DK3368519T3 - Hidtil ukendte, heterocykliske antiøstrogener - Google Patents
Hidtil ukendte, heterocykliske antiøstrogener Download PDFInfo
- Publication number
- DK3368519T3 DK3368519T3 DK16859220.2T DK16859220T DK3368519T3 DK 3368519 T3 DK3368519 T3 DK 3368519T3 DK 16859220 T DK16859220 T DK 16859220T DK 3368519 T3 DK3368519 T3 DK 3368519T3
- Authority
- DK
- Denmark
- Prior art keywords
- antiostrogenes
- heterocyclic
- hitherto unknown
- hitherto
- unknown
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4058MU2015 | 2015-10-27 | ||
| PCT/IN2016/050364 WO2017072792A1 (en) | 2015-10-27 | 2016-10-26 | Novel heterocyclic antiestrogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3368519T3 true DK3368519T3 (da) | 2022-05-23 |
Family
ID=58629986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16859220.2T DK3368519T3 (da) | 2015-10-27 | 2016-10-26 | Hidtil ukendte, heterocykliske antiøstrogener |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US10865199B2 (da) |
| EP (2) | EP4043438A1 (da) |
| JP (2) | JP6855475B2 (da) |
| KR (1) | KR20180088375A (da) |
| CN (1) | CN108699021B (da) |
| AU (1) | AU2016347679B2 (da) |
| BR (1) | BR112018008375B1 (da) |
| CA (1) | CA3001958A1 (da) |
| DK (1) | DK3368519T3 (da) |
| EA (1) | EA034131B1 (da) |
| ES (1) | ES2916223T3 (da) |
| HR (1) | HRP20220640T1 (da) |
| HU (1) | HUE059386T2 (da) |
| IL (2) | IL283559B (da) |
| LT (1) | LT3368519T (da) |
| MX (1) | MX2018005305A (da) |
| PH (1) | PH12018500829A1 (da) |
| PL (1) | PL3368519T3 (da) |
| PT (1) | PT3368519T (da) |
| RS (1) | RS63217B1 (da) |
| SA (1) | SA518391423B1 (da) |
| SG (2) | SG11201803119XA (da) |
| SI (1) | SI3368519T1 (da) |
| UA (1) | UA122348C2 (da) |
| WO (1) | WO2017072792A1 (da) |
| ZA (1) | ZA201802615B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA122348C2 (uk) * | 2015-10-27 | 2020-10-26 | Сан Фарма Адвансед Ресьорч Компані Лімітед | Нові гетероциклічні антиестрогени |
| MX2018007079A (es) | 2015-12-09 | 2018-11-12 | The Board Of Trustees Of Univ Of Illinois | Reguladores a la baja del receptor de estrogeno selectivo de benzotiofeno. |
| WO2018081168A2 (en) | 2016-10-24 | 2018-05-03 | The Board Of Trustees Of The University Of Illinois | Benzothiophene-based selective mixed estrogen receptor downregulators |
| MX2019008158A (es) | 2017-01-06 | 2019-12-09 | G1 Therapeutics Inc | Terapia de combinacion para el tratamiento del cancer. |
| US10208011B2 (en) | 2017-02-10 | 2019-02-19 | G1 Therapeutics, Inc. | Benzothiophene estrogen receptor modulators |
| JP2022541938A (ja) * | 2019-07-22 | 2022-09-28 | サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド | 選択的エストロゲン受容体分解剤 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| DE69023906T2 (de) | 1990-08-09 | 1996-04-11 | Council Scient Ind Res | Benzopyrane und Verfahren zu deren Herstellung. |
| US6060503A (en) | 1991-12-02 | 2000-05-09 | Endorecherche, Inc. | Benzopyran-containing compounds and method for their use |
| US5407947A (en) | 1993-11-05 | 1995-04-18 | Eli Lilly And Company | Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans |
| US5389646A (en) | 1993-12-30 | 1995-02-14 | Zymogenetics, Inc. | Methods for treatment and prevention of bone loss using 2,3-benzopyrans |
| US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| WO1999002512A1 (en) | 1997-07-09 | 1999-01-21 | Novo Nordisk A/S | Dl-2,3-diaryl-2h-1-benzopyrans |
| DE10013782A1 (de) * | 2000-03-15 | 2001-10-18 | Schering Ag | 4-Fluoralkyl-2H-benzopyrane mit antiestrogener Wirksamkeit, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten sowie deren Verwendung zur Herstellung von Arzneimitteln |
| WO2004091488A2 (en) * | 2003-04-14 | 2004-10-28 | Merck & Co., Inc. | Estrogen receptor modulators |
| EP1846397A1 (en) * | 2005-01-21 | 2007-10-24 | Janssen Pharmaceutica N.V. | Novel heterocyclic benzoy[c]chromene derivatives useful as modulators of the estrogen receptors |
| US20100317635A1 (en) * | 2009-06-16 | 2010-12-16 | Endorecherche, Inc. | Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators |
| CN102939287B (zh) * | 2010-06-10 | 2016-01-27 | 塞拉根制药公司 | ***受体调节剂及其用途 |
| US9193714B2 (en) | 2011-12-14 | 2015-11-24 | Seragon Pharmaceuticals, Inc. | Fluorinated estrogen receptor modulators and uses thereof |
| MD20140054A2 (ro) | 2011-12-16 | 2014-10-31 | Olema Pharmaceuticals, Inc. | Compuşi noi de benzopiran, compoziţii şi utilizări ale acestora |
| WO2014203132A1 (en) * | 2013-06-19 | 2014-12-24 | Olema Pharmaceuticals, Inc. | Substituted benzopyran compounds, compositions and uses thereof |
| WO2014205138A1 (en) | 2013-06-19 | 2014-12-24 | Seragon Pharmaceuticals, Inc. | Estrogen receptor modulator and uses thereof |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| US20160175284A1 (en) | 2014-12-18 | 2016-06-23 | Genentech, Inc. | Estrogen receptor modulators and uses thereof |
| JP6768711B2 (ja) | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
| UA122348C2 (uk) * | 2015-10-27 | 2020-10-26 | Сан Фарма Адвансед Ресьорч Компані Лімітед | Нові гетероциклічні антиестрогени |
-
2016
- 2016-10-26 UA UAA201805396A patent/UA122348C2/uk unknown
- 2016-10-26 EA EA201890981A patent/EA034131B1/ru unknown
- 2016-10-26 SG SG11201803119XA patent/SG11201803119XA/en unknown
- 2016-10-26 US US15/770,824 patent/US10865199B2/en active Active
- 2016-10-26 CA CA3001958A patent/CA3001958A1/en active Pending
- 2016-10-26 CN CN201680072702.8A patent/CN108699021B/zh active Active
- 2016-10-26 HR HRP20220640TT patent/HRP20220640T1/hr unknown
- 2016-10-26 ES ES16859220T patent/ES2916223T3/es active Active
- 2016-10-26 PT PT168592202T patent/PT3368519T/pt unknown
- 2016-10-26 PL PL16859220T patent/PL3368519T3/pl unknown
- 2016-10-26 KR KR1020187012256A patent/KR20180088375A/ko not_active Application Discontinuation
- 2016-10-26 EP EP22164031.1A patent/EP4043438A1/en active Pending
- 2016-10-26 LT LTEPPCT/IN2016/050364T patent/LT3368519T/lt unknown
- 2016-10-26 JP JP2018521529A patent/JP6855475B2/ja active Active
- 2016-10-26 BR BR112018008375-5A patent/BR112018008375B1/pt active IP Right Grant
- 2016-10-26 SI SI201631534T patent/SI3368519T1/sl unknown
- 2016-10-26 IL IL283559A patent/IL283559B/en unknown
- 2016-10-26 MX MX2018005305A patent/MX2018005305A/es unknown
- 2016-10-26 RS RS20220454A patent/RS63217B1/sr unknown
- 2016-10-26 AU AU2016347679A patent/AU2016347679B2/en active Active
- 2016-10-26 WO PCT/IN2016/050364 patent/WO2017072792A1/en active Application Filing
- 2016-10-26 DK DK16859220.2T patent/DK3368519T3/da active
- 2016-10-26 SG SG10201913001SA patent/SG10201913001SA/en unknown
- 2016-10-26 EP EP16859220.2A patent/EP3368519B1/en active Active
- 2016-10-26 HU HUE16859220A patent/HUE059386T2/hu unknown
-
2018
- 2018-04-18 PH PH12018500829A patent/PH12018500829A1/en unknown
- 2018-04-19 ZA ZA2018/02615A patent/ZA201802615B/en unknown
- 2018-04-24 SA SA518391423A patent/SA518391423B1/ar unknown
- 2018-04-26 IL IL258949A patent/IL258949B/en active IP Right Grant
-
2020
- 2020-10-28 US US17/082,488 patent/US11465990B2/en active Active
-
2021
- 2021-03-17 JP JP2021043019A patent/JP7052111B2/ja active Active
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