TR200002853T2 - Antitümör etkili indolil-3-glioksilik asit türevleri - Google Patents

Antitümör etkili indolil-3-glioksilik asit türevleri

Info

Publication number
TR200002853T2
TR200002853T2 TR2000/02853T TR200002853T TR200002853T2 TR 200002853 T2 TR200002853 T2 TR 200002853T2 TR 2000/02853 T TR2000/02853 T TR 2000/02853T TR 200002853 T TR200002853 T TR 200002853T TR 200002853 T2 TR200002853 T2 TR 200002853T2
Authority
TR
Turkey
Prior art keywords
general formula
indolyl
acid derivatives
oxides
acid addition
Prior art date
Application number
TR2000/02853T
Other languages
English (en)
Inventor
Nickel Bernd
Szelenyi Istvan
Schmidt Jurgen
Emig Peter
Reichert Dietmar
G�Nther Eckhard
Brune Kay
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of TR200002853T2 publication Critical patent/TR200002853T2/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Bulus genel formül 1'in N ile ikame edilmis indol-3-glikoksilamidlerinin antitümör maddeleri ve de atitümör etkili terkip olarak kullanilmasiyla ilgilidir, özelligi, genel formül 1'in en az bir bilesimini, ihtiyari olarak fizyolojik açidan uygun asit ekleme tuzlari veya N-oksitler halinde de içermesidir. Bundan baska bulus etki maddesi olarak bir veya daha fazla genel formül 1'e göre N ile ikame edilmis indol-3-glikoksilamid ve de ihtiyari olarak bunlarin uygun asit ekleme tuzlarini, mümkünse N-oksitlerini ve tabletler, drajeler, kapsüller, infüzyon solüsyonlari veya ampuller, fitiller, plaster, inhalatif tatbik edilebilen toz terkipleri, süspansiyonlar, krem ve melhemler seklinde farmakolojik olarak kullanilabilen bir tasiyici ve/veya inceltme veya yardimci madde içeren antitümör maddesidir.
TR2000/02853T 1998-04-02 1999-03-22 Antitümör etkili indolil-3-glioksilik asit türevleri TR200002853T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19814838A DE19814838C2 (de) 1998-04-02 1998-04-02 Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung

Publications (1)

Publication Number Publication Date
TR200002853T2 true TR200002853T2 (tr) 2001-02-21

Family

ID=7863398

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02853T TR200002853T2 (tr) 1998-04-02 1999-03-22 Antitümör etkili indolil-3-glioksilik asit türevleri

Country Status (33)

Country Link
US (4) US6232327B1 (tr)
EP (1) EP1071420B1 (tr)
JP (2) JP5253696B2 (tr)
KR (1) KR100583545B1 (tr)
CN (1) CN1148183C (tr)
AR (1) AR018175A1 (tr)
AT (1) ATE304352T1 (tr)
AU (1) AU768510B2 (tr)
BG (1) BG64838B1 (tr)
BR (1) BR9909902A (tr)
CA (1) CA2326833C (tr)
DE (2) DE19814838C2 (tr)
DK (1) DK1071420T3 (tr)
EE (1) EE04354B1 (tr)
ES (1) ES2249884T3 (tr)
GE (1) GEP20032967B (tr)
HK (1) HK1036408A1 (tr)
HR (1) HRP20000643A2 (tr)
HU (1) HUP0101530A3 (tr)
ID (1) ID26504A (tr)
IL (2) IL138737A0 (tr)
IS (1) IS2307B (tr)
NO (1) NO327721B1 (tr)
NZ (1) NZ507084A (tr)
PL (1) PL192779B1 (tr)
RS (1) RS49866B (tr)
RU (1) RU2262339C2 (tr)
SK (1) SK286393B6 (tr)
TR (1) TR200002853T2 (tr)
TW (1) TWI230608B (tr)
UA (1) UA70942C2 (tr)
WO (1) WO1999051224A1 (tr)
ZA (1) ZA200006150B (tr)

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SK14302000A3 (sk) 2001-11-06
YU59300A (sh) 2002-11-15
IS5635A (is) 2000-09-22
BR9909902A (pt) 2000-12-26
IL138737A0 (en) 2001-10-31
AR018175A1 (es) 2001-10-31
NO20004916D0 (no) 2000-09-29
GEP20032967B (en) 2003-05-27
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US20080027110A1 (en) 2008-01-31
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CA2326833C (en) 2009-06-23
NO20004916L (no) 2000-12-01
CN1299280A (zh) 2001-06-13
ATE304352T1 (de) 2005-09-15
TWI230608B (en) 2005-04-11
DE19814838C2 (de) 2001-01-18
US6232327B1 (en) 2001-05-15
CN1148183C (zh) 2004-05-05
US20030195360A1 (en) 2003-10-16
ZA200006150B (en) 2001-01-11
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RS49866B (sr) 2008-08-07
DE19814838A1 (de) 1999-10-14
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