UA117796C2 - Похідні хіназоліну, що застосовуються для лікування віл - Google Patents
Похідні хіназоліну, що застосовуються для лікування вілInfo
- Publication number
- UA117796C2 UA117796C2 UAA201707115A UAA201707115A UA117796C2 UA 117796 C2 UA117796 C2 UA 117796C2 UA A201707115 A UAA201707115 A UA A201707115A UA A201707115 A UAA201707115 A UA A201707115A UA 117796 C2 UA117796 C2 UA 117796C2
- Authority
- UA
- Ukraine
- Prior art keywords
- derivatives used
- quinazoline derivatives
- treat hiv
- compounds
- hiv
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
У даному документі описані сполуки формули (І) та їх таутомери та фармацевтично прийнятні солі, композиції та лікарські форми, що містять такі сполуки, та способи застосування та одержання таких сполук. (І)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462096748P | 2014-12-24 | 2014-12-24 | |
PCT/US2015/000460 WO2016105564A1 (en) | 2014-12-24 | 2015-12-23 | Quinazoline derivatives used to treat hiv |
Publications (1)
Publication Number | Publication Date |
---|---|
UA117796C2 true UA117796C2 (uk) | 2018-09-25 |
Family
ID=55305044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201707115A UA117796C2 (uk) | 2014-12-24 | 2015-12-23 | Похідні хіназоліну, що застосовуються для лікування віл |
Country Status (41)
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2553449T3 (es) | 2011-07-06 | 2015-12-09 | Gilead Sciences, Inc. | Compuestos para el tratamiento de VIH |
TWI699355B (zh) * | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
KR101960624B1 (ko) | 2014-12-24 | 2019-03-20 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 이소퀴놀린 화합물 |
ES2735087T3 (es) | 2014-12-24 | 2019-12-16 | Gilead Sciences Inc | Compuestos de pirimidina fusionados para el tratamiento de VIH |
KR20230130175A (ko) | 2014-12-26 | 2023-09-11 | 에모리 유니버시티 | N4-하이드록시시티딘, 이와 관련된 유도체 및 이의 항 바이러스적 용도 |
TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
SG10201912535VA (en) | 2016-08-19 | 2020-02-27 | Gilead Sciences Inc | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
TWI687415B (zh) | 2017-08-17 | 2020-03-11 | 美商基利科學股份有限公司 | Hiv蛋白質膜抑制劑之固體形式 |
BR122022008466B1 (pt) | 2017-12-07 | 2023-12-05 | Emory University | Uso de um composto |
CA3089590C (en) | 2018-02-15 | 2022-12-06 | Gilead Sciences, Inc. | Pyridine derivatives and their use for treating hiv infection |
CN116854630A (zh) | 2018-02-16 | 2023-10-10 | 吉利德科学公司 | 用于制备可用于治疗逆转录病毒科病毒感染的治疗性化合物的方法和中间体 |
CA3216031A1 (en) | 2018-07-16 | 2020-01-23 | Gilead Sciences, Inc. | Capsid inhibitors for the treatment of hiv |
WO2020214647A1 (en) | 2019-04-17 | 2020-10-22 | Gilead Sciences, Inc. | Solid forms of an hiv protease inhibitor |
TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
CA3157275A1 (en) | 2019-11-26 | 2021-06-03 | Elena BEKERMAN | Capsid inhibitors for the prevention of hiv |
EP4121437A1 (en) | 2020-03-20 | 2023-01-25 | Gilead Sciences, Inc. | Prodrugs of 4'-c-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
JP6996032B1 (ja) | 2020-04-24 | 2022-01-17 | 大日本住友製薬株式会社 | 2-ヘテロアリールアミノキナゾリノン誘導体 |
CA3181690A1 (en) | 2020-06-25 | 2021-12-30 | Chienhung CHOU | Capsid inhibitors for the treatment of hiv |
CN116437958A (zh) | 2020-11-11 | 2023-07-14 | 吉利德科学公司 | 鉴定对采用gp120 CD4结合位点导向的抗体的疗法敏感的HIV患者的方法 |
AU2022399845A1 (en) | 2021-12-03 | 2024-05-23 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
CN118369316A (zh) | 2021-12-03 | 2024-07-19 | 吉利德科学公司 | Hiv病毒感染的治疗性化合物 |
AU2022401696A1 (en) | 2021-12-03 | 2024-05-09 | Gilead Sciences, Inc. | Therapeutic compounds for hiv virus infection |
TW202400172A (zh) | 2022-04-06 | 2024-01-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
TW202402280A (zh) | 2022-07-01 | 2024-01-16 | 美商基利科學股份有限公司 | 可用於hiv病毒感染之疾病預防性或治療性治療的治療性化合物 |
US20240083984A1 (en) | 2022-08-26 | 2024-03-14 | Gilead Sciences, Inc. | Dosing and scheduling regimen for broadly neutralizing antibodies |
WO2024076915A1 (en) | 2022-10-04 | 2024-04-11 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ197420A (en) | 1980-07-01 | 1984-04-27 | Ici Australia Ltd | -(quinazolin-(2-or 4-)(oxy,ylthio or amino)phen(oxy or ylthio)alkanoic acid derivatives |
JPH11209350A (ja) | 1998-01-26 | 1999-08-03 | Eisai Co Ltd | 含窒素複素環誘導体およびその医薬 |
WO2001021598A1 (en) | 1999-09-23 | 2001-03-29 | Astrazeneca Ab | Therapeutic quinazoline compounds |
BR0015718A (pt) | 1999-11-22 | 2002-07-23 | Warner Lambert Co | Quinazolinas e seu uso para inibição de enzimas de cinase dependente de ciclina |
GB0002032D0 (en) | 2000-01-28 | 2000-03-22 | Zeneca Ltd | Chemical compounds |
EP1305291A1 (en) | 2000-08-02 | 2003-05-02 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
WO2002024667A1 (en) | 2000-09-20 | 2002-03-28 | Merck Patent Gmbh | 4-amino-quinazolines |
WO2004030672A1 (en) | 2002-10-02 | 2004-04-15 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
EA014685B1 (ru) | 2003-04-25 | 2010-12-30 | Джилид Сайэнс, Инк. | Фосфонатсодержащие антивирусные соединения (варианты) и фармацевтическая композиция на их основе |
WO2004108711A1 (en) | 2003-06-05 | 2004-12-16 | Astrazeneca Ab | Pyrazinil quinazoline derivatives for use in the treatment of tumours |
JP2007008816A (ja) | 2003-10-15 | 2007-01-18 | Ube Ind Ltd | 新規イソキノリン誘導体 |
SI2258376T1 (sl) | 2004-07-27 | 2019-04-30 | Gilead Sciences, Inc. | Analogi fosfonata spojin inhibitorjev HIV |
US20070054916A1 (en) | 2004-10-01 | 2007-03-08 | Amgen Inc. | Aryl nitrogen-containing bicyclic compounds and methods of use |
BRPI0517272A (pt) | 2004-10-29 | 2008-10-07 | Tibotec Pharm Ltd | derivados de pirimidina bicìclicos de inibição de hiv |
JP2008526734A (ja) | 2004-12-31 | 2008-07-24 | エスケー ケミカルズ カンパニー リミテッド | 糖尿及び肥満治療予防に有効なキナゾリン誘導体 |
WO2006099301A2 (en) | 2005-03-10 | 2006-09-21 | The Regents Of The University Of California | Apoptosis inhibitors |
EP1878727A4 (en) | 2005-04-28 | 2013-11-13 | Kyowa Hakko Kirin Co Ltd | 2-AMINOQUINAZOLINE DERIVATIVES |
AU2006264043B2 (en) | 2005-06-28 | 2012-04-26 | Sanofi-Aventis | Isoquinoline derivatives as inhibitors of Rho-kinase |
CN101228149B (zh) | 2005-07-26 | 2013-01-02 | 塞诺菲-安万特股份有限公司 | 作为Rho-激酶抑制剂的哌啶基取代的异喹啉酮衍生物 |
US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
KR101446499B1 (ko) | 2006-01-27 | 2014-10-06 | 피브로겐, 인크. | 저산소증 유발가능 인자(hif)를 안정시키는 시아노이소퀴놀린 화합물 |
TW200808739A (en) | 2006-04-06 | 2008-02-16 | Novartis Vaccines & Diagnostic | Quinazolines for PDK1 inhibition |
EP2024342A2 (en) | 2006-05-01 | 2009-02-18 | Pfizer Products Incorporated | Substituted 2-amino-fused heterocyclic compounds |
CA2658462C (en) | 2006-07-20 | 2011-09-27 | Amgen Inc. | Substituted pyridone compounds and methods of use |
US8027888B2 (en) | 2006-08-31 | 2011-09-27 | Experian Interactive Innovation Center, Llc | Online credit card prescreen systems and methods |
WO2008050808A1 (fr) | 2006-10-24 | 2008-05-02 | Kyowa Hakko Kirin Co., Ltd. | Dérivé de 2-aminoquinazoline |
KR101517154B1 (ko) | 2006-12-27 | 2015-04-30 | 사노피 | Rho-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체 |
RU2457203C2 (ru) | 2006-12-27 | 2012-07-27 | Санофи-Авентис | Замещенные циклоалкиламином производные изохинолона |
JP5318778B2 (ja) | 2006-12-27 | 2013-10-16 | サノフイ | シクロアルキルアミン置換イソキノロン及びイソキノリノン誘導体 |
WO2008086462A2 (en) | 2007-01-11 | 2008-07-17 | Wyeth | AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS |
JP2010523529A (ja) | 2007-04-06 | 2010-07-15 | ノバルティス アーゲー | プロテインキナーゼ調節剤としての2,6−ナフチリジン誘導体 |
WO2008157500A1 (en) | 2007-06-17 | 2008-12-24 | Kalypsys, Inc. | Aminoquinazoline cannabinoid receptor modulators for treatment of disease |
EP2757096A1 (en) | 2007-11-16 | 2014-07-23 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
US20110039845A1 (en) | 2008-04-23 | 2011-02-17 | Kyowa Hakko Kirin Co., Ltd. | 2-aminoquinazoline derivative |
WO2009155121A2 (en) | 2008-05-30 | 2009-12-23 | Amgen Inc. | Inhibitors of pi3 kinase |
GB0812969D0 (en) | 2008-07-15 | 2008-08-20 | Sentinel Oncology Ltd | Pharmaceutical compounds |
KR20110050516A (ko) | 2008-08-15 | 2011-05-13 | 바스프 에스이 | 나노 크기 유기 고체 입자 제조 방법 |
RS53347B (en) | 2008-12-09 | 2014-10-31 | Gilead Sciences, Inc. | TOLL-SIMILAR RECEPTOR MODULATORS |
MX2011007064A (es) | 2008-12-29 | 2012-01-20 | Fovea Pharmaceuticals | Compuestos de quinazolina substituidos. |
ES2493916T3 (es) | 2009-04-07 | 2014-09-12 | Infinity Pharmaceuticals, Inc. | Inhibidores de hidrolasa de amida de ácidos grasos |
US8338441B2 (en) | 2009-05-15 | 2012-12-25 | Gilead Sciences, Inc. | Inhibitors of human immunodeficiency virus replication |
WO2011035416A1 (en) | 2009-09-25 | 2011-03-31 | Aegera Therapeutics Inc. | Hsp90 modulating compounds, compositions, methods and uses |
WO2011139637A1 (en) | 2010-05-03 | 2011-11-10 | Philadelphia Health & Education Corporation | Small-molecule modulators of hiv-1 capsid stability and methods thereof |
TW201210597A (en) | 2010-06-09 | 2012-03-16 | Gilead Sciences Inc | Inhibitors of hepatitis C virus |
TW201204723A (en) | 2010-06-22 | 2012-02-01 | Fovea Pharmaceuticals | Heterocyclic compounds, their preparation and their therapeutic application |
CA2803890A1 (en) | 2010-06-25 | 2011-12-29 | Rutgers, The State University Of New Jersey | Antimicrobial agents |
AU2011274323B2 (en) | 2010-07-02 | 2015-08-06 | Gilead Sciences, Inc. | 2 -quinolinyl- acetic acid derivatives as HIV antiviral compounds |
KR20130135826A (ko) | 2010-07-02 | 2013-12-11 | 길리애드 사이언시즈, 인코포레이티드 | Aids를 치료하기 위한 나프트-2-일아세트산 유도체 |
KR20130141500A (ko) | 2010-09-29 | 2013-12-26 | 크리스탈지노믹스(주) | 단백질 키나제 억제 활성을 갖는 신규한 아미노퀴나졸린 화합물 |
KR20120038060A (ko) | 2010-10-13 | 2012-04-23 | 롬엔드하스전자재료코리아유한회사 | 신규한 유기 전자재료용 화합물 및 이를 포함하는 유기 전계 발광 소자 |
MA34836B1 (fr) | 2010-12-17 | 2014-01-02 | Hoffmann La Roche | Composes heterocycliques azotes 6;6- condenses substitues et leurs utilisations |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
US9006229B2 (en) | 2011-04-21 | 2015-04-14 | Gilead Sciences, Inc. | Benzothiazole compounds and their pharmaceutical use |
ES2553449T3 (es) | 2011-07-06 | 2015-12-09 | Gilead Sciences, Inc. | Compuestos para el tratamiento de VIH |
CN102863512B (zh) | 2011-07-07 | 2016-04-20 | 上海泓博智源医药技术有限公司 | 抗病毒化合物 |
EP2794613B1 (en) | 2011-12-20 | 2017-03-29 | Boehringer Ingelheim International GmbH | Condensed triclyclic compounds as inhibitors of hiv replication |
NZ622769A (en) | 2012-04-20 | 2017-06-30 | Gilead Sciences Inc | Benzothiazol-6-yl acetic acid derivatives and their use for treating an hiv infection |
BR122015029881B1 (pt) | 2012-12-21 | 2022-04-26 | Gilead Sciences, Inc | Compostos carbamoilpiridona policíclicos, composição farmacêutica que os compreende e seu uso farmacêutico |
EP2940019B1 (en) | 2012-12-27 | 2018-03-28 | Japan Tobacco Inc. | SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND MEDICINAL USE THEREOF AS HIV INTEGRASE INHIBITOR |
EP2769723A1 (en) | 2013-02-22 | 2014-08-27 | Ruprecht-Karls-Universität Heidelberg | Compounds for use in inhibiting HIV capsid assembly |
EP2769722A1 (en) | 2013-02-22 | 2014-08-27 | Ruprecht-Karls-Universität Heidelberg | Compounds for use in inhibiting HIV capsid assembly |
US9914709B2 (en) | 2013-06-21 | 2018-03-13 | Yale University | Compositions and methods of treating HIV-1 infections using same |
ES2735087T3 (es) | 2014-12-24 | 2019-12-16 | Gilead Sciences Inc | Compuestos de pirimidina fusionados para el tratamiento de VIH |
KR101960624B1 (ko) | 2014-12-24 | 2019-03-20 | 길리애드 사이언시즈, 인코포레이티드 | Hiv의 치료를 위한 이소퀴놀린 화합물 |
TWI699355B (zh) | 2014-12-24 | 2020-07-21 | 美商基利科學股份有限公司 | 喹唑啉化合物 |
-
2015
- 2015-12-18 TW TW104142712A patent/TWI699355B/zh active
- 2015-12-18 TW TW109122699A patent/TWI770552B/zh active
- 2015-12-18 TW TW111121406A patent/TW202237569A/zh unknown
- 2015-12-22 AR ARP150104262A patent/AR103252A1/es unknown
- 2015-12-23 HR HRP20211543TT patent/HRP20211543T1/hr unknown
- 2015-12-23 TR TR2019/03672T patent/TR201903672T4/tr unknown
- 2015-12-23 CN CN202010295176.XA patent/CN111574464A/zh active Pending
- 2015-12-23 US US14/998,042 patent/US9730936B2/en active Active
- 2015-12-23 UA UAA201707115A patent/UA117796C2/uk unknown
- 2015-12-23 CU CUP2017000089A patent/CU20170089A7/es unknown
- 2015-12-23 CN CN201580076616.XA patent/CN107278201B/zh active Active
- 2015-12-23 MY MYPI2017702362A patent/MY189761A/en unknown
- 2015-12-23 PL PL21187414.4T patent/PL3960735T3/pl unknown
- 2015-12-23 PE PE2017001139A patent/PE20171306A1/es unknown
- 2015-12-23 JP JP2017534259A patent/JP6367489B2/ja active Active
- 2015-12-23 LT LTEP18213309.0T patent/LT3521282T/lt unknown
- 2015-12-23 EP EP15832711.4A patent/EP3237398B1/en active Active
- 2015-12-23 ES ES15832711T patent/ES2715507T3/es active Active
- 2015-12-23 CR CR20170281A patent/CR20170281A/es unknown
- 2015-12-23 EA EA201791256A patent/EA035746B1/ru unknown
- 2015-12-23 EP EP21187414.4A patent/EP3960735B1/en active Active
- 2015-12-23 MA MA048448A patent/MA48448A/fr unknown
- 2015-12-23 BR BR102015032361-1A patent/BR102015032361B1/pt active IP Right Grant
- 2015-12-23 MD MDA20170070A patent/MD4650B1/ro not_active IP Right Cessation
- 2015-12-23 KR KR1020177020449A patent/KR102049476B1/ko active IP Right Grant
- 2015-12-23 EP EP23196262.2A patent/EP4302830A3/en active Pending
- 2015-12-23 EA EA202091115A patent/EA202091115A1/ru unknown
- 2015-12-23 HU HUE18213309A patent/HUE058296T2/hu unknown
- 2015-12-23 KR KR1020197034431A patent/KR102288855B1/ko active IP Right Grant
- 2015-12-23 PT PT15832711T patent/PT3237398T/pt unknown
- 2015-12-23 SG SG11201705215PA patent/SG11201705215PA/en unknown
- 2015-12-23 ES ES21187414T patent/ES2964395T3/es active Active
- 2015-12-23 PL PL15832711T patent/PL3237398T3/pl unknown
- 2015-12-23 SG SG10202101143VA patent/SG10202101143VA/en unknown
- 2015-12-23 AU AU2015371198A patent/AU2015371198B2/en active Active
- 2015-12-23 MX MX2017008521A patent/MX367574B/es active IP Right Grant
- 2015-12-23 DK DK18213309.0T patent/DK3521282T3/da active
- 2015-12-23 SI SI201530560T patent/SI3237398T1/sl unknown
- 2015-12-23 PL PL18213309T patent/PL3521282T3/pl unknown
- 2015-12-23 NZ NZ733174A patent/NZ733174A/en unknown
- 2015-12-23 PT PT182133090T patent/PT3521282T/pt unknown
- 2015-12-23 EP EP18213309.0A patent/EP3521282B1/en active Active
- 2015-12-23 CA CA2972021A patent/CA2972021C/en active Active
- 2015-12-23 SI SI201531719T patent/SI3521282T1/sl unknown
- 2015-12-23 WO PCT/US2015/000460 patent/WO2016105564A1/en active Application Filing
- 2015-12-23 ES ES18213309T patent/ES2900810T3/es active Active
-
2017
- 2017-06-21 IL IL25305917A patent/IL253059B/en active IP Right Grant
- 2017-06-22 EC ECIEPI201739611A patent/ECSP17039611A/es unknown
- 2017-06-22 CL CL2017001675A patent/CL2017001675A1/es unknown
- 2017-06-22 SV SV2017005471A patent/SV2017005471A/es unknown
- 2017-06-22 DO DO2017000151A patent/DOP2017000151A/es unknown
- 2017-06-22 CO CONC2017/0006214A patent/CO2017006214A2/es unknown
- 2017-06-23 PH PH12017501191A patent/PH12017501191A1/en unknown
- 2017-06-23 MX MX2019009932A patent/MX2019009932A/es unknown
- 2017-06-24 SA SA517381826A patent/SA517381826B1/ar unknown
- 2017-06-27 US US15/634,527 patent/US10206926B2/en active Active
-
2018
- 2018-03-12 HK HK18103444.6A patent/HK1244001B/zh unknown
- 2018-07-04 JP JP2018127603A patent/JP2018168181A/ja active Pending
-
2019
- 2019-01-04 US US16/239,578 patent/US10548898B2/en active Active
- 2019-09-25 IL IL269635A patent/IL269635B/en active IP Right Grant
- 2019-12-18 US US16/718,311 patent/US11304948B2/en active Active
-
2021
- 2021-11-10 CY CY20211100979T patent/CY1124726T1/el unknown
-
2022
- 2022-03-09 US US17/690,351 patent/US20230043136A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12017501191B1 (en) | Quinazoline derivatives used to treat hiv | |
PH12018502747A1 (en) | Boronic acid derivatives and therapeutic uses thereof | |
MX2017008520A (es) | Compuestos de pirimidina fusionada para el tratamiento del virus de inmunodeficiencia humana (vih). | |
PH12018500591A1 (en) | Heterocyclic compounds and uses thereof | |
MX2017008518A (es) | Compuestos de isoquinolina para el tratamiento de virus de inmunodeficiencia humana (vih). | |
CL2017000786A1 (es) | Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. | |
PH12016501898A1 (en) | Quinoxaline derivatives useful as fgfr kinase modulators | |
MD20160106A2 (ro) | Compuşi aril sau heteroaril biciclici condensaţi şi utilizarea acestora ca inhibitori IRAK4 | |
EA201891063A1 (ru) | Производные дигидроимидазопиразинона, применимые в лечении рака | |
MX2016015565A (es) | Ciertos inhibidores de la proteina quinasa. | |
MD4820C1 (ro) | Compuşi dihidroizochinolinonici substituiţi | |
EA201692003A1 (ru) | Макроциклические производные пиримидина | |
EA201692000A1 (ru) | Макроциклические производные пиридина | |
TW201613864A (en) | Novel compounds | |
EA201791396A1 (ru) | ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ | |
EA201791397A1 (ru) | СВЯЗАННЫЕ С ГЕТЕРОЦИКЛИЛАМИ ПРОИЗВОДНЫЕ ИМИДАЗОПИРИДАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3Kβ | |
MX2017005669A (es) | Derivados de hidroxido de bencilo, preparacion de los mismos y uso terapeutico de los mismos. |