DE69529670T2 - Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen - Google Patents
Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- DE69529670T2 DE69529670T2 DE69529670T DE69529670T DE69529670T2 DE 69529670 T2 DE69529670 T2 DE 69529670T2 DE 69529670 T DE69529670 T DE 69529670T DE 69529670 T DE69529670 T DE 69529670T DE 69529670 T2 DE69529670 T2 DE 69529670T2
- Authority
- DE
- Germany
- Prior art keywords
- compositions containing
- pharmaceutical compositions
- oxazolidinone derivatives
- present
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/36—One oxygen atom
- C07D263/38—One oxygen atom attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4394994 | 1994-03-15 | ||
JP14656594 | 1994-06-28 | ||
JP6235167A JPH0873455A (ja) | 1994-03-15 | 1994-09-29 | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
PCT/US1995/002972 WO1995025106A1 (en) | 1994-03-15 | 1995-03-14 | Oxazolidinone derivatives and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69529670D1 DE69529670D1 (de) | 2003-03-27 |
DE69529670T2 true DE69529670T2 (de) | 2003-09-18 |
Family
ID=27291734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69529670T Expired - Lifetime DE69529670T2 (de) | 1994-03-15 | 1995-03-14 | Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0750618B1 (de) |
JP (2) | JPH0873455A (de) |
KR (1) | KR100340365B1 (de) |
CN (1) | CN1143961A (de) |
AT (1) | ATE232862T1 (de) |
AU (1) | AU681953B2 (de) |
CA (1) | CA2183972C (de) |
DE (1) | DE69529670T2 (de) |
DK (1) | DK0750618T3 (de) |
ES (1) | ES2191048T3 (de) |
LV (1) | LV13155B (de) |
NZ (1) | NZ283011A (de) |
PT (1) | PT750618E (de) |
WO (1) | WO1995025106A1 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT828741E (pt) * | 1995-05-11 | 2002-02-28 | Upjohn Co | Oxazolidinonas de diazinilo espirociclico e biciclico e de carbazinilo |
DE69631347T2 (de) * | 1995-09-15 | 2004-10-07 | Upjohn Co | Aminoaryl oxazolidinone n-oxide |
GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
JP2000508312A (ja) * | 1996-04-11 | 2000-07-04 | ファルマシア・アンド・アップジョン・カンパニー | オキサゾリジノンの製法 |
GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
DE19709443C1 (de) * | 1997-03-07 | 1998-10-08 | Clariant Gmbh | Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen und N-Carboxymethyl-3-fluor-4-morpholinoanilin und N-Carboxyisobutyl-3-fluor-4-morpholinoanilin |
DE19750968A1 (de) * | 1997-03-07 | 1998-09-10 | Clariant Gmbh | Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen |
US6037354A (en) * | 1997-06-18 | 2000-03-14 | Merck & Co., Inc. | Alpha 1a adrenergic receptor antagonists |
GB9717807D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
KR100467309B1 (ko) * | 1997-09-04 | 2005-07-18 | 씨제이 주식회사 | 옥사졸리디논유도체및그의제조방법및항균제조성물 |
KR100463111B1 (ko) * | 1997-10-30 | 2005-06-13 | 씨제이 주식회사 | 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물 |
HUP0100470A3 (en) * | 1997-11-12 | 2002-08-28 | Upjohn Co | Oxazolidinone derivatives and pharmaceutical compositions containing them |
GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
US6069141A (en) * | 1998-02-13 | 2000-05-30 | Pharmacia & Upjohn Company | Substituted aminophenyl isoxazoline derivatives useful as antimicrobials |
PL363960A1 (en) | 2000-07-17 | 2004-11-29 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
AU2002256995A1 (en) | 2001-02-07 | 2002-08-28 | Ortho-Mcneil Pharmaceutical, Inc. | Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
EP1409464A4 (de) * | 2001-07-16 | 2005-11-02 | Ranbaxy Lab Ltd | Oxazolidinonderivate als potentielle antimikrobielle mittel |
US6956040B2 (en) | 2001-07-16 | 2005-10-18 | Ranbaxy Laboratories Limited | Oxazolidinone piperazinyl derivatives as potential antimicrobials |
KR100445437B1 (ko) * | 2002-02-08 | 2004-08-21 | 한국과학기술연구원 | 네오마이신-옥사졸리디논 헤테로 이합체, 그의 제조방법및 그의 용도 |
US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
AR038536A1 (es) | 2002-02-25 | 2005-01-19 | Upjohn Co | N-aril-2-oxazolidinona-5- carboxamidas y sus derivados |
EP1546140A2 (de) * | 2002-07-11 | 2005-06-29 | Wockhardt Limited | Antimikrobielle oxazolidinone, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen |
WO2004007489A2 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them |
WO2004009549A2 (en) * | 2002-07-18 | 2004-01-29 | Actelion Pharmaceuticals Ltd | Piperidines useful for the treatment of central nervous system disorders |
CA2491287A1 (en) | 2002-08-12 | 2004-02-19 | Pharmacia & Upjohn Company | N-aryl-2-oxazolidinones and their derivatives |
ES2271660T3 (es) | 2002-11-21 | 2007-04-16 | PHARMACIA & UPJOHN COMPANY LLC | Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos. |
MXPA06002188A (es) * | 2003-08-25 | 2006-04-27 | Warner Lambert Co | Nuevos compuestos antimicrobianos de ariloxazolidinona. |
US7687627B2 (en) * | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
CN100545150C (zh) * | 2003-09-12 | 2009-09-30 | 中国科学院上海药物研究所 | 含吡啶环的噁唑烷酮类化合物、制备方法及用途 |
US7304050B2 (en) | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
US20090018123A1 (en) * | 2005-06-20 | 2009-01-15 | Milind D Sindkhedkar | Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation |
AU2007251289A1 (en) * | 2006-05-09 | 2007-11-22 | Prasad Keshav Deshpande | Substituted piperidino phenyloxazolidinones |
EP2069339B1 (de) * | 2006-09-25 | 2011-05-18 | Wockhardt Research Centre | Substituierte piperidinophenyloxazolidinone |
WO2010109299A2 (en) * | 2009-03-27 | 2010-09-30 | Council Of Scientific & Industrial Research | Substituted 1, 4-dioxa-8-azaspiro [4,5] decanes useful as fungicides and a process for the preparation thereof |
WO2012059823A1 (en) | 2010-11-03 | 2012-05-10 | Wockhardt Limited | Process for the preparation of phosphoric acid mono- (l-{4- [(s) -5- (acetylaminomethyl) - 2 - oxo - oxazolidin- 3 - yl] - 2, 6 - difluorophenyl} - 4 -methoxymethylpiperidin- 4 - yl) ester |
UA112876C2 (uk) | 2011-09-29 | 2016-11-10 | Сюаньчжу Фарма Ко., Лтд. | Біарилгетероциклзаміщені оксазолідинонові антибактеріальні засоби |
CN104364240B (zh) * | 2012-06-08 | 2017-02-22 | 四川贝力克生物技术有限责任公司 | 一种用于预防或治疗分支杆菌疾病的药物 |
WO2015173664A1 (en) | 2014-05-14 | 2015-11-19 | Wockhardt Limited | Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide |
CN112543756A (zh) * | 2018-07-25 | 2021-03-23 | 卡迪拉保健有限公司 | 用于治疗哺乳动物感染的经取代噁唑烷酮类 |
US20230219941A1 (en) | 2020-06-18 | 2023-07-13 | Akagera Medicines, Inc. | Oxazolidinone compounds, liposome compositions comprising oxazolidinone compounds and methods of use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
EP0610265B1 (de) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituierte aryl- und heteroaryl-phenyloxazolidinone |
SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
-
1994
- 1994-09-29 JP JP6235167A patent/JPH0873455A/ja active Pending
-
1995
- 1995-03-14 WO PCT/US1995/002972 patent/WO1995025106A1/en active IP Right Grant
- 1995-03-14 AT AT95913624T patent/ATE232862T1/de not_active IP Right Cessation
- 1995-03-14 PT PT95913624T patent/PT750618E/pt unknown
- 1995-03-14 NZ NZ283011A patent/NZ283011A/en unknown
- 1995-03-14 CA CA002183972A patent/CA2183972C/en not_active Expired - Fee Related
- 1995-03-14 EP EP95913624A patent/EP0750618B1/de not_active Expired - Lifetime
- 1995-03-14 DE DE69529670T patent/DE69529670T2/de not_active Expired - Lifetime
- 1995-03-14 CN CN95192083A patent/CN1143961A/zh active Pending
- 1995-03-14 AU AU20999/95A patent/AU681953B2/en not_active Ceased
- 1995-03-14 ES ES95913624T patent/ES2191048T3/es not_active Expired - Lifetime
- 1995-03-14 DK DK95913624T patent/DK0750618T3/da active
- 1995-03-14 KR KR1019960705086A patent/KR100340365B1/ko not_active IP Right Cessation
- 1995-03-14 JP JP52365595A patent/JP3628329B2/ja not_active Expired - Fee Related
-
2004
- 2004-02-19 LV LVP-04-20A patent/LV13155B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK0750618T3 (da) | 2003-06-10 |
AU2099995A (en) | 1995-10-03 |
KR100340365B1 (ko) | 2002-11-23 |
JPH09512785A (ja) | 1997-12-22 |
CN1143961A (zh) | 1997-02-26 |
CA2183972A1 (en) | 1995-09-21 |
DE69529670D1 (de) | 2003-03-27 |
JPH0873455A (ja) | 1996-03-19 |
NZ283011A (en) | 1997-09-22 |
ES2191048T3 (es) | 2003-09-01 |
PT750618E (pt) | 2003-06-30 |
AU681953B2 (en) | 1997-09-11 |
CA2183972C (en) | 2005-07-05 |
ATE232862T1 (de) | 2003-03-15 |
EP0750618B1 (de) | 2003-02-19 |
JP3628329B2 (ja) | 2005-03-09 |
WO1995025106A1 (en) | 1995-09-21 |
MX9604072A (es) | 1997-09-30 |
LV13155B (en) | 2004-06-20 |
EP0750618A1 (de) | 1997-01-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |