TW288007B - - Google Patents

Info

Publication number
TW288007B
TW288007B TW082110504A TW82110504A TW288007B TW 288007 B TW288007 B TW 288007B TW 082110504 A TW082110504 A TW 082110504A TW 82110504 A TW82110504 A TW 82110504A TW 288007 B TW288007 B TW 288007B
Authority
TW
Taiwan
Prior art keywords
radical
hydrocarbon radical
pct
aliphatic hydrocarbon
carboxy
Prior art date
Application number
TW082110504A
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Application granted granted Critical
Publication of TW288007B publication Critical patent/TW288007B/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/20Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having nitrogen atoms of amidino groups acylated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51Y being a hydrogen or a carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
TW082110504A 1992-11-18 1993-12-11 TW288007B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/978,004 US5451700A (en) 1991-06-11 1992-11-18 Amidino compounds, their manufacture and methods of treatment

Publications (1)

Publication Number Publication Date
TW288007B true TW288007B (zh) 1996-10-11

Family

ID=25525722

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082110504A TW288007B (zh) 1992-11-18 1993-12-11

Country Status (22)

Country Link
US (2) US5451700A (zh)
EP (1) EP0669909B1 (zh)
JP (1) JP2795986B2 (zh)
KR (1) KR100311701B1 (zh)
AT (1) ATE161826T1 (zh)
AU (1) AU683436B2 (zh)
CA (1) CA2148930A1 (zh)
DE (1) DE69316236T2 (zh)
DK (1) DK0669909T3 (zh)
ES (1) ES2111896T3 (zh)
FI (1) FI952361A0 (zh)
GR (1) GR3025953T3 (zh)
HU (1) HU218795B (zh)
IL (1) IL107568A (zh)
MX (1) MX9307208A (zh)
NO (1) NO304978B1 (zh)
NZ (1) NZ258368A (zh)
PH (1) PH30115A (zh)
SG (1) SG49662A1 (zh)
TW (1) TW288007B (zh)
WO (1) WO1994011341A1 (zh)
ZA (1) ZA938574B (zh)

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CA2170735A1 (en) * 1993-10-21 1995-04-27 Foe S. Tjoeng Amidino derivatives useful as nitric oxide synthase inhibitors
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AU4557397A (en) 1996-09-26 1998-04-17 Novartis Ag Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
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US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
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US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
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EP2311818B1 (en) 2002-02-28 2013-01-16 Novartis AG Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug
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JP4541408B2 (ja) * 2004-07-05 2010-09-08 ドン ファ ファーマシューティカル カンパニー リミテッド N−ヒドロキシ−4−{5−[4−(5−イソプロピル−2−メチル−1,3−チアゾール−4−イル)−フェノキシ]−ペントキシ}−ベンズアミジンの改善された製造方法
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WO2012107500A1 (en) 2011-02-10 2012-08-16 Novartis Ag [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
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BR112013021638A2 (pt) 2011-02-25 2016-08-02 Irm Llc "compostos inibidores de trk, seu uso e composições que os compreendem"
EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
CA2868202C (en) 2012-04-03 2021-08-10 Novartis Ag Combination products with tyrosine kinase inhibitors and their use
CA2906542A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
TW201605450A (zh) 2013-12-03 2016-02-16 諾華公司 Mdm2抑制劑與BRAF抑制劑之組合及其用途
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CA2954862A1 (en) 2014-07-31 2016-02-04 Novartis Ag Combination therapy
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Also Published As

Publication number Publication date
US5451700A (en) 1995-09-19
EP0669909B1 (en) 1998-01-07
DK0669909T3 (da) 1998-03-30
GR3025953T3 (en) 1998-04-30
US5639768A (en) 1997-06-17
ATE161826T1 (de) 1998-01-15
CA2148930A1 (en) 1994-05-26
KR100311701B1 (ko) 2002-11-30
MX9307208A (es) 1994-07-29
JP2795986B2 (ja) 1998-09-10
NO951934D0 (no) 1995-05-16
KR950704238A (ko) 1995-11-17
NO951934L (no) 1995-06-28
JPH08503466A (ja) 1996-04-16
NZ258368A (en) 1997-10-24
DE69316236D1 (de) 1998-02-12
ES2111896T3 (es) 1998-03-16
PH30115A (en) 1996-12-27
DE69316236T2 (de) 1998-08-13
SG49662A1 (en) 1999-05-25
AU683436B2 (en) 1997-11-13
IL107568A0 (en) 1994-02-27
WO1994011341A1 (en) 1994-05-26
ZA938574B (en) 1994-08-22
HU9501452D0 (en) 1995-06-28
FI952361A (fi) 1995-05-15
EP0669909A1 (en) 1995-09-06
HUT72991A (en) 1996-06-28
HU218795B (hu) 2000-12-28
IL107568A (en) 1998-01-04
AU5599494A (en) 1994-06-08
FI952361A0 (fi) 1995-05-15
NO304978B1 (no) 1999-03-15

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