SG48237A1 - Piperidine compounds - Google Patents
Piperidine compoundsInfo
- Publication number
- SG48237A1 SG48237A1 SG1996008163A SG1996008163A SG48237A1 SG 48237 A1 SG48237 A1 SG 48237A1 SG 1996008163 A SG1996008163 A SG 1996008163A SG 1996008163 A SG1996008163 A SG 1996008163A SG 48237 A1 SG48237 A1 SG 48237A1
- Authority
- SG
- Singapore
- Prior art keywords
- sup
- sub
- hydrogen
- alkylene
- substituents
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK112991A DK112991D0 (da) | 1991-06-13 | 1991-06-13 | Carbocycliske eller heterocycliske forbindelser |
DK113191A DK113191D0 (da) | 1991-06-13 | 1991-06-13 | Spirocycliske forbindelser |
DK15792A DK15792D0 (da) | 1992-02-10 | 1992-02-10 | Spirocyclic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SG48237A1 true SG48237A1 (en) | 1998-04-17 |
Family
ID=27220471
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996008163A SG48237A1 (en) | 1991-06-13 | 1992-06-12 | Piperidine compounds |
Country Status (22)
Country | Link |
---|---|
US (4) | US5665725A (no) |
EP (4) | EP0518805A1 (no) |
JP (3) | JP2834577B2 (no) |
KR (1) | KR100212231B1 (no) |
AT (2) | ATE170523T1 (no) |
AU (1) | AU664557B2 (no) |
CA (1) | CA2111204C (no) |
CZ (1) | CZ289479B6 (no) |
DE (2) | DE69226867T2 (no) |
DK (1) | DK0593511T3 (no) |
ES (1) | ES2123557T3 (no) |
FI (2) | FI108137B (no) |
HK (1) | HK1009272A1 (no) |
HU (1) | HU210869A9 (no) |
IE (3) | IE990567A1 (no) |
IL (1) | IL102155A0 (no) |
NO (4) | NO934494D0 (no) |
NZ (1) | NZ243065A (no) |
RU (1) | RU2142952C1 (no) |
SG (1) | SG48237A1 (no) |
SK (3) | SK281748B6 (no) |
WO (1) | WO1992022554A1 (no) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
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TW263504B (no) * | 1991-10-03 | 1995-11-21 | Pfizer | |
GB9305641D0 (en) * | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
JPH08511522A (ja) * | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
GB9510459D0 (en) * | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
US5654316A (en) * | 1995-06-06 | 1997-08-05 | Schering Corporation | Piperidine derivatives as neurokinin antagonists |
EP0859777B1 (en) * | 1995-10-13 | 2007-05-23 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives, their preparation and use |
EP0901490B1 (en) * | 1996-05-13 | 2004-04-07 | Syngenta Limited | Bicyclic amines as insecticides |
WO1998008816A1 (fr) * | 1996-08-26 | 1998-03-05 | Meiji Seika Kaisha, Ltd. | Derives d'indoxyle et psychotropes |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
CN1245499A (zh) | 1996-11-26 | 2000-02-23 | 曾尼卡有限公司 | 8-氮杂双环[3.2.1]辛烷,8-氮杂双环[3.2.1]辛-6-烯,9-氮杂双环[3.3.1]壬烷,9-氮杂-3-氧双环[3.3.1]壬烷和9-氮杂-3-硫双环[3,3,1]壬烷衍生物,它们的制备以及作为杀虫剂的应用 |
GB9704948D0 (en) * | 1997-03-11 | 1997-04-30 | Knoll Ag | Therapeutic agents |
CA2291674A1 (en) * | 1997-05-29 | 1998-12-03 | Eli Lilly And Company | 5-ht1a and 5-ht1d.alpha. antagonists |
US6376505B1 (en) | 1997-05-29 | 2002-04-23 | Eli Lilly And Company | 5-HT1A and 5-HT1Dαdalpha antagonists |
DE19725664A1 (de) * | 1997-06-18 | 1998-12-24 | Merck Patent Gmbh | 3-Benzylpiperidine |
DE69801764T2 (de) | 1997-07-08 | 2002-07-04 | H. Lundbeck A/S, Kobenhavn-Valby | Verfahren zur herstellung von citalopram |
UA64769C2 (uk) | 1997-11-07 | 2004-03-15 | Х. Луннбек А/С | Гідрогалогеніди 1'-[4-[1-(4-фторофеніл)-1н-індол-3-іл]-1-бутил]-спіро[ізобензофуран-1(3н),4'-піперидину], фармацевтична композиція та спосіб лікування |
CZ292911B6 (cs) | 1997-11-11 | 2004-01-14 | H. Lundbeck A/S | Způsob výroby citalopramu |
US6013652A (en) * | 1997-12-04 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as neurokinin antagonists |
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PL342989A1 (en) | 1998-04-07 | 2001-07-16 | Lundbeck & Co As H | Treatment of panic attacks |
EP1068184B1 (en) * | 1998-04-08 | 2002-09-04 | Wyeth | N-aryloxyethylamine derivatives for the treatment of depression |
JP2002524515A (ja) | 1998-09-15 | 2002-08-06 | ハー・ルンドベック・アクチエゼルスカベット | うつ病の治療方法 |
US6506378B1 (en) * | 1998-12-16 | 2003-01-14 | Arch Development Corporation | Vesicular monoamine transporter gene therapy in Parkinson's disease |
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US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
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DE10153346A1 (de) | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
EP1474390B1 (en) | 2002-02-13 | 2009-07-22 | Meiji Dairies Corporation | Indole derivatives substituted with long-chain alcohols and medicaments containing them |
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DK1781618T3 (da) | 2004-08-27 | 2012-10-29 | Esteve Labor Dr | Sigma-receptorinhibitorer |
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JP2009542670A (ja) | 2006-06-29 | 2009-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
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EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
SG10201500832PA (en) * | 2010-02-04 | 2015-04-29 | Esteve Labor Dr | 4-[-2-[[5-methyl-1-(2-naphtalenyl)-1h-pyrazol-3-yl]oxy]ethyl]morpholine hydrochloride polymorphs and solvates |
EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
CN102762554A (zh) * | 2010-02-16 | 2012-10-31 | 辉瑞大药厂 | 5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇 |
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1992
- 1992-06-08 NZ NZ243065A patent/NZ243065A/en not_active IP Right Cessation
- 1992-06-10 IL IL102155A patent/IL102155A0/xx not_active IP Right Cessation
- 1992-06-12 DE DE69226867T patent/DE69226867T2/de not_active Expired - Fee Related
- 1992-06-12 EP EP92610044A patent/EP0518805A1/en active Pending
- 1992-06-12 JP JP5500747A patent/JP2834577B2/ja not_active Expired - Lifetime
- 1992-06-12 EP EP98101728A patent/EP0853085A1/en not_active Withdrawn
- 1992-06-12 AT AT92912044T patent/ATE170523T1/de not_active IP Right Cessation
- 1992-06-12 SK SK1005-99A patent/SK281748B6/sk not_active IP Right Cessation
- 1992-06-12 EP EP98101729A patent/EP0859004B1/en not_active Expired - Lifetime
- 1992-06-12 SG SG1996008163A patent/SG48237A1/en unknown
- 1992-06-12 CZ CZ19932726A patent/CZ289479B6/cs not_active IP Right Cessation
- 1992-06-12 WO PCT/DK1992/000183 patent/WO1992022554A1/en active IP Right Grant
- 1992-06-12 RU RU93058600A patent/RU2142952C1/ru not_active IP Right Cessation
- 1992-06-12 DE DE69233038T patent/DE69233038T2/de not_active Expired - Fee Related
- 1992-06-12 SK SK1409-93A patent/SK280899B6/sk not_active IP Right Cessation
- 1992-06-12 ES ES92912044T patent/ES2123557T3/es not_active Expired - Lifetime
- 1992-06-12 KR KR1019930703860A patent/KR100212231B1/ko not_active IP Right Cessation
- 1992-06-12 CA CA002111204A patent/CA2111204C/en not_active Expired - Fee Related
- 1992-06-12 DK DK92912044T patent/DK0593511T3/da active
- 1992-06-12 SK SK1004-99A patent/SK281747B6/sk not_active IP Right Cessation
- 1992-06-12 AT AT98101729T patent/ATE239022T1/de not_active IP Right Cessation
- 1992-06-12 EP EP92912044A patent/EP0593511B1/en not_active Expired - Lifetime
- 1992-06-12 AU AU19848/92A patent/AU664557B2/en not_active Ceased
- 1992-07-01 IE IE19990567A patent/IE990567A1/en not_active IP Right Cessation
- 1992-07-01 IE IE188292A patent/IE921882A1/en not_active IP Right Cessation
- 1992-07-01 IE IE19990568A patent/IE990568A1/en not_active IP Right Cessation
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1993
- 1993-12-09 NO NO934494D patent/NO934494D0/no unknown
- 1993-12-09 NO NO934494A patent/NO306497B1/no not_active IP Right Cessation
- 1993-12-10 FI FI935558A patent/FI108137B/fi active
- 1993-12-13 US US08/166,647 patent/US5665725A/en not_active Expired - Lifetime
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1995
- 1995-03-30 HU HU95P/P00094P patent/HU210869A9/hu unknown
- 1995-06-07 US US08/486,510 patent/US6031099A/en not_active Expired - Fee Related
- 1995-06-07 US US08/478,563 patent/US5807871A/en not_active Expired - Fee Related
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1998
- 1998-05-06 JP JP13918398A patent/JP3203230B2/ja not_active Expired - Fee Related
- 1998-05-06 JP JP10139146A patent/JPH111475A/ja active Pending
- 1998-08-12 HK HK98109879A patent/HK1009272A1/xx not_active IP Right Cessation
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1999
- 1999-09-07 US US09/391,290 patent/US6207677B1/en not_active Expired - Fee Related
- 1999-09-16 NO NO19994488A patent/NO310275B1/no not_active IP Right Cessation
- 1999-09-16 NO NO994487A patent/NO994487D0/no not_active Application Discontinuation
- 1999-10-04 FI FI992135A patent/FI112480B/fi active
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