CL2017000786A1 - Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. - Google Patents

Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

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Publication number
CL2017000786A1
CL2017000786A1 CL2017000786A CL2017000786A CL2017000786A1 CL 2017000786 A1 CL2017000786 A1 CL 2017000786A1 CL 2017000786 A CL2017000786 A CL 2017000786A CL 2017000786 A CL2017000786 A CL 2017000786A CL 2017000786 A1 CL2017000786 A1 CL 2017000786A1
Authority
CL
Chile
Prior art keywords
btk
tyrosine kinase
kinase inhibitors
heteroaryl compounds
bruton tyrosine
Prior art date
Application number
CL2017000786A
Other languages
English (en)
Inventor
Constantin Neagu
Justin Potnick
Theresa L Johnson
Andreas Goutopoulos
Brian A Sherer
Pascale Gaillard
Jeyaprakashinarayanan Seenisamy
Bujalski Lesley Liu
Richard D Carldwell
Hui Qiu
Reinaldo Jones
Annie Cho Won
Anna Gardberg
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54337891&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2017000786(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of CL2017000786A1 publication Critical patent/CL2017000786A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Obesity (AREA)

Abstract

<p>LA PRESENTE INVENCIÓN SE REFIERE A COMPUESTOS DE IMIDAZOPIRIDINA DE LA FORMULA I, Y COMPOSICIONES FARMACÉUTICAMENTE ACEPTABLES DE ÉSTOS, ÚTILES COMO INHIBIDORES DE BTK.</p>
CL2017000786A 2014-10-06 2017-03-31 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos. CL2017000786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462060249P 2014-10-06 2014-10-06

Publications (1)

Publication Number Publication Date
CL2017000786A1 true CL2017000786A1 (es) 2017-12-29

Family

ID=54337891

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000786A CL2017000786A1 (es) 2014-10-06 2017-03-31 Compuestos de heteroarilo como inhibidores de tirosina-cinasa de bruton (btk) y usos de estos.

Country Status (19)

Country Link
US (2) US10253023B2 (es)
EP (1) EP3204382B1 (es)
JP (1) JP6856526B2 (es)
KR (1) KR102523111B1 (es)
CN (1) CN107001362A (es)
AR (1) AR102177A1 (es)
AU (1) AU2015328285B2 (es)
BR (1) BR112017006305B1 (es)
CA (1) CA2960401C (es)
CL (1) CL2017000786A1 (es)
ES (1) ES2907622T3 (es)
IL (1) IL251441B (es)
MX (1) MX2017004200A (es)
NZ (1) NZ729603A (es)
PH (1) PH12017500408B1 (es)
RU (1) RU2742122C2 (es)
SG (1) SG11201701573QA (es)
WO (1) WO2016057500A1 (es)
ZA (1) ZA201701501B (es)

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TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
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AR109595A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1
ES2934230T3 (es) 2016-12-22 2023-02-20 Incyte Corp Derivados de benzooxazol como inmunomoduladores
EP3558989B1 (en) 2016-12-22 2021-04-14 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
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KR102641030B1 (ko) 2016-12-22 2024-02-29 인사이트 코포레이션 Pd-l1 내재화 유도제로서의 테트라하이드로 이미다조[4,5-c]피리딘 유도체
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
CN106939009A (zh) * 2017-03-31 2017-07-11 牡丹江医学院 一种用于治疗脑震荡的药物及其制备方法
JOP20190233A1 (ar) * 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
WO2019051199A1 (en) 2017-09-08 2019-03-14 Incyte Corporation 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS
EP3709986B1 (en) * 2017-11-14 2023-11-01 Merck Sharp & Dohme LLC Novel substituted biaryl compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
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US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
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