SMT201600089B - Composti di 3,4-diidropirazino[2,3-b]pirazin-2(1 h)-one come inibitori di chinasi mtor per indicazioni oncologiche e malattie associate al percorso mtor/p13k/akt - Google Patents
Composti di 3,4-diidropirazino[2,3-b]pirazin-2(1 h)-one come inibitori di chinasi mtor per indicazioni oncologiche e malattie associate al percorso mtor/p13k/aktInfo
- Publication number
- SMT201600089B SMT201600089B SM201600089T SM201600089T SMT201600089B SM T201600089 B SMT201600089 B SM T201600089B SM 201600089 T SM201600089 T SM 201600089T SM 201600089 T SM201600089 T SM 201600089T SM T201600089 B SMT201600089 B SM T201600089B
- Authority
- SM
- San Marino
- Prior art keywords
- mtor
- diidropirazino
- chinase
- pirazin
- inhibitors
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
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- C07D241/20—Nitrogen atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10862708P | 2008-10-27 | 2008-10-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201600089B true SMT201600089B (it) | 2016-04-29 |
Family
ID=41490345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201600089T SMT201600089B (it) | 2008-10-27 | 2016-03-29 | Composti di 3,4-diidropirazino[2,3-b]pirazin-2(1 h)-one come inibitori di chinasi mtor per indicazioni oncologiche e malattie associate al percorso mtor/p13k/akt |
Country Status (35)
Country | Link |
---|---|
US (10) | US8110578B2 (it) |
EP (5) | EP2740732B1 (it) |
JP (3) | JP5689420B2 (it) |
KR (2) | KR101815604B1 (it) |
CN (3) | CN104744475B (it) |
AR (2) | AR073995A1 (it) |
AU (1) | AU2009320137C1 (it) |
BR (1) | BRPI0920254A2 (it) |
CA (1) | CA2740975C (it) |
CO (1) | CO6501147A2 (it) |
CR (1) | CR20110223A (it) |
CY (2) | CY1117272T1 (it) |
DK (2) | DK2740733T3 (it) |
EC (1) | ECSP11011084A (it) |
ES (4) | ES2794012T3 (it) |
HK (3) | HK1154858A1 (it) |
HR (2) | HRP20160084T1 (it) |
HU (1) | HUE026834T2 (it) |
IL (1) | IL212440A (it) |
LT (1) | LT2740732T (it) |
MX (2) | MX2011004401A (it) |
MY (1) | MY159235A (it) |
NI (1) | NI201100080A (it) |
NZ (4) | NZ619458A (it) |
PE (3) | PE20130457A1 (it) |
PL (2) | PL2740732T3 (it) |
PT (1) | PT2740732T (it) |
RU (2) | RU2692796C2 (it) |
SG (3) | SG10201402267VA (it) |
SI (2) | SI2740732T1 (it) |
SM (1) | SMT201600089B (it) |
TW (3) | TWI535722B (it) |
UA (1) | UA108601C2 (it) |
WO (1) | WO2010062571A1 (it) |
ZA (1) | ZA201102813B (it) |
Families Citing this family (112)
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CA2723961C (en) | 2008-05-21 | 2017-03-21 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8110578B2 (en) | 2008-10-27 | 2012-02-07 | Signal Pharmaceuticals, Llc | Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway |
US8846664B2 (en) | 2008-11-12 | 2014-09-30 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
DE102009043260A1 (de) | 2009-09-28 | 2011-04-28 | Merck Patent Gmbh | Pyridinyl-imidazolonderivate |
EP3091021B1 (en) * | 2009-10-26 | 2019-08-28 | Signal Pharmaceuticals, LLC | Methods of synthesis and purification of heteroaryl compounds |
BR112012019459A2 (pt) * | 2010-02-03 | 2017-10-17 | Signal Pharm Llc | identificação de mutação de lkb1 como um biomarcador preditivo para sensibilidade para inibidores de tor quinase. |
US20110275699A1 (en) * | 2010-03-16 | 2011-11-10 | University Of California | Treatment For Obesity And Diabetes |
US20120028972A1 (en) * | 2010-07-30 | 2012-02-02 | Lilly Wong | Biomarker assays for detecting or measuring inhibition of tor kinase activity |
WO2012112847A1 (en) | 2011-02-18 | 2012-08-23 | Novartis Pharma Ag | mTOR/JAK INHIBITOR COMBINATION THERAPY |
WO2012122405A2 (en) * | 2011-03-08 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | Screening assays using stem cells and stem cell-derived neurons from mouse models of alzheimer's disease |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
AU2012290056B2 (en) * | 2011-08-03 | 2015-03-19 | Signal Pharmaceuticals, Llc | Identification of gene expression profile as a predictive biomarker for LKB1 status |
TWI708605B (zh) | 2011-10-19 | 2020-11-01 | 標誌製藥公司 | 以tor激酶抑制劑治療癌症 |
AU2015200318B2 (en) * | 2011-10-19 | 2016-10-20 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
EA026390B1 (ru) | 2011-12-02 | 2017-04-28 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ 7-(6-(2-ГИДРОКСИПРОПАН-2-ИЛ)ПИРИДИН-3-ИЛ)-1-((ТРАНС)-4-МЕТОКСИЦИКЛОГЕКСИЛ)-3,4-ДИГИДРОПИРАЗИНО[2,3-b]ПИРАЗИН-2(1Н)-ОНА, ИХ ТВЕРДЫЕ ФОРМЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
AU2015201807B2 (en) * | 2011-12-02 | 2016-12-08 | Signal Pharmaceuticals, Llc | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methocyclohexyl)-3,4-dihydropyrazino[2,3-b] pyrazin-2(1H)-one, a solid form thereof and methods of their use |
US10646552B2 (en) | 2012-01-17 | 2020-05-12 | Tyme, Inc. | Pharmaceutical compositions and methods |
LT2804599T (lt) * | 2012-01-17 | 2019-04-10 | Tyme, Inc. | Kombinuota terapija vėžio gydymui |
US20130183263A1 (en) | 2012-01-17 | 2013-07-18 | Steven Hoffman | Pharmaceutical compositions and methods |
US10272068B2 (en) | 2012-01-17 | 2019-04-30 | Tyme, Inc. | Pharmaceutical compositions and methods |
US8481498B1 (en) | 2012-01-17 | 2013-07-09 | Steven Hoffman | Pharmaceutical compositions and methods |
FR2986230B1 (fr) * | 2012-01-30 | 2014-03-07 | Univ Paris Diderot Paris 7 | Nouveaux composes et compositions utilises comme anticancereux |
EP2817029B1 (en) | 2012-02-24 | 2019-07-10 | Signal Pharmaceuticals, LLC | Methods for treating non-small cell lung cancer using tor kinase inhibitor combination therapy |
AU2015213400B2 (en) * | 2012-03-15 | 2017-07-27 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
BR112014022697A2 (pt) * | 2012-03-15 | 2020-06-30 | Signal Pharmaceuticals, Llc | Uso de uma quantidade eficaz de um inibidor de quinase tor,método para melhorar o critério de avaliação de resposta,método para a inibição da fosforilação, método para a inibiçãoda atividade da proteína, método para a medição da inibição dafosforilação, kit |
UA114194C2 (uk) * | 2012-03-15 | 2017-05-10 | Сігнал Фармасьютікалз, Елелсі | Лікування раку інгібітором тоr кінази |
AU2015201138B2 (en) * | 2012-03-15 | 2016-06-23 | Signal Pharmaceuticals, Llc | Treatment of cancer with TOR kinase inhibitors |
EP2825169B1 (en) * | 2012-03-15 | 2018-05-09 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
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