WO2010062038A2 - 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 - Google Patents

티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 Download PDF

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Publication number
WO2010062038A2
WO2010062038A2 PCT/KR2009/006050 KR2009006050W WO2010062038A2 WO 2010062038 A2 WO2010062038 A2 WO 2010062038A2 KR 2009006050 W KR2009006050 W KR 2009006050W WO 2010062038 A2 WO2010062038 A2 WO 2010062038A2
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WIPO (PCT)
Prior art keywords
isomer
tyrosine kinase
pharmaceutical composition
composition containing
same
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PCT/KR2009/006050
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English (en)
French (fr)
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WO2010062038A3 (ko
Inventor
양범석
김선영
조종운
이향숙
우성호
박태교
김용주
김승태
이홍범
Original Assignee
한국과학기술연구원
주식회사 레고켐 바이오사이언스
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Publication of WO2010062038A2 publication Critical patent/WO2010062038A2/ko
Publication of WO2010062038A3 publication Critical patent/WO2010062038A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Abstract

본 발명은 하기 화학식 1로 표시되는 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염에 관한 것이다. 화학식 1의 화합물은 디스코이딘 도메인 리셉터 1(DDR1)과 디스코이딘 도메인 리셉터 2(DDR2)의 티로신 키나아제 활성을 억제할 수 있어 암, 간경화증, 동맥경화, 류마티스 관절염, 골 관절염 등 디스코이딘 도메인 리셉터 1 혹은 디스코이딘 도메인 리셉터 2의 과다 활성화가 주요 원인으로 알려진 질환을 예방 또는 치료하는데 유용하게 사용될 수 있다.
PCT/KR2009/006050 2008-11-27 2009-10-20 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물 WO2010062038A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080118850A KR101126736B1 (ko) 2008-11-27 2008-11-27 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
KR10-2008-0118850 2008-11-27

Publications (2)

Publication Number Publication Date
WO2010062038A2 true WO2010062038A2 (ko) 2010-06-03
WO2010062038A3 WO2010062038A3 (ko) 2010-07-22

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PCT/KR2009/006050 WO2010062038A2 (ko) 2008-11-27 2009-10-20 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물

Country Status (2)

Country Link
KR (1) KR101126736B1 (ko)
WO (1) WO2010062038A2 (ko)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130072482A1 (en) * 2010-05-26 2013-03-21 Beom-Seok Yang Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
CN103087077A (zh) * 2011-11-03 2013-05-08 上海希迈医药科技有限公司 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2013068836A1 (en) 2011-11-07 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis
JP2013538223A (ja) * 2010-09-15 2013-10-10 エフ．ホフマン−ラ ロシュ アーゲー アザベンゾチアゾール化合物、組成物及び使用方法
CN103360407A (zh) * 2012-04-10 2013-10-23 上海希迈医药科技有限公司 一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
JPWO2015060373A1 (ja) * 2013-10-23 2017-03-09 中外製薬株式会社 キナゾリノンおよびイソキノリノン誘導体
WO2018171726A1 (zh) * 2017-03-23 2018-09-27 高雄医学大学 盘基蛋白结构域受体1的抑制剂及活化剂及其用途
WO2021239643A1 (en) 2020-05-25 2021-12-02 Chiesi Farmaceutici S.P.A. Benzylamine derivatives as ddrs inhibitors
EP4032896A1 (en) 2021-01-20 2022-07-27 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Thiazolopyrimidones as inhibitors of ddr1/2 and therapeutic uses thereof
WO2023210599A1 (ja) * 2022-04-25 2023-11-02 日本新薬株式会社 Ｄｄｒ１キナーゼ阻害剤としての化合物および医薬

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101540051B1 (ko) * 2013-11-27 2015-07-28 한국과학기술연구원 피부 노화 방지 또는 피부 상태 개선용 조성물

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Patent Citations (4)

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WO1996040142A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. Heterocyclic ring-fused pyrimidine derivatives
WO1997013771A1 (en) * 1995-10-11 1997-04-17 Glaxo Group Limited Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
KR20010031908A (ko) * 1997-11-11 2001-04-16 실버스타인 아써 에이. 항암제로 유용한 티에노피리미딘 및 티에노피리딘 유도체
US20040019065A1 (en) * 2002-03-01 2004-01-29 Romines William Henry Indolyl-urea derivatives of thienopyridines useful as antiangiogenic agents, and methods for their use

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130072482A1 (en) * 2010-05-26 2013-03-21 Beom-Seok Yang Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
US9062066B2 (en) * 2010-05-26 2015-06-23 Korea Institute Of Science And Technology Anti-inflammatory compound having inhibitory activity against multiple tyrosine kinases and pharmaceutical composition containing same
JP2013538223A (ja) * 2010-09-15 2013-10-10 エフ．ホフマン−ラ ロシュ アーゲー アザベンゾチアゾール化合物、組成物及び使用方法
US8697708B2 (en) 2010-09-15 2014-04-15 F. Hoffmann-La Roche Ag Azabenzothiazole compounds, compositions and methods of use
CN103087077B (zh) * 2011-11-03 2016-05-18 上海希迈医药科技有限公司 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2013064068A1 (zh) * 2011-11-03 2013-05-10 上海希迈医药科技有限公司 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
CN103087077A (zh) * 2011-11-03 2013-05-08 上海希迈医药科技有限公司 噻吩并嘧啶和呋喃并嘧啶类衍生物、其制备方法及其在医药上的应用
WO2013068836A1 (en) 2011-11-07 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) A ddr1 antagonist or an inhibitor of ddr1 gene expression for use in the prevention or treatment of crescentic glomerulonephritis
CN103360407A (zh) * 2012-04-10 2013-10-23 上海希迈医药科技有限公司 一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
CN103360407B (zh) * 2012-04-10 2016-06-22 上海希迈医药科技有限公司 一种噻吩并嘧啶类衍生物、其制备方法及其在医药上的应用
EP3061749A4 (en) * 2013-10-23 2017-05-31 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
JPWO2015060373A1 (ja) * 2013-10-23 2017-03-09 中外製薬株式会社 キナゾリノンおよびイソキノリノン誘導体
US10005739B2 (en) 2013-10-23 2018-06-26 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
WO2018171726A1 (zh) * 2017-03-23 2018-09-27 高雄医学大学 盘基蛋白结构域受体1的抑制剂及活化剂及其用途
US10946021B2 (en) 2017-03-23 2021-03-16 Kaohsiung Medical University Methods of treating or alleviating joint diseases by administering an inhibitor of discoidin domain receptor 1 (DDR1)
WO2021239643A1 (en) 2020-05-25 2021-12-02 Chiesi Farmaceutici S.P.A. Benzylamine derivatives as ddrs inhibitors
EP4032896A1 (en) 2021-01-20 2022-07-27 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Thiazolopyrimidones as inhibitors of ddr1/2 and therapeutic uses thereof
WO2022157166A1 (en) 2021-01-20 2022-07-28 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Thiazolopyrimidones as inhibitors of ddr1/2 and therapeutic uses thereof
WO2023210599A1 (ja) * 2022-04-25 2023-11-02 日本新薬株式会社 Ｄｄｒ１キナーゼ阻害剤としての化合物および医薬

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KR20100060300A (ko) 2010-06-07
WO2010062038A3 (ko) 2010-07-22
KR101126736B1 (ko) 2012-04-12

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