MX9604338A - Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. - Google Patents
Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene.Info
- Publication number
- MX9604338A MX9604338A MX9604338A MX9604338A MX9604338A MX 9604338 A MX9604338 A MX 9604338A MX 9604338 A MX9604338 A MX 9604338A MX 9604338 A MX9604338 A MX 9604338A MX 9604338 A MX9604338 A MX 9604338A
- Authority
- MX
- Mexico
- Prior art keywords
- medicament
- well
- utilization
- preparation
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Los compuestos de la formula (I), en la que los sustituyentes tienen los significados indicados en la memoria descriptiva, así como sus sales farmacéuticamente compatibles, se obtienen por reaccion con guanidina de un compuesto de la formula (II), en la que R(1) hasta R(5) poseen los significados indicados y L representa un grupo lábil fácilmente sustituibles de manera nucleofila. Los compuestos I son sobresalientes agentes terapéuticos cardio-circulatorios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95115240A EP0765867A1 (de) | 1995-09-27 | 1995-09-27 | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Antiarrhytmika oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9604338A true MX9604338A (es) | 1997-03-29 |
Family
ID=8219659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9604338A MX9604338A (es) | 1995-09-27 | 1996-09-26 | Benzoilguanidinas sustituidas, procedimiento para su preparacion, su utilizacion como medicamento o agente de diagnostico, asi como medicamento que las contiene. |
Country Status (20)
Country | Link |
---|---|
US (1) | US5747541A (es) |
EP (1) | EP0765867A1 (es) |
JP (1) | JPH09124584A (es) |
KR (1) | KR970015568A (es) |
AR (1) | AR004004A1 (es) |
AU (1) | AU6584696A (es) |
BR (1) | BR9603911A (es) |
CA (1) | CA2186580A1 (es) |
CZ (1) | CZ280896A3 (es) |
HR (1) | HRP960430A2 (es) |
HU (1) | HUP9602640A3 (es) |
IL (1) | IL119293A0 (es) |
MX (1) | MX9604338A (es) |
NO (1) | NO964053L (es) |
NZ (1) | NZ299445A (es) |
PL (1) | PL315050A1 (es) |
SK (1) | SK122596A3 (es) |
TR (1) | TR199600753A1 (es) |
TW (1) | TW339327B (es) |
ZA (1) | ZA968091B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19859727A1 (de) * | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
WO2001045716A1 (en) * | 1999-12-20 | 2001-06-28 | Gho'st Holding B.V. | Pharmaceutical composition comprising a physiologically acceptable vanadium compound, salt or complex and a na+/h+ exchange inhibitor |
US6410563B1 (en) | 1999-12-22 | 2002-06-25 | Merck Frosst Canada & Co. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
US6639077B2 (en) | 2000-03-23 | 2003-10-28 | Merck Frosst Canada & Co. | Tri-aryl-substituted-ethane PDE4 inhibitors |
MY123585A (en) | 2000-03-23 | 2006-05-31 | Merck Canada Inc | Tri-aryl-substituted-ethane pde4 inhibitors. |
JP2003534328A (ja) | 2000-05-25 | 2003-11-18 | メルク フロスト カナダ アンド カンパニー | フルオロアルコキシ置換ベンズアミドジクロロピリジニルn−オキシドpde4阻害剤 |
US6740666B2 (en) | 2000-12-20 | 2004-05-25 | Merck & Co., Inc. | Substituted 8-arylquinoline phosphodiesterase-4 inhibitors |
ATE303384T1 (de) | 2001-05-24 | 2005-09-15 | Merck Frosst Canada Inc | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren |
JO2311B1 (en) | 2001-08-29 | 2005-09-12 | ميرك فروست كندا ليمتد | Alkyl inhibitors Ariel phosphodiesterase-4 |
ATE486600T1 (de) | 2002-03-12 | 2010-11-15 | Merck Sharp & Dohme | Di-aryl-substituierte tetrazol-modulatoren des metabotropen glutamat-rezeptors-5 |
US7253218B2 (en) * | 2004-03-01 | 2007-08-07 | H.B. Fuller Company | Sound damping compositions and methods for applying and baking same onto substrates |
WO2007136636A1 (en) * | 2006-05-17 | 2007-11-29 | Childrens Hospital Los Angeles Research Institute | Drug combinations to treat hyperproliferative disorders |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3780027A (en) * | 1970-04-29 | 1973-12-18 | Merck & Co Inc | Anthranilic acid derivatives |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
DE59307360D1 (de) * | 1992-02-15 | 1997-10-23 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
ATE139526T1 (de) * | 1992-02-15 | 1996-07-15 | Hoechst Ag | 3,5-substituierte benzoylguanidine, mit antiarrythmischer wirkung und inhibierender wirkung auf die proliferationen von zellen |
ES2097409T3 (es) * | 1992-09-22 | 1997-04-01 | Hoechst Ag | Benzoilguanidinas, procedimiento para su preparacion, asi como su empleo como antiarritmicos. |
TW250477B (es) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
TW250479B (es) * | 1992-12-15 | 1995-07-01 | Hoechst Ag | |
ATE151071T1 (de) * | 1992-12-16 | 1997-04-15 | Hoechst Ag | 3,5-substituierte aminobenzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament |
EP0604852A1 (de) * | 1992-12-28 | 1994-07-06 | Hoechst Aktiengesellschaft | 2,4-Substituierte 5-(N-substituierte-Sulfamoyl)-Benzoylguanidine, als Antiarrythmika, Inhibitoren der Proliferationen von Zellen, und Inhibitoren des Natrium-Protonen-Antiporters |
DK0612723T3 (da) * | 1993-02-20 | 1998-03-30 | Hoechst Ag | Substituerede benzoylguanidiner, fremgangsmåde til fremstilling, deres anvendelse som lægemiddel, som inhibitor af den cellulære Na+/H+-udbytning eller som diagnostikum samt lægemiddel med indhold deraf |
IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
DE4318658A1 (de) * | 1993-06-04 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4318756A1 (de) * | 1993-06-05 | 1994-12-08 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
US5372607A (en) * | 1993-06-23 | 1994-12-13 | Medtronic, Inc. | Method and apparatus for monitoring pacemaker intervals |
DE4325822A1 (de) * | 1993-07-31 | 1995-02-02 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4327176C1 (de) * | 1993-08-13 | 1995-01-26 | Metallgesellschaft Ag | Röhrenofen für die Erzeugung kohlenmonoxidhaltiger Gasgemische |
DE4344550A1 (de) * | 1993-12-24 | 1995-06-29 | Hoechst Ag | Substituierte 1-Oxo-1,2-dihydro-isochinolinoyl- und 1,1-Dioxo-2H-1,2-benzothiazinoylguanidine, Verfahrenzu ihrer Herstellung, ihre Verwendung als Medikamentt oder Diagnostikum sowie sie enthaltendes Medikamen |
TW415937B (en) * | 1994-01-25 | 2000-12-21 | Hoechst Ag | Phenyl-substituted alkylcarboxylic acid guanidides bearing perfluoroalkyl groups, process for their preparation, their use as a medicament or diagnostic, and medicament containing them |
DE4402057A1 (de) * | 1994-01-25 | 1995-08-03 | Hoechst Ag | Perfluoralkylgruppen tragende phenyl-substituierte Alkylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4417004A1 (de) * | 1994-05-13 | 1995-11-16 | Hoechst Ag | Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4422685A1 (de) * | 1994-06-29 | 1996-01-04 | Hoechst Ag | Ortho-amino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4432106A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Mit Heterocyclen-N-Oxid-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum, sie enthaltendes Medikament sowie Zwischenprodukte zu ihrer Herstellung |
DE4432101A1 (de) * | 1994-09-09 | 1996-03-14 | Hoechst Ag | Aminosäure-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
DE4441880A1 (de) * | 1994-11-24 | 1996-05-30 | Hoechst Ag | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
EP0723956B1 (de) * | 1995-01-30 | 1999-10-13 | Hoechst Aktiengesellschaft | Basisch-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1995
- 1995-09-27 EP EP95115240A patent/EP0765867A1/de not_active Withdrawn
- 1995-11-24 TW TW084112529A patent/TW339327B/zh active
-
1996
- 1996-07-01 PL PL96315050A patent/PL315050A1/xx unknown
- 1996-09-25 NZ NZ299445A patent/NZ299445A/en unknown
- 1996-09-25 AU AU65846/96A patent/AU6584696A/en not_active Abandoned
- 1996-09-25 SK SK1225-96A patent/SK122596A3/sk unknown
- 1996-09-25 TR TR96/00753A patent/TR199600753A1/xx unknown
- 1996-09-25 CZ CZ962808A patent/CZ280896A3/cs unknown
- 1996-09-25 IL IL11929396A patent/IL119293A0/xx unknown
- 1996-09-25 KR KR1019960042324A patent/KR970015568A/ko not_active Application Discontinuation
- 1996-09-25 AR ARP960104498A patent/AR004004A1/es unknown
- 1996-09-25 HR HR95115240.4A patent/HRP960430A2/hr not_active Application Discontinuation
- 1996-09-26 HU HU9602640A patent/HUP9602640A3/hu unknown
- 1996-09-26 ZA ZA968091A patent/ZA968091B/xx unknown
- 1996-09-26 MX MX9604338A patent/MX9604338A/es unknown
- 1996-09-26 NO NO964053A patent/NO964053L/no unknown
- 1996-09-26 JP JP8254316A patent/JPH09124584A/ja active Pending
- 1996-09-26 CA CA002186580A patent/CA2186580A1/en not_active Abandoned
- 1996-09-26 BR BR9603911A patent/BR9603911A/pt not_active Application Discontinuation
-
1997
- 1997-06-12 US US08/873,825 patent/US5747541A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2186580A1 (en) | 1997-03-28 |
JPH09124584A (ja) | 1997-05-13 |
HU9602640D0 (en) | 1996-11-28 |
US5747541A (en) | 1998-05-05 |
EP0765867A1 (de) | 1997-04-02 |
TW339327B (en) | 1998-09-01 |
CZ280896A3 (en) | 1997-06-11 |
HUP9602640A2 (en) | 1997-05-28 |
AU6584696A (en) | 1997-04-10 |
NO964053D0 (no) | 1996-09-26 |
HRP960430A2 (en) | 1998-02-28 |
ZA968091B (en) | 1997-03-27 |
AR004004A1 (es) | 1998-09-30 |
NZ299445A (en) | 1997-11-24 |
HUP9602640A3 (en) | 1997-11-28 |
SK122596A3 (en) | 1997-05-07 |
BR9603911A (pt) | 1998-06-09 |
TR199600753A1 (tr) | 1997-04-22 |
IL119293A0 (en) | 1996-12-05 |
NO964053L (no) | 1997-04-01 |
PL315050A1 (en) | 1997-04-01 |
KR970015568A (ko) | 1997-04-28 |
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