CR6118A - Procedimiento para preparacion de pirazolo 4,3-d pirimidin-7-onas y sus intermedios - Google Patents

Procedimiento para preparacion de pirazolo 4,3-d pirimidin-7-onas y sus intermedios

Info

Publication number
CR6118A
CR6118A CR6118A CR6118A CR6118A CR 6118 A CR6118 A CR 6118A CR 6118 A CR6118 A CR 6118A CR 6118 A CR6118 A CR 6118A CR 6118 A CR6118 A CR 6118A
Authority
CR
Costa Rica
Prior art keywords
preparation
pirazolo
pirimidin
onas
intermediates
Prior art date
Application number
CR6118A
Other languages
English (en)
Inventor
James Dunn Peter
Charles Levett Philips
Original Assignee
Pfizer Ireland Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10840421&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR6118(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
Publication of CR6118A publication Critical patent/CR6118A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Se proporciona un procedimiento para la preparacion de un compuesto de formulas (IA) (sildenafil/ Viagra) y (IB) que comprende hacer reaccionar un compuesto de formula (IIA) y (IIB), respectivamente, en presencia de OR, siendo R, en el caso de la formacion del compuesto (IA), CH2CH2CH3, y siendo X un grupo saliente
CR6118A 1998-10-12 1999-10-07 Procedimiento para preparacion de pirazolo 4,3-d pirimidin-7-onas y sus intermedios CR6118A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof

Publications (1)

Publication Number Publication Date
CR6118A true CR6118A (es) 2005-09-16

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
CR6118A CR6118A (es) 1998-10-12 1999-10-07 Procedimiento para preparacion de pirazolo 4,3-d pirimidin-7-onas y sus intermedios

Country Status (49)

Country Link
US (3) US6207829B1 (es)
EP (1) EP0994115B1 (es)
JP (1) JP3721021B2 (es)
KR (1) KR100380954B1 (es)
CN (2) CN1473831A (es)
AP (1) AP1233A (es)
AR (1) AR019244A1 (es)
AT (1) ATE290003T1 (es)
AU (1) AU756463B2 (es)
BG (1) BG63205B1 (es)
BR (1) BR9905092A (es)
CA (1) CA2285733C (es)
CO (1) CO5150214A1 (es)
CR (1) CR6118A (es)
CU (1) CU22928A3 (es)
CZ (1) CZ296816B6 (es)
DE (1) DE69923906T2 (es)
DK (1) DK0994115T3 (es)
DZ (1) DZ2912A1 (es)
EA (1) EA003774B1 (es)
EE (1) EE04192B1 (es)
EG (1) EG22630A (es)
ES (1) ES2237049T3 (es)
GB (1) GB9822238D0 (es)
GE (1) GEP20022700B (es)
GT (1) GT199900172A (es)
HK (1) HK1027559A1 (es)
HR (1) HRP990318B1 (es)
HU (1) HU226162B1 (es)
ID (1) ID23351A (es)
IL (11) IL132273A (es)
IS (1) IS1951B (es)
MA (1) MA25007A1 (es)
MY (1) MY124620A (es)
NO (1) NO313700B1 (es)
OA (1) OA11165A (es)
PE (1) PE20001086A1 (es)
PL (1) PL198150B1 (es)
PT (1) PT994115E (es)
RS (1) RS49762B (es)
SG (1) SG118060A1 (es)
SI (1) SI0994115T1 (es)
SK (1) SK285215B6 (es)
TN (1) TNSN99189A1 (es)
TR (1) TR199902541A2 (es)
TW (1) TW589314B (es)
UA (1) UA66787C2 (es)
UY (1) UY25750A1 (es)
ZA (1) ZA996412B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
ES2223863T3 (es) * 2000-06-22 2005-03-01 Pfizer Inc. Procedimiento para la preparacion de pirazolopirimidinonas.
EP1176147A1 (en) * 2000-07-28 2002-01-30 Pfizer Limited Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
JP4554931B2 (ja) 2001-12-20 2010-09-29 メルク セローノ ソシエテ アノニム プロスタグランジン調節物質としてのピロリジン誘導体
CA2470427C (en) 2001-12-21 2012-07-10 Cytokinetics, Incorporated Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和***的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
EP2024369A4 (en) * 2006-06-05 2010-10-27 Matrix Lab Ltd NEW PROCESS FOR THE PREPARATION OF SILDENAFIL CITRATE
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
ID22834A (id) * 1997-04-25 1999-12-09 Pfizer Pirazolopimidinona untuk kelainan seksual

Also Published As

Publication number Publication date
IL152924A0 (en) 2003-06-24
EA199900822A2 (ru) 2000-04-24
MY124620A (en) 2006-06-30
ATE290003T1 (de) 2005-03-15
IS1951B (is) 2004-10-13
PL198150B1 (pl) 2008-05-30
HK1027559A1 (en) 2001-01-19
DE69923906D1 (de) 2005-04-07
AP1233A (en) 2003-12-18
UY25750A1 (es) 2001-08-27
IS5209A (is) 2000-04-13
YU48999A (sh) 2002-06-19
ES2237049T3 (es) 2005-07-16
IL152928A0 (en) 2003-06-24
EA199900822A3 (ru) 2000-08-28
NO994943L (no) 2000-04-13
IL132273A (en) 2004-06-20
EA003774B1 (ru) 2003-08-28
SG118060A1 (en) 2006-01-27
GEP20022700B (en) 2002-05-27
CA2285733A1 (en) 2000-04-12
US20030069422A1 (en) 2003-04-10
KR20000028987A (ko) 2000-05-25
IL152923A0 (en) 2003-06-24
US6207829B1 (en) 2001-03-27
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
HU226162B1 (en) 2008-05-28
RS49762B (sr) 2008-04-04
BR9905092A (pt) 2000-08-08
CO5150214A1 (es) 2002-04-29
TNSN99189A1 (fr) 2005-11-10
EG22630A (en) 2003-05-31
ID23351A (id) 2000-04-13
BG63205B1 (bg) 2001-06-29
IL152926A (en) 2004-02-19
CN1255497A (zh) 2000-06-07
CN1207295C (zh) 2005-06-22
SK285215B6 (sk) 2006-09-07
GB9822238D0 (en) 1998-12-09
BG103794A (en) 2000-09-29
UA66787C2 (en) 2004-06-15
AP9901672A0 (en) 1999-12-31
AU5358199A (en) 2000-04-13
SK138599A3 (en) 2000-05-16
HRP990318A2 (en) 2000-06-30
EP0994115A2 (en) 2000-04-19
IL152928A (en) 2007-07-04
IL152924A (en) 2004-02-19
CN1473831A (zh) 2004-02-11
IL132273A0 (en) 2001-03-19
CU22928A3 (es) 2004-02-20
OA11165A (en) 2003-04-22
TW589314B (en) 2004-06-01
IL152927A0 (en) 2003-06-24
HUP9903469A2 (hu) 2000-08-28
DZ2912A1 (fr) 2004-03-01
HU9903469D0 (en) 1999-12-28
CZ296816B6 (cs) 2006-06-14
NO994943D0 (no) 1999-10-11
NO313700B1 (no) 2002-11-18
TR199902541A2 (xx) 2000-07-21
GT199900172A (es) 2001-03-28
IL152926A0 (en) 2003-06-24
PL335959A1 (en) 2000-04-25
US20010009962A1 (en) 2001-07-26
SI0994115T1 (es) 2005-08-31
IL152923A (en) 2004-02-08
KR100380954B1 (ko) 2003-04-21
JP2000119273A (ja) 2000-04-25
HUP9903469A3 (en) 2000-10-30
IL152927A (en) 2004-06-01
EE9900507A (et) 2000-06-15
CZ353299A3 (cs) 2000-05-17
AU756463B2 (en) 2003-01-16
EE04192B1 (et) 2003-12-15
DK0994115T3 (da) 2005-06-20
CA2285733C (en) 2004-08-24
EP0994115B1 (en) 2005-03-02
EP0994115A3 (en) 2000-05-24
AR019244A1 (es) 2001-12-26
PE20001086A1 (es) 2000-10-18
DE69923906T2 (de) 2006-04-06
PT994115E (pt) 2005-06-30
JP3721021B2 (ja) 2005-11-30
HRP990318B1 (en) 2004-06-30

Similar Documents

Publication Publication Date Title
CR6118A (es) Procedimiento para preparacion de pirazolo 4,3-d pirimidin-7-onas y sus intermedios
CO4780028A1 (es) Procedimiento para la preparacion de sildenafil
UY28014A1 (es) Compuestos quimicos
CY1109313T1 (el) Ενωσις φωσφονοκεφεμιου
UY23787A1 (es) Procedimiento para la preparacion de compuestos que contienen un anillo biciclico fusionado
CO5560574A2 (es) Procesos para la preparacion de compuestos de aminopirimidina, halogenopirimidina, sulfoniloxipirimidina e hidroxipirimidina; y un compuesto de hidroxipirimidina
CO4900057A1 (es) Dihidrato d de olanzapina
ES2053439T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
DK0918776T3 (da) Totalsyntese af antitumor acylfulvener
AR006058A1 (es) Procedimientos para preparar compuestos de dicianoacetato y de 1,2-pirazol-5-amino-3-substituido
BR0212153A (pt) Compostos e respectivos processos de preparação e de isolamento de dicloreto de 2-difluormetilornitina
ECSP993154A (es) PROCEDIMIENTO PARA LA PREPARACION DE PIRAZOLO (4,3,d) -PIRIMIDIN -7-ONAS Y SUS INTERMEDIOS
BR0004787A (pt) Processo para a preparação de compostos pirazolo[4,3-d] pirimidin-7-onas-3-piridilsulfonila bem como intermediários dos mesmos
HN1999000172A (es) Procedimiento para la preparacion de pirazolo (4,3-d) pirimidin-7-onas y sus intermedios
DE69827614D1 (de) Chinoxalindionen
AR241441A1 (es) Procedimiento para la obtencion de nuevos derivados del acido 4-benzoil-5hidroxi-benzociclobuten-1-carboxilico y sus sales.
MX9605361A (es) Procedimiento para la preparacion de mezclas de isomeros de o-fenoxialquilhidroxilaminas o o-fenoxialquiloximas.
ES2188222T3 (es) Sintesis enantioselectiva.
ES2161602B1 (es) Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
HK1048630A1 (en) Synthesis of intermediates useful in preparing tricyclic compounds
DE69914763D1 (de) Verfahren zur herstellung einer 2-aminobenzophenonverbindung
MX9203518A (es) 9-amino-2-fenilbiciclo [3.3.1] nonanos y 9-amino-2-fenilbiciclo [3.3.1] non-2-enos y drogas que los contienen.
AR028729A1 (es) Nuevo procedimiento para la preparacion de pirazolopirimidinonas
DK0949250T3 (da) Fremgangsmåde til fremstilling af alpha1L-adrenoceptorantagonister
DOP2001000186A (es) Nuevo procedimiento para la preparación de pirazolopirimidinonas