MX2016014904A - Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)e til)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-car bonitrilo. - Google Patents
Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)e til)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-car bonitrilo.Info
- Publication number
- MX2016014904A MX2016014904A MX2016014904A MX2016014904A MX2016014904A MX 2016014904 A MX2016014904 A MX 2016014904A MX 2016014904 A MX2016014904 A MX 2016014904A MX 2016014904 A MX2016014904 A MX 2016014904A MX 2016014904 A MX2016014904 A MX 2016014904A
- Authority
- MX
- Mexico
- Prior art keywords
- cyanopyrimidin
- dihydropyrrolo
- ylamino
- triazine
- oxo
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
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- C—CHEMISTRY; METALLURGY
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- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/33—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems
- C07C309/34—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of six-membered aromatic rings being part of condensed ring systems formed by two rings
- C07C309/35—Naphthalene sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
La presente invención se refiere a nuevas sales de adición, farmacéuticamente aceptables, de (S)-2-(1-(6-amino-5-cianopirimidi n-4-ilamino)etil)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]t riazina-5-carbonitrilo con derivados de ácido sulfónico, en particular con ácido metanosulfónico, ácido naftaleno-2-sulfónico y ácido para-toluenosulfónico, y a los solvatos farmacéuticamente aceptables de las mismas, y su uso como inhibidores de Fosfoinositido 3-quinasa (PI3K).
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14382192 | 2014-05-27 | ||
| EP14382400 | 2014-10-17 | ||
| EP14382401 | 2014-10-17 | ||
| PCT/EP2015/061307 WO2015181052A1 (en) | 2014-05-27 | 2015-05-21 | Addition salts of (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2016014904A true MX2016014904A (es) | 2017-02-28 |
Family
ID=53269467
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014864A MX2016014864A (es) | 2014-05-27 | 2015-05-21 | Combinacion. |
| MX2016014904A MX2016014904A (es) | 2014-05-27 | 2015-05-21 | Sales de adicion de (s)-2-(1-(6-amino-5-cianopirimidin-4-ilamino)e til)-4-oxo-3-fenil-3,4-dihidropirrolo[1,2-f][1,2,4]triazina-5-car bonitrilo. |
| MX2016014861A MX2016014861A (es) | 2014-05-27 | 2015-05-21 | Uso medico. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014864A MX2016014864A (es) | 2014-05-27 | 2015-05-21 | Combinacion. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016014861A MX2016014861A (es) | 2014-05-27 | 2015-05-21 | Uso medico. |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20170189409A1 (es) |
| EP (3) | EP3148585A1 (es) |
| JP (3) | JP2017516799A (es) |
| KR (3) | KR20170010369A (es) |
| CN (3) | CN106414449A (es) |
| AU (3) | AU2015266191A1 (es) |
| BR (1) | BR112016024538A2 (es) |
| CA (3) | CA2944611A1 (es) |
| CL (2) | CL2016002970A1 (es) |
| CR (3) | CR20160537A (es) |
| EA (3) | EA201692437A1 (es) |
| IL (3) | IL247073A0 (es) |
| MA (3) | MA39828A (es) |
| MD (3) | MD20160137A2 (es) |
| MX (3) | MX2016014864A (es) |
| PE (2) | PE20170145A1 (es) |
| PH (3) | PH12016502256A1 (es) |
| SG (3) | SG11201606763VA (es) |
| TW (3) | TW201625260A (es) |
| UY (3) | UY36151A (es) |
| WO (3) | WO2015181055A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| NZ587051A (en) | 2008-01-04 | 2012-12-21 | Intellikine Llc | Isoquinolinone derivatives, compositions and methods of inhibiting phosphatidyl inositol-3 kinase (pi3 kinase) |
| CN103648499B (zh) | 2011-01-10 | 2017-02-15 | 无限药品股份有限公司 | 用于制备异喹啉酮的方法及异喹啉酮的固体形式 |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| AU2014209141B2 (en) | 2013-01-24 | 2018-05-10 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mTOR inhibitors |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US10993947B2 (en) | 2016-05-18 | 2021-05-04 | Torqur | Treatment of skin lesions |
| GB201608797D0 (en) * | 2016-05-19 | 2016-07-06 | Ucb Biopharma Sprl | Therapeutic use |
| CN107456454A (zh) * | 2016-06-06 | 2017-12-12 | 先声药业有限公司 | 一种预防或治疗炎性疾病的药物组合物 |
| WO2017223422A1 (en) | 2016-06-24 | 2017-12-28 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| WO2018129364A1 (en) | 2017-01-06 | 2018-07-12 | Palvella Therapeutics Llc | Anhydrous compositions of mtor inhibitors and methods of use |
| GB201708856D0 (en) * | 2017-06-02 | 2017-07-19 | Ucb Biopharma Sprl | Seletalisib crystalline forms |
| WO2019101853A1 (en) * | 2017-11-23 | 2019-05-31 | Piqur Therapeutics Ag | Treatment of skin disorders |
| WO2020010073A1 (en) | 2018-07-02 | 2020-01-09 | Palvella Therapeutics, Inc. | ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE |
| US11633399B2 (en) | 2018-12-25 | 2023-04-25 | Sol-Gel Technologies Ltd. | Treatment of skin disorders with compositions comprising an EGFR inhibitor |
| CN113440614A (zh) * | 2020-03-26 | 2021-09-28 | 长沙晶易医药科技有限公司 | 一种用于治疗类风湿性关节炎的组合物及其应用 |
| KR20230065591A (ko) * | 2021-11-05 | 2023-05-12 | 연세대학교 산학협력단 | 피부-특이적 T 세포(skin-specific T cell)의 억제제를 유효성분으로 포함하는 아토피피부염의 예방 또는 치료용 조성물 |
| WO2023114369A2 (en) * | 2021-12-16 | 2023-06-22 | Incyte Corporation | Topical formulations of pi3k-delta inhibitors |
| TWI823476B (zh) * | 2022-07-15 | 2023-11-21 | 中化合成生技股份有限公司 | 托法替尼檸檬酸鹽的製備方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101123968A (zh) * | 2004-06-04 | 2008-02-13 | 艾科斯有限公司 | 肥大细胞病的治疗方法 |
| WO2007023186A1 (en) * | 2005-08-26 | 2007-03-01 | Laboratoires Serono S.A. | Pyrazine derivatives and use as pi3k inhibitors |
| JP2012521994A (ja) * | 2009-03-24 | 2012-09-20 | ギリアード カリストガ エルエルシー | ２−プリニル−３−トリル−キナゾリノン誘導体のアトロプ異性体および使用方法 |
| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
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2015
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- 2015-05-21 MX MX2016014864A patent/MX2016014864A/es unknown
- 2015-05-21 CR CR20160537A patent/CR20160537A/es unknown
- 2015-05-21 KR KR1020167033156A patent/KR20170010369A/ko unknown
- 2015-05-21 WO PCT/EP2015/061312 patent/WO2015181055A1/en active Application Filing
- 2015-05-21 US US15/313,737 patent/US20170151264A1/en not_active Abandoned
- 2015-05-21 SG SG11201606763VA patent/SG11201606763VA/en unknown
- 2015-05-21 KR KR1020167033149A patent/KR20170007760A/ko unknown
- 2015-05-21 CN CN201580028179.4A patent/CN106414449A/zh active Pending
- 2015-05-21 SG SG11201607950SA patent/SG11201607950SA/en unknown
- 2015-05-21 WO PCT/EP2015/061308 patent/WO2015181053A1/en active Application Filing
- 2015-05-21 EP EP15725295.8A patent/EP3148585A1/en not_active Withdrawn
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- 2015-05-21 MA MA039828A patent/MA39828A/fr unknown
- 2015-05-21 AU AU2015266191A patent/AU2015266191A1/en not_active Abandoned
- 2015-05-21 JP JP2016569770A patent/JP2017516799A/ja active Pending
- 2015-05-21 CN CN201580028234.XA patent/CN106456777A/zh active Pending
- 2015-05-21 EP EP15726063.9A patent/EP3148586A1/en not_active Withdrawn
- 2015-05-21 EA EA201692437A patent/EA201692437A1/ru unknown
- 2015-05-21 EA EA201692435A patent/EA201692435A1/ru unknown
- 2015-05-21 CR CR20160536A patent/CR20160536A/es unknown
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