TR201906532T4 - Kinin bileşikleri ve optik izomerleri, hazırlanış yöntemleri ve tıbbi kullanımları. - Google Patents

Kinin bileşikleri ve optik izomerleri, hazırlanış yöntemleri ve tıbbi kullanımları.

Info

Publication number
TR201906532T4
TR201906532T4 TR2019/06532T TR201906532T TR201906532T4 TR 201906532 T4 TR201906532 T4 TR 201906532T4 TR 2019/06532 T TR2019/06532 T TR 2019/06532T TR 201906532 T TR201906532 T TR 201906532T TR 201906532 T4 TR201906532 T4 TR 201906532T4
Authority
TR
Turkey
Prior art keywords
optical isomers
bladder
compounds
rhinitis
above compounds
Prior art date
Application number
TR2019/06532T
Other languages
English (en)
Inventor
Wang Chunjing
Wang Junyi
Gao Zejun
Original Assignee
Beijing Shuobai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Shuobai Pharmaceutical Co Ltd filed Critical Beijing Shuobai Pharmaceutical Co Ltd
Publication of TR201906532T4 publication Critical patent/TR201906532T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Mevcut buluş, kinin bileşiklerinin bir sınıfını ve farmasötik olarak kabul edilebilir tuzları, solvatları, ön ilaçları veya optik izomerlerini açıklar. Mevcut buluşta aynı zamanda yukarıdaki bileşiklerin, M1 ve M3 reseptör alt tipleri üzerinde selektif antagonistik etkiye sahip olduğu ancak M2 reseptör alt tipi üzerinde önemli bir etkiye sahip olmadığı ve yukarıdaki bileşiklerin, rinit, nezle sonrası rinit, kronik trakit, hava yolu aşırı duyarlılığı, astım, kronik obstrüktif akciğer hastalıkları, öksürük, üriner inkontinans, sık idrara çıkma, stabil olmayan mesane sendromu, mesane spazmları, mesane inflamasyonu ve gastrointestinal hastalıklar örneğin, huzursuz bağırsak sendromu, spastik kolit ve duedenal ve mide ülserlerini tedavi etmek amacıyla kullanıldığında hızlı etki, uzun süreli etkinlik ve düşük toksik ve yan etkiler ile karakterize edildiği açıklanır.
TR2019/06532T 2013-07-13 2014-07-11 Kinin bileşikleri ve optik izomerleri, hazırlanış yöntemleri ve tıbbi kullanımları. TR201906532T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310297901 2013-07-13

Publications (1)

Publication Number Publication Date
TR201906532T4 true TR201906532T4 (tr) 2019-05-21

Family

ID=52345746

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/06532T TR201906532T4 (tr) 2013-07-13 2014-07-11 Kinin bileşikleri ve optik izomerleri, hazırlanış yöntemleri ve tıbbi kullanımları.

Country Status (13)

Country Link
US (1) US9751875B2 (tr)
EP (1) EP3023424B1 (tr)
JP (1) JP6218940B2 (tr)
KR (1) KR101823451B1 (tr)
CN (1) CN105431432B (tr)
AU (1) AU2014292722B2 (tr)
BR (1) BR112016000629B1 (tr)
CA (1) CA2921621C (tr)
ES (1) ES2726664T3 (tr)
RU (1) RU2641285C2 (tr)
TR (1) TR201906532T4 (tr)
WO (1) WO2015007073A1 (tr)
ZA (1) ZA201600997B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016140136A1 (ja) * 2015-03-02 2016-09-09 株式会社Ｌｔｔバイオファーマ キヌクリジン誘導体
ES2836113T3 (es) 2016-12-14 2021-06-24 Beijing Showby Pharmaceutical Co Ltd Clase de compuestos bifuncionales con estructura de sal de amonio cuaternario
CN109776521A (zh) * 2019-03-30 2019-05-21 山东博洛德生物科技有限公司 一种含有季铵基团的奎宁类化合物及其制备方法
CN109824662A (zh) * 2019-03-30 2019-05-31 山东博洛德生物科技有限公司 一种奎宁类化合物及其制备方法
CN109824661B (zh) * 2019-03-30 2020-06-05 山东博洛德生物科技有限公司 一种盐酸戊乙奎醚中杂质的制备方法
CN115397823A (zh) * 2020-04-26 2022-11-25 北京硕佰医药科技有限责任公司 一种m受体拮抗剂的晶体、制备方法及其应用
WO2023138478A1 (zh) * 2022-01-19 2023-07-27 北京硕佰医药科技有限责任公司 一种治疗鼻炎的溶液型鼻喷雾剂及制备方法
CN116514800A (zh) * 2023-05-06 2023-08-01 湖南一格制药有限公司 盐酸戊乙奎醚的制备方法

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
GB1219606A (en) 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DE4108393A1 (de) 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
NO2005012I1 (no) * 1994-12-28 2005-06-06 Debio Rech Pharma Sa Triptorelin og farmasoytisk akseptable salter derav
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
DE20122417U1 (de) * 2000-06-27 2005-08-04 Laboratorios S.A.L.V.A.T., S.A., Esplugues De Llobregat Von Arylalkylaminen abgeleitete Carbamate
SK287414B6 (sk) * 2000-12-28 2010-09-07 Laboratorios Almirall, S.A. Chinuklidínové deriváty a kompozície s ich obsahom
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
UY28871A1 (es) 2004-04-27 2005-11-30 Glaxo Group Ltd Antagonistas del receptor de acetilcolina muscarinico
JP4637715B2 (ja) * 2005-10-17 2011-02-23 日信工業株式会社 車両用支持構造体の製造方法
CN1951938A (zh) * 2005-10-21 2007-04-25 刘丽娅 戊乙奎醚季铵盐及其衍生物
ES2385681T3 (es) * 2006-12-19 2012-07-30 Astrazeneca Ab Derivados de quinuclidinol como antagonistas de receptores muscarínicos
KR20090107567A (ko) * 2007-02-09 2009-10-13 아스텔라스세이야쿠 가부시키가이샤 아자 가교환 화합물
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Also Published As

Publication number Publication date
EP3023424A1 (en) 2016-05-25
KR20160033146A (ko) 2016-03-25
US9751875B2 (en) 2017-09-05
CN105431432A (zh) 2016-03-23
CA2921621A1 (en) 2015-01-22
ZA201600997B (en) 2018-05-30
BR112016000629A2 (tr) 2017-07-25
EP3023424B1 (en) 2019-02-27
JP2016528199A (ja) 2016-09-15
CA2921621C (en) 2018-08-28
AU2014292722B2 (en) 2017-03-09
AU2014292722A1 (en) 2016-03-03
BR112016000629B1 (pt) 2023-10-31
ES2726664T3 (es) 2019-10-08
US20160244439A1 (en) 2016-08-25
WO2015007073A1 (zh) 2015-01-22
CN105431432B (zh) 2018-01-09
EP3023424A4 (en) 2017-01-18
JP6218940B2 (ja) 2017-10-25
RU2016104437A (ru) 2017-08-16
RU2641285C2 (ru) 2018-01-17
KR101823451B1 (ko) 2018-01-30

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