ATE61588T1 - 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents

1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Info

Publication number
ATE61588T1
ATE61588T1 AT87401799T AT87401799T ATE61588T1 AT E61588 T1 ATE61588 T1 AT E61588T1 AT 87401799 T AT87401799 T AT 87401799T AT 87401799 T AT87401799 T AT 87401799T AT E61588 T1 ATE61588 T1 AT E61588T1
Authority
AT
Austria
Prior art keywords
methyl
dihydropyridines
processes
production
medicinal products
Prior art date
Application number
AT87401799T
Other languages
English (en)
Inventor
Carlos F Torija
Ramos Joaquin A Galiano
Original Assignee
Delagrange Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delagrange Lab filed Critical Delagrange Lab
Application granted granted Critical
Publication of ATE61588T1 publication Critical patent/ATE61588T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT87401799T 1987-08-03 1987-08-03 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. ATE61588T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87401799A EP0302980B1 (de) 1987-08-03 1987-08-03 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ATE61588T1 true ATE61588T1 (de) 1991-03-15

Family

ID=8198243

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87401799T ATE61588T1 (de) 1987-08-03 1987-08-03 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Country Status (34)

Country Link
US (1) US4952592A (de)
EP (1) EP0302980B1 (de)
JP (1) JPH0733383B2 (de)
KR (1) KR960001724B1 (de)
CN (1) CN1038587C (de)
AT (1) ATE61588T1 (de)
BE (1) BE1001055A4 (de)
CA (2) CA1306261C (de)
CH (1) CH675999A5 (de)
CZ (1) CZ282077B6 (de)
DD (1) DD282008A5 (de)
DE (2) DE3768658D1 (de)
DK (1) DK430288A (de)
ES (1) ES2007543A6 (de)
FI (1) FI91406C (de)
GB (1) GB2208861B (de)
GR (2) GR880100507A (de)
HU (1) HU204523B (de)
IE (1) IE60358B1 (de)
IL (1) IL87321A (de)
IN (1) IN167550B (de)
IS (1) IS1549B (de)
IT (1) IT1235013B (de)
LU (1) LU87297A1 (de)
MA (1) MA21344A1 (de)
NO (1) NO170934C (de)
NZ (1) NZ225661A (de)
PH (1) PH25645A (de)
PT (1) PT88173B (de)
RU (1) RU2036922C1 (de)
SK (1) SK278775B6 (de)
TN (1) TNSN88081A1 (de)
YU (1) YU46547B (de)
ZA (1) ZA885684B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242933A (en) * 1990-07-10 1993-09-07 Adir Et Compagnie Piperidine, tetrahydropyridine and pyrrolidine compounds
EP0854721B1 (de) * 1995-08-02 2001-10-24 Smithkline Beecham Corporation Endothelinrezeptorantagonisten
CN100450483C (zh) * 2000-04-11 2009-01-14 三共株式会社 含有钙阻滞剂的稳定药物组合物
AP2005003232A0 (en) 2002-08-19 2005-03-31 Pfizer Prod Inc Combination therapy for hyperproliferative diseases.
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2111863B1 (de) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in Kombination mit Bosentan zur Behandlung von pulmonaler arterieller Hypertonie
EP2351569B1 (de) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Kombinationstherapie mit Fasudil zur Behandlung von pulmonaler Hypertonie
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
MX2015014666A (es) 2013-04-17 2016-03-01 Pfizer Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
EP3911648A4 (de) 2019-01-18 2022-10-26 Astrazeneca AB Pcsk9-inhibitoren und verfahren zur verwendung davon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3441648A (en) * 1967-02-07 1969-04-29 Smithkline Corp Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) * 1982-10-27 1984-05-04 Yoshitomi Pharmaceut Ind Ltd １，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES8507495A1 (es) * 1984-03-27 1985-09-01 Inst Investigacion Desarrollo Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) * 1985-02-26 1994-02-02 富山化学工業株式会社 新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (de) * 1984-09-01 1989-06-07 FISONS plc Dihydropyridine, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
JPH01207267A (ja) * 1987-03-05 1989-08-21 Yamanouchi Pharmaceut Co Ltd ピリジン誘導体及び該化合物を含有する肝疾患治療剤

Also Published As

Publication number Publication date
PH25645A (en) 1991-08-21
EP0302980A1 (de) 1989-02-15
PT88173A (pt) 1989-06-30
DE3825962A1 (de) 1989-02-16
JPH0733383B2 (ja) 1995-04-12
NO170934B (no) 1992-09-21
DK430288D0 (da) 1988-08-02
LU87297A1 (fr) 1989-02-02
FI883603A0 (fi) 1988-08-01
DD282008A5 (de) 1990-08-29
GR3001984T3 (en) 1992-11-23
NZ225661A (en) 1990-08-28
CH675999A5 (en) 1990-11-30
CN1031531A (zh) 1989-03-08
EP0302980B1 (de) 1991-03-13
NO883406L (no) 1989-02-06
YU147088A (en) 1990-04-30
GB2208861B (en) 1991-07-17
IS3378A7 (is) 1989-02-04
CA1306261C (fr) 1992-08-11
SK541388A3 (en) 1998-02-04
HU204523B (en) 1992-01-28
KR960001724B1 (ko) 1996-02-03
YU46547B (sh) 1993-11-16
MA21344A1 (fr) 1989-04-01
IL87321A0 (en) 1989-01-31
CN1038587C (zh) 1998-06-03
IE60358B1 (en) 1994-06-29
JPH01294675A (ja) 1989-11-28
BE1001055A4 (fr) 1989-06-20
KR890003743A (ko) 1989-04-17
HUT54142A (en) 1991-01-28
ZA885684B (en) 1989-04-26
IS1549B (is) 1994-06-08
IN167550B (de) 1990-11-10
PT88173B (pt) 1995-03-01
CZ541388A3 (en) 1997-01-15
NO170934C (no) 1992-12-30
IT8848259A0 (it) 1988-08-02
RU2036922C1 (ru) 1995-06-09
AU606441B2 (en) 1991-02-07
ES2007543A6 (es) 1989-06-16
IE882364L (en) 1989-02-03
GB2208861A (en) 1989-04-19
IT1235013B (it) 1992-06-16
US4952592A (en) 1990-08-28
SK278775B6 (sk) 1998-02-04
CZ282077B6 (cs) 1997-05-14
IL87321A (en) 1993-04-04
TNSN88081A1 (fr) 1990-07-10
DK430288A (da) 1989-02-03
CA1306262C (fr) 1992-08-11
NO883406D0 (no) 1988-08-01
GB8818356D0 (en) 1988-09-07
GR880100507A (el) 1989-05-25
AU2033088A (en) 1989-02-09
FI91406B (fi) 1994-03-15
FI91406C (fi) 1994-06-27
FI883603A (fi) 1989-02-04
DE3768658D1 (de) 1991-04-18

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