DK0861235T3 - Substituerede benzylaminopiperidinforbindelser - Google Patents

Substituerede benzylaminopiperidinforbindelser

Info

Publication number
DK0861235T3
DK0861235T3 DK96914375T DK96914375T DK0861235T3 DK 0861235 T3 DK0861235 T3 DK 0861235T3 DK 96914375 T DK96914375 T DK 96914375T DK 96914375 T DK96914375 T DK 96914375T DK 0861235 T3 DK0861235 T3 DK 0861235T3
Authority
DK
Denmark
Prior art keywords
compounds
substituted
substituted benzylaminopiperidine
benzylaminopiperidine compounds
benzylaminopiperidine
Prior art date
Application number
DK96914375T
Other languages
English (en)
Inventor
Kunio Satake
Yuji Shishido
Hiroaki Wakabayashi
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0861235T3 publication Critical patent/DK0861235T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK96914375T 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser DK0861235T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9500683 1995-08-24
PCT/IB1996/000572 WO1997008144A1 (en) 1995-08-24 1996-06-10 Substituted benzylaminopiperidine compounds

Publications (1)

Publication Number Publication Date
DK0861235T3 true DK0861235T3 (da) 2001-12-27

Family

ID=11004362

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01108350T DK1114817T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser
DK96914375T DK0861235T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK01108350T DK1114817T3 (da) 1995-08-24 1996-06-10 Substituerede benzylaminopiperidinforbindelser

Country Status (42)

Country Link
US (1) US6506775B1 (da)
EP (2) EP0861235B1 (da)
JP (1) JP3084069B2 (da)
KR (1) KR100288673B1 (da)
CN (1) CN1153764C (da)
AP (1) AP643A (da)
AR (1) AR006305A1 (da)
AT (2) ATE208377T1 (da)
AU (1) AU702698B2 (da)
BG (1) BG64126B1 (da)
BR (1) BR9609989A (da)
CA (1) CA2227814C (da)
CO (1) CO4480738A1 (da)
CZ (1) CZ297543B6 (da)
DE (2) DE69631390T2 (da)
DK (2) DK1114817T3 (da)
DZ (1) DZ2086A1 (da)
ES (2) ES2211684T3 (da)
HK (1) HK1014935A1 (da)
HR (1) HRP960386B1 (da)
HU (1) HU225480B1 (da)
IL (1) IL119078A (da)
IS (1) IS1947B (da)
MA (1) MA23961A1 (da)
MX (1) MX9801467A (da)
MY (1) MY114800A (da)
NO (1) NO310720B1 (da)
NZ (1) NZ308207A (da)
OA (1) OA10666A (da)
PE (2) PE1398A1 (da)
PL (1) PL186773B1 (da)
PT (2) PT1114817E (da)
RO (1) RO119299B1 (da)
RU (1) RU2152930C2 (da)
SI (2) SI0861235T1 (da)
SK (1) SK282925B6 (da)
TN (1) TNSN96107A1 (da)
TR (1) TR199800300T1 (da)
TW (1) TW340842B (da)
UA (1) UA48981C2 (da)
WO (1) WO1997008144A1 (da)
YU (1) YU49122B (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9706196A (es) * 1996-08-14 1998-02-28 Pfizer Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p.
TW426667B (en) * 1997-11-19 2001-03-21 Pfizer Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance P antagonists
US6777428B1 (en) 1999-02-10 2004-08-17 Eli Lilly And Company 5-HT1f agonist
OA11864A (en) * 1999-05-06 2006-03-03 Pfizer Prod Inc Substituted benzolactam compounds.
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
TR200103332T2 (tr) 1999-05-21 2002-04-22 Pfizer Products Inc. 1-Triflorometil-4-hidroksi-7-piperidinil-aminometilkroman türevleri.
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (en) * 2000-09-28 2003-03-26 Pfizer Products Inc. Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist
US6911544B2 (en) 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
JP2006523692A (ja) 2003-04-18 2006-10-19 イーライ リリー アンド カンパニー 5−ht1f作用薬としての(ピペリジニルオキシ)フェニル、(ピペリジニルオキシ)ピリジニル、(ピペリジニルスルファニル)フェニル、および(ピペリジニルスルファニル)ピリジニル化合物
MXPA06013484A (es) * 2004-05-21 2007-01-23 Pfizer Prod Inc Metabolitos de (+)-(2s, 3s)-3-(2- metoxi-5- trifluorometoxibencilamino) -2-fenil- piperidina.
ZA200701232B (en) 2004-07-15 2008-08-27 Amr Technology Inc Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
ATE550019T1 (de) 2005-05-17 2012-04-15 Merck Sharp & Dohme Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs
US7956050B2 (en) 2005-07-15 2011-06-07 Albany Molecular Research, Inc. Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
EP1940842B1 (en) 2005-09-29 2012-05-30 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
GB0603041D0 (en) 2006-02-15 2006-03-29 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2698157B1 (en) 2006-09-22 2015-05-20 Merck Sharp & Dohme Corp. Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2109608B1 (en) 2007-01-10 2011-03-23 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
AU2008233662B2 (en) 2007-04-02 2012-08-23 Msd K.K. Indoledione derivative
US8389553B2 (en) 2007-06-27 2013-03-05 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CN102014631A (zh) 2008-03-03 2011-04-13 泰格尔医药科技公司 酪氨酸激酶抑制剂
JP5511080B2 (ja) 2008-03-31 2014-06-04 興和株式会社 1,3−ジヒドロイソベンゾフラン誘導体
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
CA2760837C (en) 2009-05-12 2018-04-03 Albany Molecular Research, Inc. 7-([1,2,4]triazolo[1,5-.alpha.]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
JP5739415B2 (ja) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー (S)−7−([1,2,4]トリアゾロ[1,5−a]ピリジン−6−イル)−4−(3,4−ジクロロフェニル)−1,2,3,4−テトラヒドロイソキノリンの結晶形態およびその使用
WO2010132437A1 (en) 2009-05-12 2010-11-18 Albany Molecular Research, Inc. Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
EP2488028B1 (en) 2009-10-14 2020-08-19 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CN103068980B (zh) 2010-08-02 2017-04-05 瑟纳治疗公司 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制
KR102072631B1 (ko) 2010-08-17 2020-02-03 시르나 쎄러퓨틱스 인코퍼레이티드 짧은 간섭 핵산 (siNA)을 사용한 B형 간염 바이러스 (HBV) 유전자 발현의 RNA 간섭 매개 억제
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en) 2010-09-01 2012-03-08 Schering Corporation Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en) 2010-10-29 2021-01-20 Sirna Therapeutics, Inc. Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
WO2012087772A1 (en) 2010-12-21 2012-06-28 Schering Corporation Indazole derivatives useful as erk inhibitors
US20140046059A1 (en) 2011-04-21 2014-02-13 Piramal Enterprises Limited Process for the preparation of morpholino sulfonyl indole derivatives
US9023865B2 (en) 2011-10-27 2015-05-05 Merck Sharp & Dohme Corp. Compounds that are ERK inhibitors
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神***病を処置するための方法および組成物
ES2651347T3 (es) 2012-11-28 2018-01-25 Merck Sharp & Dohme Corp. Composiciones y métodos para el tratamiento del cáncer
CA2895504A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
WO2020033282A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232929A (en) * 1990-11-28 1993-08-03 Pfizer Inc. 3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5364943A (en) * 1991-11-27 1994-11-15 Pfizer Inc. Preparation of substituted piperidines
WO1992017449A1 (en) * 1991-03-26 1992-10-15 Pfizer Inc. Stereoselective preparation of substituted piperidines
ES2092113T3 (es) * 1991-06-20 1996-11-16 Pfizer Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
US5340826A (en) * 1993-02-04 1994-08-23 Pfizer Inc. Pharmaceutical agents for treatment of urinary incontinence
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis
EP0653208A3 (en) * 1993-11-17 1995-10-11 Pfizer Substance P antagonists for the treatment or prevention of sunburn.
EP0655246A1 (en) * 1993-11-30 1995-05-31 Pfizer Inc. Substance P antagonists for the treatment of disorders caused by helicobacter pylori or other spiral urease-positive gram-negative bacteria
PT780375E (pt) * 1995-12-21 2002-12-31 Pfizer 3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia p
US5990125A (en) 1996-01-19 1999-11-23 Pfizer Inc. NK-1 receptor antagonists for the treatment of cancer

Also Published As

Publication number Publication date
IL119078A (en) 2003-11-23
DE69631390T2 (de) 2004-11-25
CZ52198A3 (cs) 1999-01-13
RU2152930C2 (ru) 2000-07-20
OA10666A (en) 2002-11-25
DE69616817D1 (de) 2001-12-13
PL325332A1 (en) 1998-07-20
AU5776996A (en) 1997-03-19
HRP960386A2 (en) 1998-04-30
HUP9901159A3 (en) 2000-05-29
NO980751L (no) 1998-02-23
ES2211684T3 (es) 2004-07-16
DE69616817T2 (de) 2002-04-04
MA23961A1 (fr) 1997-04-01
AP9600850A0 (en) 1996-10-31
YU47896A (sh) 1998-12-23
PL186773B1 (pl) 2004-02-27
TR199800300T1 (xx) 1998-06-22
CN1193961A (zh) 1998-09-23
DZ2086A1 (fr) 2002-07-22
EP0861235B1 (en) 2001-11-07
PT1114817E (pt) 2004-05-31
IS1947B (is) 2004-10-13
AR006305A1 (es) 1999-08-25
UA48981C2 (uk) 2002-09-16
PT861235E (pt) 2002-03-28
SK20798A3 (en) 1999-03-12
BG64126B1 (bg) 2004-01-30
MY114800A (en) 2003-01-31
CA2227814C (en) 2002-12-31
WO1997008144A1 (en) 1997-03-06
SK282925B6 (sk) 2003-01-09
NO310720B1 (no) 2001-08-20
CZ297543B6 (cs) 2007-02-07
US6506775B1 (en) 2003-01-14
AP643A (en) 1998-04-24
HU225480B1 (en) 2006-12-28
NZ308207A (en) 1998-07-28
PE20010700A1 (es) 2001-07-09
HRP960386B1 (en) 2002-04-30
PE1398A1 (es) 1998-02-27
RO119299B1 (ro) 2004-07-30
NO980751D0 (no) 1998-02-23
CN1153764C (zh) 2004-06-16
AU702698B2 (en) 1999-03-04
MX9801467A (es) 1998-05-31
EP1114817B1 (en) 2004-01-21
DK1114817T3 (da) 2004-04-26
SI1114817T1 (en) 2004-06-30
SI0861235T1 (en) 2002-04-30
IL119078A0 (en) 1996-11-14
BG102288A (en) 1998-09-30
YU49122B (sh) 2004-03-12
JP3084069B2 (ja) 2000-09-04
EP0861235A1 (en) 1998-09-02
HUP9901159A2 (hu) 1999-07-28
BR9609989A (pt) 1999-07-06
TNSN96107A1 (fr) 2005-03-15
DE69631390D1 (de) 2004-02-26
CO4480738A1 (es) 1997-07-09
ATE208377T1 (de) 2001-11-15
EP1114817A1 (en) 2001-07-11
ES2163017T3 (es) 2002-01-16
IS4644A (is) 1997-12-30
HK1014935A1 (en) 1999-10-08
JPH10510554A (ja) 1998-10-13
TW340842B (en) 1998-09-21
KR19990044077A (ko) 1999-06-25
CA2227814A1 (en) 1997-03-06
ATE258166T1 (de) 2004-02-15
KR100288673B1 (ko) 2001-05-02

Similar Documents

Publication Publication Date Title
DK0861235T3 (da) Substituerede benzylaminopiperidinforbindelser
ID16345A (id) Senyawa-senyawa heterosiklik
FI972970A (fi) Uusia yhdisteitä
BR9600534A (pt) Novos compostos
DK0777671T3 (da) Spiro-azabicykliske forbindelser
NO964683L (no) Omstillingsverktöy
DE59609887D1 (de) Substituierte cyanophenyluracile
DE69608259T2 (de) Verbunddamenbinde
BR9600251A (pt) Composto
DE69630414D1 (de) 5B4T-Kodierungsschema
IS4739A (is) Efnasambönd
ATA135896A (de) Skibob
NO974170D0 (no) Polyazacykloalkan-forbindelser
DE59610332D1 (de) Substituierte aminouracile
FI970151A (fi) Viruksenvastaisesti vaikuttavia difluoristatoniyhdisteitä
BR9601295A (pt) Composto
BR9608890A (pt) N-metilenotiouréias substituídas
BR9609319A (pt) Carbonilaminofeniluracilas substituídas
BR9611576A (pt) Composto
ATE198470T1 (de) Alkenyl-benzoylguanidine
BR9603376A (pt) Tetrahidro-5-nitro-pirimidinas substituídas
DE59607732D1 (de) Substituierte benzylidencyanessigester
ID18956A (id) Senyawa-senyawa herbisida
DE59607958D1 (de) Substituierte phenyluracile
ATE240972T1 (de) Cyclopeptolide