SI3386500T1 - Selektivni regulatorji za znižanje ravni receptorja za estrogen na osnovi benzotiofena - Google Patents

Selektivni regulatorji za znižanje ravni receptorja za estrogen na osnovi benzotiofena

Info

Publication number
SI3386500T1
SI3386500T1 SI201631640T SI201631640T SI3386500T1 SI 3386500 T1 SI3386500 T1 SI 3386500T1 SI 201631640 T SI201631640 T SI 201631640T SI 201631640 T SI201631640 T SI 201631640T SI 3386500 T1 SI3386500 T1 SI 3386500T1
Authority
SI
Slovenia
Prior art keywords
benzothiophene
estrogen receptor
selective estrogen
based selective
receptor downregulators
Prior art date
Application number
SI201631640T
Other languages
English (en)
Slovenian (sl)
Inventor
Gregory R. Thatcher
Rui Xiong
Jiong Zhao
Debra A. Tonetti
Original Assignee
The Board Of Trustees Of The University Of Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Trustees Of The University Of Illinois filed Critical The Board Of Trustees Of The University Of Illinois
Publication of SI3386500T1 publication Critical patent/SI3386500T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
SI201631640T 2015-12-09 2016-12-09 Selektivni regulatorji za znižanje ravni receptorja za estrogen na osnovi benzotiofena SI3386500T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US201662322878P 2016-04-15 2016-04-15
PCT/US2016/066023 WO2017100712A1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators
EP16874012.4A EP3386500B1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators

Publications (1)

Publication Number Publication Date
SI3386500T1 true SI3386500T1 (sl) 2023-01-31

Family

ID=59013340

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201631640T SI3386500T1 (sl) 2015-12-09 2016-12-09 Selektivni regulatorji za znižanje ravni receptorja za estrogen na osnovi benzotiofena

Country Status (24)

Country Link
US (7) US10118910B2 (pl)
EP (2) EP3386500B1 (pl)
JP (2) JP6920709B2 (pl)
KR (1) KR20180088457A (pl)
CN (2) CN108699024B (pl)
AU (1) AU2016366680B2 (pl)
BR (1) BR112018011607B1 (pl)
CA (1) CA3008020C (pl)
DK (1) DK3386500T3 (pl)
EA (1) EA038180B1 (pl)
ES (1) ES2935125T3 (pl)
HR (1) HRP20221462T1 (pl)
HU (1) HUE061065T2 (pl)
IL (1) IL259566B (pl)
LT (1) LT3386500T (pl)
MX (2) MX2020006991A (pl)
NZ (1) NZ743651A (pl)
PL (1) PL3386500T3 (pl)
PT (1) PT3386500T (pl)
RS (1) RS63791B1 (pl)
RU (1) RU2747802C2 (pl)
SI (1) SI3386500T1 (pl)
WO (2) WO2017100715A1 (pl)
ZA (2) ZA201803422B (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10118910B2 (en) 2015-12-09 2018-11-06 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
US10599150B2 (en) 2016-09-29 2020-03-24 The Charles Stark Kraper Laboratory, Inc. Autonomous vehicle: object-level fusion
CN110177554B (zh) * 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法
CN110461853A (zh) 2017-02-10 2019-11-15 G1治疗公司 苯并噻吩***受体调节剂
CN110913861B (zh) 2017-06-29 2024-01-09 G1治疗公司 G1t38的形态学形式及其制造方法
WO2019157020A1 (en) 2018-02-06 2019-08-15 The Board Of Trustees Of The University Of Illinois Substituted benzothiophene analogs as selective estrogen receptor degraders
US10741313B1 (en) 2019-02-06 2020-08-11 Eaton Intelligent Power Limited Bus bar assembly with integrated surge arrestor
US11249184B2 (en) 2019-05-07 2022-02-15 The Charles Stark Draper Laboratory, Inc. Autonomous collision avoidance through physical layer tracking
WO2021007330A1 (en) * 2019-07-08 2021-01-14 Dermavant Sciences GmbH Cerdulatinib-containing topical skin pharmaceutical compositions and uses thereof
CN115710248A (zh) * 2022-11-18 2023-02-24 南京中医药大学 新型选择性***受体下调剂化合物、制备方法及用途

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
DE4126999A1 (de) 1991-08-16 1993-02-18 Basf Ag Herbizide mittel, enthaltend 3-aminobenzo(b)thiophene als antidots
EP0545478A1 (en) 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
JPH05345780A (ja) * 1991-12-24 1993-12-27 Kumiai Chem Ind Co Ltd ピリミジンまたはトリアジン誘導体及び除草剤
CZ285937B6 (cs) 1992-01-16 1999-12-15 Hoechst Aktiengesellschaft Arylcykloalkylové deriváty, způsob přípravy těchto derivátů a jejich použití
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
EP0622673B1 (en) 1993-04-24 1998-02-04 Kodak Limited Photographic colour couplers and photographic materials containing them
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
EP0752421B1 (en) 1995-07-07 2005-10-12 AstraZeneca AB Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists
US6458811B1 (en) 1996-03-26 2002-10-01 Eli Lilly And Company Benzothiophenes formulations containing same and methods
US5780497A (en) 1996-04-19 1998-07-14 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
US5880137A (en) 1996-04-19 1999-03-09 American Home Products Corporation 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents
TW397821B (en) 1996-04-19 2000-07-11 American Home Produits Corp 3-[4-(2-phenyl-indole-1-ylmethyl)-phenyl]-acrylamides and 2-phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol as well as pharmaceutical compositions of estrogenic agents thereof
US5998402A (en) 1996-04-19 1999-12-07 American Home Products Corporation 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents
UA70925C2 (uk) * 1997-08-15 2004-11-15 Дюк Юнівесіті Спосіб лікування естрогенстимульованого раку
AU9399898A (en) 1997-10-03 1999-04-27 Eli Lilly And Company Benzothiophenes
US6005102A (en) 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
US6326392B1 (en) 1997-11-06 2001-12-04 American Home Products Corporation Anti-estrogen plus progestin containing oral contraceptives
UA68365C2 (en) 1997-11-06 2004-08-16 Wyeth Corp Peroral contraception by combination of anti-estrogen and progestin
US6583170B1 (en) 1998-05-15 2003-06-24 Wyeth 2-Phenyl-1-[4-(amino-1-yl-alk-1-ynyl)-benzyl]-1H-indol-5-ol and estrogen formulations
US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
GB0000313D0 (en) 2000-01-10 2000-03-01 Astrazeneca Uk Ltd Formulation
CO5271697A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el tratamiento de afecciones que responden a un aumento de testosterona
CO5271709A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
CO5271696A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Procedimiento para reducir la morbilidad y el riesgo de mortalidad
CO5251465A1 (es) 2000-01-26 2003-02-28 Pfizer Prod Inc Composiciones y procedimientos para tratar la osteoporosis y reducir el colesterol
US7091240B2 (en) 2000-03-10 2006-08-15 Oxigene, Inc. Tubulin binding ligands and corresponding prodrug constructs
US20020013327A1 (en) 2000-04-18 2002-01-31 Lee Andrew G. Compositions and methods for treating female sexual dysfunction
CN1452497A (zh) 2000-07-06 2003-10-29 惠氏公司 Ssri和***制剂的联合药物形式
CA2415052A1 (en) 2000-07-06 2002-01-17 Wyeth Combinations of bisphosphonates, estrogenic agents and optionally estrogens
WO2002003989A2 (en) 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating sphincter incontinence
WO2002003992A2 (en) 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating prosthesis-related bone degeneration
AR030064A1 (es) 2000-07-06 2003-08-13 Wyeth Corp Metodos para inhibir los efectos uterotroficos de los agentes estrogenicos
US6509332B2 (en) 2000-07-06 2003-01-21 Wyeth Methods of treating excessive intraocular pressure
WO2002003988A2 (en) 2000-07-06 2002-01-17 Wyeth Use of substituted indole compounds for treating neuropeptide y-related conditions
MXPA02012896A (es) 2000-07-06 2003-10-24 Wyeth Corp Combinaciones de estatinas, agentes estrogenicos y opcionalmente estrogenos.
EP1296674A2 (en) 2000-07-06 2003-04-02 Wyeth Use of substituted indole compounds for increasing nitric oxide synthase activity
US20020016318A1 (en) 2000-07-06 2002-02-07 American Home Products Corporation Methods of treating breast disorders
EP1177787A3 (en) 2000-07-28 2003-09-10 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating cataracts
AU2001283139A1 (en) 2000-08-11 2002-02-25 Wyeth Method of treating estrogen receptor positive carcinoma
EP1192945A3 (en) 2000-09-21 2004-03-03 Pfizer Products Inc. Use of an estrogen agonist/antagonist for treating osteoarthritis
IL145838A (en) 2000-10-16 2008-11-03 Pfizer Prod Inc Use of an estrogen agonist / antagonist to produce a drug for the treatment of vaginitis
AU781168B2 (en) 2001-01-26 2005-05-12 Pfizer Products Inc. Method of treating certain cancers using an estrogen agonist/antagonist
WO2004009603A1 (en) * 2002-07-24 2004-01-29 Eli Lilly And Company Dihydro-dibenzo[b,e]oxepine based selective estrogen receptor modulators, compositions and methods
US7371757B2 (en) 2003-08-15 2008-05-13 Astrazeneca Ab Fused heterocycles as inhibitors of glutamate racemase(MURI)
JP2005129430A (ja) 2003-10-27 2005-05-19 Konica Minolta Holdings Inc 光電変換材料用半導体、光電変換素子及び太陽電池
FR2862646B1 (fr) * 2003-11-20 2006-02-24 Merck Sante Sas Nouveaux composes antidiabetiques contenant des derives benzofuranes, benzothiophenes
BRPI0417407A (pt) 2003-12-15 2007-04-03 Theramex derivados de 1-n-fenil-amino-1h-imidazol e composições farmacêuticas contendo estes
WO2006078834A1 (en) 2005-01-21 2006-07-27 Janssen Pharmaceutica N.V. Novel heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors
US8278290B2 (en) 2005-02-14 2012-10-02 Biononics Limited Tubulin polymerisation inhibitors
AU2007211840B2 (en) 2006-02-03 2012-03-01 Bionomics Limited Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors
ES2436028T3 (es) 2006-06-23 2013-12-26 Radius Health, Inc. Tratamiento de síntomas vasomotores con moduladores selectivos de receptores de estrógeno
EP1947085A1 (en) 2007-01-19 2008-07-23 Laboratorios del Dr. Esteve S.A. Substituted indole sulfonamide compounds, their preparation and use as medicaments
EP2183237A1 (en) 2007-07-25 2010-05-12 F. Hoffmann-Roche AG Benzofuran- and benzo[b]thiophene-2-carboxylic acid amide derivatives and use thereof as histamine 3 receptor modulators
WO2010093578A1 (en) 2009-02-10 2010-08-19 Glaxo Group Limited Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors
WO2010127452A1 (en) 2009-05-04 2010-11-11 The Royal Institution For The Advancement Of Learning/Mcgill University 5-oxo-ete receptor antagonist compounds
RU2012114902A (ru) 2009-09-16 2013-10-27 Авила Терапьютикс, Инк. Конъюгаты и ингибиторы протеинкиназы
BR112012027745A2 (pt) 2010-04-27 2017-01-10 Univ Johns Hopkins método e composição imunogênica para tratamento de neoplásia
CA2800673A1 (en) 2010-06-10 2011-12-15 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
WO2011159769A2 (en) 2010-06-17 2011-12-22 Aragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
US10005750B2 (en) 2010-10-06 2018-06-26 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
US9540361B2 (en) 2010-12-24 2017-01-10 Merck Sharp & Dohme B.V. N-substituted azetidine derivatives
DE102011087987A1 (de) 2011-12-08 2013-06-13 Bayer Intellectual Property Gmbh 6,7-Dihydro-5H-benzo[7]annulen-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln
US9187460B2 (en) 2011-12-14 2015-11-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
MX2014007198A (es) 2011-12-16 2014-10-13 Olema Pharmaceuticals Inc Compuestos novedosos de benzopirano, composiciones y usos de los mismos.
BR112014017985A8 (pt) * 2012-01-31 2017-07-11 Novartis Ag Combinação de um inibidor de rtk com um antiestrogênio e uso da mesma para o tratamento de cancer
US9499538B2 (en) 2012-03-20 2016-11-22 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
EP2871891B1 (en) 2012-08-01 2017-03-29 Huawei Technologies Co., Ltd. Synchronization method, apparatus, and system
CN104583099A (zh) 2012-09-05 2015-04-29 皇家飞利浦有限公司 用于饮料的制备的胶囊、设备和方法
EP2912033A4 (en) 2012-10-24 2016-09-14 Univ Illinois COMPOSITIONS AND METHODS FOR TREATING ESTROGEN-MEDIATED ILLNESSES
EP2911660B1 (en) * 2012-10-24 2019-12-04 The Board of Trustees of the University of Illionis Compositions and methods for treating estrogen-related medical disorders
BR112015018882B1 (pt) * 2013-02-19 2021-09-14 Novartis Ag Derivados de benzotiofeno e composições dos mesmos como degradadores de receptor de estrogênio seletivo
MX2015011132A (es) 2013-03-14 2015-11-30 Seragon Pharmaceuticals Inc Moduladores policiclicos del receptor de estrogenos y sus usos.
PE20160874A1 (es) 2013-05-28 2016-09-04 Astrazeneca Ab Compuestos quimicos
WO2014203129A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Combinations of benzopyran compounds, compositions and uses thereof
WO2014203132A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Substituted benzopyran compounds, compositions and uses thereof
CA2912853A1 (en) 2013-06-19 2014-12-24 Seragon Pharmaceuticals, Inc. Estrogen receptor modulator and uses thereof
BR112015030595A2 (pt) 2013-06-19 2017-07-25 Seragon Pharmaceuticals Inc moduladores de receptor de estrogênio de azetidina e usos dos mesmos
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
WO2015028409A1 (de) 2013-08-27 2015-03-05 Bayer Pharma Aktiengesellschaft 6,7-dihydro-5h-benzo[7]annulen-derivate, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
WO2015092634A1 (en) 2013-12-16 2015-06-25 Novartis Ag 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders
CA2941161A1 (en) 2014-03-13 2015-09-17 F.Hoffmann-La Roche Ag Methods and compositions for modulating estrogen receptor mutants
MA39741A (fr) 2014-03-13 2017-01-18 Hoffmann La Roche Combinaisons thérapeutiques avec des modulateurs du récepteur des œstrogènes
SI3122426T1 (sl) 2014-03-28 2023-04-28 Duke University Zdravljenje raka dojk z uporabo selektivnih modulatorjev estrogenskih receptorjev
CN112457310A (zh) 2014-12-18 2021-03-09 豪夫迈·罗氏有限公司 四氢-吡啶并[3,4-b]吲哚***受体调节剂及其用途
US9845291B2 (en) 2014-12-18 2017-12-19 Genentech, Inc. Estrogen receptor modulators and uses thereof
EP3233818A1 (en) 2014-12-18 2017-10-25 F. Hoffmann-La Roche AG Derivatives of 2,3-diphenylchromene useful for the treatment of cancer
WO2016174551A1 (en) 2015-04-27 2016-11-03 Pfizer Inc. Anti-estrogenic compounds
JP6768711B2 (ja) 2015-05-26 2020-10-14 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 複素環式エストロゲン受容体モジュレーター及びその使用
JP2018521988A (ja) 2015-06-16 2018-08-09 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． ピペリジン誘導体およびその製造方法および医薬用途
HUE055321T2 (hu) 2015-10-01 2021-11-29 Olema Pharmaceuticals Inc Tetrahidro-1H-pirido[3,4-b]indol anti-ösztrogén hatóanyagok
WO2017056115A1 (en) 2015-10-03 2017-04-06 Sun Pharma Advanced Research Company Limited Novel n-aryl containing fused heterocyclic compounds
JP2018533561A (ja) 2015-10-07 2018-11-15 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト （ｅ）−３−（４−（（ｅ）−２−（２−クロロ−４−フルオロフェニル）−１−（１ｈ−インダゾール−５−イル）ブタ−１−エン−１−イル）フェニル）アクリル酸を調製するためのプロセス
DK3368519T3 (da) 2015-10-27 2022-05-23 Sun Pharma Advanced Res Co Ltd Hidtil ukendte, heterocykliske antiøstrogener
EP3374356A1 (en) 2015-11-09 2018-09-19 H. Hoffnabb-La Roche Ag Tetrahydronaphthalene estrogen receptor modulators and uses thereof
JP6592197B2 (ja) 2015-11-12 2019-10-16 浙江海正薬業股▲ふん▼有限公司Ｚｈｅｊｉａｎｇ Ｈｉｓｕｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌ ＣＯ．，ＬＴＤ． アクリル酸誘導体、製造方法、および医薬としてのその使用
US10118910B2 (en) * 2015-12-09 2018-11-06 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulators
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
CN110177554B (zh) 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法

Also Published As

Publication number Publication date
US20220194917A1 (en) 2022-06-23
DK3386500T3 (da) 2022-12-12
MX2020006991A (es) 2022-07-14
JP2019502675A (ja) 2019-01-31
HUE061065T2 (hu) 2023-05-28
PL3386500T3 (pl) 2023-03-13
US20170166550A1 (en) 2017-06-15
PT3386500T (pt) 2023-01-06
EP3386968A4 (en) 2019-09-25
CA3008020C (en) 2024-02-20
US20200079752A1 (en) 2020-03-12
US10377735B2 (en) 2019-08-13
RS63791B1 (sr) 2022-12-30
WO2017100712A1 (en) 2017-06-15
WO2017100715A1 (en) 2017-06-15
US11072595B2 (en) 2021-07-27
HRP20221462T1 (hr) 2023-01-20
RU2747802C2 (ru) 2021-05-14
CA3008020A1 (en) 2017-06-15
JP6920709B2 (ja) 2021-08-18
BR112018011607B1 (pt) 2024-01-30
IL259566B (en) 2021-09-30
RU2018125046A (ru) 2020-01-09
EP3386500A4 (en) 2019-05-22
AU2016366680B2 (en) 2021-06-24
US10118910B2 (en) 2018-11-06
EP3386500A1 (en) 2018-10-17
AU2016366680A1 (en) 2018-07-12
US11447461B2 (en) 2022-09-20
KR20180088457A (ko) 2018-08-03
ES2935125T3 (es) 2023-03-01
US10807964B2 (en) 2020-10-20
EA201891376A1 (ru) 2019-02-28
BR112018011607A2 (pt) 2018-11-27
MX2018007079A (es) 2018-11-12
US20200123126A1 (en) 2020-04-23
CN108495628B (zh) 2022-01-11
CN108495628A (zh) 2018-09-04
ZA201803422B (en) 2020-08-26
US20210047286A1 (en) 2021-02-18
US20170166551A1 (en) 2017-06-15
RU2018125046A3 (pl) 2020-02-10
US20190055209A1 (en) 2019-02-21
IL259566A (en) 2018-07-31
CN108699024B (zh) 2022-03-11
EA038180B1 (ru) 2021-07-20
NZ743651A (en) 2023-07-28
ZA202003023B (en) 2022-12-21
EP3386968A1 (en) 2018-10-17
LT3386500T (lt) 2022-12-27
JP2021169498A (ja) 2021-10-28
CN108699024A (zh) 2018-10-23
EP3386500B1 (en) 2022-09-07

Similar Documents

Publication Publication Date Title
ZA202003023B (en) Benzothiophene-based selective estrogen receptor downregulators
GB201514875D0 (en) Receptor
HK1252163A1 (zh) 受體
GB201522592D0 (en) T cell receptors
HK1253695A1 (zh) T細胞受體特異性抗體
HK1256799A1 (zh) 集成的開關濾波器網絡
SG11201708313QA (en) T cell receptor
GB201702617D0 (en) Receptor
HK1256291A1 (zh) 衛生潔具沖水系統
PL3529267T3 (pl) Receptor komórek t
EP3350167A4 (en) Androgen receptor Antagonist
GB2542922B (en) Support Harness
PL3155011T3 (pl) Mutacje receptora hormonu glikoproteinowego
GB2528775B (en) Mixing device
GB2544560B (en) Mixing bowl
GB201701887D0 (en) Receptor
GB201700926D0 (en) Receptor
PL3500265T3 (pl) Selektywne ligandy receptora estrogenowego beta
GB201518991D0 (en) T cell receptors
HUE052830T2 (hu) Keverõszerkezet
GB201520136D0 (en) Fixing device for chairs
GB201515020D0 (en) Seat
GB201504285D0 (en) Receptor modulation
HUP1500233A2 (hu) Volfrám alapú metatézis katalizátorok
AU361668S (en) A swinging seat