EA199900822A2 - СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО [4,3-d] ПИРИМИДИН-7-ОНОВ И ИХ ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ - Google Patents

СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО [4,3-d] ПИРИМИДИН-7-ОНОВ И ИХ ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ

Info

Publication number
EA199900822A2
EA199900822A2 EA199900822A EA199900822A EA199900822A2 EA 199900822 A2 EA199900822 A2 EA 199900822A2 EA 199900822 A EA199900822 A EA 199900822A EA 199900822 A EA199900822 A EA 199900822A EA 199900822 A2 EA199900822 A2 EA 199900822A2
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrazolo
pyrimidin
intermediates
ones
preparation
Prior art date
Application number
EA199900822A
Other languages
English (en)
Other versions
EA199900822A3 (ru
EA003774B1 (ru
Inventor
Питер Джеймс Данн
Филип Чарлз Леветт
Original Assignee
Пфайзер Рисеч Энд Дивелопмент Компани, Н.В./С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA199900822(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Рисеч Энд Дивелопмент Компани, Н.В./С.А. filed Critical Пфайзер Рисеч Энд Дивелопмент Компани, Н.В./С.А.
Publication of EA199900822A2 publication Critical patent/EA199900822A2/ru
Publication of EA199900822A3 publication Critical patent/EA199900822A3/ru
Publication of EA003774B1 publication Critical patent/EA003774B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложен способ получения соединения формул (IA) (силденафил/виагра™) и (IB)включающий реакцию соединения формулы (IIA) и (IIB), соответственно, в присутствииOR, где R, в случае образования соединения (IA), представляет CHCHи R, в случае образования соединения (IB), представляет CHCHCH, где X представляет уходящую группу
EA199900822A 1998-10-12 1999-10-11 СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО [4,3-d] ПИРИМИДИН-7-ОНОВ И ИХ ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ EA003774B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (3)

Publication Number Publication Date
EA199900822A2 true EA199900822A2 (ru) 2000-04-24
EA199900822A3 EA199900822A3 (ru) 2000-08-28
EA003774B1 EA003774B1 (ru) 2003-08-28

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900822A EA003774B1 (ru) 1998-10-12 1999-10-11 СПОСОБ ПОЛУЧЕНИЯ ПИРАЗОЛО [4,3-d] ПИРИМИДИН-7-ОНОВ И ИХ ПРОМЕЖУТОЧНЫЕ ПРОДУКТЫ

Country Status (49)

Country Link
US (3) US6207829B1 (ru)
EP (1) EP0994115B1 (ru)
JP (1) JP3721021B2 (ru)
KR (1) KR100380954B1 (ru)
CN (2) CN1473831A (ru)
AP (1) AP1233A (ru)
AR (1) AR019244A1 (ru)
AT (1) ATE290003T1 (ru)
AU (1) AU756463B2 (ru)
BG (1) BG63205B1 (ru)
BR (1) BR9905092A (ru)
CA (1) CA2285733C (ru)
CO (1) CO5150214A1 (ru)
CR (1) CR6118A (ru)
CU (1) CU22928A3 (ru)
CZ (1) CZ296816B6 (ru)
DE (1) DE69923906T2 (ru)
DK (1) DK0994115T3 (ru)
DZ (1) DZ2912A1 (ru)
EA (1) EA003774B1 (ru)
EE (1) EE04192B1 (ru)
EG (1) EG22630A (ru)
ES (1) ES2237049T3 (ru)
GB (1) GB9822238D0 (ru)
GE (1) GEP20022700B (ru)
GT (1) GT199900172A (ru)
HK (1) HK1027559A1 (ru)
HR (1) HRP990318B1 (ru)
HU (1) HU226162B1 (ru)
ID (1) ID23351A (ru)
IL (11) IL132273A (ru)
IS (1) IS1951B (ru)
MA (1) MA25007A1 (ru)
MY (1) MY124620A (ru)
NO (1) NO313700B1 (ru)
OA (1) OA11165A (ru)
PE (1) PE20001086A1 (ru)
PL (1) PL198150B1 (ru)
PT (1) PT994115E (ru)
RS (1) RS49762B (ru)
SG (1) SG118060A1 (ru)
SI (1) SI0994115T1 (ru)
SK (1) SK285215B6 (ru)
TN (1) TNSN99189A1 (ru)
TR (1) TR199902541A2 (ru)
TW (1) TW589314B (ru)
UA (1) UA66787C2 (ru)
UY (1) UY25750A1 (ru)
ZA (1) ZA996412B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
ES2223863T3 (es) * 2000-06-22 2005-03-01 Pfizer Inc. Procedimiento para la preparacion de pirazolopirimidinonas.
EP1176147A1 (en) * 2000-07-28 2002-01-30 Pfizer Limited Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
JP4554931B2 (ja) 2001-12-20 2010-09-29 メルク セローノ ソシエテ アノニム プロスタグランジン調節物質としてのピロリジン誘導体
CA2470427C (en) 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和***的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
ID22834A (id) * 1997-04-25 1999-12-09 Pfizer Pirazolopimidinona untuk kelainan seksual

Also Published As

Publication number Publication date
IL152924A0 (en) 2003-06-24
MY124620A (en) 2006-06-30
ATE290003T1 (de) 2005-03-15
IS1951B (is) 2004-10-13
PL198150B1 (pl) 2008-05-30
HK1027559A1 (en) 2001-01-19
DE69923906D1 (de) 2005-04-07
AP1233A (en) 2003-12-18
UY25750A1 (es) 2001-08-27
IS5209A (is) 2000-04-13
YU48999A (sh) 2002-06-19
ES2237049T3 (es) 2005-07-16
IL152928A0 (en) 2003-06-24
EA199900822A3 (ru) 2000-08-28
NO994943L (no) 2000-04-13
IL132273A (en) 2004-06-20
EA003774B1 (ru) 2003-08-28
SG118060A1 (en) 2006-01-27
GEP20022700B (en) 2002-05-27
CA2285733A1 (en) 2000-04-12
US20030069422A1 (en) 2003-04-10
KR20000028987A (ko) 2000-05-25
IL152923A0 (en) 2003-06-24
US6207829B1 (en) 2001-03-27
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
HU226162B1 (en) 2008-05-28
RS49762B (sr) 2008-04-04
BR9905092A (pt) 2000-08-08
CO5150214A1 (es) 2002-04-29
TNSN99189A1 (fr) 2005-11-10
EG22630A (en) 2003-05-31
CR6118A (es) 2005-09-16
ID23351A (id) 2000-04-13
BG63205B1 (bg) 2001-06-29
IL152926A (en) 2004-02-19
CN1255497A (zh) 2000-06-07
CN1207295C (zh) 2005-06-22
SK285215B6 (sk) 2006-09-07
GB9822238D0 (en) 1998-12-09
BG103794A (en) 2000-09-29
UA66787C2 (en) 2004-06-15
AP9901672A0 (en) 1999-12-31
AU5358199A (en) 2000-04-13
SK138599A3 (en) 2000-05-16
HRP990318A2 (en) 2000-06-30
EP0994115A2 (en) 2000-04-19
IL152928A (en) 2007-07-04
IL152924A (en) 2004-02-19
CN1473831A (zh) 2004-02-11
IL132273A0 (en) 2001-03-19
CU22928A3 (es) 2004-02-20
OA11165A (en) 2003-04-22
TW589314B (en) 2004-06-01
IL152927A0 (en) 2003-06-24
HUP9903469A2 (hu) 2000-08-28
DZ2912A1 (fr) 2004-03-01
HU9903469D0 (en) 1999-12-28
CZ296816B6 (cs) 2006-06-14
NO994943D0 (no) 1999-10-11
NO313700B1 (no) 2002-11-18
TR199902541A2 (xx) 2000-07-21
GT199900172A (es) 2001-03-28
IL152926A0 (en) 2003-06-24
PL335959A1 (en) 2000-04-25
US20010009962A1 (en) 2001-07-26
SI0994115T1 (ru) 2005-08-31
IL152923A (en) 2004-02-08
KR100380954B1 (ko) 2003-04-21
JP2000119273A (ja) 2000-04-25
HUP9903469A3 (en) 2000-10-30
IL152927A (en) 2004-06-01
EE9900507A (et) 2000-06-15
CZ353299A3 (cs) 2000-05-17
AU756463B2 (en) 2003-01-16
EE04192B1 (et) 2003-12-15
DK0994115T3 (da) 2005-06-20
CA2285733C (en) 2004-08-24
EP0994115B1 (en) 2005-03-02
EP0994115A3 (en) 2000-05-24
AR019244A1 (es) 2001-12-26
PE20001086A1 (es) 2000-10-18
DE69923906T2 (de) 2006-04-06
PT994115E (pt) 2005-06-30
JP3721021B2 (ja) 2005-11-30
HRP990318B1 (en) 2004-06-30

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Legal Events

Date Code Title Description
PC4A Registration of transfer of a eurasian patent by assignment
TC4A Change in name of a patent proprietor in a eurasian patent

Designated state(s): AM AZ BY KZ KG MD TJ TM RU

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU