PT88173A - Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos - Google Patents

Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos

Info

Publication number: PT88173A
Authority: PT; Portugal
Prior art keywords: methyl; dihydro; hydropyridines; medicines; preparation
Prior art date: 1987-08-03

Application number

PT88173A

Other languages

English (en)

Other versions

PT88173B (pt

Original Assignee

Delagrange Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-03

Filing date

1988-08-02

Publication date

1989-06-30

1988-08-02 Application filed by Delagrange Lab filed Critical Delagrange Lab

1989-06-30 Publication of PT88173A publication Critical patent/PT88173A/pt

1995-03-01 Publication of PT88173B publication Critical patent/PT88173B/pt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

PT88173A 1987-08-03 1988-08-02 Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos PT88173B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP87401799A EP0302980B1 (fr)	1987-08-03	1987-08-03	1,4-Dihydropyridines, leur procédé de préparation et leur application comme médicaments

Publications (2)

Publication Number	Publication Date
PT88173A true PT88173A (pt)	1989-06-30
PT88173B PT88173B (pt)	1995-03-01

Family

ID=8198243

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT88173A PT88173B (pt)	1987-08-03	1988-08-02	Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos

Country Status (34)

Country	Link
US (1)	US4952592A (pt)
EP (1)	EP0302980B1 (pt)
JP (1)	JPH0733383B2 (pt)
KR (1)	KR960001724B1 (pt)
CN (1)	CN1038587C (pt)
AT (1)	ATE61588T1 (pt)
BE (1)	BE1001055A4 (pt)
CA (2)	CA1306261C (pt)
CH (1)	CH675999A5 (pt)
CZ (1)	CZ282077B6 (pt)
DD (1)	DD282008A5 (pt)
DE (2)	DE3768658D1 (pt)
DK (1)	DK430288A (pt)
ES (1)	ES2007543A6 (pt)
FI (1)	FI91406C (pt)
GB (1)	GB2208861B (pt)
GR (2)	GR880100507A (pt)
HU (1)	HU204523B (pt)
IE (1)	IE60358B1 (pt)
IL (1)	IL87321A (pt)
IN (1)	IN167550B (pt)
IS (1)	IS1549B (pt)
IT (1)	IT1235013B (pt)
LU (1)	LU87297A1 (pt)
MA (1)	MA21344A1 (pt)
NO (1)	NO170934C (pt)
NZ (1)	NZ225661A (pt)
PH (1)	PH25645A (pt)
PT (1)	PT88173B (pt)
RU (1)	RU2036922C1 (pt)
SK (1)	SK541388A3 (pt)
TN (1)	TNSN88081A1 (pt)
YU (1)	YU46547B (pt)
ZA (1)	ZA885684B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5242933A (en) *	1990-07-10	1993-09-07	Adir Et Compagnie	Piperidine, tetrahydropyridine and pyrrolidine compounds
WO1997004781A1 (en) *	1995-08-02	1997-02-13	Smithkline Beecham Corporation	Endothelin receptor antagonists
CN100450483C (zh) *	2000-04-11	2009-01-14	三共株式会社	含有钙阻滞剂的稳定药物组合物
CN1681495B (zh)	2002-08-19	2010-05-12	辉瑞产品公司	用于治疗过度增生性疾病的组合物
BRPI0513866A (pt) *	2004-07-26	2008-05-20	Cotherix Inc	composição, micropartìculas, método para o tratamento da hipertensão pulmonar, e dispositivo de inalação
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7893050B2 (en) *	2005-10-26	2011-02-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en)	2005-10-26	2012-08-22	Asahi Kasei Pharma Corporation	Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
TW200806648A (en) *	2005-11-29	2008-02-01	Sankyo Co	Acid addition salts of dihydropyridine derivatives
TW200736245A (en) *	2005-11-29	2007-10-01	Sankyo Co	Acid addition salts of optically active dihydropyridine derivatives
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8883844B2 (en)	2010-09-24	2014-11-11	Nitrogenix Inc.	Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
WO2014170786A1 (en)	2013-04-17	2014-10-23	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
CN113574055A (zh)	2019-01-18	2021-10-29	阿斯利康(瑞典)有限公司	Pcsk9抑制剂及其使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3441648A (en) *	1967-02-07	1969-04-29	Smithkline Corp	Compositions and methods for lowering blood pressure with 1,4-dihydropyridines
US4031104A (en) *	1972-04-18	1977-06-21	Bayer Aktiengesellschaft	1,4-Dihydropyridine carboxylic acid esters
JPS5978186A (ja) *	1982-10-27	1984-05-04	Yoshitomi Pharmaceut Ind Ltd	１，４−ジヒドロピリジン−３，５−ジカルボン酸エステル誘導体
ES8507495A1 (es) *	1984-03-27	1985-09-01	Inst Investigacion Desarrollo	Un procedimiento para la preparacion de nuevas 1,4-dihidropirinas-4-(polioxialquilfenil)-sustituidas
IE57810B1 (en) *	1984-03-27	1993-04-21	Delagrange Lab	1,4-dihydropyridine derivatives,their preparation and their use
JPH068294B2 (ja) *	1985-02-26	1994-02-02	富山化学工業株式会社	新規な１，４−ジヒドロピリジン誘導体およびその塩
EP0174131A3 (en) *	1984-09-01	1989-06-07	FISONS plc	Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them
JPH01207267A (ja) *	1987-03-05	1989-08-21	Yamanouchi Pharmaceut Co Ltd	ピリジン誘導体及び該化合物を含有する肝疾患治療剤

1987
- 1987-08-03 EP EP87401799A patent/EP0302980B1/fr not_active Expired - Lifetime
- 1987-08-03 DE DE8787401799T patent/DE3768658D1/de not_active Expired - Lifetime
- 1987-08-03 AT AT87401799T patent/ATE61588T1/de active
1988
- 1988-07-27 LU LU87297A patent/LU87297A1/fr unknown
- 1988-07-29 CA CA000573422A patent/CA1306261C/fr not_active Expired - Lifetime
- 1988-07-29 DE DE3825962A patent/DE3825962A1/de not_active Withdrawn
- 1988-07-29 YU YU147088A patent/YU46547B/sh unknown
- 1988-08-01 NO NO883406A patent/NO170934C/no unknown
- 1988-08-01 MA MA21587A patent/MA21344A1/fr unknown
- 1988-08-01 JP JP63192591A patent/JPH0733383B2/ja not_active Expired - Lifetime
- 1988-08-01 FI FI883603A patent/FI91406C/fi not_active IP Right Cessation
- 1988-08-01 DD DD88318537A patent/DD282008A5/de not_active IP Right Cessation
- 1988-08-02 IL IL87321A patent/IL87321A/xx not_active IP Right Cessation
- 1988-08-02 US US07/227,373 patent/US4952592A/en not_active Expired - Fee Related
- 1988-08-02 IS IS3378A patent/IS1549B/is unknown
- 1988-08-02 TN TNTNSN88081A patent/TNSN88081A1/fr unknown
- 1988-08-02 GB GB8818356A patent/GB2208861B/en not_active Expired - Lifetime
- 1988-08-02 CN CN88106537A patent/CN1038587C/zh not_active Expired - Fee Related
- 1988-08-02 CH CH2922/88A patent/CH675999A5/fr not_active IP Right Cessation
- 1988-08-02 IT IT8848259A patent/IT1235013B/it active
- 1988-08-02 SK SK5413-88A patent/SK541388A3/sk unknown
- 1988-08-02 IE IE236488A patent/IE60358B1/en not_active IP Right Cessation
- 1988-08-02 GR GR880100507A patent/GR880100507A/el unknown
- 1988-08-02 CZ CS885413A patent/CZ282077B6/cs not_active IP Right Cessation
- 1988-08-02 ES ES8802413A patent/ES2007543A6/es not_active Expired
- 1988-08-02 NZ NZ225661A patent/NZ225661A/xx unknown
- 1988-08-02 DK DK430288A patent/DK430288A/da not_active Application Discontinuation
- 1988-08-02 PT PT88173A patent/PT88173B/pt not_active IP Right Cessation
- 1988-08-02 BE BE8800893A patent/BE1001055A4/fr not_active IP Right Cessation
- 1988-08-02 KR KR1019880009867A patent/KR960001724B1/ko not_active IP Right Cessation
- 1988-08-02 HU HU884065A patent/HU204523B/hu not_active IP Right Cessation
- 1988-08-03 ZA ZA885684A patent/ZA885684B/xx unknown
- 1988-08-03 PH PH37337A patent/PH25645A/en unknown
- 1988-08-03 IN IN556/MAS/88A patent/IN167550B/en unknown
1990
- 1990-08-28 CA CA000615848A patent/CA1306262C/fr not_active Expired - Lifetime
1991
- 1991-05-22 GR GR91400660T patent/GR3001984T3/el unknown
1992
- 1992-03-31 RU SU925011204A patent/RU2036922C1/ru active

Also Published As

Publication number	Publication date
YU147088A (en)	1990-04-30
IE60358B1 (en)	1994-06-29
IL87321A0 (en)	1989-01-31
SK278775B6 (sk)	1998-02-04
FI91406B (fi)	1994-03-15
NO170934B (no)	1992-09-21
FI91406C (fi)	1994-06-27
CA1306261C (fr)	1992-08-11
GB2208861A (en)	1989-04-19
ZA885684B (en)	1989-04-26
ATE61588T1 (de)	1991-03-15
AU606441B2 (en)	1991-02-07
NO883406L (no)	1989-02-06
ES2007543A6 (es)	1989-06-16
NZ225661A (en)	1990-08-28
YU46547B (sh)	1993-11-16
AU2033088A (en)	1989-02-09
CZ282077B6 (cs)	1997-05-14
CN1038587C (zh)	1998-06-03
EP0302980A1 (fr)	1989-02-15
LU87297A1 (fr)	1989-02-02
HUT54142A (en)	1991-01-28
CA1306262C (fr)	1992-08-11
FI883603A0 (fi)	1988-08-01
IT8848259A0 (it)	1988-08-02
MA21344A1 (fr)	1989-04-01
GR880100507A (el)	1989-05-25
IL87321A (en)	1993-04-04
CN1031531A (zh)	1989-03-08
PT88173B (pt)	1995-03-01
IS1549B (is)	1994-06-08
RU2036922C1 (ru)	1995-06-09
GB8818356D0 (en)	1988-09-07
TNSN88081A1 (fr)	1990-07-10
CZ541388A3 (en)	1997-01-15
KR960001724B1 (ko)	1996-02-03
FI883603A (fi)	1989-02-04
DE3825962A1 (de)	1989-02-16
DE3768658D1 (de)	1991-04-18
KR890003743A (ko)	1989-04-17
EP0302980B1 (fr)	1991-03-13
CH675999A5 (en)	1990-11-30
PH25645A (en)	1991-08-21
SK541388A3 (en)	1998-02-04
US4952592A (en)	1990-08-28
HU204523B (en)	1992-01-28
NO883406D0 (no)	1988-08-01
IE882364L (en)	1989-02-03
IN167550B (pt)	1990-11-10
GB2208861B (en)	1991-07-17
DD282008A5 (de)	1990-08-29
GR3001984T3 (en)	1992-11-23
IT1235013B (it)	1992-06-16
BE1001055A4 (fr)	1989-06-20
IS3378A7 (is)	1989-02-04
DK430288D0 (da)	1988-08-02
JPH01294675A (ja)	1989-11-28
DK430288A (da)	1989-02-03
NO170934C (no)	1992-12-30
JPH0733383B2 (ja)	1995-04-12

Legal Events

Date	Code	Title	Description
1995-03-01	FG3A	Patent granted, date of granting	Effective date: 19940822
1996-06-28	PC3A	Transfer or assignment	Free format text: 960403 PRODESFARMA S.A. ES
1998-04-30	PC3A	Transfer or assignment	Free format text: 980202 ALMIRALL-PRODESFARMA, SOCIEDAD ANONIMA ES
2001-06-29	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20010228

Publication	Publication Date	Title
PT88173A (pt)	1989-06-30	Processo para a preparacao de 1,4-di-hidropiridinas e sua aplicacao como medicamentos
FI875229A0 (fi)	1987-11-27	Menetelmä uusien farmakologisesti aktiivisten katekolijohdoksien valmistamiseksi
NO901657L (no)	1990-10-18	Fuktende baeremiddel for topisk administrering av vitamin a syre.
ATE53376T1 (de)	1990-06-15	Entzuendungshemmende agentien.
SE9300758L (sv)	1993-09-11	Förfarande för framställning av kavulansyrasalter
FI900145A (fi)	1990-01-11	Menetelmä farmaseuttisesti käyttökelpoisten 1,1-diokso-kefem-4-karbotiolihappojohdannaisten valmistamiseksi
FI99013B (fi)	1997-06-13	Analogiamenetelmä terapeuttisesti käyttökelpoisten bentsimidatsolijohdannaisten valmistamiseksi
ES541215A0 (es)	1986-04-16	Un metodo para preparar un cianoimidazol-nucleosido
FI93725B (fi)	1995-02-15	Menetelmä optisesti aktiivisten, oikealle kiertävien okso-isoindolinyylijohdannaisten valmistamiseksi
SE8605255L (sv)	1987-06-10	4h-benso(4,5)cyklohepta(1,2-b)tiofen-derivat
FI93008B (fi)	1994-10-31	Menetelmä bakteerien vastaisten 6-fluori-1,4-dihydrokinol-4-oni-3-karboksyylihappojohdannaisten valmistamiseksi
IT8620997A0 (it)	1986-07-01	Processo per la preparazione dipirido benzotiazine ad attivita'antibatterica e loro sali con acidi solfonici.
DE3764457D1 (de)	1990-09-27	Empfaengnisverhuetende, waessrig-saure zusammensetzung und verfahren zu ihrer herstellung.
IT8019354A0 (it)	1980-01-22	Derivati dell'acido nicotinico adattivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche.