SMT201300110B - Processi intermedi per la preparazione di analoghidi 1'-cianocarbonucleoside - Google Patents

Processi intermedi per la preparazione di analoghidi 1'-cianocarbonucleoside

Info

Publication number
SMT201300110B
SMT201300110B SM201300110T SM201300110T SMT201300110B SM T201300110 B SMT201300110 B SM T201300110B SM 201300110 T SM201300110 T SM 201300110T SM 201300110 T SM201300110 T SM 201300110T SM T201300110 B SMT201300110 B SM T201300110B
Authority
SM
San Marino
Prior art keywords
cyanocarbonucleoside
analogous
preparation
intermediate processes
processes
Prior art date
Application number
SM201300110T
Other languages
English (en)
Italian (it)
Inventor
Thomas Butler
Benjamin R Graetz
Samuel E Metobo
Andrew W Waltman
Lijun Zhang
Aesop Cho
Choung U Kim
Oliver L Saunders
Jie Xu
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SMT201300110B publication Critical patent/SMT201300110B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
SM201300110T 2009-09-21 2013-10-04 Processi intermedi per la preparazione di analoghidi 1'-cianocarbonucleoside SMT201300110B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24429909P 2009-09-21 2009-09-21
PCT/US2010/049508 WO2011035250A1 (en) 2009-09-21 2010-09-20 Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs

Publications (1)

Publication Number Publication Date
SMT201300110B true SMT201300110B (it) 2013-11-08

Family

ID=42988364

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201300110T SMT201300110B (it) 2009-09-21 2013-10-04 Processi intermedi per la preparazione di analoghidi 1'-cianocarbonucleoside

Country Status (23)

Country Link
US (3) US10023600B2 (xx)
EP (1) EP2480559B1 (xx)
JP (3) JP5767643B2 (xx)
KR (1) KR101848099B1 (xx)
CN (1) CN102596979B (xx)
AU (1) AU2010295392B2 (xx)
BR (1) BR112012006180A2 (xx)
CA (1) CA2773773C (xx)
DK (1) DK2480559T3 (xx)
ES (1) ES2428725T3 (xx)
HK (1) HK1173451A1 (xx)
HR (1) HRP20130862T1 (xx)
IL (1) IL218752A (xx)
ME (1) ME01528B (xx)
MX (1) MX2012003126A (xx)
NZ (1) NZ599404A (xx)
PL (1) PL2480559T3 (xx)
PT (1) PT2480559E (xx)
RS (1) RS52954B (xx)
SI (1) SI2480559T1 (xx)
SM (1) SMT201300110B (xx)
TW (1) TWI483950B (xx)
WO (1) WO2011035250A1 (xx)

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