SI2953941T1 - Modulatorji metil-modificirajočih encimov, sestavki in uporabe le-teh - Google Patents
Modulatorji metil-modificirajočih encimov, sestavki in uporabe le-tehInfo
- Publication number
- SI2953941T1 SI2953941T1 SI201430274T SI201430274T SI2953941T1 SI 2953941 T1 SI2953941 T1 SI 2953941T1 SI 201430274 T SI201430274 T SI 201430274T SI 201430274 T SI201430274 T SI 201430274T SI 2953941 T1 SI2953941 T1 SI 2953941T1
- Authority
- SI
- Slovenia
- Prior art keywords
- modulators
- compositions
- modifying enzymes
- methyl modifying
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2013/025639 WO2013120104A2 (en) | 2012-02-10 | 2013-02-11 | Modulators of methyl modifying enzymes, compositions and uses thereof |
EP14708987.4A EP2953941B1 (en) | 2013-02-11 | 2014-02-11 | Modulators of methyl modifying enzymes, compositions and uses thereof |
PCT/US2014/015706 WO2014124418A1 (en) | 2013-02-11 | 2014-02-11 | Modulators of methyl modifying enzymes, compositions and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2953941T1 true SI2953941T1 (sl) | 2017-08-31 |
Family
ID=50239937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201430274T SI2953941T1 (sl) | 2013-02-11 | 2014-02-11 | Modulatorji metil-modificirajočih encimov, sestavki in uporabe le-teh |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP2953941B1 (sl) |
KR (1) | KR102219441B1 (sl) |
CN (1) | CN105102446B (sl) |
CL (1) | CL2015002239A1 (sl) |
CR (1) | CR20150457A (sl) |
HK (1) | HK1218648A1 (sl) |
IL (1) | IL239985B (sl) |
MA (1) | MA38341B1 (sl) |
ME (1) | ME02730B (sl) |
PE (1) | PE20160044A1 (sl) |
PH (1) | PH12015501720A1 (sl) |
PL (1) | PL2953941T3 (sl) |
RS (1) | RS56207B1 (sl) |
SG (1) | SG11201506077XA (sl) |
SI (1) | SI2953941T1 (sl) |
TW (1) | TWI629273B (sl) |
WO (1) | WO2014124418A1 (sl) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011160206A1 (en) | 2010-06-23 | 2011-12-29 | Morin Ryan D | Biomarkers for non-hodgkin lymphomas and uses thereof |
EP2780013A4 (en) | 2011-11-18 | 2015-07-01 | Constellation Pharmaceuticals Inc | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF |
US9085583B2 (en) | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
MY186837A (en) | 2014-12-23 | 2021-08-25 | Novartis Ag | Triazolopyrimidine compounds and uses thereof |
WO2016130396A1 (en) * | 2015-02-13 | 2016-08-18 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
WO2017018975A1 (en) | 2015-07-24 | 2017-02-02 | Constellation Pharmaceuticals, Inc. | Combination therapies for modulation of histone methyl modifying enzymes |
JP2018522045A (ja) * | 2015-08-03 | 2018-08-09 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドConstellation Pharmaceuticals,Inc. | Ezh2阻害剤および制御性t細胞機能の調節 |
KR20180042356A (ko) | 2015-08-24 | 2018-04-25 | 에피자임, 인코포레이티드 | 암 치료 방법 |
TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ezh2抑制劑 |
WO2017040190A1 (en) * | 2015-08-28 | 2017-03-09 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (r)-n-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1h-indole-3-carboxamide |
KR20180058829A (ko) | 2015-10-06 | 2018-06-01 | 에피자임, 인코포레이티드 | Ezh2 억제제로 수모세포종을 치료하는 방법 |
EP3674709A1 (en) | 2015-11-05 | 2020-07-01 | Epizyme Inc | Flow cytometry for monitoring histone h3 methylation status |
JP2019503391A (ja) | 2016-01-29 | 2019-02-07 | エピザイム,インコーポレイティド | 癌を処置するための併用療法 |
CN105669647B (zh) * | 2016-02-22 | 2018-05-04 | 上海皓元生物医药科技有限公司 | 一种组蛋白甲基化酶ezh2抑制剂中间体的合成方法 |
JP2019521988A (ja) | 2016-06-17 | 2019-08-08 | エピザイム,インコーポレイティド | 癌を処置するためのezh2阻害剤 |
RU2754856C2 (ru) | 2016-06-20 | 2021-09-08 | Новартис Аг | Кристаллические формы соединения триазолопиримидина |
CN109906224B (zh) | 2016-06-20 | 2022-02-25 | 诺华股份有限公司 | ***吡啶化合物及其应用 |
JP2019524872A (ja) * | 2016-06-20 | 2019-09-05 | ノバルティス アーゲー | 癌の治療に有用なイミダゾピリミジン化合物 |
CA3039059A1 (en) | 2016-10-19 | 2018-04-26 | Constellation Pharmaceuticals, Inc. | Synthesis of inhibitors of ezh2 |
AU2017367768A1 (en) | 2016-12-02 | 2019-07-18 | Epizyme, Inc. | Combination therapy for treating cancer |
CN110191722B (zh) | 2017-01-19 | 2022-03-01 | 第一三共株式会社 | 用于治疗htlv-1相关性脊髓病的药物组合物 |
US10266542B2 (en) | 2017-03-15 | 2019-04-23 | Mirati Therapeutics, Inc. | EZH2 inhibitors |
US11642346B2 (en) | 2017-03-31 | 2023-05-09 | Epizyme, Inc. | Combination therapy for treating cancer |
WO2018231973A1 (en) | 2017-06-13 | 2018-12-20 | Epizyme, Inc. | Inhibitors of ezh2 and methods of use thereof |
US20210161883A1 (en) | 2017-07-10 | 2021-06-03 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibitor-induced gene expression |
WO2019094552A1 (en) * | 2017-11-09 | 2019-05-16 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
JP7201400B2 (ja) | 2017-11-14 | 2023-01-10 | ファイザー・インク | Ezh2阻害剤組合せ療法 |
CN109879790B (zh) * | 2017-12-06 | 2022-09-20 | 华东师范大学 | 以吲哚或吲哚类似物为母核结构的酰胺类小分子有机化合物、用途及其制备方法 |
CN111757734A (zh) | 2017-12-28 | 2020-10-09 | 星座制药公司 | 通过组合疗法的ezh2抑制剂的药代动力学增强 |
ES2923290T3 (es) | 2018-01-31 | 2022-09-26 | Mirati Therapeutics Inc | Inhibidores de PRC2 |
CN110229157B (zh) * | 2018-03-06 | 2022-06-21 | 上海海和药物研究开发股份有限公司 | 嘧啶并五元芳香杂环类化合物、其制备方法及用途 |
CN110229151B (zh) * | 2018-03-06 | 2021-09-10 | 上海海和药物研究开发股份有限公司 | 吲嗪类化合物、其制备方法及用途 |
JP7453916B2 (ja) | 2018-03-14 | 2024-03-21 | バイオジェン・エムエイ・インコーポレイテッド | O-糖タンパク質-2-アセトアミド-2-デオキシ-3-d-グリコピラノシダーゼ阻害剤 |
WO2019226491A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
CA3104209A1 (en) | 2018-07-09 | 2020-01-16 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
SG11202102379XA (en) | 2018-09-19 | 2021-04-29 | Biogen Ma Inc | O-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors |
US20220017506A1 (en) | 2018-12-05 | 2022-01-20 | Biogen Ma Inc. | Morpholinyl, piperazinyl, oxazepanyl and diazepanyl o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors |
WO2020139339A1 (en) | 2018-12-27 | 2020-07-02 | Constellation Pharmaceuticals, Inc. | Ezh2 and androgen receptor signaling inhibitors as tools for targeting prostate cancer |
US20220106305A1 (en) | 2019-02-04 | 2022-04-07 | Biogen Ma Inc. | Bicyclic ether o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors |
JP2022524077A (ja) | 2019-03-08 | 2022-04-27 | バイオジェン・エムエイ・インコーポレイテッド | アゼチジニルo-糖タンパク質-2-アセトアミド-2-デオキシ-3-d-グルコピラノシダーゼ阻害剤 |
EP4003343A1 (en) | 2019-07-24 | 2022-06-01 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibition in combination therapies for the treatment of cancers |
WO2021086966A1 (en) | 2019-10-29 | 2021-05-06 | Biogen Ma Inc. | Spirocyclic o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors |
US20230286972A1 (en) | 2020-08-03 | 2023-09-14 | Biogen Ma Inc. | Crystaline forms of an o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitor |
CN112679505B (zh) * | 2020-12-25 | 2022-04-22 | 杭州澳赛诺生物科技有限公司 | 一种4-甲基-7H-吡咯并[2,3-d]嘧啶的合成方法 |
WO2022150962A1 (en) | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
WO2023111810A1 (en) | 2021-12-14 | 2023-06-22 | Pfizer Inc. | Combination therapies and uses for treating cancer |
WO2023209591A1 (en) | 2022-04-27 | 2023-11-02 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8536179B2 (en) * | 2010-05-07 | 2013-09-17 | Glaxosmithkline Llc | Indoles |
ES2951688T3 (es) * | 2011-02-28 | 2023-10-24 | Epizyme Inc | Compuestos de heteroarilo biciclico fusionados en 6,5 sustituidos |
JO3438B1 (ar) * | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
US9085583B2 (en) * | 2012-02-10 | 2015-07-21 | Constellation—Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
-
2014
- 2014-02-11 WO PCT/US2014/015706 patent/WO2014124418A1/en active Application Filing
- 2014-02-11 RS RS20170680A patent/RS56207B1/sr unknown
- 2014-02-11 PE PE2015001728A patent/PE20160044A1/es active IP Right Grant
- 2014-02-11 TW TW103104340A patent/TWI629273B/zh active
- 2014-02-11 ME MEP-2017-141A patent/ME02730B/me unknown
- 2014-02-11 EP EP14708987.4A patent/EP2953941B1/en active Active
- 2014-02-11 MA MA38341A patent/MA38341B1/fr unknown
- 2014-02-11 KR KR1020157024901A patent/KR102219441B1/ko active IP Right Grant
- 2014-02-11 PL PL14708987T patent/PL2953941T3/pl unknown
- 2014-02-11 SI SI201430274T patent/SI2953941T1/sl unknown
- 2014-02-11 CN CN201480019417.0A patent/CN105102446B/zh active Active
- 2014-02-11 SG SG11201506077XA patent/SG11201506077XA/en unknown
-
2015
- 2015-07-16 IL IL239985A patent/IL239985B/en active IP Right Grant
- 2015-08-05 PH PH12015501720A patent/PH12015501720A1/en unknown
- 2015-08-11 CL CL2015002239A patent/CL2015002239A1/es unknown
- 2015-09-02 CR CR20150457A patent/CR20150457A/es unknown
-
2016
- 2016-06-08 HK HK16106614.5A patent/HK1218648A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
IL239985A0 (en) | 2015-09-24 |
MA38341B1 (fr) | 2018-11-30 |
MA38341A1 (fr) | 2018-01-31 |
TWI629273B (zh) | 2018-07-11 |
ME02730B (me) | 2017-10-20 |
CL2015002239A1 (es) | 2016-02-05 |
EP2953941A1 (en) | 2015-12-16 |
SG11201506077XA (en) | 2015-08-28 |
PE20160044A1 (es) | 2016-02-11 |
EP2953941B1 (en) | 2017-04-05 |
RS56207B1 (sr) | 2017-11-30 |
KR102219441B1 (ko) | 2021-02-23 |
CN105102446B (zh) | 2018-01-23 |
PH12015501720B1 (en) | 2015-11-09 |
PL2953941T3 (pl) | 2017-11-30 |
WO2014124418A1 (en) | 2014-08-14 |
HK1218648A1 (zh) | 2017-03-03 |
CN105102446A (zh) | 2015-11-25 |
CR20150457A (es) | 2015-10-20 |
PH12015501720A1 (en) | 2015-11-09 |
KR20150119201A (ko) | 2015-10-23 |
TW201443038A (zh) | 2014-11-16 |
IL239985B (en) | 2018-11-29 |
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