MX2009011997A - Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos. - Google Patents
Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.Info
- Publication number
- MX2009011997A MX2009011997A MX2009011997A MX2009011997A MX2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrrolopyrimidin
- pharmaceuticals
- derivatives
- compounds
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Se describen compuestos de la fórmula (I) o sales farmacéuticamente aceptables de los mismos (ver fórmula (I)) en donde R1, R2, R3, R4 y R5 son como se define en la descripción, así como sales y composiciones farmacéuticas que incluyen los compuestos. Son útiles en terapia, en particular en el manejo de dolor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91658807P | 2007-05-08 | 2007-05-08 | |
PCT/SE2008/050525 WO2008136756A1 (en) | 2007-05-08 | 2008-05-07 | Pyrrolopyrimidin-7-one derivatives and their use as pharmaceuticals |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011997A true MX2009011997A (es) | 2009-11-19 |
Family
ID=39943763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011997A MX2009011997A (es) | 2007-05-08 | 2008-05-07 | Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20090099195A1 (es) |
EP (1) | EP2155751A1 (es) |
JP (1) | JP2010526138A (es) |
KR (1) | KR20100017688A (es) |
CN (1) | CN101687875A (es) |
AR (1) | AR066475A1 (es) |
AU (1) | AU2008246351A1 (es) |
BR (1) | BRPI0811436A2 (es) |
CA (1) | CA2686707A1 (es) |
CL (1) | CL2008001335A1 (es) |
MX (1) | MX2009011997A (es) |
PE (1) | PE20090816A1 (es) |
RU (1) | RU2009140469A (es) |
TW (1) | TW200846001A (es) |
UY (1) | UY31068A1 (es) |
WO (1) | WO2008136756A1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2742897A1 (en) * | 2008-11-06 | 2010-05-14 | Astrazeneca Ab | Modulators of amyloid beta. |
WO2010066629A2 (en) * | 2008-12-09 | 2010-06-17 | F. Hoffmann-La Roche Ag | Novel azaindoles |
PT2399910E (pt) | 2009-02-13 | 2014-05-02 | Shionogi & Co | Novo derivado de triazina e composição farmacéutica que contém o mesmo |
UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
TWI468402B (zh) * | 2009-07-31 | 2015-01-11 | 必治妥美雅史谷比公司 | 降低β-類澱粉生成之化合物 |
US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
ES2442797T3 (es) | 2009-11-18 | 2014-02-13 | Neomed Institute | Compuestos de benzoimidazol y sus utilizaciones |
CN102939282B (zh) | 2010-04-16 | 2015-12-02 | Ac免疫有限公司 | 用于治疗与淀粉状蛋白或淀粉状蛋白样蛋白有关的疾病的化合物 |
WO2011133659A2 (en) * | 2010-04-20 | 2011-10-27 | Emory University | Inhibitors of hif and angiogenesis |
CN103140221A (zh) * | 2010-08-10 | 2013-06-05 | 盐野义制药株式会社 | 新型杂环衍生物和含有其的药物组合物 |
US9718790B2 (en) | 2010-08-10 | 2017-08-01 | Shionogi & Co., Ltd. | Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same |
US9381260B2 (en) | 2011-12-27 | 2016-07-05 | Emory University | Hypoxia inducible factor-1 pathway inhibitors and uses as anticancer and imaging agents |
JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
RU2656593C2 (ru) | 2013-01-31 | 2018-06-06 | Неомед Инститьют | Соединения имидазопиридина, полезные при лечении состояния, связанного с активностью p2x3 и/или p2x2/3 |
TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
WO2016088838A1 (ja) * | 2014-12-04 | 2016-06-09 | 塩野義製薬株式会社 | プリン誘導体およびその医薬組成物 |
UY36422A (es) | 2014-12-09 | 2016-06-30 | Evotec Ag | Benzamidas sustituidas con 1,3-tiazol-2-ilo |
WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2017209267A1 (ja) * | 2016-06-03 | 2017-12-07 | 塩野義製薬株式会社 | プリン誘導体 |
JP6856471B2 (ja) * | 2017-01-04 | 2021-04-07 | 株式会社トクヤマ | ラクトン化合物の製造方法、および該ラクトン化合物を使用したビオチンの製造方法 |
WO2019065794A1 (ja) | 2017-09-27 | 2019-04-04 | 国立大学法人鹿児島大学 | Pac1受容体拮抗薬を用いた鎮痛薬 |
MX2020004981A (es) * | 2017-10-27 | 2020-08-24 | Bayer Ag | Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3. |
CN107778282B (zh) * | 2017-11-03 | 2020-04-10 | 中山大学 | 喹啉-吲哚衍生物及其在制备治疗阿尔茨海默病的药品中的应用 |
US11279668B2 (en) | 2018-03-21 | 2022-03-22 | Piramal Pharma Limited | Asymmetric synthesis of alpha-(diarylmethyl) alkyl amines |
EP3932490A4 (en) | 2019-02-27 | 2022-11-16 | Kagoshima University | ANTIPRURIC AGENT USING PAC1 RECEPTOR ANTAGONISTS |
WO2021058018A1 (en) * | 2019-09-29 | 2021-04-01 | Beigene, Ltd. | Inhibitors of kras g12c |
CN114555597A (zh) * | 2019-10-12 | 2022-05-27 | 浙江迈同生物医药有限公司 | 异柠檬酸脱氢酶(idh)抑制剂 |
WO2021173923A1 (en) * | 2020-02-28 | 2021-09-02 | Erasca, Inc. | Pyrrolidine-fused heterocycles |
LT4103566T (lt) * | 2020-03-13 | 2023-11-10 | Astrazeneca Ab | Kondensuoti pirimidino junginiai, kaip kcc2 moduliatoriai |
JP7049637B1 (ja) | 2020-05-08 | 2022-04-07 | 国立大学法人 鹿児島大学 | Pac1受容体拮抗薬を用いた抗うつ・抗不安薬 |
EP4214204A1 (en) | 2020-09-18 | 2023-07-26 | Bayer Aktiengesellschaft | Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors |
WO2022067462A1 (en) * | 2020-09-29 | 2022-04-07 | Beigene (Beijing) Co., Ltd. | Process for preparing inhibitors of kras g12c |
EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
CN117843618A (zh) * | 2022-08-29 | 2024-04-09 | 北京沐华生物科技有限责任公司 | 一种ep300/cbp调节剂及其制备方法和用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1352659A4 (en) * | 2000-12-22 | 2004-06-30 | Takeda Chemical Industries Ltd | COMBINATION DRUGS |
DE60237425D1 (de) * | 2002-03-28 | 2010-10-07 | Univerzita Palackeho V Olomouc | PyrazoloÄ4,3-dÜpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung |
WO2007035873A1 (en) * | 2005-09-21 | 2007-03-29 | Pharmacopeia, Inc. | Purinone derivatives for treating neurodegenerative diseases |
-
2008
- 2008-05-05 US US12/115,169 patent/US20090099195A1/en not_active Abandoned
- 2008-05-06 TW TW097116651A patent/TW200846001A/zh unknown
- 2008-05-07 EP EP08767136A patent/EP2155751A1/en not_active Withdrawn
- 2008-05-07 BR BRPI0811436-6A2A patent/BRPI0811436A2/pt not_active Application Discontinuation
- 2008-05-07 RU RU2009140469/04A patent/RU2009140469A/ru unknown
- 2008-05-07 AU AU2008246351A patent/AU2008246351A1/en not_active Abandoned
- 2008-05-07 CN CN200880023961A patent/CN101687875A/zh active Pending
- 2008-05-07 MX MX2009011997A patent/MX2009011997A/es unknown
- 2008-05-07 AR ARP080101934A patent/AR066475A1/es unknown
- 2008-05-07 UY UY31068A patent/UY31068A1/es unknown
- 2008-05-07 WO PCT/SE2008/050525 patent/WO2008136756A1/en active Application Filing
- 2008-05-07 KR KR1020097025526A patent/KR20100017688A/ko not_active Application Discontinuation
- 2008-05-07 CA CA002686707A patent/CA2686707A1/en not_active Abandoned
- 2008-05-07 CL CL2008001335A patent/CL2008001335A1/es unknown
- 2008-05-07 JP JP2010507363A patent/JP2010526138A/ja active Pending
- 2008-05-08 PE PE2008000804A patent/PE20090816A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
PE20090816A1 (es) | 2009-07-25 |
AR066475A1 (es) | 2009-08-19 |
TW200846001A (en) | 2008-12-01 |
RU2009140469A (ru) | 2011-06-20 |
UY31068A1 (es) | 2009-01-05 |
AU2008246351A1 (en) | 2008-11-13 |
CL2008001335A1 (es) | 2008-11-14 |
BRPI0811436A2 (pt) | 2014-12-16 |
WO2008136756A1 (en) | 2008-11-13 |
US20090099195A1 (en) | 2009-04-16 |
EP2155751A1 (en) | 2010-02-24 |
CN101687875A (zh) | 2010-03-31 |
JP2010526138A (ja) | 2010-07-29 |
CA2686707A1 (en) | 2008-11-13 |
KR20100017688A (ko) | 2010-02-16 |
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