UA66787C2 - A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds - Google Patents

A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds

Info

Publication number: UA66787C2
Authority: UA; Ukraine
Prior art keywords: preparation; methylpiperazine; ethoxyphenyl; pyrazolo; pyrimidine
Prior art date: 1998-10-12

Application number

UA99105491A

Other languages

English (en)

Inventor

Peter James Dann

Philippe Charles Levett

Original Assignee

Pfizer Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-12

Filing date

1999-10-08

Publication date

2004-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA66787(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-10-08 Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev

2004-06-15 Publication of UA66787C2 publication Critical patent/UA66787C2/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Reproductive Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Gynecology & Obstetrics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

UA99105491A 1998-10-12 1999-10-08 A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds UA66787C2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9822238.3A GB9822238D0 (en)	1998-10-12	1998-10-12	Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number	Publication Date
UA66787C2 true UA66787C2 (en)	2004-06-15

Family

ID=10840421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA99105491A UA66787C2 (en)	1998-10-12	1999-10-08	A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds

Country Status (49)

Country	Link
US (3)	US6207829B1 (xx)
EP (1)	EP0994115B1 (xx)
JP (1)	JP3721021B2 (xx)
KR (1)	KR100380954B1 (xx)
CN (2)	CN1207295C (xx)
AP (1)	AP1233A (xx)
AR (1)	AR019244A1 (xx)
AT (1)	ATE290003T1 (xx)
AU (1)	AU756463B2 (xx)
BG (1)	BG63205B1 (xx)
BR (1)	BR9905092A (xx)
CA (1)	CA2285733C (xx)
CO (1)	CO5150214A1 (xx)
CR (1)	CR6118A (xx)
CU (1)	CU22928A3 (xx)
CZ (1)	CZ296816B6 (xx)
DE (1)	DE69923906T2 (xx)
DK (1)	DK0994115T3 (xx)
DZ (1)	DZ2912A1 (xx)
EA (1)	EA003774B1 (xx)
EE (1)	EE04192B1 (xx)
EG (1)	EG22630A (xx)
ES (1)	ES2237049T3 (xx)
GB (1)	GB9822238D0 (xx)
GE (1)	GEP20022700B (xx)
GT (1)	GT199900172A (xx)
HK (1)	HK1027559A1 (xx)
HR (1)	HRP990318B1 (xx)
HU (1)	HU226162B1 (xx)
ID (1)	ID23351A (xx)
IL (11)	IL132273A (xx)
IS (1)	IS1951B (xx)
MA (1)	MA25007A1 (xx)
MY (1)	MY124620A (xx)
NO (1)	NO313700B1 (xx)
OA (1)	OA11165A (xx)
PE (1)	PE20001086A1 (xx)
PL (1)	PL198150B1 (xx)
PT (1)	PT994115E (xx)
RS (1)	RS49762B (xx)
SG (1)	SG118060A1 (xx)
SI (1)	SI0994115T1 (xx)
SK (1)	SK285215B6 (xx)
TN (1)	TNSN99189A1 (xx)
TR (1)	TR199902541A2 (xx)
TW (1)	TW589314B (xx)
UA (1)	UA66787C2 (xx)
UY (1)	UY25750A1 (xx)
ZA (1)	ZA996412B (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5204800A (en) *	1999-06-21	2001-01-09	Biochemical Pharmaceutical Factory of Zhuhai Sez, The	Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
WO2001098284A1 (en) *	2000-06-22	2001-12-27	Pfizer Limited	Process for the preparation of pyrazolopyrimidinones
US6667398B2 (en)	2000-06-22	2003-12-23	Pfizer Inc	Process for the preparation of pyrazolopyrimidinones
EP1176147A1 (en) *	2000-07-28	2002-01-30	Pfizer Limited	Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) *	2000-07-28	2002-01-30	Pfizer Inc.	Process for the preparation of pyrazoles
US6407259B1 (en)	2000-07-28	2002-06-18	Pfizer Inc.	Process for the preparation of pyrazoles
PE20020394A1 (es)	2000-08-18	2002-06-21	Agouron Pharma	Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
AU2002358772B2 (en)	2001-12-20	2008-11-20	Merck Serono Sa	Pyrrolidine derivatives as prostaglandin modulators
US6908923B2 (en)	2001-12-21	2005-06-21	Cytokinetics, Inc.	Compositions and methods for treating heart failure
SI1509525T1 (sl)	2002-05-31	2006-12-31	Schering Corp	Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) *	2003-02-11	2004-08-26	Pfizer Limited	Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) *	2003-03-27	2011-09-14	Cytokinetics, Inc.	Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) *	2003-12-18	2008-01-09	中国人民解放军军事医学科学院放射与辐射医学研究所	用于预防或治疗阳萎和***的新吡唑并嘧啶类化合物
US20070010525A1 (en) *	2005-06-27	2007-01-11	Meyer Jackson	Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) *	2005-11-10	2009-02-17	Pfizer Prod Inc	1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (en) *	2006-06-05	2007-12-13	Matrix Laboratories Limited	Novel process for the preparation of sildenafil citrate
CZ308056B6 (cs) *	2015-07-20	2019-11-27	Ustav Experimentalni Botaniky Av Cr V V I	5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en)	2016-04-02	2017-10-05	N4 Pharma Uk Limited	New pharmaceutical forms of sildenafil
CN107759603B (zh) *	2016-08-18	2020-09-01	四川科伦药物研究院有限公司	一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3992441A (en) *	1972-12-26	1976-11-16	Pfizer Inc.	Sulfamylbenzoic acids
GB9013750D0 (en) *	1990-06-20	1990-08-08	Pfizer Ltd	Therapeutic agents
GB9612514D0 (en) *	1996-06-14	1996-08-14	Pfizer Ltd	Novel process
BR9810233A (pt) *	1997-04-25	2000-10-17	Pfizer	Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.

1998
- 1998-10-12 GB GBGB9822238.3A patent/GB9822238D0/en not_active Ceased
1999
- 1999-09-22 TW TW088116306A patent/TW589314B/zh not_active IP Right Cessation
- 1999-09-22 CU CU1999142A patent/CU22928A3/es unknown
- 1999-09-27 RS YUP-489/99A patent/RS49762B/sr unknown
- 1999-10-05 GT GT199900172A patent/GT199900172A/es unknown
- 1999-10-06 CZ CZ0353299A patent/CZ296816B6/cs not_active IP Right Cessation
- 1999-10-07 IL IL13227399A patent/IL132273A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292499A patent/IL152924A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292399A patent/IL152923A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292799A patent/IL152927A/en not_active IP Right Cessation
- 1999-10-07 AP APAP/P/1999/001672A patent/AP1233A/en active
- 1999-10-07 CR CR6118A patent/CR6118A/es unknown
- 1999-10-07 PE PE1999001016A patent/PE20001086A1/es not_active Application Discontinuation
- 1999-10-07 IL IL152928A patent/IL152928A/en not_active IP Right Cessation
- 1999-10-07 IL IL15292699A patent/IL152926A/en not_active IP Right Cessation
- 1999-10-08 SK SK1385-99A patent/SK285215B6/sk not_active IP Right Cessation
- 1999-10-08 CA CA002285733A patent/CA2285733C/en not_active Expired - Lifetime
- 1999-10-08 AR ARP990105109A patent/AR019244A1/es active IP Right Grant
- 1999-10-08 MY MYPI99004353A patent/MY124620A/en unknown
- 1999-10-08 OA OA9900224A patent/OA11165A/en unknown
- 1999-10-08 US US09/415,440 patent/US6207829B1/en not_active Expired - Fee Related
- 1999-10-08 UA UA99105491A patent/UA66787C2/xx unknown
- 1999-10-08 IS IS5209A patent/IS1951B/is unknown
- 1999-10-09 CN CNB991239180A patent/CN1207295C/zh not_active Expired - Fee Related
- 1999-10-09 CN CNA031427383A patent/CN1473831A/zh active Pending
- 1999-10-11 AU AU53581/99A patent/AU756463B2/en not_active Ceased
- 1999-10-11 BR BR9905092-7A patent/BR9905092A/pt not_active IP Right Cessation
- 1999-10-11 PT PT99307996T patent/PT994115E/pt unknown
- 1999-10-11 HU HU9903469A patent/HU226162B1/hu not_active IP Right Cessation
- 1999-10-11 DE DE69923906T patent/DE69923906T2/de not_active Expired - Lifetime
- 1999-10-11 KR KR10-1999-0043836A patent/KR100380954B1/ko not_active IP Right Cessation
- 1999-10-11 ES ES99307996T patent/ES2237049T3/es not_active Expired - Lifetime
- 1999-10-11 ID IDP990941A patent/ID23351A/id unknown
- 1999-10-11 TN TNTNSN99189A patent/TNSN99189A1/fr unknown
- 1999-10-11 DZ DZ990212A patent/DZ2912A1/xx active
- 1999-10-11 EP EP99307996A patent/EP0994115B1/en not_active Expired - Lifetime
- 1999-10-11 SI SI9930773T patent/SI0994115T1/xx unknown
- 1999-10-11 ZA ZA9906412A patent/ZA996412B/xx unknown
- 1999-10-11 EA EA199900822A patent/EA003774B1/ru not_active IP Right Cessation
- 1999-10-11 MA MA25812A patent/MA25007A1/fr unknown
- 1999-10-11 EG EG126999A patent/EG22630A/xx active
- 1999-10-11 AT AT99307996T patent/ATE290003T1/de active
- 1999-10-11 NO NO19994943A patent/NO313700B1/no not_active IP Right Cessation
- 1999-10-11 DK DK99307996T patent/DK0994115T3/da active
- 1999-10-11 BG BG103794A patent/BG63205B1/bg unknown
- 1999-10-12 HR HR990318A patent/HRP990318B1/xx not_active IP Right Cessation
- 1999-10-12 JP JP29009999A patent/JP3721021B2/ja not_active Expired - Fee Related
- 1999-10-12 CO CO99064776A patent/CO5150214A1/es unknown
- 1999-10-12 PL PL335959A patent/PL198150B1/pl not_active IP Right Cessation
- 1999-10-12 EE EEP199900507A patent/EE04192B1/xx not_active IP Right Cessation
- 1999-10-12 UY UY25750A patent/UY25750A1/es not_active Application Discontinuation
- 1999-10-12 GE GEAP19995027A patent/GEP20022700B/en unknown
- 1999-10-12 SG SG1999005097A patent/SG118060A1/en unknown
- 1999-10-12 TR TR1999/02541A patent/TR199902541A2/xx unknown
2000
- 2000-10-10 HK HK00106399A patent/HK1027559A1/xx not_active IP Right Cessation
2001
- 2001-01-16 US US09/761,376 patent/US20010009962A1/en not_active Abandoned
2002
- 2002-09-23 US US10/253,029 patent/US20030069422A1/en not_active Abandoned
- 2002-11-18 IL IL15292402A patent/IL152924A0/xx unknown
- 2002-11-18 IL IL15292802A patent/IL152928A0/xx active IP Right Grant
- 2002-11-18 IL IL15292702A patent/IL152927A0/xx unknown
- 2002-11-18 IL IL15292602A patent/IL152926A0/xx unknown
- 2002-11-18 IL IL15292302A patent/IL152923A0/xx unknown

Also Published As

Publication number	Publication date
TNSN99189A1 (fr)	2005-11-10
EG22630A (en)	2003-05-31
IL152927A (en)	2004-06-01
HU9903469D0 (en)	1999-12-28
IS1951B (is)	2004-10-13
IL152923A (en)	2004-02-08
CR6118A (es)	2005-09-16
AP9901672A0 (en)	1999-12-31
SK138599A3 (en)	2000-05-16
AU756463B2 (en)	2003-01-16
TW589314B (en)	2004-06-01
US6207829B1 (en)	2001-03-27
IL132273A0 (en)	2001-03-19
HUP9903469A3 (en)	2000-10-30
PL335959A1 (en)	2000-04-25
US20030069422A1 (en)	2003-04-10
IL152928A0 (en)	2003-06-24
PL198150B1 (pl)	2008-05-30
DE69923906T2 (de)	2006-04-06
EA199900822A3 (ru)	2000-08-28
IL152927A0 (en)	2003-06-24
IL132273A (en)	2004-06-20
KR20000028987A (ko)	2000-05-25
TR199902541A2 (xx)	2000-07-21
IL152923A0 (en)	2003-06-24
EA199900822A2 (ru)	2000-04-24
NO994943L (no)	2000-04-13
ID23351A (id)	2000-04-13
OA11165A (en)	2003-04-22
EP0994115A3 (en)	2000-05-24
RS49762B (sr)	2008-04-04
JP3721021B2 (ja)	2005-11-30
HK1027559A1 (en)	2001-01-19
DZ2912A1 (fr)	2004-03-01
AP1233A (en)	2003-12-18
CA2285733A1 (en)	2000-04-12
NO994943D0 (no)	1999-10-11
EP0994115B1 (en)	2005-03-02
IL152928A (en)	2007-07-04
IS5209A (is)	2000-04-13
EE9900507A (et)	2000-06-15
CN1207295C (zh)	2005-06-22
MA25007A1 (fr)	2000-07-01
ZA996412B (en)	2001-04-11
EE04192B1 (et)	2003-12-15
CZ296816B6 (cs)	2006-06-14
BR9905092A (pt)	2000-08-08
AU5358199A (en)	2000-04-13
GEP20022700B (en)	2002-05-27
CN1255497A (zh)	2000-06-07
CO5150214A1 (es)	2002-04-29
BG103794A (en)	2000-09-29
DK0994115T3 (da)	2005-06-20
SI0994115T1 (xx)	2005-08-31
HU226162B1 (en)	2008-05-28
IL152924A0 (en)	2003-06-24
PT994115E (pt)	2005-06-30
GB9822238D0 (en)	1998-12-09
IL152926A0 (en)	2003-06-24
SG118060A1 (en)	2006-01-27
HRP990318A2 (en)	2000-06-30
ES2237049T3 (es)	2005-07-16
KR100380954B1 (ko)	2003-04-21
UY25750A1 (es)	2001-08-27
EP0994115A2 (en)	2000-04-19
CN1473831A (zh)	2004-02-11
SK285215B6 (sk)	2006-09-07
NO313700B1 (no)	2002-11-18
CZ353299A3 (cs)	2000-05-17
ATE290003T1 (de)	2005-03-15
HUP9903469A2 (hu)	2000-08-28
US20010009962A1 (en)	2001-07-26
HRP990318B1 (en)	2004-06-30
CU22928A3 (es)	2004-02-20
IL152926A (en)	2004-02-19
PE20001086A1 (es)	2000-10-18
JP2000119273A (ja)	2000-04-25
BG63205B1 (bg)	2001-06-29
DE69923906D1 (de)	2005-04-07
EA003774B1 (ru)	2003-08-28
IL152924A (en)	2004-02-19
AR019244A1 (es)	2001-12-26
YU48999A (sh)	2002-06-19
CA2285733C (en)	2004-08-24
GT199900172A (es)	2001-03-28
MY124620A (en)	2006-06-30

Publication	Publication Date	Title
UA66787C2 (en)	2004-06-15	A process for the preparation of 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1h-pyrazolo[4,3-d]pyrimidine-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine and intermediary compounds
HUT36328A (en)	1985-09-30	Fungicides containing 7-amino-azolo /1,5-a/ pyrimidine-derivatives and process for the production of the agents
TR200800474T2 (tr)	2008-04-21	Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
CA2095587A1 (en)	1994-02-27	Process for preparing aryl piperazinyl-hetero-cyclic compounds
MXPA02004448A (es)	2004-09-10	Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii.
MY117092A (en)	2004-05-31	Chemotherapeutic pyrrolocarbazole derivatives
MX9708696A (es)	1998-08-30	Cefalosporinas antibacterianas.
ATE294779T1 (de)	2005-05-15	Arylpiperidinopropanol und arylpiperazinopropanol derivate und die selbe enthaltende pharmazeutika
PL328789A1 (en)	1999-03-29	Novel heterocyclic compounds, method of obtaining them, their application in production of a pharmaceutic agent and pharmaceutic agent obtained thereby
BG103778A (en)	2001-05-31	Process for preparing pyrazole derivatives
CA2452036A1 (en)	2003-01-09	6-'2-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity
AU1465301A (en)	2001-06-06	Process for preparing n-(4-hydroxy-phenyl)-n'-(4'-aminophenyl)-piperazine
MX9604338A (es)	1997-03-29	Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.
EP1092720A3 (en)	2001-09-19	Process for the preparation of pyrazolo [4,3-d] pyrimidin-7-ones-3-pyridylsulphonyl compounds and intermediates thereof
TR199900321T2 (xx)	1999-04-21	N-(1-nbutil - 4 - piperidil)metil) -3,4-dihidro -2H- (1,3) oksazino (3.2A) indol-10- Karboksamit haz�rlama prosesi ve prosesteki tuzlar ve ara �r�nler.
DE3477380D1 (en)	1989-04-27	Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
MY130190A (en)	2007-06-29	Method for the preparation of 4-halo-2'- nitrobutyrophenone compounds
SE0101323D0 (sv)	2001-04-12	New process
AU3350195A (en)	1996-04-09	Bicyclic carboxamides as 5-HT-1A antagonists
AU7206898A (en)	1998-10-20	Method for producing 1,3-di-substituted 2-nitroguanidines
CA2245484A1 (en)	1999-02-27	Novel urea derivatives
WO2001077143A3 (en)	2002-01-24	Process for the preparation of 3-amino-1, 5-benzodiazepine derivatives
MY127737A (en)	2006-12-29	Novel process for the preparation of pyrazolopyrimidinones
HK1036978A1 (en)	2002-01-25	Enantioselective synthesis
CA2201219A1 (en)	1997-10-09	Process for the preparation of substituted pyrimidines