SG11202104136YA - Heterodimeric fc-fused proteins - Google Patents

Heterodimeric fc-fused proteins

Info

Publication number
SG11202104136YA
SG11202104136YA SG11202104136YA SG11202104136YA SG11202104136YA SG 11202104136Y A SG11202104136Y A SG 11202104136YA SG 11202104136Y A SG11202104136Y A SG 11202104136YA SG 11202104136Y A SG11202104136Y A SG 11202104136YA SG 11202104136Y A SG11202104136Y A SG 11202104136YA
Authority
SG
Singapore
Prior art keywords
heterodimeric
fused proteins
fused
proteins
Prior art date
Application number
SG11202104136YA
Other languages
English (en)
Inventor
Ann Cheung
Jean-Marie Cuillerot
Asya Grinberg
Eva Gutierrez
William Haney
Nicolai Wagtmann
Original Assignee
Dragonfly Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dragonfly Therapeutics Inc filed Critical Dragonfly Therapeutics Inc
Publication of SG11202104136YA publication Critical patent/SG11202104136YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
SG11202104136YA 2018-10-23 2019-10-23 Heterodimeric fc-fused proteins SG11202104136YA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201862749489P 2018-10-23 2018-10-23
US201862781898P 2018-12-19 2018-12-19
US201962788499P 2019-01-04 2019-01-04
US201962827347P 2019-04-01 2019-04-01
US201962895889P 2019-09-04 2019-09-04
PCT/US2019/057721 WO2020086758A1 (fr) 2018-10-23 2019-10-23 Protéines hétérodimères fusionnées à un fragment fc

Publications (1)

Publication Number Publication Date
SG11202104136YA true SG11202104136YA (en) 2021-05-28

Family

ID=68583501

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202104136YA SG11202104136YA (en) 2018-10-23 2019-10-23 Heterodimeric fc-fused proteins

Country Status (17)

Country Link
US (2) US20220119533A1 (fr)
EP (1) EP3870598A1 (fr)
JP (1) JP2022505871A (fr)
KR (1) KR20210080460A (fr)
CN (1) CN113286808A (fr)
AU (1) AU2019366956A1 (fr)
BR (1) BR112021007175A2 (fr)
CA (1) CA3117212A1 (fr)
CL (2) CL2021001058A1 (fr)
CO (1) CO2021006474A2 (fr)
IL (1) IL281954A (fr)
MA (1) MA53982A (fr)
MX (1) MX2021004711A (fr)
PE (1) PE20211279A1 (fr)
SG (1) SG11202104136YA (fr)
TW (1) TW202033547A (fr)
WO (1) WO2020086758A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016104657A1 (fr) * 2014-12-26 2016-06-30 橋本 正 Agent thérapeutique contre le cancer
CA3033475A1 (fr) 2016-08-10 2018-02-15 Ajou University Industry-Academic Cooperation Foundation Cytokine a fusion fc heterodimerique et composition pharmaceutique la comprenant
CN110944651A (zh) 2017-02-08 2020-03-31 蜻蜓疗法股份有限公司 用于自然杀伤细胞激活的多特异性结合蛋白及其治疗癌症的治疗性用途
PE20220278A1 (es) 2018-02-08 2022-02-25 Dragonfly Therapeutics Inc Dominios variables de anticuerpos que se dirigen al receptor nkg2d
AU2019218125A1 (en) * 2018-02-08 2020-08-20 Dragonfly Therapeutics, Inc. Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells
MA52366A (fr) 2018-04-25 2021-03-03 Prometheus Biosciences Inc Anticorps anti-tl1a optimisés
EP3818083A2 (fr) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Molécules d'anticorps anti-tcr et leurs utilisations
MX2021003543A (es) 2018-09-27 2021-06-23 Xilio Dev Inc Polipeptidos de citocinas enmascaradas.
US11358999B2 (en) 2018-10-03 2022-06-14 Xencor, Inc. IL-12 heterodimeric Fc-fusion proteins
PE20211279A1 (es) 2018-10-23 2021-07-19 Dragonfly Therapeutics Inc Proteinas heterodimericas fusionadas con fc
US20210130495A1 (en) * 2019-09-27 2021-05-06 Agenus Inc. Heterodimeric proteins
CA3157024A1 (fr) 2019-10-03 2021-04-08 Xencor, Inc. Proteines de fusion fc heterodimeres d'il-12 ciblees
KR20220103721A (ko) 2019-10-24 2022-07-22 프로메테우스 바이오사이언시즈, 인크. Tnf 유사 리간드 1a(tl1a)에 대한 인간화 항체 및 그의 용도
IL297225A (en) 2020-04-10 2022-12-01 Cytomx Therapeutics Inc Activatable cytokine constructs and related compositions and methods
EP4138778A1 (fr) * 2020-04-22 2023-03-01 Dragonfly Therapeutics, Inc. Formulation, schéma posologique et procédé de fabrication de protéines fusionnées avec fc hétérodimères
CN115803091A (zh) * 2020-05-22 2023-03-14 福迈康股份公司 Ace2-fc融合蛋白及其用途
WO2022090469A2 (fr) * 2020-10-29 2022-05-05 Formycon Ag Protéines de fusion ace2 et leurs utilisations
TW202304958A (zh) 2021-03-16 2023-02-01 美商Ｃｙｔｏｍｘ生物製藥公司 經遮蔽之可活化之細胞介素構築體及相關之組成物及方法
KR20240036570A (ko) * 2021-07-22 2024-03-20 에프. 호프만-라 로슈 아게 이종이량체 Fc 도메인 항체
CN115925984A (zh) * 2021-08-24 2023-04-07 广东东阳光药业有限公司 Gdf15融合蛋白及其用途
WO2023070056A2 (fr) * 2021-10-20 2023-04-27 Synthekine, Inc. Cytokines fc hétérodimères et leurs utilisations
WO2023086772A1 (fr) 2021-11-12 2023-05-19 Xencor, Inc. Anticorps bispécifiques se liant à b7h3 et à nkg2d
WO2024086739A1 (fr) 2022-10-20 2024-04-25 Synthekine, Inc. Procédés et compositions de mutéines il12 et de mutéines il2

Family Cites Families (125)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4722848A (en) 1982-12-08 1988-02-02 Health Research, Incorporated Method for immunizing animals with synthetically modified vaccinia virus
WO1988007089A1 (fr) 1987-03-18 1988-09-22 Medical Research Council Anticorps alteres
US5391481A (en) 1990-08-31 1995-02-21 The Trustees Of Columbia University Antibody which is directed against and inhibits collagen binding to a VLA-1 epitope and uses thereof
GB9022040D0 (en) 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
US5851794A (en) 1990-10-22 1998-12-22 Alfa Laval Ab Collagen binding protein as well as its preparation
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
CA2117780A1 (fr) 1992-04-10 1993-10-28 Paul F. Goetinck Proteine structurale de cartilage et modes d'emploi
US5491130A (en) 1992-11-10 1996-02-13 The United States Of America As Represented By The Department Of Health And Human Services Peptide inhibitors of fibronectin and related collagen-binding proteins
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5849589A (en) 1996-03-11 1998-12-15 Duke University Culturing monocytes with IL-4, TNF-α and GM-CSF TO induce differentiation to dendric cells
EP0950068B1 (fr) 1996-05-16 2005-11-09 THE TEXAS A&M UNIVERSITY SYSTEM Compositions de proteine de liaison du collagene et procedes d'utilisation
US7951917B1 (en) 1997-05-02 2011-05-31 Genentech, Inc. Method for making multispecific antibodies having heteromultimeric and common components
WO1999029732A2 (fr) 1997-12-08 1999-06-17 Lexigen Pharmaceuticals Corporation Proteines de fusion heterodymeres utiles en therapie immune ciblee et a une stimulation immune generale
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6387663B1 (en) 1998-07-31 2002-05-14 University Of Southern California Targeting pharmaceutical agents to injured tissues
WO2000021989A1 (fr) 1998-10-09 2000-04-20 Medimmune, Inc. Proteines dbp a et b liant la decorine et gene codant pour elles
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US7183387B1 (en) 1999-01-15 2007-02-27 Genentech, Inc. Polypeptide variants with altered effector function
US6566489B1 (en) 1999-03-15 2003-05-20 The General Hospital Corporation Syndecan-4 binding protein (S4BP) and uses thereof
US6864235B1 (en) 1999-04-01 2005-03-08 Eva A. Turley Compositions and methods for treating cellular response to injury and other proliferating cell disorders regulated by hyaladherin and hyaluronans
US6908994B1 (en) 1999-05-10 2005-06-21 The Texas A&M University System Collagen-binding proteins from enterococcal bacteria
AU5495500A (en) 1999-06-16 2001-01-02 The Texas A & M University System Decorin binding protein essential peptides and methods of use
AU5622800A (en) 1999-06-18 2001-01-09 Med Immune, Inc. Combined decorin binding protein and outer surface protein compositions and methods of use
CA2394576A1 (fr) 1999-12-15 2001-06-21 Research Development Foundation Betaglycane utilise comme recepteur de l'inhibine et ses utilisations
US6777547B1 (en) 2000-01-31 2004-08-17 Andreas Podbielski Collagen-binding proteins from streptococcus pyogenes
US6517838B1 (en) 2000-06-16 2003-02-11 The Texas A&M University System Decorin binding protein essential peptides and methods of use
WO2002024223A2 (fr) 2000-09-21 2002-03-28 The Brigham And Women's Hospital, Inc. Prevention et traitement d'une infection streptococcique et staphylococcique
JP4281869B2 (ja) 2001-06-22 2009-06-17 中外製薬株式会社 抗グリピカン３抗体を含む細胞増殖抑制剤
US8192744B2 (en) 2002-08-26 2012-06-05 Ibcc Holding As Drug for treating states related to the inhibition of angiogenesis and/or endothelial cell proliferation
US7488792B2 (en) 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
GB0406415D0 (en) 2004-03-22 2004-04-21 Inst Of Cancer Res The Materials and methods for treatment of cancer
WO2005114186A1 (fr) 2004-05-20 2005-12-01 Wako Pure Chemical Industries, Ltd. Procédé de dosage de l'acide hyaluronique en utilisant une protéine liant l'acide hyaluronique
WO2005124356A2 (fr) 2004-06-18 2005-12-29 Roche Diagnostics Gmbh Utilisation d'une proteine cbp2 en tant que marqueur pour un cancer colorectal
NZ579543A (en) 2004-07-09 2011-07-29 Chugai Pharmaceutical Co Ltd Anti-glypican 3 antibody
US7820401B2 (en) 2004-08-23 2010-10-26 Albert Einstein College Of Medicine Of Yeshiva University Collagen VI and cancer
US20090142345A1 (en) 2005-03-15 2009-06-04 Takeda Pharmaceutical Company Limited Prophylactic/therapeutic agent for cancer
JP5140579B2 (ja) 2005-06-08 2013-02-06 カンジェーン コーポレイション 病原菌に対する生体防御を増強するヒアルロン酸結合性ペプチド
CN104356236B (zh) 2005-07-01 2020-07-03 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
EP1999154B1 (fr) 2006-03-24 2012-10-24 Merck Patent GmbH Domaines de proteine heterodimerique d'ingenierie
EP1864996A1 (fr) 2006-06-06 2007-12-12 Helmholtz-Zentrum für Infektionsforschung GmbH Peptide associé de la fievre rhumatismale et son utilisation comme marquer diagnostique.
HU0600578D0 (en) 2006-07-13 2006-09-28 Szilak Labor Bioinformatikai E Nuclear protein transport
CA2660455A1 (fr) 2006-08-08 2008-02-14 Seikagaku Corporation Procede de determination du poids moleculaire d'un acide hyaluronique
WO2008089448A2 (fr) 2007-01-19 2008-07-24 Cornell Presearch Foundation, Inc. Procédés et compositions pour la favorisation de la survie et de la prolifération de cellules endothéliales et la stimulation d'angiogenèse
US8680247B2 (en) 2007-07-17 2014-03-25 Medarex, L.L.C. Monoclonal antibodies against glypican-3
WO2009089004A1 (fr) 2008-01-07 2009-07-16 Amgen Inc. Méthode de fabrication de molécules hétérodimères fc d'anticorps utilisant les effets de conduite électrostatique
US8663929B2 (en) 2008-03-17 2014-03-04 University Of Miyazaki Method for detection of liver cancer cell using anti-glypican-3 antibody
US20090297479A1 (en) 2008-03-28 2009-12-03 Kiyoshi Ariizumi Dc-hil conjugates for treatment of t-cell disorders
CA2720368C (fr) 2008-04-02 2017-08-22 Macrogenics, Inc. Anticorps specifiques de her2/neu et procedes d'utilisation de ceux-ci
JP5477287B2 (ja) 2008-04-15 2014-04-23 和光純薬工業株式会社 新規なヒアルロン酸結合能を有するタンパク質及びこれを用いたヒアルロン酸の測定方法
WO2010033866A2 (fr) 2008-09-19 2010-03-25 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Anticorps monoclonaux de cspg4 utilises dans le diagnostic et le traitement du carcinome mammaire de type basal
GB0818273D0 (en) 2008-10-06 2008-11-12 Cambridge Entpr Ltd Modulation of cellular activity and differentiation
KR101105428B1 (ko) 2009-02-12 2012-01-17 경북대학교 산학협력단 글리피칸-3 단백질과 특이적으로 결합하는 펩타이드
EP2417159A1 (fr) 2009-04-07 2012-02-15 Roche Glycart AG Anticorps anti-erbb-3/anti-c-met bispécifiques
US20120100106A1 (en) 2009-05-04 2012-04-26 Purdue Research Foundation Collagen-binding synthetic peptidoglycans for wound healing
JP5764127B2 (ja) 2009-08-17 2015-08-12 ロシュ グリクアート アーゲー 標的化イムノコンジュゲート
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
SG184427A1 (en) * 2010-04-20 2012-11-29 Genmab As Heterodimeric antibody fc-containing proteins and methods for production thereof
RU2624027C2 (ru) 2010-04-23 2017-06-30 Дженентек, Инк. Получение гетеромультимерных белков
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
WO2012032080A1 (fr) 2010-09-07 2012-03-15 F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H Fc humain stabilisé
US8906649B2 (en) 2010-09-27 2014-12-09 Janssen Biotech, Inc. Antibodies binding human collagen II
JP6167040B2 (ja) 2010-11-05 2017-07-19 ザイムワークス，インコーポレイテッド Ｆｃドメイン中に突然変異を有する、安定したヘテロ二量体抗体の設計
JP6100694B2 (ja) 2010-11-15 2017-03-22 ピエリス ファーマシューティカルズ ゲーエムベーハー グリピカン−３（ｇｐｃ３）に対して親和性を有するヒトリポカリン２の突然変異タンパク質
BR112013013311A2 (pt) * 2010-11-30 2017-09-19 Chugai Pharmaceutical Co Ltd agente terapêutico de indução de citotoxicidade
US10689447B2 (en) 2011-02-04 2020-06-23 Genentech, Inc. Fc variants and methods for their production
DK3489255T3 (da) * 2011-02-10 2021-08-23 Roche Glycart Ag Muterede interleukin-2-polypeptider
EP3590965A1 (fr) 2011-03-29 2020-01-08 Roche Glycart AG Variants de fc d'anticorps
EP3070104B1 (fr) 2011-04-19 2017-12-27 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps monoclonaux humains spécifiques au glypican-3 et leur utilisation
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
ES2708076T3 (es) 2011-05-24 2019-04-08 Symic Ip Llc Peptidoglicanos sintéticos que se unen al ácido hialurónico, preparación y métodos de uso
PL3351261T3 (pl) * 2011-10-11 2021-12-06 Universität Zürich Lek złożony zawierający IL-12 i środek do blokowania cząsteczek hamujących komórki T w terapii nowotworów
US20140322216A1 (en) 2011-11-08 2014-10-30 The Trustees Of The University Of Pennsylvania Glypican-3-specific antibody and uses thereof
EP2804586A4 (fr) 2012-01-19 2016-03-16 Univ Johns Hopkins Biomatériaux comprenant des peptides se liant à l'acide hyaluronique et des molécules biopolymères bifonctionnelles pour des applications de rétention d'acide hyaluronique et d'ingénierie tissulaire
NZ630551A (en) 2012-04-20 2017-11-24 Merus Nv Methods and means for the production of ig-like molecules
WO2013163766A1 (fr) 2012-05-04 2013-11-07 Cangene Corporation Compositions antimicrobiennes comprenant un peptide de liaison à l'acide hyaluronique et un antibiotique β-lactame
WO2013174783A1 (fr) 2012-05-23 2013-11-28 Pieris Ag Mutéines de lipocaline avec affinité de liaison pour le glypican-3 (gpc-3) et utilisation de mutéines de lipocaline pour la délivrance spécifique de la cible aux cellules exprimant le gpc-3
JP6494507B2 (ja) 2012-06-01 2019-04-03 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ グリピカン−３に対する高親和性モノクローナル抗体およびその使用
DK2880170T3 (en) 2012-08-02 2016-10-24 Hoffmann La Roche PROCEDURE FOR PREPARING SOLUBLE FcR AS Fc FUSION WITH INERT IMMUNOGLOBULIN Fc REGION AND APPLICATIONS THEREOF
SG11201408530YA (en) 2012-08-02 2015-03-30 Hoffmann La Roche Method for producing monomeric and multimeric molecules and uses thereof
MX365382B (es) 2012-08-07 2019-05-31 Roche Glycart Ag Una combinación de inmunoconjugado y anticuerpo para usarse en el tratamiento de cáncer.
US9951145B2 (en) 2012-11-27 2018-04-24 Ajou University Industry—Academic Cooperation Foundation CH3 domain variant pair inducing formation of heterodimer of heavy chain constant region of antibody at high efficiency, method for preparing same, and use thereof
US20140302037A1 (en) * 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
SG11201507429TA (en) * 2013-03-15 2015-10-29 Genentech Inc Il-22 polypeptides and il-22 fc fusion proteins and methods of use
AU2014232416B2 (en) 2013-03-15 2017-09-28 Xencor, Inc. Modulation of T Cells with Bispecific Antibodies and FC Fusions
US10047167B2 (en) 2013-03-15 2018-08-14 Eli Lilly And Company Methods for producing fabs and bi-specific antibodies
EP2992010B1 (fr) 2013-04-29 2021-03-24 F.Hoffmann-La Roche Ag Anticorps asymétrique modifié de liaison fc-receptor et procédés d'utilisation
US10093745B2 (en) 2013-05-29 2018-10-09 The Regents Of The University Of California Anti-CSPG4 fusions with interferon for the treatment of malignancy
AR096891A1 (es) 2013-07-12 2016-02-03 Hanmi Pharm Ind Co Ltd Conjugado de monómero polipéptido biológicamente activo y conjugado de fragmento fc de inmunoglobulina, que muestra aclaramiento mediado por receptor reducido, y el método para la preparación del mismo
UA117289C2 (uk) 2014-04-02 2018-07-10 Ф. Хоффманн-Ля Рош Аг Мультиспецифічне антитіло
US20160032007A1 (en) 2014-04-28 2016-02-04 Duke University Human Antibody Fragments Against Chondroitin Sulfate Proteoglycan 4 (CSPG4)
BR122021009041B1 (pt) 2014-05-06 2022-11-29 Genentech, Inc Métodos para a preparação de uma proteína heteromultimérica
CA2952727A1 (fr) 2014-06-27 2015-12-30 Innate Pharma Proteines de liaison nkp46 multispecifiques
WO2016007919A2 (fr) 2014-07-11 2016-01-14 Regents Of The University Of Minnesota Fragments d'anticorps pour détecter un cancer et méthodes d'utilisation
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
RU2713131C1 (ru) 2014-11-06 2020-02-03 Ф. Хоффманн-Ля Рош Аг ВАРИАНТЫ Fc-ОБЛАСТИ С МОДИФИЦИРОВАННЫМИ СВОЙСТВАМИ СВЯЗЫВАНИЯ FcRn И БЕЛКА А
SI3215528T1 (sl) 2014-11-06 2019-11-29 Hoffmann La Roche Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe
CA2967350C (fr) 2014-11-12 2021-11-23 The General Hospital Corporation Anticorps anti-proteoglycane de chondroitine-sulfate 4 et utilisations de ceux-ci
WO2016154019A1 (fr) 2015-03-20 2016-09-29 Orbsen Therapeutics Limited Modulateurs de de syndécane 2 et leurs utilisations
US10881711B2 (en) 2015-04-06 2021-01-05 The General Hospital Corporation Anti-CSPG4 reagents and methods of treating cancer
WO2016208754A1 (fr) 2015-06-24 2016-12-29 学校法人慶應義塾 Récepteur antigénique immunisant anti-glypicane-1
RU2740672C2 (ru) * 2015-08-07 2021-01-19 ЭйЭлЭкс Онколоджи Инк. Конструкции, имеющие sirp-альфа домен или его вариант
AU2016322919B2 (en) 2015-09-14 2022-12-22 Regents Of The University Of Minnesota NK cells exhibiting an adaptive phenotype and methods for preparing and for using
ES2809125T3 (es) 2015-09-23 2021-03-03 Bristol Myers Squibb Co Moléculas de armazón a base de fibronectina de unión a glipicano-3
WO2017062604A1 (fr) 2015-10-06 2017-04-13 Regents Of The University Of Minnesota Composés thérapeutiques et procédés
KR101851380B1 (ko) 2015-10-12 2018-04-23 아주대학교산학협력단 효모접합을 이용한 항체 ch3 도메인 이종이중체 돌연변이쌍 제조 방법 및 이에 의하여 제조된 ch3 돌연변이체 쌍
KR101796688B1 (ko) 2015-10-29 2017-12-01 재단법인 목암생명과학연구소 신규 항-글리피칸 3 항체 및 이를 포함하는 약학적 조성물
JP6983824B2 (ja) 2016-07-04 2021-12-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 新規抗体フォーマット
AU2017305170A1 (en) 2016-08-02 2019-02-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies targeting glypican-2 (GPC2) and use thereof
WO2018030806A1 (fr) * 2016-08-10 2018-02-15 아주대학교산학협력단 Cytokine fusionnée à un hétérodimère fc d'immunoglobuline et composition pharmaceutique la contenant
CA3033475A1 (fr) 2016-08-10 2018-02-15 Ajou University Industry-Academic Cooperation Foundation Cytokine a fusion fc heterodimerique et composition pharmaceutique la comprenant
CN110214148A (zh) * 2016-10-14 2019-09-06 Xencor股份有限公司 含有IL-15/IL-15Rα Fc融合蛋白和PD-1抗体片段的双特异性异源二聚体融合蛋白
CA3054079A1 (fr) 2017-02-20 2018-08-23 Dragonfly Therapeutics, Inc. Proteines se liant a her2, nkg2d et cd16
CN110831634A (zh) 2017-03-08 2020-02-21 密歇根大学董事会 磷脂酰肌醇蛋白聚糖-3肽试剂和方法
RU2019133202A (ru) 2017-03-27 2021-04-28 Ф. Хоффманн-Ля Рош Аг Улучшенные антигенсвязывающие рецепторы
US11242403B2 (en) 2017-04-26 2022-02-08 Mitsubishi Tanabe Pharma Corporation Syndecan-1 (CD138) binding agents and uses thereof
WO2018199318A1 (fr) 2017-04-28 2018-11-01 国立大学法人高知大学 Anticorps anti-gpc-1
JP2019014449A (ja) 2017-07-10 2019-01-31 トヨタ自動車株式会社 車両用動力伝達装置
CA3112984A1 (fr) 2017-09-07 2019-03-14 Dragonfly Therapeutics, Inc. Proteines de liaison a nkg2d, cd16 et un antigene associe a une tumeur
EP3684791A1 (fr) * 2017-09-21 2020-07-29 Merck Patent GmbH Protéine de fusion comprenant une fraction fgf-18
BR112020005676A2 (pt) * 2017-09-22 2020-10-20 WuXi Biologics Ireland Limited novos complexos polipeptídicos biespecíficos
CN111246885A (zh) 2017-10-20 2020-06-05 豪夫迈·罗氏有限公司 从单特异性抗体生成多特异性抗体的方法
AU2019218125A1 (en) 2018-02-08 2020-08-20 Dragonfly Therapeutics, Inc. Combination therapy of cancer involving multi-specific binding proteins that activate natural killer cells
DE102018208278A1 (de) 2018-05-25 2019-11-28 Robert Bosch Gmbh Betriebsassistenzverfahren, Steuereinheit, Betriebsassistenzsystem und Arbeitsvorrichtung
MX2021000287A (es) * 2018-07-11 2021-09-08 Momenta Pharmaceuticals Inc Composiciones y métodos relacionados con constructos de dominio de unión a antígeno-fc modificados genéticamente.
PE20211279A1 (es) 2018-10-23 2021-07-19 Dragonfly Therapeutics Inc Proteinas heterodimericas fusionadas con fc

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US20230033425A1 (en) 2023-02-02
CA3117212A1 (fr) 2020-04-30
KR20210080460A (ko) 2021-06-30
MX2021004711A (es) 2021-07-02
US20220119533A1 (en) 2022-04-21
EP3870598A1 (fr) 2021-09-01
US11787864B2 (en) 2023-10-17
MA53982A (fr) 2022-01-26
BR112021007175A2 (pt) 2021-08-10
CL2022000900A1 (es) 2023-01-20
JP2022505871A (ja) 2022-01-14
CL2021001058A1 (es) 2021-11-12
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CO2021006474A2 (es) 2021-06-10
CN113286808A (zh) 2021-08-20

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