EA201692000A1 - Макроциклические производные пиридина - Google Patents

Макроциклические производные пиридина

Info

Publication number
EA201692000A1
EA201692000A1 EA201692000A EA201692000A EA201692000A1 EA 201692000 A1 EA201692000 A1 EA 201692000A1 EA 201692000 A EA201692000 A EA 201692000A EA 201692000 A EA201692000 A EA 201692000A EA 201692000 A1 EA201692000 A1 EA 201692000A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
present
pyridine
inhibitory activity
relates
Prior art date
Application number
EA201692000A
Other languages
English (en)
Other versions
EA029758B1 (ru
Inventor
Гастон Станислас Марселла Дилс
Брюно Схунтьес
Маттиас Люк Эме Версель
Дидье Жан-Клод Бертло
Марк Виллемс
Марсель Вьейевуа
Франсуа Мария Соммен
Бертольд Вробловски
Ливен Мерпул
Original Assignee
Янссен Фармацевтика Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201692000A1 publication Critical patent/EA201692000A1/ru
Publication of EA029758B1 publication Critical patent/EA029758B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

Настоящее изобретение относится к замещенным макроциклическим производным пиримидина формулы (I)где переменные имеют значение, определенное в формуле изобретения. Соединения в соответствии с настоящим изобретением обладают EF2K-ингибирующей активностью и необязательно также Vps34-ингибирующей активностью. Настоящее изобретение, кроме того, относится к способам получения таких новых соединений, к фармацевтическим композициям, содержащим указанные соединения в качестве активного ингредиента, а также к применению указанных соединений в качестве лекарственного препарата.
EA201692000A 2014-04-03 2015-04-02 Макроциклические производные пиридина EA029758B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14163442 2014-04-03
EP14183823 2014-09-05
PCT/EP2015/057401 WO2015150557A1 (en) 2014-04-03 2015-04-02 Macrocylic pyridine derivatives

Publications (2)

Publication Number Publication Date
EA201692000A1 true EA201692000A1 (ru) 2017-01-30
EA029758B1 EA029758B1 (ru) 2018-05-31

Family

ID=52781118

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201692000A EA029758B1 (ru) 2014-04-03 2015-04-02 Макроциклические производные пиридина

Country Status (22)

Country Link
US (1) US20170022201A1 (ru)
EP (1) EP3126365B1 (ru)
JP (1) JP6420362B2 (ru)
KR (1) KR102390274B1 (ru)
CN (1) CN106132964B (ru)
AU (1) AU2015239100B2 (ru)
BR (1) BR112016022700B1 (ru)
CA (1) CA2942751C (ru)
CL (1) CL2016002495A1 (ru)
EA (1) EA029758B1 (ru)
ES (1) ES2665797T3 (ru)
IL (1) IL248001B (ru)
MA (1) MA39823A (ru)
MX (1) MX369799B (ru)
MY (1) MY185500A (ru)
NZ (1) NZ725406A (ru)
PE (1) PE20161365A1 (ru)
PH (1) PH12016501962A1 (ru)
SG (1) SG11201608241UA (ru)
UA (1) UA118120C2 (ru)
WO (1) WO2015150557A1 (ru)
ZA (1) ZA201606768B (ru)

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US10407442B2 (en) 2015-09-24 2019-09-10 Cyclenium Pharma Inc. Libraries of heteroaryl-containing macrocyclic compounds and methods of making and using the same
RS60900B1 (sr) 2016-02-19 2020-11-30 Sprint Bioscience Ab Jedinjenja 6-heterociklil-4-morfolin-4-ilpiridin-2-ona korisna za lečenje kancera i dijabetesa
HUE050863T2 (hu) 2016-02-19 2021-01-28 Sprint Bioscience Ab Rák és cukorbetegség kezelésére alkalmazható 6-aril-4-(morfolin-4-il)-1H-piridin-2-on vegyületek
US11046685B2 (en) 2017-02-28 2021-06-29 Morphic Therapeutic, Inc. Inhibitors of (α-v)(β-6) integrin
US20180244648A1 (en) 2017-02-28 2018-08-30 Lazuli, Inc. Inhibitors of (alpha-v)(beta-6) integrin
US11242356B2 (en) 2017-03-28 2022-02-08 Bayer Aktiengesellschaft PTEFb inhibiting macrocyclic compounds
PL3601253T3 (pl) 2017-03-28 2022-01-17 Bayer Aktiengesellschaft Nowe hamujące ptefb związki makrocykliczne
US20200190083A1 (en) * 2017-06-22 2020-06-18 Cyclenium Pharma Inc. Libraries of pyridine-containing macrocyclic compounds and methods of making and using the same
JP7199738B2 (ja) 2017-08-23 2023-01-06 スプリント バイオサイエンス アクティエボラーグ アザインドリルピリドンおよびジアザインドリルピリドン化合物
CA3073142A1 (en) 2017-08-23 2019-02-28 Sprint Bioscience Ab Morpholinylpyridone compounds
ES2910839T3 (es) 2017-08-23 2022-05-13 Sprint Bioscience Ab Compuestos de piridilpiridona
US11208423B2 (en) 2017-08-23 2021-12-28 Sprint Bioscience Ab Pyridinamine-pyridone and pyrimidinamine- pyridone compounds
CR20210109A (es) 2018-08-29 2021-06-24 Morphic Therapeutic Inc INHIBICIÓN DE LA INTEGRINA av ß6
CN115260128B (zh) * 2022-09-21 2022-12-09 苏州凯瑞医药科技有限公司 一种新型jak抑制剂关键中间体的制备方法

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WO2004078682A2 (en) * 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
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US8318929B2 (en) * 2008-03-10 2012-11-27 Janssen Pharmaceutica Nv 4-aryl-2-anilino-pyrimidines
KR20110031318A (ko) 2008-06-13 2011-03-25 노파르티스 아게 Ｉａ 심부전 및 암 치료에 유용한 단백질 키나제 ｄ 억제제로서의 2,4'-비피리디닐 화합물

Also Published As

Publication number Publication date
CN106132964B (zh) 2019-07-19
ZA201606768B (en) 2018-11-28
CA2942751C (en) 2023-03-21
NZ725406A (en) 2022-08-26
EA029758B1 (ru) 2018-05-31
BR112016022700B1 (pt) 2022-01-11
AU2015239100B2 (en) 2019-06-27
EP3126365B1 (en) 2018-01-10
MX369799B (es) 2019-11-21
US20170022201A1 (en) 2017-01-26
BR112016022700A2 (ru) 2017-08-15
CL2016002495A1 (es) 2017-02-24
KR102390274B9 (ko) 2023-03-03
ES2665797T3 (es) 2018-04-27
MA39823A (fr) 2018-01-09
MX2016012994A (es) 2016-12-07
PH12016501962B1 (en) 2017-01-09
UA118120C2 (uk) 2018-11-26
IL248001B (en) 2018-11-29
KR102390274B1 (ko) 2022-04-22
CA2942751A1 (en) 2015-10-08
SG11201608241UA (en) 2016-10-28
AU2015239100A1 (en) 2016-09-29
WO2015150557A1 (en) 2015-10-08
JP2017509685A (ja) 2017-04-06
EP3126365A1 (en) 2017-02-08
MY185500A (en) 2021-05-19
PE20161365A1 (es) 2016-12-17
PH12016501962A1 (en) 2017-01-09
CN106132964A (zh) 2016-11-16
JP6420362B2 (ja) 2018-11-07
KR20160140739A (ko) 2016-12-07

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KG TJ TM