WO2010099138A3 - Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation - Google Patents

Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation Download PDF

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Publication number
WO2010099138A3
WO2010099138A3 PCT/US2010/025137 US2010025137W WO2010099138A3 WO 2010099138 A3 WO2010099138 A3 WO 2010099138A3 US 2010025137 W US2010025137 W US 2010025137W WO 2010099138 A3 WO2010099138 A3 WO 2010099138A3
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WO
WIPO (PCT)
Prior art keywords
emt
agents
tumor cell
inhibit
identification
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Application number
PCT/US2010/025137
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French (fr)
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WO2010099138A2 (en
Inventor
Julie Kan
Original Assignee
Osi Pharmaceuticals, Inc.
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Publication date
Application filed by Osi Pharmaceuticals, Inc. filed Critical Osi Pharmaceuticals, Inc.
Publication of WO2010099138A2 publication Critical patent/WO2010099138A2/en
Publication of WO2010099138A3 publication Critical patent/WO2010099138A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity

Abstract

The present invention provides tumor cell preparations for use as models of the EMT process for use in the identification of anti-cancer agents, wherein said tumor cell preparations comprise cells of the epithelial tumor cell line H292, which are stimulated by receptor ligands to induce EMT, or which have been engineered to inducibly express a protein that stimulates EMT. The present invention also provides methods of identifying potential anti-cancer agents by using such tumor cell preparations to identify agents that inhibit EMT, stimulate MET, or inhibit the growth of mesenchymal-like cells. Such agents should be particularly useful when used in conjunction with other anti-cancer drugs such as EGFR and IGF-IR kinase inhibitors, which appear to be less effective at inhibiting tumor cells that have undergone an EMT.
PCT/US2010/025137 2009-02-27 2010-02-24 Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation WO2010099138A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20884109P 2009-02-27 2009-02-27
US61/208,841 2009-02-27

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WO2010099138A2 WO2010099138A2 (en) 2010-09-02
WO2010099138A3 true WO2010099138A3 (en) 2010-12-02

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013055530A1 (en) * 2011-09-30 2013-04-18 Genentech, Inc. Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells
CN108456691A (en) * 2018-02-05 2018-08-28 上海交通大学医学院附属仁济医院 Double luminous reporting systems and application thereof
EP3880803A4 (en) * 2018-11-12 2022-07-06 Agency for Science, Technology and Research Methods for manipulating cell state transitions in cancer

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