MX2010006799A - Benzofuropirimidinonas como inhibidores de la proteina cinasa. - Google Patents

Benzofuropirimidinonas como inhibidores de la proteina cinasa.

Info

Publication number
MX2010006799A
MX2010006799A MX2010006799A MX2010006799A MX2010006799A MX 2010006799 A MX2010006799 A MX 2010006799A MX 2010006799 A MX2010006799 A MX 2010006799A MX 2010006799 A MX2010006799 A MX 2010006799A MX 2010006799 A MX2010006799 A MX 2010006799A
Authority
MX
Mexico
Prior art keywords
sup
benzofuropyrimidinones
protein kinase
kinase inhibitors
formula
Prior art date
Application number
MX2010006799A
Other languages
English (en)
Inventor
Patrick Kearney
S David Brown
Hongwang Du
Elena S Koltun
Amy L Tsuhako
Ping Huang
Moon Hwan Kim
Cristiana A Zaharia
Maurizio Franzini
Adam Antoni Galan
Steven James Richards
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40383673&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010006799(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of MX2010006799A publication Critical patent/MX2010006799A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se describe un compuesto de acuerdo con la fórmula I: (FORMULA) o su sal aceptable para uso farmacéutico, donde R1, R2, R3a, R3b, R3c y R3d son como se definieron en la descripción, sus composiciones farmacéuticas, y sus métodos de uso.
MX2010006799A 2007-12-21 2008-12-22 Benzofuropirimidinonas como inhibidores de la proteina cinasa. MX2010006799A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US890707P 2007-12-21 2007-12-21
US7097108P 2008-03-25 2008-03-25
PCT/US2008/087939 WO2009086264A1 (en) 2007-12-21 2008-12-22 Benzofuropyrimidinones as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2010006799A true MX2010006799A (es) 2010-10-05

Family

ID=40383673

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006799A MX2010006799A (es) 2007-12-21 2008-12-22 Benzofuropirimidinonas como inhibidores de la proteina cinasa.

Country Status (20)

Country Link
US (1) US20090247559A1 (es)
EP (1) EP2097419B1 (es)
JP (1) JP2011507908A (es)
KR (1) KR20100098714A (es)
CN (1) CN101965351A (es)
AR (1) AR069869A1 (es)
AT (1) ATE510839T1 (es)
AU (1) AU2008345560A1 (es)
BR (1) BRPI0821573A2 (es)
CA (1) CA2712358A1 (es)
CL (1) CL2008003873A1 (es)
CO (1) CO6321258A2 (es)
EA (1) EA019785B1 (es)
IL (1) IL206416A0 (es)
MX (1) MX2010006799A (es)
NZ (1) NZ586936A (es)
PE (1) PE20091669A1 (es)
TW (1) TW200930375A (es)
WO (1) WO2009086264A1 (es)
ZA (1) ZA201004243B (es)

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DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
ES2616051T3 (es) 2008-12-02 2017-06-09 Wave Life Sciences Japan, Inc. Método para la síntesis de ácidos nucleicos modificados en el átomo de fósforo
KR101663335B1 (ko) 2008-12-22 2016-10-06 메르크 파텐트 게엠베하 6-（1-메틸-1ｈ-피라졸-4-일）-2-｛3-［5-（2-모르폴린-4-일-에톡시）-피리미딘-2-일］-벤질｝-2ｈ-피리다진-3-온디히드로겐포스페이트의 신규한 다형체 및 이의 제조 방법
AU2010270714B2 (en) 2009-07-06 2015-08-13 Wave Life Sciences Ltd. Novel nucleic acid prodrugs and methods use thereof
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
EP2734208B1 (en) 2011-07-19 2017-03-01 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
MX2015000577A (es) 2012-07-13 2015-08-14 Wave Life Sciences Pte Ltd Control quiral.
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
CN107011400B (zh) 2012-07-13 2021-05-25 波涛生命科学有限公司 不对称辅助基团
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
CN103044370A (zh) * 2012-12-28 2013-04-17 山东邹平大展新材料有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法
CN104045642B (zh) * 2013-03-14 2016-08-24 上海医药工业研究院 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
US10144933B2 (en) 2014-01-15 2018-12-04 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
US10149905B2 (en) 2014-01-15 2018-12-11 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having antitumor effect and antitumor agent
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
US9974795B2 (en) 2014-01-31 2018-05-22 Carna Biosciences, Inc. Anticancer agent composition
EP3110794A1 (en) 2014-02-27 2017-01-04 Merck Patent GmbH Heterocyclic compounds as nav channel inhibitors and uses thereof
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
ES2877140T3 (es) 2016-11-08 2021-11-16 Cancer Research Tech Ltd Derivados de pirimidinona como inhibidores de Cdc7
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
MA53726A (fr) 2018-09-25 2022-05-11 Incyte Corp Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr
CN111689947B (zh) * 2019-03-13 2023-07-14 鲁南制药集团股份有限公司 替加氟-l-脯氨酸共晶体及其制备方法
WO2021156774A1 (en) * 2020-02-03 2021-08-12 Gain Therapeutics Sa Combination therapy for treating mps1
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
EP4227308A1 (en) 2020-10-05 2023-08-16 Japan Tobacco Inc. Tetrahydrobenzofurodiazepinone compounds and pharmaceutical applications thereof
CN117043302A (zh) 2021-03-18 2023-11-10 默克专利有限公司 用于有机电致发光器件的杂芳族化合物
WO2023156386A2 (en) * 2022-02-16 2023-08-24 Duke Street Bio Limited Pharmaceutical compound

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
WO2002051849A1 (fr) 2000-12-26 2002-07-04 Daiichi Pharmaceutical Co., Ltd. Inhibiteurs cdk4
MXPA03009650A (es) * 2001-04-20 2005-03-07 Vertex Pharma Derivados de 9-deazoguanidina como inhibidores de gsk-3.
US7345046B2 (en) * 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
WO2006023381A1 (en) 2004-08-16 2006-03-02 Taigen Biotechnology Pyrimidinone compounds
EP1776982A1 (en) 2005-10-18 2007-04-25 Argenta Discovery Limited Pyrimidine compounds as histamine modulators
JP2008519794A (ja) 2004-11-11 2008-06-12 アージェンタ・ディスカバリー・リミテッド ピリミジン化合物

Also Published As

Publication number Publication date
ZA201004243B (en) 2011-03-30
EP2097419A1 (en) 2009-09-09
US20090247559A1 (en) 2009-10-01
BRPI0821573A2 (pt) 2016-08-09
EA201070786A1 (ru) 2011-02-28
CA2712358A1 (en) 2009-07-09
AR069869A1 (es) 2010-02-24
EA019785B1 (ru) 2014-06-30
JP2011507908A (ja) 2011-03-10
WO2009086264A1 (en) 2009-07-09
KR20100098714A (ko) 2010-09-08
NZ586936A (en) 2012-07-27
CO6321258A2 (es) 2011-09-20
ATE510839T1 (de) 2011-06-15
PE20091669A1 (es) 2009-12-06
CL2008003873A1 (es) 2009-06-26
TW200930375A (en) 2009-07-16
EP2097419B1 (en) 2011-05-25
CN101965351A (zh) 2011-02-02
IL206416A0 (en) 2010-12-30
AU2008345560A1 (en) 2009-07-09

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