BR9810233A - Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual. - Google Patents

Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.

Info

Publication number
BR9810233A
BR9810233A BR9810233-8A BR9810233A BR9810233A BR 9810233 A BR9810233 A BR 9810233A BR 9810233 A BR9810233 A BR 9810233A BR 9810233 A BR9810233 A BR 9810233A
Authority
BR
Brazil
Prior art keywords
treatment
sexual dysfunction
optionally substituted
cgmp pde5
alkyl
Prior art date
Application number
BR9810233-8A
Other languages
English (en)
Inventor
Mark Edward Bunnage
John Poul Mathias
Stephen Derek Albert Street
Anthony Wood
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268823&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9810233(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9708406.5A external-priority patent/GB9708406D0/en
Priority claimed from GB9715380A external-priority patent/GB9715380D0/en
Priority claimed from GBGB9722954.6A external-priority patent/GB9722954D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of BR9810233A publication Critical patent/BR9810233A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom

Abstract

Patente de Invenção: <B>"PIRAZOLPIRIMIDINONAS QUE INIBEM FOSFODIESTERASE DA GUANOSINA 3', 5'-MONOFOSFATO CìCLICO DO TIPO 5 (cGMP PDE5) PARA O TRATAMENTO DA DISFUNçãO SEXUAL"<D>. Compostos de fórmula (IA) e (IB): os seus sais farmaceuticamente ou veterinariamente aceitáveis, ou um solvato farmaceuticamente ou veterinariamente aceitável de qualquer uma das entidades, onde R^ 1^ é um alquila C~ 1~ a C~ 3~ substituído com ciclo-alquila C~ 3~ a C~ 6~ CONR^ 5^R^ 6^ ou um grupo heterocíclico ligado pelo N; (CH~ 2~)~ n~Het ou (CH~ 2~)~ n~Ar; R^ 2^ é alquila C~ 1~ a C~ 6~; R^ 3^ é alquila C~ 1~ a C~ 6~ opcionalmente substituída com alcóxi C~ 1~- C~ 4~; R^ 4^ é SO~ 2~NR^ 7^R^ 8^; R^ 5^ e R^ 6^ são, cada qual independentemente, escolhidos a partir de H e alquila C~ 1~ a C~ 4~ a opcionalmente substituída com alcóxi C~ 1~ a C~ 4~, ou, juntamente com o átomo de nitrogênio ao qual eles estão ligados, formam um grupo heterocíclico de 5 ou 6 membros; R^ 7^ e R^ 8^, juntamente com o átomo de nitrogênio ao qual eles estão ligados, formam, um grupo 4-R^ 10^ -piperazinila; R^ 10^ é H ou alquila C~ 1~ a C~ 4~ opcionalmente substituída com OH, alcóxi C~ 1~ a C~ 4~ ou CONH~ 2~; Het é um grupo heterocíclico de 5 ou 6 membros ligado pelo C; Ar e fenila opcionalmente substituído; n é 0 ou 1; são inibidores cGMP PDE5 potentes e seletivos úteis no tratamento de, entre outros, disfunção eréctil masculina e da disfunção sexual feminina.
BR9810233-8A 1997-04-25 1998-04-10 Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual. BR9810233A (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9708406.5A GB9708406D0 (en) 1997-04-25 1997-04-25 Therapeutic agents
GB9715380A GB9715380D0 (en) 1997-07-22 1997-07-22 Therapeutic agents
GBGB9722954.6A GB9722954D0 (en) 1997-10-30 1997-10-30 Therapeutic agents
PCT/EP1998/002257 WO1998049166A1 (en) 1997-04-25 1998-04-10 PYRAZOLOPYRIMIDINONES WHICH INHIBIT TYPE 5 CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE (cGMP PDE5) FOR THE TREATMENT OF SEXUAL DYSFUNCTION

Publications (1)

Publication Number Publication Date
BR9810233A true BR9810233A (pt) 2000-10-17

Family

ID=27268823

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9810233-8A BR9810233A (pt) 1997-04-25 1998-04-10 Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.

Country Status (32)

Country Link
US (2) US6723719B1 (pt)
EP (1) EP0977756A1 (pt)
JP (2) JP3563078B2 (pt)
KR (2) KR100441229B1 (pt)
CN (2) CN1281588C (pt)
AP (1) AP1002A (pt)
AR (1) AR015595A1 (pt)
AU (1) AU730670B2 (pt)
BG (1) BG103828A (pt)
BR (1) BR9810233A (pt)
CA (1) CA2288910C (pt)
CO (1) CO4940472A1 (pt)
CZ (1) CZ299633B6 (pt)
DZ (1) DZ2465A1 (pt)
EA (2) EA004315B1 (pt)
HK (1) HK1027808A1 (pt)
HR (1) HRP980222B1 (pt)
ID (1) ID22834A (pt)
IL (5) IL132276A0 (pt)
IS (1) IS5200A (pt)
MA (1) MA24529A1 (pt)
NO (1) NO314585B1 (pt)
NZ (1) NZ338075A (pt)
OA (1) OA11168A (pt)
PA (1) PA8450401A1 (pt)
PE (1) PE68699A1 (pt)
PL (1) PL336586A1 (pt)
RS (1) RS50118B (pt)
SK (1) SK285991B6 (pt)
TN (1) TNSN98053A1 (pt)
TR (1) TR199902646T2 (pt)
WO (1) WO1998049166A1 (pt)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423910D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
IL120266A (en) 1996-02-28 2005-05-17 Pfizer Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
TR199902646T2 (xx) 1997-04-25 2000-05-22 Pfizer Inc. Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar.
GB9722520D0 (en) 1997-10-24 1997-12-24 Pfizer Ltd Compounds
CN1229349C (zh) * 1998-04-20 2005-11-30 美国辉瑞有限公司 吡啶－3－羧酸衍生物
DE19827640A1 (de) 1998-06-20 1999-12-23 Bayer Ag 7-Alkyl- und Cycloalkyl-substituierte Imidazotriazinone
GB9822238D0 (en) * 1998-10-12 1998-12-09 Pfizer Ltd Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823102D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823101D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
KR100353014B1 (ko) * 1998-11-11 2002-09-18 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
US6225315B1 (en) 1998-11-30 2001-05-01 Pfizer Inc Method of treating nitrate-induced tolerance
EP1173167A4 (en) * 1999-04-30 2004-07-14 Lilly Icos Llc TREATMENT OF FEMALE SEXUAL STIMULATION DISORDERS
MXPA00003997A (es) * 1999-04-30 2002-03-08 Lilly Icos Llc Articulos de fabricacion.
US6242444B1 (en) 1999-06-04 2001-06-05 The Jordanian Pharmaceutical Manufacturing And Medical Equipment Co., Ltd. Compounds and pharmaceutical compositions containing the same
ATE228134T1 (de) * 1999-06-04 2002-12-15 Jordanian Pharmaceutical Mfg A Kondensierte pyrimidinderivate und diese enthaltende pharmazeutische zubereitungen
ES2166270B1 (es) * 1999-07-27 2003-04-01 Almirall Prodesfarma Sa Derivados de 8-fenil-6,9-dihidro-(1,2,4,)triazolo(3,4-i)purin-5-ona.
DE19942474A1 (de) * 1999-09-06 2001-03-15 Merck Patent Gmbh Pyrazolo[4,3-d]pyrimidine
TWI265925B (en) * 1999-10-11 2006-11-11 Pfizer Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them
GB9923968D0 (en) * 1999-10-11 1999-12-15 Pfizer Ltd Therapeutic agents
YU59100A (sh) * 1999-10-11 2003-10-31 Pfizer Inc. Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera
US6350751B1 (en) 1999-10-11 2002-02-26 Pfizer Inc. Therapeutic agents
JP2003511452A (ja) 1999-10-11 2003-03-25 ファイザー・インク ホスホジエステラーゼ阻害剤としての５−（２−置換−５−ヘテロシクリルスルホニルピリド−３−イル）−ジヒドロピラゾロ［４，３−ｄ］ピリミジン−７−オン
TW200400821A (en) * 1999-11-02 2004-01-16 Pfizer Pharmaceutical composition (II) useful for treating or preventing pulmonary hypertension in a patient
BR0017043A (pt) 1999-12-24 2003-01-07 Bayer Ag Imidazo[1,3,5]triazinonas e sua aplicação
ES2231311T3 (es) * 1999-12-24 2005-05-16 Bayer Healthcare Ag Triazolotriazinonas y su uso.
KR100358083B1 (ko) * 2000-02-17 2002-10-25 에스케이케미칼주식회사 피롤로피리미디논 유도체와 이의 제조방법, 그리고 이의용도
WO2001087888A1 (en) * 2000-05-17 2001-11-22 Sk Chemicals Co., Ltd. Pyrazolopyrimidinone derivatives, process for their preparation and their use
KR100377782B1 (ko) * 2000-06-23 2003-03-29 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
HUP0300725A3 (en) * 2000-08-11 2005-11-28 Pfizer Treatment of the insulin resistance syndrome with selective cgmp pde5 inhibitors
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
AU2000267375A1 (en) * 2000-08-23 2002-03-04 Lg Life Sciences Ltd. Polyethoxylated pyrazolo pyrimidinone derivatives, process for preparation thereof and pharmaceutical compositions comprising the same for the treatment of impotence
US6821978B2 (en) 2000-09-19 2004-11-23 Schering Corporation Xanthine phosphodiesterase V inhibitors
GB0025782D0 (en) * 2000-10-20 2000-12-06 Pfizer Ltd Use of inhibitors
US6548508B2 (en) 2000-10-20 2003-04-15 Pfizer, Inc. Use of PDE V inhibitors for improved fecundity in mammals
SE0004780D0 (sv) 2000-12-22 2000-12-22 Jordanian Pharmaceutical Mfg & Novel compunds
MXPA04004370A (es) 2001-11-09 2004-08-11 Schering Corp Derivados policiclicos de guanina inhibidores de fosfodiesterasa v.
GB0129274D0 (en) * 2001-12-06 2002-01-23 Pfizer Ltd Novel kit
DE60237425D1 (de) 2002-03-28 2010-10-07 Univerzita Palackeho V Olomouc PyrazoloÄ4,3-dÜpyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung
GB0219961D0 (en) 2002-08-28 2002-10-02 Pfizer Ltd Oxytocin inhibitors
US7323462B2 (en) 2002-12-10 2008-01-29 Pfizer Inc. Morpholine dopamine agonists
WO2004054560A1 (en) 2002-12-13 2004-07-01 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
EP1620437B1 (en) 2003-04-29 2009-06-17 Pfizer Limited 5,7-diaminopyrazolo¬4,3-d pyrimidines useful in the traetment of hypertension
WO2005012256A1 (en) 2003-07-22 2005-02-10 Astex Therapeutics Limited 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
US7291640B2 (en) 2003-09-22 2007-11-06 Pfizer Inc. Substituted triazole derivatives as oxytocin antagonists
US7572799B2 (en) 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
EP1779852A3 (en) * 2004-01-05 2007-05-09 Teva Pharmaceutical Industries Ltd. Processes for the production of sildenafil base and citrate salt
US7618976B2 (en) 2004-01-05 2009-11-17 Teva Pharmaceutical Industries Ltd Methods for the production of sildenafil base and citrate salt
BRPI0506994A (pt) 2004-01-22 2007-07-03 Pfizer derivados de triazol que inibem a atividade antagonista da vasopressina
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
CA2562244A1 (en) * 2004-04-07 2005-10-27 Takeda Pharmaceutical Company Limited Cyclic compounds
JP2007532526A (ja) 2004-04-07 2007-11-15 ファイザー・インク ピラゾロ［４，３−ｄ］ピリミジン類
JP5070052B2 (ja) 2004-08-17 2012-11-07 ザ・ジョンズ・ホプキンス・ユニバーシティ Ｐｄｅ５阻害剤組成物及び心臓疾患を治療する方法
TWI367098B (en) * 2004-12-23 2012-07-01 Kowa Co Treating agent for glaucoma
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
JP2008533192A (ja) 2005-03-21 2008-08-21 ファイザー・リミテッド オキシトシンアンタゴニストとしての置換されたトリアゾール誘導体
SI2366393T1 (sl) 2005-04-19 2013-12-31 Takeda Gmbh Roflumilast za zdravljenje pljučne hipertenzije
US8506934B2 (en) 2005-04-29 2013-08-13 Robert I. Henkin Methods for detection of biological substances
PL1881985T3 (pl) 2005-05-12 2011-05-31 Pfizer Bezwodne krystaliczne postacie N-[1-(2-etoksyetylo)-5-(N-etylo-N-metyloamino)-7-(4-metylopirydyn-2-yloamino)-1H-pirazolo[4,3-d]pirymidyno-3-karbonylo]metano-sulfonoamidu
US8067433B2 (en) 2005-11-09 2011-11-29 Zalicus Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
JP2007169278A (ja) * 2005-12-20 2007-07-05 Pfizer Prod Inc Ｌｕｔｓ処置用の医薬組合せ
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2008095136A2 (en) 2007-01-31 2008-08-07 Henkin Robert I Methods for detection of biological substances
US8580801B2 (en) 2008-07-23 2013-11-12 Robert I. Henkin Phosphodiesterase inhibitor treatment
CN101747282A (zh) 2008-12-10 2010-06-23 上海特化医药科技有限公司 一类含有嘧啶酮苯基的化合物、其药物组合物及其制备方法和用途
JP2012513464A (ja) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク ホスホジエステラーゼ阻害剤及びその使用
GB0903493D0 (en) 2009-02-27 2009-04-08 Vantia Ltd New compounds
TWI462739B (zh) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
MX343905B (es) 2010-11-03 2016-11-28 Dow Agrosciences Llc Composiciones pesticidas y procesos relacionados a las mismas.
CN102134242B (zh) * 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物
WO2013036081A2 (en) * 2011-09-09 2013-03-14 Sk Chemicals Co., Ltd. Composition for reducing skin wrinkles including pde5 inhibitor
CN104010505B (zh) 2011-10-26 2017-03-15 陶氏益农公司 杀虫组合物和与其相关的方法
US9402877B2 (en) 2011-11-04 2016-08-02 Xion Pharmaceuticals Corporation Methods and compositions for oral administration of melanocortin receptor agonist compounds
EP2804603A1 (en) 2012-01-10 2014-11-26 President and Fellows of Harvard College Beta-cell replication promoting compounds and methods of their use
WO2013109738A1 (en) 2012-01-17 2013-07-25 The Trustees Of Columbia University In The City Of New York Novel phosphodiesterase inhibitors and uses thereof
US9708288B2 (en) 2012-04-27 2017-07-18 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
US9282739B2 (en) 2012-04-27 2016-03-15 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
CA2870090A1 (en) 2012-04-27 2013-10-31 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
EP2903619B1 (en) 2012-10-05 2019-06-05 Robert I. Henkin Phosphodiesterase inhibitors for treating taste and smell disorders
EP3470070B1 (en) 2012-12-21 2021-04-28 Mayo Foundation for Medical Education and Research Methods and materials for treating calcific aortic valve stenosis
CN103265479B (zh) * 2013-06-14 2017-12-08 南开大学 一种6‑氯甲基烟酸叔丁酯的合成方法
ES2776353T3 (es) 2013-07-17 2020-07-30 Univ Columbia Inhibidores de la fosfodiesterasa novedosos y usos de los mismos
CN105636444B (zh) 2013-10-17 2018-04-27 美国陶氏益农公司 制备杀虫化合物的方法
WO2015058022A1 (en) 2013-10-17 2015-04-23 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
KR20160072155A (ko) 2013-10-17 2016-06-22 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
MX2016004948A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de un compuesto pesticida.
US9102654B2 (en) 2013-10-17 2015-08-11 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
MX2016004946A (es) 2013-10-17 2016-06-28 Dow Agrosciences Llc Procesos para la preparacion de compuestos plaguicidas.
BR112016008070B8 (pt) 2013-10-17 2022-08-23 Dow Agrosciences Llc Compostos pesticidas, e seus processos de preparação
CA2927206A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
CA2926431A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
KR20160074585A (ko) 2013-10-22 2016-06-28 다우 아그로사이언시즈 엘엘씨 상승작용적 살충 조성물 및 관련 방법
TW201519778A (zh) 2013-10-22 2015-06-01 Dow Agrosciences Llc 協同性殺蟲組成物及相關方法（十）
RU2656888C2 (ru) 2013-10-22 2018-06-07 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции и связанные с ними способы
KR20160074633A (ko) 2013-10-22 2016-06-28 다우 아그로사이언시즈 엘엘씨 상승작용적 살충 조성물 및 관련 방법
AR098100A1 (es) 2013-10-22 2016-05-04 Dow Agrosciences Llc Composiciones plaguicidas y los métodos relacionados
MX2016005316A (es) 2013-10-22 2017-03-01 Dow Agrosciences Llc Composiciones pesticidas sinergicas y metodos relacionados.
MX2016005310A (es) 2013-10-22 2016-08-08 Dow Agrosciences Llc Composiciones pesticidas sinergicas y metodos relacionados.
EP3060051A4 (en) 2013-10-22 2017-04-05 Dow AgroSciences LLC Synergistic pesticidal compositions and related methods
EP3071036A4 (en) 2013-10-22 2017-08-23 Dow AgroSciences LLC Pesticidal compositions and related methods
AU2014340413B2 (en) 2013-10-22 2017-09-07 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
CA2926433A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Pesticidal compositions and related methods
TW201519777A (zh) 2013-10-22 2015-06-01 Dow Agrosciences Llc 協同性殺蟲組成物及相關方法（九）
AU2014340430B2 (en) 2013-10-22 2017-05-25 Dow Agrosciences Llc Pesticidal compositions and related methods
JP2016535739A (ja) 2013-10-22 2016-11-17 ダウ アグロサイエンシィズ エルエルシー 農薬組成物および関連する方法
CA2926345A1 (en) 2013-10-22 2015-04-30 Dow Agrosciences Llc Synergistic pesticidal compositions and related methods
CN106233141B (zh) 2014-02-18 2018-08-21 罗伯特·I·汉金 用于诊断和治疗味觉或嗅觉的损失和/或失真的方法和组合物
BR112017000293A2 (pt) 2014-07-31 2017-10-31 Dow Agrosciences Llc processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
AR098110A1 (es) 2014-07-31 2016-05-04 Dow Agrosciences Llc Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina
CA2954631A1 (en) 2014-07-31 2016-02-04 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1h-pyrazol-1-yl)pyridine
US9024031B1 (en) 2014-08-19 2015-05-05 Dow Agrosciences Llc Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine
JP2017528469A (ja) 2014-09-12 2017-09-28 ダウ アグロサイエンシィズ エルエルシー ３−（３−クロロ−１ｈ−ピラゾール−１−イル）ピリジンの調製方法
ES2857567T3 (es) * 2014-09-17 2021-09-29 Intra Cellular Therapies Inc Derivados de 7,8-dihidro-[2h]-imidazo-[1,2-a]pirazolo[4,3-e]pirimidin-4(5h)-ona como inhibidores de fosfodiesterasa 1 (PDE1) para tratar enfermedades, trastornos o lesiones del sistema nervioso central (SNC)
WO2016145614A1 (en) 2015-03-17 2016-09-22 Merck Sharp & Dohme Corp. Triazolyl pyrimidinone compounds as pde2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
AU2017322427B2 (en) 2016-09-09 2021-12-23 Incyte Corporation Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
AR109595A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1
CN110325036B (zh) 2016-12-29 2021-10-26 美国陶氏益农公司 用于制备杀虫化合物的方法
WO2018125815A1 (en) 2016-12-29 2018-07-05 Dow Agrosciences Llc Processes for the preparation of pesticidal compounds
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
PL3755703T3 (pl) 2018-02-20 2022-11-07 Incyte Corporation Pochodne n-(fenylo)-2-(fenylo)pirymidyno-4-karboksyamidu i związki pokrewne jako inhibitory hpk1 do leczenia nowotworu
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
WO2019164847A1 (en) 2018-02-20 2019-08-29 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
MA53726A (fr) 2018-09-25 2022-05-11 Incyte Corp Composés pyrazolo[4,3-d]pyrimidine en tant que modulateurs des alk2 et/ou fgfr
KR20210096626A (ko) * 2018-11-28 2021-08-05 토파두르 파마 아게 가용성 구아닐레이트 사이클라제 활성제 및 포스포디에스테라제 억제제의 신규한 이중 작용 방식 및 이의 용도
CA3147918A1 (en) 2019-08-06 2021-02-11 Incyte Corporation Solid forms of an hpk1 inhibitor
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
CN113754612B (zh) * 2021-10-26 2023-09-26 山东安舜制药有限公司 一种西地那非中间体的制备方法
CN115785101B (zh) * 2022-11-23 2023-10-13 西安市食品药品检验所 一种含有苯基哌嗪结构的那非类化合物及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
DE3420985A1 (de) 1983-10-15 1985-04-25 Bayer Ag, 5090 Leverkusen Substituierte 5-acylamino-1-phenylpyrazole
US4871843A (en) 1983-10-18 1989-10-03 Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions
US4663326A (en) 1985-04-04 1987-05-05 Warner-Lambert Company Pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)dione or -5-thione-7-one analogs
US4666908A (en) * 1985-04-05 1987-05-19 Warner-Lambert Company 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
US5075310A (en) 1988-07-01 1991-12-24 Smith Kline & French Laboratories, Ltd. Pyrimidone derivatives as bronchodilators
GB8817651D0 (en) * 1988-07-25 1988-09-01 Smith Kline French Lab Chemical compounds
GB8827988D0 (en) 1988-11-30 1989-01-05 Smith Kline French Lab Chemical compounds
GB8928346D0 (en) 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
US5250534A (en) 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9119704D0 (en) 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic agents
GB9121028D0 (en) 1991-10-03 1991-11-13 Pfizer Ltd Therapeutic agents
GB9126260D0 (en) 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9202238D0 (en) 1992-02-03 1992-03-18 Wellcome Found Compounds
US5294612A (en) 1992-03-30 1994-03-15 Sterling Winthrop Inc. 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof
GB9213623D0 (en) 1992-06-26 1992-08-12 Pfizer Ltd Therapeutic agents
US5734053A (en) 1992-06-26 1998-03-31 Pfizer Inc Purinone antianginal agents
JP2657760B2 (ja) 1992-07-15 1997-09-24 小野薬品工業株式会社 ４−アミノキナゾリン誘導体およびそれを含有する医薬品
GB9218322D0 (en) 1992-08-28 1992-10-14 Pfizer Ltd Therapeutic agents
GB9301192D0 (en) * 1993-06-09 1993-06-09 Trott Francis W Flower shaped mechanised table
GB9315017D0 (en) 1993-07-20 1993-09-01 Glaxo Lab Sa Chemical compounds
GB9423911D0 (en) 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9423910D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
AU708809B2 (en) 1995-03-10 1999-08-12 Sanofi Pharmaceuticals, Inc. 6-aryl pyrazolo{3,4-d}pyrimidin-4-ones and compositions and methods of use thereof
US5656629A (en) 1995-03-10 1997-08-12 Sanofi Winthrop, Inc. 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof
GB9612514D0 (en) 1996-06-14 1996-08-14 Pfizer Ltd Novel process
TR199902646T2 (xx) 1997-04-25 2000-05-22 Pfizer Inc. Seks�el bozuklu�un tedavisi i�in pirazolopirimidinonlar.
CN1229349C (zh) 1998-04-20 2005-11-30 美国辉瑞有限公司 吡啶－3－羧酸衍生物
US6087368A (en) 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase

Also Published As

Publication number Publication date
EA199900866A1 (ru) 2000-04-24
JP2004196820A (ja) 2004-07-15
US6916927B2 (en) 2005-07-12
HRP980222A2 (en) 1999-02-28
AP1002A (en) 2001-08-14
TR199902646T2 (xx) 2000-05-22
EA004315B1 (ru) 2004-02-26
KR20010020285A (ko) 2001-03-15
JP4036836B2 (ja) 2008-01-23
PL336586A1 (en) 2000-07-03
US6723719B1 (en) 2004-04-20
YU52499A (pt) 2002-08-12
AP9801228A0 (en) 1998-06-30
NO995211D0 (no) 1999-10-25
CN1626516A (zh) 2005-06-15
EA002057B1 (ru) 2001-12-24
IL132276A0 (en) 2001-03-19
SK285991B6 (sk) 2008-01-07
IL157647A (en) 2007-05-15
EP0977756A1 (en) 2000-02-09
IL132276A (en) 2006-06-11
WO1998049166A1 (en) 1998-11-05
EA200100504A1 (ru) 2002-02-28
IS5200A (is) 1999-09-28
RS50118B (sr) 2009-03-25
CZ299633B6 (cs) 2008-09-24
CN1281588C (zh) 2006-10-25
OA11168A (en) 2003-04-28
JP3563078B2 (ja) 2004-09-08
NZ338075A (en) 2000-10-27
HRP980222B1 (en) 2003-12-31
MA24529A1 (fr) 1998-12-31
IL157646A (en) 2006-12-10
CO4940472A1 (es) 2000-07-24
AU730670B2 (en) 2001-03-08
PE68699A1 (es) 1999-07-10
CA2288910C (en) 2003-06-24
KR100441229B1 (ko) 2004-07-22
JP2000510485A (ja) 2000-08-15
CN1188415C (zh) 2005-02-09
US20040180944A1 (en) 2004-09-16
CZ376799A3 (cs) 2000-04-12
CA2288910A1 (en) 1998-11-05
NO314585B1 (no) 2003-04-14
DZ2465A1 (fr) 2003-01-18
SK144699A3 (en) 2001-03-12
HK1027808A1 (en) 2001-01-23
CN1253561A (zh) 2000-05-17
ID22834A (id) 1999-12-09
AU7644598A (en) 1998-11-24
BG103828A (en) 2000-06-30
TNSN98053A1 (fr) 2005-03-15
NO995211L (no) 1999-10-25
PA8450401A1 (es) 2000-05-24
IL157645A (en) 2007-03-08
AR015595A1 (es) 2001-05-16
KR100390612B1 (ko) 2003-07-07

Similar Documents

Publication Publication Date Title
BR9810233A (pt) Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual.
BR9909808A (pt) Pirazolopirimidinonas inibidoras de cgmp pde5 para o tratamento da disfunção sexual
EA200200337A1 (ru) ПРОИЗВОДНЫЕ ПИРАЗОЛО[4,3-d]ПИРИМИДИНА
EA200400304A1 (ru) Производные пиримидина, ингибирующие вич
BG103785A (en) Pyrrolo[2,3-d]pyrimidines and their application as tyrosine kinase inhibitors
ES2192864T3 (es) Inhibidores de p38.
AR039648A1 (es) Compuestos de aril cetona pirrolo triazina utiles como inhibidores de cinasa y las composiciones farmaceuticas que las contienen
PE20020976A1 (es) Pirido-pirimidinas 6-sustituidas como inhibidores de quinasas
ATE298753T1 (de) Pyrazolopyrimidinone cgmp pde5 inhibitoren zur behandlung der sexuellen dysfunktion
MX2009003941A (es) Derivados de 3-(dihidro-1h-pirazolo[4,3-d]pirimidin-5-il)-4-propox ibencenosulfonamida y metodos de uso.
CO5690551A2 (es) Derivados de tetrazol y metodos para el tratamiento con los mismos de trastornos relacionados con el metabolismo
MXPA05008584A (es) Compuestos heterociclicos utiles como activadores de nurr-1.
UY25795A1 (es) Procedimiento para preparar pirazolopirimidinonas que inhiben la guanosina 3&#39;,5&#39;- monofosfato cíclico fodfodiesterasa 5 (gmpc pde5).
WO2002000657A3 (en) Condensed pyrazindione derivatives
AP9901578A0 (en) Sulfonylbenzene compounds as anti-inflammatory/analgesic agents.
AR035650A1 (es) Procedimiento para la preparacion de compuestos de pirazolo[4,3-d]pirimidin-7-ona
NO20090332L (no) 4-amino-3-arylamino-6-arylpyrazol[3,4-D]pyrimidinderivater, fremgangsmater for deres fremstilling og dere anvendelse som antivirale midler
WO2002000656A3 (en) Pirazino &#39;1$m(1)2$m(1) :1, 6! pyrido &#39;3,4-b! indole derivatives
JPS55124784A (en) Hexacyclic indole derivative
PE20070237A1 (es) Derivados de pirido[3&#39;,2&#39;:4,5]furo[3,2-d]pirimidina como inhibidores de pde4
IL91541A0 (en) Aryloxy-,arylthio-,heteroaryloxy-,and heteroarylthioalkenylene derivatives of amines,their preparation and pharmaceutical compositions containing them
HN1999000041A (es) Pirazolipirimidinonas inhibidoras de gmpc pde5 para el tratamiento de la disfucion sexual
ECSP982484A (es) Pirazolopirimidonas para la disfuncion sexual
CO4810228A1 (es) Derivados de pirazol piridazina, procesos para su preparacion y composiciones farmaceuticas que los contienen
ECSP992915A (es) PIRAZOLOPIRIMIDINONAS INHIBIDORAS DE GMPc PDES PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: C07D 295/22, A61K 31/519, A61K 31/5377, A61K 31/505, A61K 31/415, C07D 231/40, C07D 401/06, C07D 487/04, A61P 1/00, A61P 9/00, A61P 9/04, A61P 9/10, A61P 9/12, A61P 11/00, A61P 11/02, A61P 11/06, A61P 13/08, A61P 13/10, A61P 15/00, A61P 15/10, A61P 37/08, A61P 43/00

Ipc: C07D 295/22 (2007.01), A61K 31/519 (2007.01), A61K

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time