SK278775B6 - Deriváty 1,4-dihydropyridínu, spôsob ich výroby, f - Google Patents

Deriváty 1,4-dihydropyridínu, spôsob ich výroby, f Download PDF

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Publication number
SK278775B6
SK278775B6 SK5413-88A SK541388A SK278775B6 SK 278775 B6 SK278775 B6 SK 278775B6 SK 541388 A SK541388 A SK 541388A SK 278775 B6 SK278775 B6 SK 278775B6
Authority
SK
Slovakia
Prior art keywords
ethyl
methyl
methylenedioxyphenyl
dihydropyridine
formula
Prior art date
Application number
SK5413-88A
Other languages
English (en)
Slovak (sk)
Other versions
SK541388A3 (en
Inventor
Fernandez C. Torija
Galiano A. J. Ramos
Original Assignee
Prodesfarma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodesfarma filed Critical Prodesfarma
Publication of SK278775B6 publication Critical patent/SK278775B6/sk
Publication of SK541388A3 publication Critical patent/SK541388A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK5413-88A 1987-08-03 1988-08-02 1,4-dihydropyridine derivatives, method for producing the same, pharmaceutical composition containing the same SK541388A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (fr) 1987-08-03 1987-08-03 1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (2)

Publication Number Publication Date
SK278775B6 true SK278775B6 (sk) 1998-02-04
SK541388A3 SK541388A3 (en) 1998-02-04

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
SK5413-88A SK541388A3 (en) 1987-08-03 1988-08-02 1,4-dihydropyridine derivatives, method for producing the same, pharmaceutical composition containing the same

Country Status (34)

Country Link
US (1) US4952592A (ru)
EP (1) EP0302980B1 (ru)
JP (1) JPH0733383B2 (ru)
KR (1) KR960001724B1 (ru)
CN (1) CN1038587C (ru)
AT (1) ATE61588T1 (ru)
BE (1) BE1001055A4 (ru)
CA (2) CA1306261C (ru)
CH (1) CH675999A5 (ru)
CZ (1) CZ282077B6 (ru)
DD (1) DD282008A5 (ru)
DE (2) DE3768658D1 (ru)
DK (1) DK430288A (ru)
ES (1) ES2007543A6 (ru)
FI (1) FI91406C (ru)
GB (1) GB2208861B (ru)
GR (2) GR880100507A (ru)
HU (1) HU204523B (ru)
IE (1) IE60358B1 (ru)
IL (1) IL87321A (ru)
IN (1) IN167550B (ru)
IS (1) IS1549B (ru)
IT (1) IT1235013B (ru)
LU (1) LU87297A1 (ru)
MA (1) MA21344A1 (ru)
NO (1) NO170934C (ru)
NZ (1) NZ225661A (ru)
PH (1) PH25645A (ru)
PT (1) PT88173B (ru)
RU (1) RU2036922C1 (ru)
SK (1) SK541388A3 (ru)
TN (1) TNSN88081A1 (ru)
YU (1) YU46547B (ru)
ZA (1) ZA885684B (ru)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
WO1997004781A1 (en) * 1995-08-02 1997-02-13 Smithkline Beecham Corporation Endothelin receptor antagonists
CN100450483C (zh) * 2000-04-11 2009-01-14 三共株式会社 含有钙阻滞剂的稳定药物组合物
CN1681495B (zh) 2002-08-19 2010-05-12 辉瑞产品公司 用于治疗过度增生性疾病的组合物
BRPI0513866A (pt) * 2004-07-26 2008-05-20 Cotherix Inc composição, micropartìculas, método para o tratamento da hipertensão pulmonar, e dispositivo de inalação
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2014170786A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CN113574055A (zh) 2019-01-18 2021-10-29 阿斯利康(瑞典)有限公司 Pcsk9抑制剂及其使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES8507495A1 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
YU147088A (en) 1990-04-30
IE60358B1 (en) 1994-06-29
IL87321A0 (en) 1989-01-31
FI91406B (fi) 1994-03-15
NO170934B (no) 1992-09-21
FI91406C (fi) 1994-06-27
CA1306261C (fr) 1992-08-11
GB2208861A (en) 1989-04-19
ZA885684B (en) 1989-04-26
ATE61588T1 (de) 1991-03-15
AU606441B2 (en) 1991-02-07
NO883406L (no) 1989-02-06
ES2007543A6 (es) 1989-06-16
NZ225661A (en) 1990-08-28
YU46547B (sh) 1993-11-16
AU2033088A (en) 1989-02-09
CZ282077B6 (cs) 1997-05-14
CN1038587C (zh) 1998-06-03
EP0302980A1 (fr) 1989-02-15
LU87297A1 (fr) 1989-02-02
HUT54142A (en) 1991-01-28
CA1306262C (fr) 1992-08-11
FI883603A0 (fi) 1988-08-01
IT8848259A0 (it) 1988-08-02
MA21344A1 (fr) 1989-04-01
GR880100507A (el) 1989-05-25
IL87321A (en) 1993-04-04
CN1031531A (zh) 1989-03-08
PT88173B (pt) 1995-03-01
IS1549B (is) 1994-06-08
RU2036922C1 (ru) 1995-06-09
GB8818356D0 (en) 1988-09-07
TNSN88081A1 (fr) 1990-07-10
CZ541388A3 (en) 1997-01-15
KR960001724B1 (ko) 1996-02-03
FI883603A (fi) 1989-02-04
DE3825962A1 (de) 1989-02-16
DE3768658D1 (de) 1991-04-18
KR890003743A (ko) 1989-04-17
EP0302980B1 (fr) 1991-03-13
CH675999A5 (en) 1990-11-30
PH25645A (en) 1991-08-21
SK541388A3 (en) 1998-02-04
US4952592A (en) 1990-08-28
HU204523B (en) 1992-01-28
NO883406D0 (no) 1988-08-01
IE882364L (en) 1989-02-03
IN167550B (ru) 1990-11-10
PT88173A (pt) 1989-06-30
GB2208861B (en) 1991-07-17
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
IT1235013B (it) 1992-06-16
BE1001055A4 (fr) 1989-06-20
IS3378A7 (is) 1989-02-04
DK430288D0 (da) 1988-08-02
JPH01294675A (ja) 1989-11-28
DK430288A (da) 1989-02-03
NO170934C (no) 1992-12-30
JPH0733383B2 (ja) 1995-04-12

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