TNSN96107A1 - Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant - Google Patents

Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant

Info

Publication number
TNSN96107A1
TNSN96107A1 TNTNSN96107A TNSN96107A TNSN96107A1 TN SN96107 A1 TNSN96107 A1 TN SN96107A1 TN TNSN96107 A TNTNSN96107 A TN TNSN96107A TN SN96107 A TNSN96107 A TN SN96107A TN SN96107 A1 TNSN96107 A1 TN SN96107A1
Authority
TN
Tunisia
Prior art keywords
benzylaminopiperidines
substituted
compositions containing
pharmaceutical compositions
compounds
Prior art date
Application number
TNTNSN96107A
Other languages
English (en)
Inventor
Satake Kunio
Shishido Yuji
Wakabayashi Hiroaki
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN96107A1 publication Critical patent/TNSN96107A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES BENZYLAMINOPIPERIDINES SUBSTITUES UTILES EN CHIMIE MEDICALE ET THERAPEUTIQUE. CES COMPOSES REPONDENT A LA FORMULE : DANS LAQUELLE R, R1, et X CHOISIS ENTRE L’HYDROGENE ET DIVERS SUBSTITUANTS ORGANIQUES. APPLICATION : UTILISATION DE COMPOSITIONS RENFERMANT CES COMPOSES POUR LE TRAITEMENT DE DIVERSES MALADIES ET AFFECTIONS, NOTAMMENT DU TRACTUS GASTRO-INTESTINAL ET DU SYSTEME NERVEUX CENTRAL, CHEZ UN MAMMIFERE, EN PARTICULIER L'HOMME.
TNTNSN96107A 1995-08-24 1996-06-10 Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant TNSN96107A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24

Publications (1)

Publication Number Publication Date
TNSN96107A1 true TNSN96107A1 (fr) 2005-03-15

Family

ID=11004362

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN96107A TNSN96107A1 (fr) 1995-08-24 1996-06-10 Benzylaminopiperidines substitues et compositions pharmaceutiques les contenant

Country Status (42)

Country Link
US (1) US6506775B1 (fr)
EP (2) EP0861235B1 (fr)
JP (1) JP3084069B2 (fr)
KR (1) KR100288673B1 (fr)
CN (1) CN1153764C (fr)
AP (1) AP643A (fr)
AR (1) AR006305A1 (fr)
AT (2) ATE208377T1 (fr)
AU (1) AU702698B2 (fr)
BG (1) BG64126B1 (fr)
BR (1) BR9609989A (fr)
CA (1) CA2227814C (fr)
CO (1) CO4480738A1 (fr)
CZ (1) CZ297543B6 (fr)
DE (2) DE69631390T2 (fr)
DK (2) DK1114817T3 (fr)
DZ (1) DZ2086A1 (fr)
ES (2) ES2211684T3 (fr)
HK (1) HK1014935A1 (fr)
HR (1) HRP960386B1 (fr)
HU (1) HU225480B1 (fr)
IL (1) IL119078A (fr)
IS (1) IS1947B (fr)
MA (1) MA23961A1 (fr)
MX (1) MX9801467A (fr)
MY (1) MY114800A (fr)
NO (1) NO310720B1 (fr)
NZ (1) NZ308207A (fr)
OA (1) OA10666A (fr)
PE (2) PE20010700A1 (fr)
PL (1) PL186773B1 (fr)
PT (2) PT861235E (fr)
RO (1) RO119299B1 (fr)
RU (1) RU2152930C2 (fr)
SI (2) SI0861235T1 (fr)
SK (1) SK282925B6 (fr)
TN (1) TNSN96107A1 (fr)
TR (1) TR199800300T1 (fr)
TW (1) TW340842B (fr)
UA (1) UA48981C2 (fr)
WO (1) WO1997008144A1 (fr)
YU (1) YU49122B (fr)

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WO2000071538A2 (fr) * 1999-05-21 2000-11-30 Pfizer Products Inc. Derives 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchromane
JP2001172178A (ja) * 1999-10-25 2001-06-26 Pfizer Prod Inc 偏頭痛治療用のｎｋ−１レセプターアンタゴニスト及びエレトリプタン
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (fr) * 2000-09-28 2003-03-26 Pfizer Products Inc. Composition pour le traitement de la dépression et de l'anxieté contenant un antagoniste du recepteur NK-3 et un antagoniste du récepteur NK-1
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
WO2004094380A1 (fr) 2003-04-18 2004-11-04 Eli Lilly And Company Composes (piperidinyloxy)phenyle, (piperidinyloxy)pyridinyle, (piperidinylsulfanyl)phenyle et (piperidinylsulfanyl)pyridinyle utilises comme agonistes des recepteurs 5-ht1f
CA2566920A1 (fr) * 2004-05-21 2005-12-01 Pfizer Products Inc. Metabolites de (+)-(2s, 3s)-3-(2-methoxy-5-trifluoromethoxybenzylamino)-2-phenyl-piperidine
US7541357B2 (en) 2004-07-15 2009-06-02 Amr Technology, Inc. Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
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CA2664113C (fr) 2006-09-22 2013-05-28 Merck & Co., Inc. Utilisation de la platencine et de la platensimycine en tant qu'inhibiteurs de la synthese des acides gras pour traiter l'obesite, lediabete et le cancer
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP4611444B2 (ja) 2007-01-10 2011-01-12 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
CA2682727C (fr) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Derive d'indoledione
EP3103791B1 (fr) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. Dérivés de 4-carboxybenzylamino utilisés comme inhibiteurs de l'histone désacétylase
US8598184B2 (en) 2008-03-03 2013-12-03 Tiger Pharmatech Protein kinase inhibitors
US7951822B2 (en) 2008-03-31 2011-05-31 Kowa Company, Ltd. 1,3-dihydroisobenzofuran derivatives
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (fr) 2009-04-01 2010-10-07 Merck Sharp & Dohme Corp. Inhibiteurs de l'activité akt
PE20120373A1 (es) 2009-05-12 2012-05-17 Albany Molecular Res Inc 7-([1,2,4]triazolo[1,5-a]piridin-6-il)-4-(3,4-diclorofenil)-1,2,3,4-tetrahidroisoquinolina
WO2010132487A1 (fr) 2009-05-12 2010-11-18 Bristol-Myers Squibb Company Formes cristallines de (s)-7-([1,2,4]triazolo[1,5-a] pyridin -6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline et leurs utilisations
CN102458123A (zh) 2009-05-12 2012-05-16 阿尔巴尼分子研究公司 芳基、杂芳基和杂环取代的四氢异喹啉及其用途
JP5099731B1 (ja) 2009-10-14 2012-12-19 メルク・シャープ・アンド・ドーム・コーポレーション ｐ５３活性を増大する置換ピペリジン及びその使用
EP2584903B1 (fr) 2010-06-24 2018-10-24 Merck Sharp & Dohme Corp. Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
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WO2014120748A1 (fr) 2013-01-30 2014-08-07 Merck Sharp & Dohme Corp. Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
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EP3706742B1 (fr) 2017-11-08 2023-03-15 Merck Sharp & Dohme LLC Inhibiteurs de prmt5
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Also Published As

Publication number Publication date
PT1114817E (pt) 2004-05-31
DE69616817T2 (de) 2002-04-04
MA23961A1 (fr) 1997-04-01
IL119078A0 (en) 1996-11-14
CA2227814C (fr) 2002-12-31
CN1153764C (zh) 2004-06-16
SK20798A3 (en) 1999-03-12
DK0861235T3 (da) 2001-12-27
NO310720B1 (no) 2001-08-20
AP643A (en) 1998-04-24
PT861235E (pt) 2002-03-28
DE69631390T2 (de) 2004-11-25
EP0861235A1 (fr) 1998-09-02
BG64126B1 (bg) 2004-01-30
HRP960386A2 (en) 1998-04-30
HRP960386B1 (en) 2002-04-30
AP9600850A0 (en) 1996-10-31
KR19990044077A (ko) 1999-06-25
IS4644A (is) 1997-12-30
ES2211684T3 (es) 2004-07-16
TW340842B (en) 1998-09-21
IS1947B (is) 2004-10-13
BG102288A (en) 1998-09-30
RO119299B1 (ro) 2004-07-30
YU47896A (sh) 1998-12-23
NO980751L (no) 1998-02-23
KR100288673B1 (ko) 2001-05-02
NZ308207A (en) 1998-07-28
TR199800300T1 (xx) 1998-06-22
YU49122B (sh) 2004-03-12
EP0861235B1 (fr) 2001-11-07
CZ52198A3 (cs) 1999-01-13
CO4480738A1 (es) 1997-07-09
ATE208377T1 (de) 2001-11-15
CA2227814A1 (fr) 1997-03-06
JPH10510554A (ja) 1998-10-13
US6506775B1 (en) 2003-01-14
SI0861235T1 (en) 2002-04-30
DZ2086A1 (fr) 2002-07-22
DE69616817D1 (de) 2001-12-13
CN1193961A (zh) 1998-09-23
SI1114817T1 (en) 2004-06-30
EP1114817B1 (fr) 2004-01-21
PL186773B1 (pl) 2004-02-27
PL325332A1 (en) 1998-07-20
ES2163017T3 (es) 2002-01-16
EP1114817A1 (fr) 2001-07-11
NO980751D0 (no) 1998-02-23
PE20010700A1 (es) 2001-07-09
SK282925B6 (sk) 2003-01-09
HUP9901159A3 (en) 2000-05-29
OA10666A (en) 2002-11-25
DE69631390D1 (de) 2004-02-26
HU225480B1 (en) 2006-12-28
AU5776996A (en) 1997-03-19
HK1014935A1 (en) 1999-10-08
PE1398A1 (es) 1998-02-27
ATE258166T1 (de) 2004-02-15
AU702698B2 (en) 1999-03-04
BR9609989A (pt) 1999-07-06
WO1997008144A1 (fr) 1997-03-06
MY114800A (en) 2003-01-31
RU2152930C2 (ru) 2000-07-20
JP3084069B2 (ja) 2000-09-04
IL119078A (en) 2003-11-23
UA48981C2 (uk) 2002-09-16
AR006305A1 (es) 1999-08-25
MX9801467A (es) 1998-05-31
HUP9901159A2 (hu) 1999-07-28
DK1114817T3 (da) 2004-04-26
CZ297543B6 (cs) 2007-02-07

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