TNSN97091A1 - CONJUGUE PEG-IFN α PHYSIOLOGIQUEMENT ACTIF, PROCEDE POUR SA PREPARATION, COMPOSITIONS PHARMACEUTIQUES LE CONTENANT ET LEUR UTILISATION - Google Patents
CONJUGUE PEG-IFN α PHYSIOLOGIQUEMENT ACTIF, PROCEDE POUR SA PREPARATION, COMPOSITIONS PHARMACEUTIQUES LE CONTENANT ET LEUR UTILISATIONInfo
- Publication number
- TNSN97091A1 TNSN97091A1 TNTNSN97091A TNSN97091A TNSN97091A1 TN SN97091 A1 TNSN97091 A1 TN SN97091A1 TN TNSN97091 A TNTNSN97091 A TN TNSN97091A TN SN97091 A TNSN97091 A TN SN97091A TN SN97091 A1 TNSN97091 A1 TN SN97091A1
- Authority
- TN
- Tunisia
- Prior art keywords
- ifn
- preparation
- pharmaceutical compositions
- compositions containing
- physiologically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'INVENTION CONCERNE DES CONJUGES PEG-IFN α , PHYSIOLOGIQUEMENTACTIF, DE FORMULE I : AYANT UNE ACTIVITE ANTIPROLIFERATIVE ACCRUE ET UNE ACTIVITE ANTIVIRALE DIMINUEE PAR COMPARAISON AVEC L'IFN α, UN PROCEDE POUR LEUR PREPARATION, DES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR UTILISATION POUR LE TRAITEMENT OU LA PROPHYLAXIE DE TROUBLES IMUNOMODULATEURS, TELS QUE DES MALADIES NEOPLASIQUES OU DES MALADIES INFECTUEUSES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1883496P | 1996-05-31 | 1996-05-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN97091A1 true TNSN97091A1 (fr) | 2005-03-15 |
Family
ID=21790006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN97091A TNSN97091A1 (fr) | 1996-05-31 | 1997-05-27 | CONJUGUE PEG-IFN α PHYSIOLOGIQUEMENT ACTIF, PROCEDE POUR SA PREPARATION, COMPOSITIONS PHARMACEUTIQUES LE CONTENANT ET LEUR UTILISATION |
Country Status (48)
Families Citing this family (134)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
JP2000507917A (ja) | 1995-11-02 | 2000-06-27 | シェーリング コーポレイション | 持続的低用量サイトカイン注入治療 |
US5908621A (en) | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
US5981709A (en) * | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
HU228877B1 (en) * | 1998-03-26 | 2013-06-28 | Merck Sharp & Dohme | Formulations for stabilization of peg-interferon alpha conjugates and method for preparation such formulations |
US6180096B1 (en) | 1998-03-26 | 2001-01-30 | Schering Corporation | Formulations for protection of peg-interferon alpha conjugates |
DK1421956T3 (da) * | 1998-04-28 | 2007-10-01 | Applied Research Systems | Polyol-IFN-beta-konjugater |
TWI277424B (en) | 1998-05-15 | 2007-04-01 | Schering Corp | Combination therapy for eradicating detectable NCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection |
AU767131B2 (en) * | 1998-06-08 | 2003-10-30 | F. Hoffmann-La Roche Ag | Use of PEG-IFN-alpha and ribavirin for the treatment of chronic hepatitis C |
US6277830B1 (en) * | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
IL129299A0 (en) * | 1999-03-31 | 2000-02-17 | Mor Research Applic Ltd | Monoclonal antibodies antigens and diagnosis of malignant diseases |
PE20010027A1 (es) | 1999-04-08 | 2001-02-05 | Schering Corp | Uso de interferon alfa pegilado en pacientes con melanoma |
US6362162B1 (en) | 1999-04-08 | 2002-03-26 | Schering Corporation | CML Therapy |
US6923966B2 (en) | 1999-04-08 | 2005-08-02 | Schering Corporation | Melanoma therapy |
BR0009642A (pt) * | 1999-04-08 | 2002-01-08 | Schering Corp | Terapia de leucemia mielocìtica crÈnica |
US6605273B2 (en) | 1999-04-08 | 2003-08-12 | Schering Corporation | Renal cell carcinoma treatment |
CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
ATE435033T1 (de) | 2000-01-10 | 2009-07-15 | Maxygen Holdings Ltd | G-csf konjugate |
EP1908477A3 (fr) * | 2000-01-24 | 2008-06-11 | Schering Corporation | Combinaison de témozolomide et interféron alpha pégylé pour le traitement du cancer |
EP1251866A1 (fr) * | 2000-01-24 | 2002-10-30 | Schering Corporation | Combinaison de temozolomide et d'alpha-interferon pegyle pour le traitement du cancer |
RU2278123C2 (ru) | 2000-02-11 | 2006-06-20 | Максиджен Холдингз Лтд. | Молекулы, подобные фактору vii или viia |
US6476062B2 (en) | 2000-03-30 | 2002-11-05 | Schering Corporation | Chemokine receptor antagonists |
US6777387B2 (en) | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
US6756037B2 (en) | 2000-03-31 | 2004-06-29 | Enzon, Inc. | Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups |
US6924270B2 (en) | 2000-04-20 | 2005-08-02 | Schering Corporation | Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection |
WO2002002627A2 (fr) | 2000-06-30 | 2002-01-10 | Zymogenetics, Inc. | Proteine zcyto21de type interferon |
WO2002060978A1 (fr) | 2001-01-30 | 2002-08-08 | Kyowa Hakko Kogyo Co., Ltd. | Polyalkylene glycols ramifies |
BR0207576A (pt) | 2001-02-27 | 2004-04-27 | Maxygen Aps | Variante glicosilada de um polipeptìdeo de interferon beta precursor (ifnb), processos de aumentar a glicosilação in vivo de uma molécula de ifnb precursora, de produzir uma molécula de ifnb glicosilada, para preparar uma variante conjugada e de tratar um mamìfero com esclerose múltiplam composição farmacêutica, molécula de ifnb variante, sequência de nucleotìdeo, vetor de expressão, célula hospedeira de glicosilação conjugado, e, uso de um conjugado |
DE10112825A1 (de) | 2001-03-16 | 2002-10-02 | Fresenius Kabi De Gmbh | HESylierung von Wirkstoffen in wässriger Lösung |
WO2003062290A1 (fr) | 2002-01-16 | 2003-07-31 | Biocompatibles Uk Limited | Conjugues polymeres |
KR100888371B1 (ko) * | 2002-01-17 | 2009-03-13 | 동아제약주식회사 | 가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제 |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
UA86744C2 (en) | 2002-06-21 | 2009-05-25 | Ново Нордиск Хэлс Кеа Аг | Pegylated factor vii glycoforms |
AU2003258518B2 (en) | 2002-07-24 | 2007-01-18 | F. Hoffmann-La Roche Ag | Polyalkylene glycol acid additives |
IL166506A0 (en) * | 2002-09-11 | 2006-01-15 | Fresenius Kabi De Gmbh | Hasylated polypeptides especially hasylated erythropoietin |
EP1681303B1 (fr) * | 2002-09-11 | 2013-09-04 | Fresenius Kabi Deutschland GmbH | Polypeptides HASylés, en particulier érythropoiétine HASylée |
EP1400533A1 (fr) * | 2002-09-11 | 2004-03-24 | Fresenius Kabi Deutschland GmbH | Polypeptides hasylés, érythropoiétine hasylée en particulier |
ES2314238T3 (es) | 2002-10-08 | 2009-03-16 | Fresenius Kabi Deutschland Gmbh | Conjugados de oligosacaridos farmaceuticamente activos. |
US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
BR0316324A (pt) * | 2002-11-18 | 2005-09-27 | Maxygen Inc | Polipeptìdeos e conjugados de interferon-alfa |
GB0301014D0 (en) * | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
CA2458085A1 (fr) | 2003-03-21 | 2004-09-21 | F. Hoffmann-La Roche Ag | Analyse d'activite transcriptionnelle |
WO2005014655A2 (fr) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugues d'amidon d'hydroxyalkyle et de proteine |
DE602004029173D1 (de) | 2003-10-10 | 2010-10-28 | Novo Nordisk As | Il-21-derivate |
EP2641611A3 (fr) | 2003-10-17 | 2013-12-18 | Novo Nordisk A/S | Thérapie combinée |
JP2007519422A (ja) | 2004-02-02 | 2007-07-19 | アンブレツクス・インコーポレイテツド | 修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用 |
CN100355784C (zh) * | 2004-02-12 | 2007-12-19 | 江苏恒瑞医药股份有限公司 | 聚乙二醇修饰α-干扰素1b的制备方法 |
CN101659704A (zh) | 2004-03-11 | 2010-03-03 | 弗雷泽纽斯卡比德国有限公司 | 通过还原氨基化制备的羟烷基淀粉和蛋白质的偶联物 |
MXPA06013412A (es) | 2004-05-19 | 2007-01-23 | Maxygen Inc | Polipeptidos de interferon-alfa y conjugados. |
MXPA06014684A (es) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novedosos polipeptidos de enlace antigeno y sus usos. |
US20060029573A1 (en) * | 2004-06-30 | 2006-02-09 | Chun Shen | Pegylated interferon alpha-1b |
JP4971160B2 (ja) | 2004-08-12 | 2012-07-11 | シェーリング コーポレイション | 安定するpeg化インターフェロン処方物 |
BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
EP1861125A2 (fr) * | 2005-03-23 | 2007-12-05 | Nektar Therapeutics Al, Corporation | Conjugues d'un fragment de hgh et d'un polymere |
AU2006299901A1 (en) | 2005-05-18 | 2007-04-19 | Maxygen, Inc. | Evolved interferon-alpha polypeptides |
EP2360170A3 (fr) | 2005-06-17 | 2012-03-28 | Novo Nordisk Health Care AG | Réduction et dérivatisation de protéines obtenues par génie génétique comprenant au moins une cystéine non native |
WO2007002233A2 (fr) * | 2005-06-20 | 2007-01-04 | Pepgen Corporation | Analogues d'interferon-alpha humains a circulation longue et faible toxicite |
JP4261531B2 (ja) | 2005-09-06 | 2009-04-30 | 株式会社Nrlファーマ | ラクトフェリン複合体及びその製造方法 |
EP2339014B1 (fr) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Procédés et compositions comprenant des acides aminés non naturels |
CN101002944B (zh) * | 2006-01-17 | 2012-07-25 | 中国科学院过程工程研究所 | 支链聚乙二醇-干扰素结合物及其制备方法 |
CN101002945B (zh) | 2006-01-20 | 2012-09-05 | 清华大学 | 一种用于肿瘤治疗的新型复合物 |
CN100475270C (zh) | 2006-01-20 | 2009-04-08 | 清华大学 | 一种***的药物及其应用 |
AU2007250739A1 (en) | 2006-05-16 | 2007-11-22 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition for treating or preventing HCV infection |
US20090252720A1 (en) | 2006-05-24 | 2009-10-08 | Novo Nordisk Health Care Ag | Prolonged FIX Analogues and Derivatives |
NZ574721A (en) | 2006-09-08 | 2012-02-24 | Ambrx Inc | Hybrid suppressor trna for vertebrate cells |
EP2069396B1 (fr) | 2006-09-08 | 2015-10-21 | Ambrx, Inc. | Polypeptide plasmatique humain modifie ou squelettes de fc et leurs utilisations |
CN1966547B (zh) * | 2006-11-06 | 2011-11-09 | 中国药科大学 | 双链结构的聚乙二醇衍生物的制备及其与药物分子的结合 |
ATE459659T1 (de) * | 2006-11-07 | 2010-03-15 | Dsm Ip Assets Bv | Carbamat, thiocarbamat oder carbamid mit einer biomolekularen gruppierung |
KR101079993B1 (ko) | 2006-11-17 | 2011-11-04 | 동아제약주식회사 | 폴리에틸렌글리콜 과립구 콜로니 자극인자 접합체 |
CN101219219B (zh) | 2007-01-10 | 2013-02-13 | 北京普罗吉生物科技发展有限公司 | 包含血管抑素或其片段的复合物、其制备方法及应用 |
JP5515224B2 (ja) | 2007-02-28 | 2014-06-11 | 日油株式会社 | 多分岐鎖ポリオキシアルキレン誘導体 |
BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
CL2008002399A1 (es) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
PL2186830T3 (pl) | 2007-09-04 | 2012-09-28 | Biosteed Gene Expression Tech Co Ltd | Interferon alfa 2b zmodyfikowany glikolem polietylenowym, jego wytwarzanie i zastosowanie |
EP2196475B1 (fr) | 2007-09-04 | 2012-06-06 | Biosteed Gene Expression Tech. CO., LTD. | INTERFERON ALPHA 2a MODIFIÉ PAR POLYETHYLÈNEGLYCOL, SON PROCESSUS DE SYNTHÈSE ET SON APPLICATION |
NZ603812A (en) | 2007-11-20 | 2014-06-27 | Ambrx Inc | Modified insulin polypeptides and their uses |
EP2070950A1 (fr) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Dérivés hydroxyalkylés de l'amidon et leur procédé de préparation |
CN107033233A (zh) * | 2008-01-18 | 2017-08-11 | 弗·哈夫曼-拉罗切有限公司 | 非糖基化蛋白质的纯化 |
US8906847B2 (en) * | 2008-02-01 | 2014-12-09 | Ascendis Pharma A/S | Prodrug comprising a drug linker conjugate |
SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
WO2009121210A1 (fr) | 2008-04-03 | 2009-10-08 | 厦门伯赛基因转录技术有限公司 | Hormone de croissance modifiée par polyéthylèneglycol double brin, son procédé de préparation et son application |
JP6112766B2 (ja) * | 2008-04-29 | 2017-04-12 | アセンディス ファーマ グロウス ディスオーダーズ ディヴィジョン エー/エス | Peg化された組換えヒト成長ホルモン化合物 |
TW201010692A (en) | 2008-06-19 | 2010-03-16 | Public Univ Corp Nagoya City Univ | Pharmaceutical composition for treatment or prevention of hbv infection |
EA020766B1 (ru) | 2008-07-08 | 2015-01-30 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Ингибиторы пролиферации и активации переносчика сигнала и активатора транскрипции (stats) |
NZ591235A (en) | 2008-07-23 | 2012-07-27 | Ambrx Inc | Modified bovine g-csf polypeptides comprising non natural amino acid and their uses treating infections such as mastitis |
PL2342223T3 (pl) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
TR201802361T4 (tr) | 2008-09-26 | 2018-03-21 | Ambrx Inc | Doğal olmayan amino asit replikasyonuna bağımlı mikroorganizmalar ve aşılar. |
IT1399351B1 (it) | 2009-06-16 | 2013-04-16 | Fidia Farmaceutici | Procedimento per la sintesi di coniugati di glicosamminoglicani (gag) con molecole biologicamente attive, coniugati polimerici e usi relativi |
WO2011014882A1 (fr) | 2009-07-31 | 2011-02-03 | Medtronic, Inc. | Administration continue par voie sous-cutanée d'interféron-α à des patients infectés par le virus de l'hépatite c |
EA201200650A1 (ru) | 2009-10-30 | 2012-12-28 | Бёрингер Ингельхайм Интернациональ Гмбх | Курсы комбинированного лечения вируса гепатита с, включающие bi201335, интерферон-альфа и рибавирин |
CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
NZ600361A (en) | 2009-12-21 | 2014-06-27 | Ambrx Inc | Modified bovine somatotropin polypeptides and their uses |
JP6148013B2 (ja) | 2010-03-05 | 2017-06-14 | リグショスピタレト | 補体活性化のキメラ抑制分子 |
EP2569331A1 (fr) | 2010-05-10 | 2013-03-20 | Perseid Therapeutics LLC | Polypeptides inhibiteurs de vla4 |
EP2585065A1 (fr) | 2010-06-24 | 2013-05-01 | Panmed Ltd. | Traitement de maladies associées au virus de l'hépatite c utilisant de l'hydroxychloroquine ou de l'hydroxychloroquine associée à un agent antiviral |
RU2447083C1 (ru) * | 2010-07-20 | 2012-04-10 | Закрытое Акционерное Общество "Биокад" | НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ |
CA2805564A1 (fr) | 2010-08-05 | 2012-02-09 | Stefan Jenewein | Proteine de fusion anticorps anti-cmh cytokine antivirale |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
MY162837A (en) | 2010-08-17 | 2017-07-31 | Ambrx Inc | Modified relaxin polypeptides and their uses |
AR083006A1 (es) | 2010-09-23 | 2013-01-23 | Lilly Co Eli | Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas |
WO2012146630A1 (fr) | 2011-04-29 | 2012-11-01 | F. Hoffmann-La Roche Ag | Polypeptides acylés en position n-terminale, leurs procédés de préparation et leurs utilisations |
CN102229667A (zh) * | 2011-06-03 | 2011-11-02 | 北京伟嘉人生物技术有限公司 | 一种聚乙二醇修饰的猪α-干扰素及其制备方法和应用 |
CN103930440A (zh) | 2011-07-01 | 2014-07-16 | 拜耳知识产权有限责任公司 | 松弛素融合多肽及其用途 |
EA201490399A1 (ru) | 2011-08-03 | 2014-06-30 | Ситерис | Иммунотерапия hcv (вируса гепатита c) |
WO2013137869A1 (fr) | 2012-03-14 | 2013-09-19 | Boehringer Ingelheim International Gmbh | Polythérapie pour le traitement d'une infection par le hcv dans une population de patients co-infectés hcv-hiv |
JP2015512900A (ja) | 2012-03-28 | 2015-04-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 特別な患者の遺伝子亜型分集団のhcv感染症を治療するための併用療法 |
EP2859017B1 (fr) | 2012-06-08 | 2019-02-20 | Sutro Biopharma, Inc. | Anticorps comprenant des résidus d'acides aminés non endogènes spécifiques d'un site, leurs procédés de préparation et leurs procédés d'utilisation |
DK2863955T3 (en) | 2012-06-26 | 2017-01-23 | Sutro Biopharma Inc | MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF |
EP3584255B1 (fr) | 2012-08-31 | 2022-02-16 | Sutro Biopharma, Inc. | Acides aminés modifiés comprenant un groupe azido |
EA022617B1 (ru) * | 2013-03-28 | 2016-02-29 | Илья Александрович МАРКОВ | Монопегилированный интерферон-альфа разветвленной структуры и фармацевтическая композиция для приготовления лекарственного средства, обладающего активностью интерферона-альфа |
EA023323B1 (ru) * | 2013-03-28 | 2016-05-31 | Илья Александрович МАРКОВ | Разветвленный ацилазидный пегилирующий агент, способ его получения и способ получения пегилированного интерферона |
EA021610B1 (ru) * | 2013-03-28 | 2015-07-30 | Илья Александрович МАРКОВ | Жидкое противовирусное лекарственное средство |
US9764039B2 (en) | 2013-07-10 | 2017-09-19 | Sutro Biopharma, Inc. | Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use |
US9840493B2 (en) | 2013-10-11 | 2017-12-12 | Sutro Biopharma, Inc. | Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use |
EP2907512A1 (fr) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibiteurs de MMP-12 en tant qu'agents antiviraux |
RU2554761C1 (ru) * | 2014-05-13 | 2015-06-27 | Закрытое акционерное общество "Сибирский центр фармакологии и биотехнологии" | Противоэнтеровирусное и иммуностимулирующее средство |
UY36370A (es) | 2014-10-24 | 2016-04-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Polipéptidos fgf-21 modificados y sus usos |
HRP20231732T1 (hr) | 2014-11-06 | 2024-03-15 | Pharmaessentia Corporation | Režim doziranja pegiliranog interferona |
HRP20211734T8 (hr) | 2014-11-21 | 2022-03-04 | Ascendis Pharma Endocrinology Division A/S | Dozni oblici dugodjelujućeg hormona rasta |
BR112018009009A8 (pt) | 2015-11-03 | 2019-02-26 | Hoffmann La Roche | terapia combinada de um inibidor de formação de capsídeo hbv e um interferon |
CN106749608B (zh) * | 2015-11-18 | 2021-10-15 | 石药集团中奇制药技术(石家庄)有限公司 | 干扰素α缀合物 |
WO2018087345A1 (fr) | 2016-11-14 | 2018-05-17 | F. Hoffmann-La Roche Ag | Polythérapie comprenant un inhibiteur d'un antigène de hbsag, un analogue nucléosidique ou nucléotidique et un interféron |
ES2963839T3 (es) | 2017-02-08 | 2024-04-02 | Bristol Myers Squibb Co | Polipéptidos de relaxina modificados que comprenden un potenciador farmacocinético y usos de los mismos |
RU2678332C1 (ru) | 2017-09-08 | 2019-01-28 | Общество с ограниченной ответственностью "Саентифик Фьючер Менеджмент" (ООО "СФМ") | Пегилированный интерферон лямбда, обладающий высокой биодоступностью при пероральном применении, и способ его получения |
HRP20240016T1 (hr) | 2018-09-11 | 2024-03-29 | Ambrx, Inc. | Konjugati polipeptida interleukina-2 i njihove uporabe |
CN113366015A (zh) | 2018-10-19 | 2021-09-07 | Ambrx公司 | 白细胞介素-10多肽缀合物、其二聚体及其用途 |
BR112021015832A2 (pt) | 2019-02-12 | 2022-01-18 | Ambrx Inc | Composições que contêm conjugados de anticorpo-agonista de tlr, métodos e usos dos mesmos |
WO2021183832A1 (fr) | 2020-03-11 | 2021-09-16 | Ambrx, Inc. | Conjugués polypeptidiques d'interleukine-2 et leurs procédés d'utilisation |
AU2021327396A1 (en) | 2020-08-20 | 2023-03-23 | Ambrx, Inc. | Antibody-TLR agonist conjugates, methods and uses thereof |
AU2022249223A1 (en) | 2021-04-03 | 2023-10-12 | Ambrx, Inc. | Anti-her2 antibody-drug conjugates and uses thereof |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4609546A (en) | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
WO1984004745A1 (fr) | 1983-05-31 | 1984-12-06 | Takeda Chemical Industries Ltd | Nouveaux polypeptides et leur utilisation |
US4681848A (en) | 1982-09-22 | 1987-07-21 | Takeda Chemical Industries, Ltd. | Novel peptide and use thereof |
GB8430252D0 (en) * | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
JP2524586B2 (ja) | 1985-06-26 | 1996-08-14 | シタス コーポレイション | ポリマ−接合を利用する医薬組成物用蛋白質の可溶化 |
DE3719046A1 (de) | 1987-06-06 | 1988-12-15 | Basf Ag | Verwendung von salzen von sulfonamidcarbonsaeuren als korrosionsinhibitoren in waessrigen systemen |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5145773A (en) * | 1989-05-25 | 1992-09-08 | Sloan-Kettering Institute For Cancer Research | Method to detect sensitivity to alpha-interferon therapy |
ATE136315T1 (de) * | 1989-05-27 | 1996-04-15 | Sumitomo Pharma | Verfahren für die herstellung von polyethylenglykolderivate und modifizierte proteine. |
US5238915A (en) | 1991-02-08 | 1993-08-24 | Wakunaga Seiyaku K.K. | Aromatic composition and method for controlling aroma |
US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
GB9111967D0 (en) | 1991-06-04 | 1991-07-24 | Erba Carlo Spa | 2,5'-nucleotide analogs as antiviral agents |
US5281698A (en) * | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
ZA933926B (en) | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
US5359030A (en) | 1993-05-10 | 1994-10-25 | Protein Delivery, Inc. | Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
DK0730470T3 (da) * | 1993-11-10 | 2002-06-03 | Enzon Inc | Forbedrede interferonpolymerkonjugater |
AU1916295A (en) * | 1994-02-08 | 1995-08-29 | Amgen, Inc. | Oral delivery of chemically modified proteins |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5738846A (en) * | 1994-11-10 | 1998-04-14 | Enzon, Inc. | Interferon polymer conjugates and process for preparing the same |
US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
TW426523B (en) | 1995-04-06 | 2001-03-21 | Hoffmann La Roche | Interferon solution |
CA2458085A1 (fr) * | 2003-03-21 | 2004-09-21 | F. Hoffmann-La Roche Ag | Analyse d'activite transcriptionnelle |
-
1997
- 1997-04-19 TW TW086105104A patent/TW517067B/zh not_active IP Right Cessation
- 1997-04-23 CA CA002203480A patent/CA2203480C/fr not_active Expired - Lifetime
- 1997-05-07 RS YU17597A patent/RS49533B/sr unknown
- 1997-05-09 TR TR97/00358A patent/TR199700358A3/tr unknown
- 1997-05-12 SG SG1997001485A patent/SG55314A1/en unknown
- 1997-05-14 SA SA97180030A patent/SA97180030B1/ar unknown
- 1997-05-22 DE DE69720320T patent/DE69720320T2/de not_active Expired - Lifetime
- 1997-05-22 ES ES97108261T patent/ES2110386T3/es not_active Expired - Lifetime
- 1997-05-22 SI SI9730506T patent/SI0809996T1/xx unknown
- 1997-05-22 DE DE0809996T patent/DE809996T1/de active Pending
- 1997-05-22 AT AT97108261T patent/ATE235920T1/de active
- 1997-05-22 EP EP97108261A patent/EP0809996B1/fr not_active Expired - Lifetime
- 1997-05-22 PT PT97108261T patent/PT809996E/pt unknown
- 1997-05-22 DE DE2003199018 patent/DE10399018I1/de active Pending
- 1997-05-22 DK DK97108261T patent/DK0809996T3/da active
- 1997-05-23 IL IL12090297A patent/IL120902A/en not_active IP Right Cessation
- 1997-05-26 NZ NZ314903A patent/NZ314903A/xx not_active IP Right Cessation
- 1997-05-26 ZA ZA974583A patent/ZA974583B/xx unknown
- 1997-05-27 PA PA19978431001A patent/PA8431001A1/es unknown
- 1997-05-27 EG EG46597A patent/EG24292A/xx active
- 1997-05-27 TN TNTNSN97091A patent/TNSN97091A1/fr unknown
- 1997-05-28 SK SK673-97A patent/SK284458B6/sk not_active IP Right Cessation
- 1997-05-28 HR HR970298A patent/HRP970298B1/xx not_active IP Right Cessation
- 1997-05-28 HU HU9700959A patent/HU227992B1/hu unknown
- 1997-05-28 PL PL97320251A patent/PL186949B1/pl unknown
- 1997-05-29 CN CN97113049A patent/CN1088721C/zh not_active Expired - Lifetime
- 1997-05-29 MY MYPI97002342A patent/MY117909A/en unknown
- 1997-05-29 AR ARP970102305A patent/AR008378A1/es active IP Right Grant
- 1997-05-29 JP JP9139807A patent/JP2980569B2/ja not_active Expired - Lifetime
- 1997-05-29 CO CO97029836A patent/CO4950528A1/es unknown
- 1997-05-30 OA OA70015A patent/OA10488A/fr unknown
- 1997-05-30 MA MA24641A patent/MA24193A1/fr unknown
- 1997-05-30 BG BG101540A patent/BG62273B1/bg unknown
- 1997-05-30 UA UA97052543A patent/UA56989C2/uk unknown
- 1997-05-30 RU RU97108698/14A patent/RU2180595C2/ru active
- 1997-05-30 KR KR1019970022223A patent/KR100254097B1/ko not_active IP Right Cessation
- 1997-05-30 TJ TJ97000465A patent/TJ328B/xx unknown
- 1997-05-30 AU AU23723/97A patent/AU725195B2/en not_active Expired
- 1997-05-30 UY UY24572A patent/UY24572A1/es not_active IP Right Cessation
- 1997-05-30 IS IS4491A patent/IS1988B/is unknown
- 1997-05-30 NO NO19972480A patent/NO322964B1/no not_active IP Right Cessation
- 1997-05-30 SV SV1997000049A patent/SV1997000049A/es not_active Application Discontinuation
- 1997-05-30 CZ CZ19971679A patent/CZ292775B6/cs not_active IP Right Cessation
- 1997-06-02 BR BR9703421A patent/BR9703421A/pt not_active IP Right Cessation
-
1998
- 1998-01-30 GR GR970300063T patent/GR970300063T1/el unknown
- 1998-05-21 HK HK98104388A patent/HK1005225A1/xx not_active IP Right Cessation
-
2003
- 2003-02-27 US US10/377,892 patent/US7201897B2/en not_active Expired - Fee Related
- 2003-05-08 NL NL300127C patent/NL300127I2/nl unknown
- 2003-06-25 LU LU91029C patent/LU91029I2/fr unknown
-
2004
- 2004-03-19 CY CY0400021A patent/CY2433B1/xx unknown
-
2005
- 2005-04-05 CY CY200500006C patent/CY2005006I1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TNSN97091A1 (fr) | CONJUGUE PEG-IFN α PHYSIOLOGIQUEMENT ACTIF, PROCEDE POUR SA PREPARATION, COMPOSITIONS PHARMACEUTIQUES LE CONTENANT ET LEUR UTILISATION | |
Fichtenbaum et al. | Use of paromomycin for treatment of cryptosporidiosis in patients with AIDS | |
EA200100524A1 (ru) | Амиды антраниловой кислоты и их применение в качестве лекарственных средств | |
TW262461B (fr) | ||
DE69529670T2 (de) | Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen | |
BG101118A (en) | Therapeutical compounds | |
RU94041223A (ru) | Средство для лечения мотонейроновых заболеваний | |
BG104727A (en) | Pharmaceutical composition of topiramate | |
BE901737A (fr) | Composition pharmaceutique pour le traitement de l'ischemie myocardique aigue. | |
TNSN97192A1 (fr) | Derives de pyrimidine bicycliques condenses, procede pour leur preparation et compositions pharmaceutiques les contenant. | |
EE9400356A (et) | Polüetüleenglükool proteiin konjugaadid, ühendid, nende kasutamine, meetod konjugaatide valmistamiseks ja ravimvormid | |
CA2079342A1 (fr) | Composes pharmaceutiques multifonctionnels, leur methode de fabrication et leurs utilisations | |
MA26608A1 (fr) | Procede de preparation d'une composition pharmaceutique destinee au traitement de l'insuffisance cardiaque. | |
EP0315591A3 (en) | Physiologically active substances, a process for the preparation thereof and pharmaceutical compositions containing them | |
MA27676A1 (fr) | 2-amino-6-(2-substitue-4-phenoxy)-substitue-pyridines, procede pour leur preparation et compositions pharmaceutiques les contenant | |
FR2711140B1 (fr) | 1-Naphtylpyrazole-3-carboxamides substitués actifs sur la neurotensine, leur préparation, les compositions pharmaceutiques en contenant. | |
TNSN90021A1 (fr) | Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales | |
TW197423B (fr) | ||
CA2038744A1 (fr) | Composition pharmaceutique contenant un medicament legerement hydrosoluble | |
BR9503572A (pt) | Composto composiçao farmaceutica e método de tratamento ou prevençao de uma doença | |
HUP9802431A2 (hu) | Pentozán-poliszulfátot tartalmazó, krónikus progresszív érbetegségek kezelésére alkalmas gyógyszerkészítmények | |
FR2393579A1 (fr) | Agent antiviral et son application au traitement des affections virales | |
FR2362587A1 (fr) | Agents antimicrobie | |
FR2434623A1 (fr) | Composition antibacterienne a la trimethoprime comprenant un sulfonamide et du phenoxyethanol | |
DE69621786T2 (de) | Aminotetralinderivat zur behandlung von herzkreislauferkrankung |