the ID reader 20 identifies sample information, the sample information management unit 202 of the control computer 200 is inquired. The control computer 200 checks the state of the opening and closing device 401 and the transfer lines 451 and 452 (a state where the opening and closing treatment of the other sample container is performed by the opening and closing device 4 or another sample container different from the sample container).
- the transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the first transport line 83. In the present embodiment, the case where the sample rack is carried into the transfer line 451 will be described below.
- the chuck mechanism (412, 414) of the opening / closing device 4 opens the stopper (72, 74) of the sample container (62, 64) of the rack 51.
- the chucking mechanism (412, 414) holds the opened plug (72, 74) (FIG. 5B).
- the sample probe 13 performs a dispensing process on the sample (61 to 65) (FIG. 5E).
- the control computer 200 refers to the information recorded in the sample information management unit 202, and identifies the same open / close device 401 as the open / close device that has performed the opening process in the process 1-1 to the process 1-3.
- the condition of the opening / closing device 401 and the transfer lines 451 and 452 (the condition in which the opening / closing device 4 performs the opening process or closing process of another sample container, or the stopper of another sample container different from the sample container The presence or absence of another sample rack on the transfer lines 451, 452, etc.) is referred to to determine whether the sample container can be transported.
- the transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the second transport line 84. In this embodiment, it is assumed that the transfer line 451 is permitted to carry in the sample rack.
- the corresponding rack 51 is transported to the open / close position where the original plug body (71 to 75) is held (FIG. 5F).
- Process 2-1 At the same timing as in Process 1-7, the second rack 52 to be newly opened is carried into the first transfer line via the supply line 81, and the opening process by the opening / closing device 4 To the transfer line 452 where the The transfer line 452 (opening / closing position of the stopper) is determined by the ID reader 20 and the control computer 200 not shown in the figure.
- the determination processing when the ID reader 20 identifies the information of the second rack 52, the sample information management unit 202 of the control computer 200 is inquired.
- the control computer 200 refers to the information recorded in the information management unit 202, the status of the opening / closing device 401, and the status of the transfer lines 451, 452 (the opening / closing processing of the other sample container is performed by the opening / closing device 401). Refer to the current situation, the condition that holds the stopper of another sample container different from the sample container, or the presence of another sample rack on the transfer line 451, 452, etc. To determine whether the sample container can be transported. The transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the second transport line 84. In the present embodiment, since the rack 51 performs the closing process on the transfer line 451, the control computer 200 permits the rack 52 to be carried into the transfer line 452 (FIG. 5G).
- the chuck mechanism (412, 414) of the opening / closing device 4 opens the stopper (72, 74) of the sample container (62, 64) of the second rack 52 simultaneously with the process 1-8. .
- the chucking mechanism (412, 414) holds the opened plug (72, 74) (FIG. 5H).
- the sample probe 13 performs a dispensing process on the sample (61 to 65) (FIG. 5K).
- the rack 52 for which sample dispensing has been completed is transported from the sample line 12 to the second transport line 84. Thereafter, it is transported to a position where the plugging process can be performed by the same opening and closing apparatus 4 as the opening and closing apparatus which has performed the opening process in the processes 2-1 to 2-3.
- the plugging process can be performed by the same opening and closing apparatus 4 as the opening and closing apparatus which has performed the opening process in the processes 2-1 to 2-3.
- there are two lines accessible by the opening / closing device 4, the transfer line 451 and the transfer line 452, but in which transfer line the plugging process should be performed is the sample information identification device 14 disposed on the sample line.
- the control computer 200 In the determination process, when the ID reader 20 identifies the sample information of the sample container for which the dispensing process is completed, the control computer 200 is inquired.
- the control computer 200 refers to the information recorded in the sample information management unit 202 and identifies the same open / close device 401 as the open / close device that has performed the opening process in the processes 2-1 to 2-3.
- the open / close device 401 the condition of the transfer line (451, 452) (the condition where the open / close treatment of the open / close device 4 is performing opening / closing processing of another sample container, Whether the sample container can be transported or not is determined with reference to the state in which the stopper is held or whether another sample rack is present on the transfer line (451, 452).
- the transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the second transfer line 84.
- the transfer line 451 is permitted to carry in the sample rack.
- the rack 52 is instructed to be transported to the transfer line 451 in order to perform plugging processing by the opening / closing device 401 in which the original plug body (71 to 75) is held (FIG. 5L). .
- Process 3-1 At the same timing as in Process 2-7, the next rack 53 to be newly opened is carried into the first transfer line 83 through the supply line 81, and the opening process by the opening / closing device 4 is performed. It is transported onto a possible transport line 452.
- the transfer line 452 (opening / closing position of the stopper) is determined by the ID reader 20 and the control computer 200 not shown in the figure. In the determination process, when the ID reader 20 identifies the information of the third rack 53, the sample information management unit 202 of the control computer 200 is inquired.
- the control computer 200 refers to the information recorded in the information management unit 202, the status of the opening / closing device 401, and the status of the transfer lines (451, 452) (the opening / closing processing of the other sample containers Whether the processing is being performed, the stopper of another sample container different from the sample container is held, or is there another sample rack on the transfer line (451, 452), etc. Whether or not the sample container can be transported is determined with reference to.
- the transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the first transport line 83.
- the control computer 200 permits the rack 52 to be carried into the transfer line 452.
- the rack 52 in the transfer line 451 is being subjected to the plugging process, and therefore, the rack 52 is carried into the transfer line 452 (FIG. 5M).
- the chuck mechanism (412, 414) of the opening / closing device 4 opens the stopper (72, 74) of the sample container (62, 64) of the rack 53.
- the chucking mechanism (412, 414) holds the opened plug (52, 54) (FIG. 5N).
- the sample probe 13 dispenses the sample (61 to 65) (FIG. 5Q).
- the rack 53 for which sample dispensing has been completed, is transported from the sample line 12 to the second transport line 84, and is transported by the transport device 3 to a position where closure processing can be performed by the opening / closing device 4.
- the transfer line 451 (opening / closing position of the stopper) is determined by the ID reader 20 and the control computer 200 not shown in the figure. In the determination process, when the ID reader 20 identifies the sample information of the sample container for which the dispensing process is completed, the control computer 200 is inquired.
- the control computer 200 refers to the information recorded in the sample information management unit 202 and identifies the same open / close device 401 as the open / close device that has performed the opening process in the processes 3-1 to 3-3.
- the condition of the opening / closing device 401 and the transfer lines 451 and 452 (the condition in which the opening / closing device 4 performs the opening process or closing process of another sample container, or the stopper of another sample container different from the sample container
- the presence or absence of another sample rack on the transfer lines 451, 452, etc.) is referred to to determine whether the sample container can be transported.
- the transport device 8 transports the sample container to the transfer line 451 or 452 based on the determination result, or causes the sample container to stand by on the second transport line 84.
- the rack 53 is transported to the open / closed position where the original plug body (51 to 55) is held with respect to the rack 53 (FIG. 5R).
- the rack 54 requiring the opening process is carried into the first transfer line 83 through the supply line 81 to a position where the opening / closing process by the opening / closing device 4 is possible. Be transported.
- the transfer line 452 (opening / closing position of the stopper) is determined by the ID reader 20 and the control computer 200 not shown in the figure. The determination method is the same as that of the racks 51 to 53 described above (FIG. 5S).
- FIG. 6 is a flow chart of operation patterns in the case of one transfer line A 45 (FIG. 6A) and the case of two transfer lines A (FIG. 6B), focusing on the first opening / closing device 401.
- FIG. 6B when there are two transfer lines A45, there is a timing at which the opening process and the closing process can be performed simultaneously (for example, processes 1-7 to 1-9 and 2-1). Process 2-3) The throughput of the apparatus is improved.
- the present embodiment is configured to include one opening / closing device 401, the present invention is not limited thereto. If a plurality of opening and closing devices are provided, it is possible to improve the opening and closing processing efficiency accordingly.
- FIGS. 3F and 3G are schematic plan views in the case where the first opening / closing device 401 and the second opening / closing device 402 are provided, and the transfer line 45 and the transfer line 46 are provided as the third transfer line of each opening / closing device. Show.
- the open / close position of the holder 5 transferred by the transfer device 8 is determined by the sample information identification device 14 on the condition of the plug. If the control computer determines that the opening process is necessary, the control device refers to the sample information management unit 202 to that effect, and replies to the transport apparatus about the opening / closing device capable of performing the opening process on the rack.
- the transport device transports the holder along the first transport line.
- the ID reader 20 installed around the branch.
- the identification information of the sample container or the holder is read by The read identification information is transmitted to the sample information management unit 202 of the control computer, and is stored together with information for identifying the opening / closing device on which the opening process is performed.
- the opening and closing devices (401, 402) of the stopper perform the opening and closing processing of the stopper, and the chuck mechanism (41, 42) for holding and managing the stopper, the transport arm (43, 44) for transporting the chuck mechanism, and the holder 5
- a transfer line 45 capable of reciprocating transfer and a transfer line 46 are generally provided.
- the transfer arm (43, 44) generally includes a drive mechanism capable of moving the chuck mechanism (41, 42) in three axial directions (X direction, Y direction, Z direction). By this chuck mechanism (41, 42), the plug 7 can be opened and closed, and the plug 7 that has been opened and removed can be held until the plugging processing.
- the transport arm may move the chuck mechanism in two axial directions and move the test tube accordingly.
- FIG. 3F is a schematic view in which the chuck mechanisms (41, 42) and the transfer arms (43, 44) of the stopper opening / closing device (401, 402) are hidden.
- a transfer line 45 is provided as a transfer line to be opened and closed by the first opening and closing device 401
- a transfer line 46 is provided as a transfer line to be opened and closed by the second opening and closing device 402.
- the sample container 6 mounted on the plurality of holders 5 can be opened and closed at one time.
- FIGS. 3H and 3I show schematic plan views in the case of providing the opening / closing device 4, the transfer device 8 and the transfer line 45 as the transfer line of the opening / closing device.
- the open / close position of the holder 5 transferred by the transfer device 8 is determined by the sample information identification device 14 on the condition of the plug. If the control computer determines that the opening process is necessary, the control device refers to the sample information management unit 202 to that effect, and replies to the transport apparatus about the opening / closing device capable of performing the opening process on the rack.
- the transport device transports the holder along the first transport line.
- the specimen is read by the ID reader 20 installed around the holder.
- the identity of the container or holder is read.
- the read identification information is transmitted to the sample information management unit 202 of the control computer, and is stored together with information for identifying the opening / closing device on which the opening process is performed.
- the stopper opening / closing device (401) performs opening / closing processing of the stopper, and a chuck mechanism (41) for holding and managing the stopper, a transfer arm (43) for transferring the chuck mechanism, and a transfer line capable of reciprocating the holder 5 It has approximately 45 and.
- the transfer arm (43) generally includes a drive mechanism capable of moving the chuck mechanism (41) in three axial directions (X direction, Y direction, Z direction). By means of this chuck mechanism (41), the plug 7 can be opened and closed, and the plug 7 that has been opened and removed can be held until the plugging processing.
- the transport arm may move the chuck mechanism in two axial directions and move the test tube accordingly.
- FIG. 3I is a schematic view in which the chuck mechanism (41) and the transfer arm (43) of the stopper opening / closing device (401) are not displayed.
- a transfer line 45 consisting of a transfer line 451 is provided as a transfer line to be opened and closed by the opening and closing device 401.
- opening and closing processing can be performed on the sample containers 6 mounted on a plurality of holders 5 at one time.
- FIG. 9 shows, as an example of the prior art, an automatic analysis system provided with a mechanism for rotating a plurality of open / close units as the open / close device 4 of the stopper.
- the opening process of the stopper, the dispensing process of the sample, and the closing process of the stopper after dispensing are all performed on the sample line 12.
- the time required for one cycle of processing from opening to closing may depend on the time required for opening or closing processing. For example, if the opening processing is 6 seconds / processing and the closing processing is 3 seconds / processing, the processing speed of the sample collection processing is 6 seconds / processing, that is, it takes 1 cycle of processing from opening to closing Because the time is 15 seconds / process, it was kept at 600 processes / hour.
- a dedicated transfer line (transfer line A45) for transporting the sample to the opening / closing device 401 in order to plug the stopper 7 removed from the sample container 6 back to the same sample container 6 again.
- transfer line A45 transfer line for transporting the sample to the opening / closing device 401 in order to plug the stopper 7 removed from the sample container 6 back to the same sample container 6 again.
- transfer line A45 transfer line for transporting the sample to the opening / closing device 401 in order to plug the stopper 7 removed from the sample container 6 back to the same sample container 6 again.
- a management system for managing sample information and plug information is provided, and the transport path of the sample container is optimally selected based on the information of the management system, so that the original plug before opening can be closed. Therefore, it is possible to reliably perform the plug closure that is optimal for the sample container.
- the opening and closing device can operate the plurality of opening and closing means together, it is possible to simultaneously open and close the plurality of sample containers, and the processing speed can be expected to be improved as compared with the prior art.
- the invention is achieved by providing a branch point of the transport line to the switchgear at positions upstream and downstream of the sample line.
- Racks that require opening processing and closing processing are carried at this branch point to a dedicated transfer line that performs these processing, and opening and closing processing is carried out respectively.
- the racks for which the opening and closing process and closing process have been completed are returned to the original line again.
- an automatic analysis system refers to an analysis system for measuring the physical properties of a sample (for example, a biological sample such as serum or urine, or a mixture of these and a reagent), and prior to the physical property measurement of the sample. And a system that integrates the pretreatment system and the analysis system.
- the automatic analysis system includes a processing unit that executes various processes such as a container opening process, a dispensing process, a container closing process, a stirring process, and an analysis process, and a transfer device that transfers a sample between the processing units.
- an automatic analyzer may be included in the system, the system may be at least provided with an opening / closing / dispensing device, and a delivery device for delivering the sample between them.
- the stopper is molded of rubber, plastic, or the like so that the sample contained in the sample container does not leak out, and may be screw-in type, or may be only pressed in. It is good.
- the sample container is a container in which a sample to be measured is sealed, and it may be transferable even if it is mounted on a rack or mounted on a holder.
- the plug opening / closing device may be any device as long as it holds a plurality of removed plugs and is controlled so as to be able to perform plugging processing of the held plugs.
- the robot arm may perform holding and management
- the turntable may perform rotation holding and management
- the elevator may perform vertical holding and management.
- the holding and control of the plug body may be anything as long as contamination of the plug body and the container can be prevented. In general, those with shielding, those with suction and disposal, and those with cleaning and sterilization are generally used.
- the transport device for the sample container may be anything as long as it can transport the rack and the holder. In general, belt conveyors, claws, and a robot arm are used.
- Reference Signs List 1 case 2 reaction disk 3 reagent disk 4 opening / closing device 5 rack 6 sample container 7 plug 8 transport device 9 reaction container 10 reagent probe 11 reagent container 12 sample line 13 sample probe 14 sample information identification device 15 stirring device 16 stirring device 16 light source 17 detection Optical device 18 Container cleaning mechanism 19 Cleaning port 20 ID reader 21 Specimen information management mechanism 41, 42 Chuck mechanism 43, 44 Transport arm 45 Transfer line A 46 Transfer line B 121 Sampling position 200 Control computer 202 Sample information management unit 401, 402 Switchgear 451, 452 Transfer line
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Priority Applications (4)
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JP2013522867A JP5766800B2 (ja) | 2011-06-30 | 2012-06-26 | 自動分析システム |
US14/129,598 US9535081B2 (en) | 2011-06-30 | 2012-06-26 | Automatic analysis system |
CN201280032719.2A CN103635809B (zh) | 2011-06-30 | 2012-06-26 | 自动分析*** |
EP12805062.2A EP2728362B1 (en) | 2011-06-30 | 2012-06-26 | Automatic analysis system |
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JP2011145165 | 2011-06-30 | ||
JP2011-145165 | 2011-06-30 |
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US (1) | US9535081B2 (zh) |
EP (1) | EP2728362B1 (zh) |
JP (1) | JP5766800B2 (zh) |
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WO (1) | WO2013002213A1 (zh) |
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US20160238627A1 (en) * | 2015-02-13 | 2016-08-18 | Abbott Laboratories | Decapping and capping apparatus, systems and methods for use in diagnostic analyzers |
US9505507B2 (en) | 2011-06-30 | 2016-11-29 | Hitachi High-Technologies Corporation | Cap opening and closing mechanism and automatic analyzer including the same |
WO2020162484A1 (ja) * | 2019-02-05 | 2020-08-13 | 株式会社日立ハイテク | 検体処理システム |
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ES2805628T3 (es) * | 2016-12-21 | 2021-02-15 | Milestone Srl | Aparato de medición |
SG11201906814YA (en) * | 2017-03-09 | 2019-09-27 | Hologic Inc | Systems and methods for automated preparation of biological specimens |
EP3489694A1 (en) * | 2017-11-24 | 2019-05-29 | Roche Diagnostics GmbH | Sample vessel and cap transportation |
JP7104069B2 (ja) * | 2017-12-25 | 2022-07-20 | 株式会社日立ハイテク | 検体処理システム |
DE102018111064A1 (de) * | 2018-05-08 | 2019-11-14 | Lockcon Ag | Öffnungsmaschinenvorrichtung und Probenbehälter zur Verwendung mit der Öffnungsmaschinenvorrichtung |
JP7068463B2 (ja) * | 2018-07-27 | 2022-05-16 | 株式会社日立ハイテク | 自動分析システム |
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US10247743B2 (en) | 2013-11-12 | 2019-04-02 | Hitachi High-Technologies Corporation | Analyte testing automation system, biological sample check module, and biological sample check method |
WO2015072358A1 (ja) * | 2013-11-12 | 2015-05-21 | 株式会社日立ハイテクノロジーズ | 検体検査自動化システムおよび生体試料チェックモジュールならびに生体試料のチェック方法 |
US10775399B2 (en) | 2015-02-13 | 2020-09-15 | Abbott Laboratories | Automated storage modules for diagnostic analyzer liquids and related systems and methods |
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JPWO2020162484A1 (ja) * | 2019-02-05 | 2021-10-14 | 株式会社日立ハイテク | 検体処理システム |
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JP2023500412A (ja) * | 2019-11-12 | 2023-01-05 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 液体容器とマニホルドとの間の改良された封止部を含むシステム |
JP7402978B2 (ja) | 2019-11-12 | 2023-12-21 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 液体容器とマニホルドとの間の改良された封止部を含むシステム |
US12005027B2 (en) | 2019-11-12 | 2024-06-11 | Siemens Healthcare Diagnostics Inc. | System with improved seal between a liquid container and a manifold |
JP7150929B1 (ja) | 2021-04-14 | 2022-10-11 | 株式会社椿本チエイン | チューブデキャッパ |
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Also Published As
Publication number | Publication date |
---|---|
CN103635809A (zh) | 2014-03-12 |
JPWO2013002213A1 (ja) | 2015-02-23 |
EP2728362A1 (en) | 2014-05-07 |
JP5766800B2 (ja) | 2015-08-19 |
CN103635809B (zh) | 2015-07-15 |
US9535081B2 (en) | 2017-01-03 |
EP2728362A4 (en) | 2015-05-27 |
EP2728362B1 (en) | 2016-03-02 |
US20140314623A1 (en) | 2014-10-23 |
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