EP2307015A4 - A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt - Google Patents

A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Info

Publication number: EP2307015A4
Authority: EP; European Patent Office
Prior art keywords: salts; salt; preventing; pharmaceutical composition; treating osteoporosis
Prior art date: 2008-08-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP09803174A

Other languages

German (de)

French (fr)

Other versions

EP2307015A2 (en

Inventor

Jin Soo Lee

Yun Ha Hwang

Jei Man Ryu

Jae Hoon Park

Duk Kyun Chung

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Dong Wha Pharm Co Ltd

Original Assignee

Dong Wha Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-08-01

Filing date

2009-07-31

Publication date

2012-05-16

2009-07-31 Application filed by Dong Wha Pharm Co Ltd filed Critical Dong Wha Pharm Co Ltd

2011-04-13 Publication of EP2307015A2 publication Critical patent/EP2307015A2/en

2012-05-16 Publication of EP2307015A4 publication Critical patent/EP2307015A4/en

Status Withdrawn legal-status Critical Current

Links

150000003839 salts Chemical class 0.000 title 2
OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 title 1
208000001132 Osteoporosis Diseases 0.000 title 1
229960004343 alendronic acid Drugs 0.000 title 1
150000003937 benzamidines Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

EP09803174A 2008-08-01 2009-07-31 A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt Withdrawn EP2307015A4 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
KR20080075792		2008-08-01
PCT/KR2009/004277 WO2010013969A2 (en)	2008-08-01	2009-07-31	A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Publications (2)

Publication Number	Publication Date
EP2307015A2 EP2307015A2 (en)	2011-04-13
EP2307015A4 true EP2307015A4 (en)	2012-05-16

Family

ID=41610865

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP09803174A Withdrawn EP2307015A4 (en)	2008-08-01	2009-07-31	A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt

Country Status (6)

Country	Link
EP (1)	EP2307015A4 (en)
JP (1)	JP2011529875A (en)
KR (1)	KR20100014173A (en)
CN (1)	CN102149380B (en)
CA (1)	CA2732863A1 (en)
WO (1)	WO2010013969A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20100014090A (en) *	2008-08-01	2010-02-10	동화약품주식회사	A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003007947A1 (en) *	2001-07-19	2003-01-30	Dong Wha Pharm. Ind. Co., Ltd.	Use of 4-[(4-thiazolyl)phenoxl] alkoxy-benzamidine derivatives for treatment of osteoporosis
WO2006004369A1 (en) *	2004-07-05	2006-01-12	Dong Wha Pharmaceutical. Ind. Co., Ltd.	Pharmaceutical composition for the treatment of bone fracture
WO2010013975A2 (en) *	2008-08-01	2010-02-04	Dong Wha Pharmaceutical Co., Ltd.	A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
CN1144806A (en) *	1996-07-25	1997-03-12	南京药物研究所	Amino-diphosphinic acids bone absorption inhibitor and preparation method of its sodium salt
KR100513302B1 (en) *	1997-02-04	2005-11-11	동화약품공업주식회사	3-amino-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
US5998390A (en) *	1998-09-28	1999-12-07	The Research Foundation Of State University Of New York	Combination of bisphosphonate and tetracycline
KR100317935B1 (en) *	1999-10-20	2001-12-22	유승필	Pharmaceutical compositions and preparations for treatment of metabolic bone disease
JP2003292453A (en) *	2002-04-02	2003-10-15	Asahi Kasei Corp	Medicinal agent composition for treating bone disease
US20060173009A1 (en) *	2003-01-07	2006-08-03	Hiroyuki Kanoh	Agent inducing increase in bone mass
JP2007502300A (en) *	2003-08-13	2007-02-08	カイロン　コーポレイション	GSK-3 inhibitor and use thereof
AU2005237501A1 (en) *	2004-04-28	2005-11-10	Merck Sharp & Dohme Corp.	Fluorinated 4-azasteroids as androgen receptor modulators
JP2009017222A (en) *	2007-07-04	2009-01-22	Panasonic Corp	Color adjustment apparatus, color adjustment method, and integrated circuit of color adjustment apparatus

2009
- 2009-07-31 CA CA2732863A patent/CA2732863A1/en not_active Abandoned
- 2009-07-31 EP EP09803174A patent/EP2307015A4/en not_active Withdrawn
- 2009-07-31 JP JP2011521043A patent/JP2011529875A/en active Pending
- 2009-07-31 WO PCT/KR2009/004277 patent/WO2010013969A2/en active Application Filing
- 2009-07-31 KR KR1020090070534A patent/KR20100014173A/en not_active Application Discontinuation
- 2009-07-31 CN CN2009801335635A patent/CN102149380B/en not_active Expired - Fee Related

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003007947A1 (en) *	2001-07-19	2003-01-30	Dong Wha Pharm. Ind. Co., Ltd.	Use of 4-[(4-thiazolyl)phenoxl] alkoxy-benzamidine derivatives for treatment of osteoporosis
WO2006004369A1 (en) *	2004-07-05	2006-01-12	Dong Wha Pharmaceutical. Ind. Co., Ltd.	Pharmaceutical composition for the treatment of bone fracture
WO2010013975A2 (en) *	2008-08-01	2010-02-04	Dong Wha Pharmaceutical Co., Ltd.	A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivative or its salt, and bisphosphonate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BLACK D M ET AL: "THE EFFECTS OF PARATHYROID HORMONE AND ALENDRONATE ALONE OR IN COMBINATION IN POSTMENOPAUSAL OSTEOPOROSIS", NEW ENGLAND JOURNAL OF MEDICINE, vol. 349, no. 13, 25 September 2003 (2003-09-25), MASSACHUSETTS MEDICAL SOCIETY, BOSTON, MA, US, pages 1207 - 1215, XP009045315, ISSN: 1533-4406, DOI: 10.1056/NEJMOA031975 *
GREENSPAN SUSAN L ET AL: "Combination therapy with hormone replacement and alendronate for prevention of bone loss in elderly women: A randomized controlled trial.", JAMA (JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION), vol. 289, no. 19, 21 May 2003 (2003-05-21), pages 2525 - 2533+CORR, XP002672632, ISSN: 0098-7484 *

Also Published As

Publication number	Publication date
CA2732863A1 (en)	2010-02-04
CN102149380B (en)	2012-12-05
KR20100014173A (en)	2010-02-10
WO2010013969A2 (en)	2010-02-04
CN102149380A (en)	2011-08-10
JP2011529875A (en)	2011-12-15
EP2307015A2 (en)	2011-04-13
WO2010013969A3 (en)	2010-05-27

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Legal Events

Date	Code	Title	Description
2011-03-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2011-04-13	17P	Request for examination filed	Effective date: 20110201
2011-04-13	AK	Designated contracting states	Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
2011-04-13	AX	Request for extension of the european patent	Extension state: AL BA RS
2011-11-09	DAX	Request for extension of the european patent (deleted)
2012-05-09	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 19/10 20060101ALI20120405BHEP Ipc: A61K 31/663 20060101ALI20120405BHEP Ipc: A61K 31/426 20060101AFI20120405BHEP
2012-05-16	A4	Supplementary search report drawn up and despatched	Effective date: 20120416
2013-02-20	17Q	First examination report despatched	Effective date: 20130123
2013-09-13	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
2013-10-16	18D	Application deemed to be withdrawn	Effective date: 20130403