SG52988G - Dihydropyridines with a positive inotropic activity,their use in pharmaceutical preparations,and processes for their preparation - Google Patents

Dihydropyridines with a positive inotropic activity,their use in pharmaceutical preparations,and processes for their preparation

Info

Publication number
SG52988G
SG52988G SG52988A SG52988A SG52988G SG 52988 G SG52988 G SG 52988G SG 52988 A SG52988 A SG 52988A SG 52988 A SG52988 A SG 52988A SG 52988 G SG52988 G SG 52988G
Authority
SG
Singapore
Prior art keywords
dihydropyridines
processes
preparation
pharmaceutical preparations
positive inotropic
Prior art date
Application number
SG52988A
Other languages
English (en)
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25794943&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG52988(G) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19813130041 external-priority patent/DE3130041A1/de
Priority claimed from DE19823206671 external-priority patent/DE3206671A1/de
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SG52988G publication Critical patent/SG52988G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
SG52988A 1981-07-30 1988-04-22 Dihydropyridines with a positive inotropic activity,their use in pharmaceutical preparations,and processes for their preparation SG52988G (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19813130041 DE3130041A1 (de) 1981-07-30 1981-07-30 Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung
DE19823206671 DE3206671A1 (de) 1982-02-25 1982-02-25 Dihydropyridine mit positiv inotroper wirkung, neue verbindungen, ihre verwendung in arzneimitteln und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
SG52988G true SG52988G (en) 1993-02-19

Family

ID=25794943

Family Applications (1)

Application Number Title Priority Date Filing Date
SG52988A SG52988G (en) 1981-07-30 1988-04-22 Dihydropyridines with a positive inotropic activity,their use in pharmaceutical preparations,and processes for their preparation

Country Status (21)

Country Link
US (1) US4532248A (fr)
EP (1) EP0071819B2 (fr)
JP (2) JPH066535B2 (fr)
KR (2) KR890001566B1 (fr)
AU (1) AU566502B2 (fr)
CA (1) CA1212672A (fr)
CH (1) CH656530A5 (fr)
DE (1) DE3276112D1 (fr)
DK (1) DK339782A (fr)
ES (1) ES514525A0 (fr)
FI (1) FI822643L (fr)
FR (1) FR2511247B1 (fr)
GB (1) GB2105989B (fr)
HK (1) HK19389A (fr)
IE (1) IE54259B1 (fr)
IL (1) IL66405A (fr)
IT (1) IT1190929B (fr)
NL (1) NL8202958A (fr)
NZ (1) NZ201395A (fr)
PH (1) PH23086A (fr)
SG (1) SG52988G (fr)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2111978B (en) * 1981-10-19 1985-05-01 Maruko Pharmaceutical Co 1 4-dihydropyridine compounds
EP0080220B1 (fr) * 1981-11-17 1986-02-19 FISONS plc Dihydropyridines, leur procédé de préparation, leurs compositions et leur application comme médicaments
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
DE3209274A1 (de) * 1982-03-13 1983-09-15 Bayer Ag, 5090 Leverkusen Pyridincarbonsaeureester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4414213A (en) * 1982-03-22 1983-11-08 Mead Johnson & Company Dihydropyridyl cyclic imidate esters and their pharmaceutical use
DE3363743D1 (en) * 1982-07-22 1986-07-03 Pfizer Ltd Dihydropyridine anti-ischaemic and antihypertensive agents
DE3235221A1 (de) * 1982-09-23 1984-03-29 Bayer Ag, 5090 Leverkusen Ringverbrueckte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0106275B1 (fr) * 1982-10-15 1991-03-13 Kyowa Hakko Kogyo Co., Ltd. Dérivés de 1,4-dihydropyridine
JPS5970666A (ja) * 1982-10-15 1984-04-21 Kyowa Hakko Kogyo Co Ltd １，４−ジヒドロピリジン誘導体
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
EP0111453A1 (fr) * 1982-12-10 1984-06-20 Ciba-Geigy Ag Dérivés d'amides
EP0111455A3 (fr) * 1982-12-10 1984-07-25 Ciba-Geigy Ag Lactones non-saturés
GR79111B (fr) * 1982-12-20 1984-10-02 Lepetit Spa
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EP0125803A3 (fr) * 1983-04-27 1987-01-21 FISONS plc Dihydropyridines pharmaceutiquement actives
DE3319956A1 (de) * 1983-06-01 1984-12-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents
EP0141221A1 (fr) * 1983-09-26 1985-05-15 Nissan Chemical Industries Ltd. Ester d'acide dihydro-1,4-pyridinephosphonique-5
EP0141222B1 (fr) * 1983-09-26 1989-04-12 Nissan Chemical Industries Ltd. Ester cyclique de l'acide dihydropyridine-phosphonique-5
FR2554109A1 (fr) * 1983-11-01 1985-05-03 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation en therapeutique comme medicaments
US5137889A (en) * 1983-12-02 1992-08-11 Otsuka Pharmaceutical Co., Ltd. Dihydropyridine derivatives and process for preparing the same
DE3343658A1 (de) * 1983-12-02 1985-06-13 Bayer Ag, 5090 Leverkusen Hydroxy-tetrahydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
JPS60156671A (ja) * 1984-01-25 1985-08-16 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体およびその製造法
GB8403866D0 (en) * 1984-02-14 1984-03-21 Recordati Chem Pharm Diphenylalkylaminoalkyl esters
DE3410645A1 (de) * 1984-03-23 1985-09-26 Bayer Ag, 5090 Leverkusen L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
US4567268A (en) * 1984-04-03 1986-01-28 Merck & Co., Inc. Process for preparation of certain tetrahydrofuro[3,4-b]pyridines
DE3414801A1 (de) * 1984-04-19 1985-10-24 Bayer Ag, 5090 Leverkusen 4-(nitrophenyl)-tetrahydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4672068A (en) * 1984-05-04 1987-06-09 Fujirebio Kabushiki Kaisha Antihypertensive 1,4-dihydropyridines having a conjugated ester
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GB8415386D0 (en) * 1984-06-15 1984-07-18 Pfizer Ltd Therapeutic agents
US4731370A (en) * 1984-06-25 1988-03-15 Toyama Chemical Co., Ltd. Pyridyl ester containing 1,4-dihydropyridine derivatives and salts thereof and pharmaceutical composition containing the same
GB2162513B (en) * 1984-06-25 1988-01-20 Toyama Chemical Co Ltd Dihydropyridine derivatives
FI852359L (fi) * 1984-06-27 1985-12-28 Hoffmann La Roche Dihydropyridinderivat.
JPS6112662A (ja) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体及びその製法
GB8421039D0 (en) * 1984-08-17 1984-09-19 Wyeth John & Brother Ltd Heterocyclic compounds
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
DE3431152A1 (de) * 1984-08-24 1986-03-06 Cassella Ag, 6000 Frankfurt Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel
DE3587851D1 (de) * 1984-09-28 1994-07-21 Byk Gulden Lomberg Chem Fab Neue Diarylverbindungen.
JPS6191185A (ja) * 1984-10-11 1986-05-09 Sumitomo Seiyaku Kk 新規なオキサジアゾリル−１，４−ジヒドロピリジン誘導体
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
US4616002A (en) * 1984-11-09 1986-10-07 Ciba-Geigy Corporation Dihydro pyridine compounds, compositions and use
DE3443179A1 (de) * 1984-11-27 1986-05-28 Cassella Ag, 6000 Frankfurt 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung
US4678796A (en) * 1984-11-30 1987-07-07 Warner-Lambert Company 2-alkylidene derivatives of 1,2,3,4-tetrahydropyridine-2,5-pyridine carboxylic acid dialkyl esters useful for treatment of cardiovascular disorders
NL8503262A (nl) * 1984-12-10 1986-07-01 Sandoz Ag 1,4-dihydropyridinederivaten, werkwijze voor het bereiden van deze derivaten en farmaceutische preparaten die ze bevatten.
JPH0676405B2 (ja) * 1986-06-13 1994-09-28 日清製粉株式会社 １，４―ジヒドロピリジン誘導体およびそれを含有する医薬組成物
DE3447169A1 (de) * 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
DE3501855A1 (de) * 1985-01-22 1986-07-24 Bayer Ag, 5090 Leverkusen 5-aryl-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US4652573A (en) * 1985-03-14 1987-03-24 Nelson Research & Development Co. Calcium antagonist N-hetero ester 1,4-dihydropyridines
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
ATE78816T1 (de) * 1985-03-15 1992-08-15 Suntory Ltd N-substituierte 3,4-dihydropyrimidinderivate, verfahren zu deren herstellung und diese enthaltende zusammenstellung fuer die behandlung von anordnungen eines kardiovascularen systems.
DE3517473A1 (de) * 1985-05-15 1986-11-20 Bayer Ag, 5090 Leverkusen Pyrimidinyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US4728652A (en) * 1985-05-20 1988-03-01 E. R. Squibb & Sons, Inc. 2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure
CA1267416A (fr) * 1985-06-17 1990-04-03 Ila Sircar Derives de la 1,4-dihydropyridine utiles pour le traitement de desordres cardiovasculaires
DE3521761A1 (de) * 1985-06-19 1987-01-02 Bayer Ag Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
ZA863578B (en) * 1985-06-21 1987-02-25 Hoffmann La Roche Dihydropyridine derivatives
JPS6210087A (ja) * 1985-07-03 1987-01-19 Shionogi & Co Ltd ４，７−ジヒドロチエノ〔２，３−ｂ〕ピリジン誘導体，その製造法および循環器系疾患治療剤
IT1215298B (it) * 1985-08-06 1990-01-31 Boehringer Biochemia Srl 2-(eteroalchil)-1,4-diidropiridine ed un processo per la loro produzione.
DE3528602A1 (de) * 1985-08-09 1987-02-12 Bayer Ag 1,4-dihydropyridinderivate, ihre herstellung und ihre verwendung in arzneimitteln
IT1201454B (it) * 1985-08-19 1989-02-02 Boehringer Biochemia Srl 1,4-diidropiridine-2-sostituite
EP0226271B1 (fr) * 1985-08-21 1990-11-22 GLAXO S.p.A. Dihydro-1,4 pyridines, leur préparation et composition pharmaceutique
IT1190405B (it) * 1985-10-22 1988-02-16 Recordati Chem Pharm Derivati del flavone
GB8527698D0 (en) * 1985-11-09 1985-12-11 Pfizer Ltd Dihydropyridine antiischaemic & antihypertensive agents
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
DE3544693A1 (de) * 1985-12-18 1987-06-19 Bayer Ag 4-thienyl-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5162338A (en) * 1986-01-11 1992-11-10 Bayer Aktiengesellschaft Circulation active 4-aminoaryldihydropryidine lactones
DE3600594A1 (de) * 1986-01-11 1987-07-16 Bayer Ag Methioninsubstituierte 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung
DE3600596A1 (de) * 1986-01-11 1987-07-16 Bayer Ag 4-aminoaryldihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3601196A1 (de) * 1986-01-17 1987-07-23 Merck Patent Gmbh 1,4-dihydropyridine
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IT1204459B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
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US4684656A (en) * 1986-03-14 1987-08-04 E. R. Squibb & Sons, Inc. 1,2,3,4-tetrahydro-6-substituted-4-aryl-3-(substituted sulfonyl)-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and method of using them to lower blood pressure
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JPS5826872A (ja) 1983-02-17
EP0071819A1 (fr) 1983-02-16
DE3276112D1 (en) 1987-05-27
KR890001567B1 (ko) 1989-05-08
FI822643L (fi) 1983-02-01
IL66405A (en) 1987-12-31
NL8202958A (nl) 1983-02-16
IT8222620A1 (it) 1984-01-28
IT1190929B (it) 1988-02-24
KR840000494A (ko) 1984-02-22
JPH066535B2 (ja) 1994-01-26
FI822643A0 (fi) 1982-07-28
US4532248A (en) 1985-07-30
GB2105989B (en) 1986-01-08
GB2105989A (en) 1983-04-07
IL66405A0 (en) 1982-11-30
IE54259B1 (en) 1989-08-02
EP0071819B2 (fr) 1992-06-10
JPH05271078A (ja) 1993-10-19
ES8305716A1 (es) 1983-04-16
DK339782A (da) 1983-01-31
IT8222620A0 (it) 1982-07-28
IE821827L (en) 1983-01-30
FR2511247B1 (fr) 1986-03-07
CH656530A5 (de) 1986-07-15
NZ201395A (en) 1987-02-20
CA1212672A (fr) 1986-10-14
AU8594582A (en) 1983-02-03
ES514525A0 (es) 1983-04-16
EP0071819B1 (fr) 1987-04-22
AU566502B2 (en) 1987-10-22
FR2511247A1 (fr) 1983-02-18
KR890001566B1 (ko) 1989-05-08
HK19389A (en) 1989-03-17
PH23086A (en) 1989-04-10

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