HUP0300721A2 - Antibakteriális hatású (amino-piperidino)-kinolinok és aza-izoszter analógjaik, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents
Antibakteriális hatású (amino-piperidino)-kinolinok és aza-izoszter analógjaik, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásukInfo
- Publication number
- HUP0300721A2 HUP0300721A2 HU0300721A HUP0300721A HUP0300721A2 HU P0300721 A2 HUP0300721 A2 HU P0300721A2 HU 0300721 A HU0300721 A HU 0300721A HU P0300721 A HUP0300721 A HU P0300721A HU P0300721 A2 HUP0300721 A2 HU P0300721A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- hydrogen atom
- cr1a
- producing
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RUAZBTOBQDHQDX-UHFFFAOYSA-N piperidin-1-amine;quinoline Chemical class NN1CCCCC1.N1=CC=CC2=CC=CC=C21 RUAZBTOBQDHQDX-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
A találmány (I) általános képletű új vegyületekre, - amelyekképletében Z1, Z2, Z3, Z4 és Z5 közül az egyiknek a jelentésenitrogénatom, egy másiknak a jelentése <CR1a általános képletűcsoport, és a többinek a jelentése metincsoport, vagy Z1, Z2, Z3, Z4és Z5 közül egynek vagy kettőnek a jelentése egymástól függetlenül<CR1a általános képletű csoport, és a többinek a jelentésemetincsoport R1 és R1a előnyösen hidrogénatom, hidroxicsoport vagyadott esetben szubsztituált alkoxicsoport, azzal a megkötéssel, hogyha Z1, Z2, Z3, Z4 és Z5 jelentése <CR1a általános képletű csoport vagymetincsoport, akkor R1 jelentése hidrogénatomtól eltérő; R2hidrogénatom, vagy adott esetben szubsztituált alkil-, vagyalkenilcsoport; R3 jelentése hidrogénatom, vagy R3 a 2-es, 3-as vagy4-es helyzetben van és jelentése előnyösen karboxi-, alkoxi-, vagykarbamoilcsoport. R4 jelentése -U-R5 általános képletű csoport,amelyben n 0 vagy 1; A NR11, oxigénatom vagy NR6R7 csoport, és B NR11,oxigénatom, szulfonil- vagy NR8R9 csoport és gyógyászatilag elfogadható származékaikra, a vegyületekettartalmazó gyógyszerkészítmények, valamint a vegyületekantibakteriális hatóanyagokként törtérnő felhasználására vonatkozik.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0018351A GB0018351D0 (en) | 2000-07-26 | 2000-07-26 | Compounds |
GB0101629A GB0101629D0 (en) | 2001-01-22 | 2001-01-22 | Compounds |
PCT/EP2001/008604 WO2002008224A1 (en) | 2000-07-26 | 2001-07-25 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0300721A2 true HUP0300721A2 (hu) | 2005-08-29 |
HUP0300721A3 HUP0300721A3 (en) | 2006-02-28 |
Family
ID=26244729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0300721A HUP0300721A3 (en) | 2000-07-26 | 2001-07-25 | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity, process for producing them, pharmaceutical compositions containing them and use thereof |
Country Status (20)
Country | Link |
---|---|
US (2) | US6962917B2 (hu) |
EP (1) | EP1305308B1 (hu) |
JP (2) | JP2004504397A (hu) |
KR (1) | KR20030019621A (hu) |
CN (1) | CN1452619A (hu) |
AT (1) | ATE348826T1 (hu) |
AU (2) | AU2001289749B9 (hu) |
BR (1) | BR0112750A (hu) |
CA (1) | CA2417192A1 (hu) |
CZ (1) | CZ2003243A3 (hu) |
DE (1) | DE60125373T2 (hu) |
ES (1) | ES2278778T3 (hu) |
HK (1) | HK1056166A1 (hu) |
HU (1) | HUP0300721A3 (hu) |
IL (1) | IL154107A0 (hu) |
MX (1) | MXPA03000708A (hu) |
NO (1) | NO20030345L (hu) |
NZ (1) | NZ523749A (hu) |
PL (1) | PL366335A1 (hu) |
WO (1) | WO2002008224A1 (hu) |
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GB0101577D0 (en) * | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
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HRP970371A2 (en) * | 1996-07-13 | 1998-08-31 | Kathryn Jane Smith | Heterocyclic compounds |
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GB9822440D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
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GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
GB9917408D0 (en) * | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
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FR2798656B1 (fr) | 1999-09-17 | 2004-12-17 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
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FR2816618B1 (fr) | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
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GB0031086D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
US6602884B2 (en) | 2001-03-13 | 2003-08-05 | Aventis Pharma S.A. | Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them |
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GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
-
2001
- 2001-07-25 DE DE60125373T patent/DE60125373T2/de not_active Expired - Lifetime
- 2001-07-25 IL IL15410701A patent/IL154107A0/xx unknown
- 2001-07-25 AU AU2001289749A patent/AU2001289749B9/en not_active Ceased
- 2001-07-25 JP JP2002514130A patent/JP2004504397A/ja not_active Withdrawn
- 2001-07-25 ES ES01969509T patent/ES2278778T3/es not_active Expired - Lifetime
- 2001-07-25 CZ CZ2003243A patent/CZ2003243A3/cs unknown
- 2001-07-25 MX MXPA03000708A patent/MXPA03000708A/es unknown
- 2001-07-25 AU AU8974901A patent/AU8974901A/xx active Pending
- 2001-07-25 CN CN01815242A patent/CN1452619A/zh active Pending
- 2001-07-25 WO PCT/EP2001/008604 patent/WO2002008224A1/en active IP Right Grant
- 2001-07-25 AT AT01969509T patent/ATE348826T1/de not_active IP Right Cessation
- 2001-07-25 EP EP01969509A patent/EP1305308B1/en not_active Expired - Lifetime
- 2001-07-25 CA CA002417192A patent/CA2417192A1/en not_active Abandoned
- 2001-07-25 NZ NZ523749A patent/NZ523749A/en unknown
- 2001-07-25 BR BR0112750-0A patent/BR0112750A/pt not_active IP Right Cessation
- 2001-07-25 KR KR10-2003-7001147A patent/KR20030019621A/ko not_active Application Discontinuation
- 2001-07-25 US US10/333,829 patent/US6962917B2/en not_active Expired - Fee Related
- 2001-07-25 PL PL01366335A patent/PL366335A1/xx not_active Application Discontinuation
- 2001-07-25 HU HU0300721A patent/HUP0300721A3/hu unknown
-
2003
- 2003-01-23 NO NO20030345A patent/NO20030345L/no unknown
- 2003-09-22 HK HK03106792.4A patent/HK1056166A1/zh unknown
-
2005
- 2005-09-02 US US11/219,148 patent/US7534793B2/en not_active Expired - Fee Related
-
2009
- 2009-08-21 JP JP2009192318A patent/JP2010001306A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2010001306A (ja) | 2010-01-07 |
WO2002008224A1 (en) | 2002-01-31 |
KR20030019621A (ko) | 2003-03-06 |
ATE348826T1 (de) | 2007-01-15 |
NO20030345L (no) | 2003-03-10 |
HUP0300721A3 (en) | 2006-02-28 |
EP1305308B1 (en) | 2006-12-20 |
AU2001289749B9 (en) | 2004-08-19 |
DE60125373T2 (de) | 2007-10-18 |
US7534793B2 (en) | 2009-05-19 |
EP1305308A1 (en) | 2003-05-02 |
ES2278778T3 (es) | 2007-08-16 |
CN1452619A (zh) | 2003-10-29 |
DE60125373D1 (de) | 2007-02-01 |
US20040038998A1 (en) | 2004-02-26 |
JP2004504397A (ja) | 2004-02-12 |
CZ2003243A3 (cs) | 2003-09-17 |
AU2001289749B2 (en) | 2004-06-17 |
PL366335A1 (en) | 2005-01-24 |
AU8974901A (en) | 2002-02-05 |
CA2417192A1 (en) | 2002-01-31 |
US20060014749A1 (en) | 2006-01-19 |
US6962917B2 (en) | 2005-11-08 |
BR0112750A (pt) | 2003-09-09 |
NZ523749A (en) | 2005-03-24 |
IL154107A0 (en) | 2003-07-31 |
MXPA03000708A (es) | 2003-06-04 |
NO20030345D0 (no) | 2003-01-23 |
HK1056166A1 (zh) | 2004-02-06 |
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